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磷酸吡哆醛

35篇引用文献
  • CAS编号: 54-47-7
  • 分子式: C8H10NO6P
  • 分子量: 247.14
  • PubChem编号: 1051
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货号 (SKU) 包装规格 是否现货 价格 数量
P101874-1g
 1g 现货 Stock Image
P101874-5g
 5g 现货 Stock Image
P101874-10g
 10g 现货 Stock Image
P101874-25g
 25g 现货 Stock Image
P101874-100g
 100g 现货 Stock Image
P101874-500g
 500g 期货 Stock Image
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Anti-infection (2825) Reverse Transcriptase (71)
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基本描述

别名 吡哆醛磷酸 | 3-羟基-2-甲基-5-([磷酰氧基]甲基)-4-吡啶甲醛 | 吡哆醛5-磷酸 | 辅脱羧酶
英文别名 PLP | Vitazechs | FT-0631236 | P5P | P-5'-P | Pyromijin | 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate | CCG-266929 | EX-A980 | MC-1 | Pyridoxal 5/'-phosphate (hydrate) | SGCUT00188 | VITAMIN B6 (PYRIDOXAL 5-PHOSPHATE) | 3-hydroxy-2-
规格或纯度 Moligand™, ≥98%
英文名称 Pyridoxal phosphate
生化机理 5′- 磷酸吡哆醛（PLP）作为一种辅助因子，有助于碳水化合物和脂肪的新陈代谢。它主要负责催化涉及鞘脂合成和神经递质（多巴胺和血清素）合成的酶促反应。PLP 用于研究依赖 PLP 的酶活性位点。PLP 还是多种酶的辅助因子，包括线粒体 5-氨基乙酰丙酸合成酶（ALAS）、半胱氨酸脱硫酶、胱硫醚 γ 合成酶（CGS）、鸟氨酸 4,5-氨基变构酶（OAM）和 D-丝氨酸脱水酶。
储存温度 -20°C储存
运输条件 超低温冰袋运输
产品介绍


Pyridoxal 5′-phosphate (PLP) is synthesized in a multiple-step process. The two pathways inlcude pyridoxal phosphate biosynthetic protein (PdxA)- pyridoxine-5′-phosphate synthase (PdxJ) pathway and the pyridoxal 5′-phosphate synthase subunit PDX1/PDX2 pathway. It is the active form of pyridoxine.  Pyridoxal 5′-phosphate hydrate has also been used: • as a reference standard to quantify vitamin B6 in feed and digesta samples using high performance liquid chromatography (HPLC) • in D-amino acid transaminase reaction(10) • as a cofactor for L-glutamic acid decarboxylase

AI解读

关联靶点（人）

P2RX1 Tchem P2X嘌呤受体1(P2X purinoceptor 1) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
F2 Tclin Thrombin (11687 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2RX4 Tchem P2X purinoceptor 4 (516 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2RX1 Tchem P2X purinoceptor 1 (328 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAD Tchem Dihydroorotase (27 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTPRB Tchem Receptor-type tyrosine-protein phosphatase beta (330 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACP1 Tchem Low molecular weight phosphotyrosine protein phosphatase (1161 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

P2rx2 P2X purinoceptor 2 (106 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
P2rx3 P2X purinoceptor 3 (632 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trans-sialidase (51 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 小分子
IUPAC Name (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate
INCHI InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChi Key NGVDGCNFYWLIFO-UHFFFAOYSA-N
Canonical SMILES CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O
Isomeric SMILES CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O
PubChem CID 1051
分子量 247.14

化学和物理性质

溶解性 Soluble in oxygen-free H2O. Insoluble in most organic solvents.
密度 1.638
敏感性 对湿度敏感
熔点 140-143°C
分子量 247.140 g/mol
XLogP3 -1.100
氢键供体数Hydrogen Bond Donor Count 3
氢键受体数Hydrogen Bond Acceptor Count 7
可旋转键计数Rotatable Bond Count 4
精确质量Exact Mass 247.025 Da
单同位素质量Monoisotopic Mass 247.025 Da
拓扑极表面积Topological Polar Surface Area 117.000 Ų
重原子数Heavy Atom Count 16
形式电荷Formal Charge 0
复杂度Complexity 292.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

 SDS英文版

技术规格说明书

Water by Karl Fischer 0-1（%）
Purity(HPLC) 98-100（%）
Appearance（P101874) Off-white to yellow crystals or powder
Proton NMR spectrum Conforms to Structure
Solubility in 1 M HCl，Colorless to Yellow-Green,Clear,50 mg/ml pass

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找到24个结果

批号(Lot Number) 证书类型 日期 货号
E2529154 分析证书 25-06-02 P101874
D2527454 分析证书 25-04-28 P101874
G2305718 分析证书 25-03-27 P101874
G2305813 分析证书 25-03-27 P101874
G2305814 分析证书 25-03-27 P101874
G2305815 分析证书 25-03-27 P101874
G2305816 分析证书 25-03-27 P101874
G2305817 分析证书 25-03-27 P101874
G2305818 分析证书 25-03-27 P101874
G2305819 分析证书 25-03-27 P101874
G2305820 分析证书 25-03-27 P101874
G2305821 分析证书 25-03-27 P101874
G2305822 分析证书 25-03-27 P101874
E2209052 分析证书 24-02-23 P101874
E2209054 分析证书 24-02-23 P101874
E2209055 分析证书 24-02-23 P101874
I2126311 分析证书 23-07-10 P101874
I2126310 分析证书 23-07-10 P101874
B2327530 分析证书 23-03-01 P101874
B2327513 分析证书 23-03-01 P101874
B2327667 分析证书 23-03-01 P101874
G2305812 分析证书 23-01-12 P101874
F2428046 分析证书 23-01-12 P101874
A2303251 分析证书 22-11-23 P101874

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谷氨酸与GABA的合成与代谢
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29. Zhang Zhi-Jun, Cai Rui-Feng, Xu Jian-He.  (2018)  Characterization of a new nitrilase from Hoeflea phototrophica DFL-43 for a two-step one-pot synthesis of (S)-β-amino acids.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,  102  (14): (6047-6056).  [PMID:29744634] [10.1007/s00253-018-9057-7]
30. Qian Wang, Xiao-Mei He, Xi Chen, Gang-Tian Zhu, Ren-Qi Wang, Yu-Qi Feng.  (2017)  Pyridoxal 5′-phosphate mediated preparation of immobilized metal affinity material for highly selective and sensitive enrichment of phosphopeptides.  JOURNAL OF CHROMATOGRAPHY A,  1499  (30).  [PMID:28390667] [10.1016/j.chroma.2017.03.085]
31. Wu Hua-Lei, Zhang Jian-Dong, Zhang Chao-Feng, Fan Xiao-Jun, Chang Hong-Hong, Wei Wen-Long.  (2017)  Characterization of Four New Distinct ω-Transaminases from Pseudomonas putida NBRC 14164 for Kinetic Resolution of Racemic Amines and Amino Alcohols.  APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,  181  (3): (972-985).  [PMID:27714638] [10.1007/s12010-016-2263-9]
32. Ailin Xiao, Jing Li, Tianjian Liu, Zhuxi Liu, Chuanfei Wei, Xiaomeng Xu, Qin Li, Jingxin Li.  (2016)  l-Cysteine enhances nutrient absorption via a cystathionine-β-synthase-derived H2S pathway in rodent jejunum.  CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,  43  (5): (562-568).  [PMID:26901099] [10.1111/1440-1681.12562]
33. S. Tang, D. Huang, N. An, D. Chen, D. Zhao.  (2016)  A novel pathway for the production of H2S by DAO in rat jejunum.  NEUROGASTROENTEROLOGY AND MOTILITY,  28  (5): (687-692).  [PMID:26813142] [10.1111/nmo.12765]
34. Miao Chen, Liya Rong, Xiaoqing Chen.  (2015)  A simple and sensitive detection of glutamic-pyruvic transaminase activity based on fluorescence quenching of bovine serum albumin.  RSC Advances,  5  (125): (103557-103562).  [10.1039/C5RA24162F]
35. Ailin Xiao,Hongjuan Wang,Xin Lu,Jianchun Zhu,Di Huang,Tonghui Xu,Jianqiang Guo,Chuanyong Liu,Jingxin Li.  (2015-11-05)  H2S, a novel gasotransmitter, involves in gastric accommodation..  Scientific reports,  5  (16086-16086).  [PMID:26531221]

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32. Ailin Xiao, Jing Li, Tianjian Liu, Zhuxi Liu, Chuanfei Wei, Xiaomeng Xu, Qin Li, Jingxin Li.  (2016)  l-Cysteine enhances nutrient absorption via a cystathionine-β-synthase-derived H2S pathway in rodent jejunum.  CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,  43  (5): (562-568).  [PMID:26901099] [10.1111/1440-1681.12562]
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