LRRK2 - 自噬 - 按“信号通路”分类

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IKK-16(IKK抑制剂VII)

规格或纯度 :

≥99%

CAS号 : 873225-46-8 Compound CID : 9549298

分子式: C₂₈H₂₉N₅OS 分子量: 483.63

IUPAC Name: [4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone

SMILES: C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5

InChIKey: BWZJBXAPRCVCKQ-UHFFFAOYSA-N

InChI: InChI=1S/C28H29N5OS/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31)

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LRRK2-IN-1,帕金森氏病激酶LRRK2的有效抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号 : 1234480-84-2 Compound CID : 46843906

分子式: C₃₁H₃₈N₈O₃ 分子量: 570.7

IUPAC Name: 2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one

SMILES: CN1CCN(CC1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)NC4=NC=C5C(=N4)N(C6=CC=CC=C6C(=O)N5C)C)OC

InChIKey: IWMCPJZTADUIFX-UHFFFAOYSA-N

InChI: InChI=1S/C31H38N8O3/c1-35-15-17-38(18-16-35)22-11-13-39(14-12-22)29(40)21-9-10-24(27(19-21)42-4)33-31-32-20-26-28(34-31)36(2)25-8-6-5-7-23(25)30(41)37(26)3/h5-10,19-20,22H,11-18H2,1-4H3,(H,32,33,34)

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吲唑

规格或纯度 :

≥99%

CAS号 : 271-44-3 Compound CID : 9221

分子式: C₇H₆N₂ 分子量: 118.14

IUPAC Name: 1H-indazole

SMILES: C1=CC=C2C(=C1)C=NN2

InChIKey: BAXOFTOLAUCFNW-UHFFFAOYSA-N

InChI: InChI=1S/C7H6N2/c1-2-4-7-6(3-1)5-8-9-7/h1-5H,(H,8,9)

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GSK2578215A,LRRK2抑制剂

规格或纯度 :

≥98%(HPLC)

CAS号 : 1285515-21-0 Compound CID : 68107965

分子式: C₂₄H₁₈FN₃O₂ 分子量: 399.42

IUPAC Name: 5-(2-fluoropyridin-4-yl)-2-phenylmethoxy-N-pyridin-3-ylbenzamide

SMILES: C1=CC=C(C=C1)COC2=C(C=C(C=C2)C3=CC(=NC=C3)F)C(=O)NC4=CN=CC=C4

InChIKey: WCIGMFCFPXZRMQ-UHFFFAOYSA-N

InChI: InChI=1S/C24H18FN3O2/c25-23-14-19(10-12-27-23)18-8-9-22(30-16-17-5-2-1-3-6-17)21(13-18)24(29)28-20-7-4-11-26-15-20/h1-15H,16H2,(H,28,29)

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IKK-16,IκB激酶抑制剂

规格或纯度 :

≥98%

CAS号 : 1186195-62-9 Compound CID : 56972179

分子式: C₂₈H₂₉N₅OS • HCl 分子量: 520.09

IUPAC Name: [4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone;hydrochloride

SMILES: C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl

InChIKey: XFVDIVQCZWDBCW-UHFFFAOYSA-N

InChI: InChI=1S/C28H29N5OS.ClH/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26;/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31);1H

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JH-II-127,LRRK2抑制剂

规格或纯度 :

≥98%

CAS号 : 1700693-08-8 Compound CID : 112499966

分子式: C₁₉H₂₁ClN₆O₃ 分子量: 416.87

IUPAC Name: [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone

SMILES: CNC1=NC(=NC2=C1C(=CN2)Cl)NC3=C(C=C(C=C3)C(=O)N4CCOCC4)OC

InChIKey: HUEKBQXFNHWTQQ-UHFFFAOYSA-N

InChI: InChI=1S/C19H21ClN6O3/c1-21-16-15-12(20)10-22-17(15)25-19(24-16)23-13-4-3-11(9-14(13)28-2)18(27)26-5-7-29-8-6-26/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24,25)

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GNE7915,LRRK2抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号 : 1351761-44-8 Compound CID : 58539171

分子式: C₁₉H₂₁F₄N₅O₃ 分子量: 443.4

IUPAC Name: [4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone

SMILES: CCNC1=NC(=NC=C1C(F)(F)F)NC2=C(C=C(C(=C2)F)C(=O)N3CCOCC3)OC

InChIKey: XCFLWTZSJYBCPF-UHFFFAOYSA-N

InChI: InChI=1S/C19H21F4N5O3/c1-3-24-16-12(19(21,22)23)10-25-18(27-16)26-14-9-13(20)11(8-15(14)30-2)17(29)28-4-6-31-7-5-28/h8-10H,3-7H2,1-2H3,(H2,24,25,26,27)

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MLi-2,LRRK2抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号 : 1627091-47-7 Compound CID : 78319901

分子式: C₂₁H₂₅N₅O₂ 分子量: 379.46

IUPAC Name: (2R,6S)-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1H-indazol-3-yl]pyrimidin-4-yl]morpholine

SMILES: CC1CN(CC(O1)C)C2=NC=NC(=C2)C3=NNC4=C3C=C(C=C4)OC5(CC5)C

InChIKey: ATUUNJCZCOMUKD-OKILXGFUSA-N

InChI: InChI=1S/C21H25N5O2/c1-13-10-26(11-14(2)27-13)19-9-18(22-12-23-19)20-16-8-15(28-21(3)6-7-21)4-5-17(16)24-25-20/h4-5,8-9,12-14H,6-7,10-11H2,1-3H3,(H,24,25)/t13-,14+

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CZC 54252 盐酸盐

规格或纯度 :

≥98%(HPLC)

CAS号 : 1784253-05-9 Compound CID : 90488950

分子式: C₂₂H₂₆Cl₂N₆O₄S 分子量: 541.45

IUPAC Name: N-[2-[[5-chloro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanesulfonamide;hydrochloride

SMILES: COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)Cl.Cl

InChIKey: KWCBHUPLQMUKAF-UHFFFAOYSA-N

InChI: InChI=1S/C22H25ClN6O4S.ClH/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31;/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);1H

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CZC 25146,LRRK2抑制剂

规格或纯度 :

≥98%(HPLC)

CAS号 : 1191911-26-8 Compound CID : 44252884

分子式: C₂₂H₂₅FN₆O₄S 分子量: 488.54

IUPAC Name: N-[2-[[5-fluoro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanesulfonamide

SMILES: COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)F

InChIKey: XXHHOTZUJIXPJX-UHFFFAOYSA-N

InChI: InChI=1S/C22H25FN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27)

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HG-10-102-01

规格或纯度 :

Moligand™

≥98%

CAS号 : 1351758-81-0 Compound CID : 58539301

分子式: C₁₇H₂₀ClN₅O₃ 分子量: 377.83

IUPAC Name: [4-[[5-chloro-4-(methylamino)pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone

SMILES: CNC1=NC(=NC=C1Cl)NC2=C(C=C(C=C2)C(=O)N3CCOCC3)OC

InChIKey: YEVOZZZLKJKCCD-UHFFFAOYSA-N

InChI: InChI=1S/C17H20ClN5O3/c1-19-15-12(18)10-20-17(22-15)21-13-4-3-11(9-14(13)25-2)16(24)23-5-7-26-8-6-23/h3-4,9-10H,5-8H2,1-2H3,(H2,19,20,21,22)

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