PCSK9 - 代谢酶/蛋白酶 - 按“信号通路”分类

Anacetrapib,胆固醇脂转移蛋白阻滞剂

规格或纯度 :

≥98%

CAS号 : 875446-37-0 Compound CID : 11556427

分子式: C₃₀H₂₅F₁₀NO₃ 分子量: 637.51

IUPAC Name: (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[[2-(4-fluoro-2-methoxy-5-propan-2-ylphenyl)-5-(trifluoromethyl)phenyl]methyl]-4-methyl-1,3-oxazolidin-2-one

SMILES: CC1C(OC(=O)N1CC2=C(C=CC(=C2)C(F)(F)F)C3=CC(=C(C=C3OC)F)C(C)C)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F

InChIKey: MZZLGJHLQGUVPN-HAWMADMCSA-N

InChI: InChI=1S/C30H25F10NO3/c1-14(2)22-11-23(25(43-4)12-24(22)31)21-6-5-18(28(32,33)34)9-17(21)13-41-15(3)26(44-27(41)42)16-7-19(29(35,36)37)10-20(8-16)30(38,39)40/h5-12,14-15,26H,13H2,1-4H3/t15-,26-/m0/s1

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Alirocumab (anti-PCSK9)

规格或纯度 :

Moligand™

≥95%
75mg/ml in buffer

关联靶标: PCSK9

亚型: Human IgG1

CAS号 : 1245916-14-6

SMILES: C(C(COP(=O)(O)O)O)O.[Na].[Na]

InChIKey: CATWCRUATKKAAQ-UHFFFAOYSA-N

InChI: InChI=1S/C3H9O6P.2Na/c4-1-3(5)2-9-10(6,7)8;;/h3-5H,1-2H2,(H2,6,7,8);;

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Pep 2-8，强效的PCSK9抑制剂

规格或纯度 :

≥95%

CAS号 : 1541011-97-5 Compound CID : 124221781

分子式: C₈₃H₁₁₀N₁₆O₂₄ 分子量: 1715.88

IUPAC Name: (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-acetamido-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

SMILES: CC(C)CC(C(=O)NC(CC(=O)O)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(C(C)C)C(=O)N)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC4=CNC5=CC=CC=C54)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC6=CC=CC=C6)NC(=O)C(C(C)C)NC(=O)C(C(C)O)NC(=O)C

InChIKey: ORPZALWAWWEEDP-NXXUBLNKSA-N

InChI: InChI=1S/C83H110N16O24/c1-40(2)31-57(74(114)94-62(36-66(109)110)77(117)92-61(79(119)97-67(41(3)4)71(84)111)35-49-38-86-54-22-16-14-20-52(49)54)90-75(115)58(33-47-23-25-50(104)26-24-47)91-73(113)56(28-30-65(107)108)88-72(112)55(27-29-64(105)106)89-76(116)60(34-48-37-85-53-21-15-13-19-51(48)53)93-80(120)63(39-100)96-82(122)70(44(8)102)99-78(118)59(32-46-17-11-10-12-18-46)95-81(121)68(42(5)6)98-83(123)69(43(7)101)87-45(9)103/h10-26,37-38,40-44,55-63,67-70,85-86,100-102,104H,27-36,39H2,1-9H3,(H2,84,111)(H,87,103)(H,88,112)(H,89,116)(H,90,115)(H,91,113)(H,92,117)(H,93,120)(H,94,114)(H,95,121)(H,96,122)(H,97,119)(H,98,123)(H,99,118)(H,105,106)(H,107,108)(H,109,110)/t43-,44-,55+,56+,57+,58+,59+,60+,61+,62+,63+,67+,68+,69+,70+/m1/s1

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2-羟基-5-甲氧基-3-十一烷基-[1,4]苯醌

CAS号 : 56005-10-8 Compound CID : 171489

分子式: C₁₈H₂₈O₄ 分子量: 308.418

IUPAC Name: 2-hydroxy-5-methoxy-3-undecylcyclohexa-2,5-diene-1,4-dione

SMILES: CCCCCCCCCCCC1=C(C(=O)C=C(C1=O)OC)O

InChIKey: KHBJLRRAMCJZLZ-UHFFFAOYSA-N

InChI: InChI=1S/C18H28O4/c1-3-4-5-6-7-8-9-10-11-12-14-17(20)15(19)13-16(22-2)18(14)21/h13,20H,3-12H2,1-2H3

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SBC-110736

规格或纯度 :

≥98%

CAS号 : 1629166-02-4 Compound CID : 78425817

分子式: C₂₆H₂₇N₃O₂ 分子量: 413.51

IUPAC Name: N-[4-[4-(4-methylphenyl)-2-phenylpiperazine-1-carbonyl]phenyl]acetamide

SMILES: CC1=CC=C(C=C1)N2CCN(C(C2)C3=CC=CC=C3)C(=O)C4=CC=C(C=C4)NC(=O)C

InChIKey: PILMFSWQYWYOJC-UHFFFAOYSA-N

InChI: InChI=1S/C26H27N3O2/c1-19-8-14-24(15-9-19)28-16-17-29(25(18-28)21-6-4-3-5-7-21)26(31)22-10-12-23(13-11-22)27-20(2)30/h3-15,25H,16-18H2,1-2H3,(H,27,30)

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PF-06446846

规格或纯度 :

≥98%

CAS号 : 1632250-49-7 Compound CID : 86271238

分子式: C₂₂H₂₀ClN₇O 分子量: 433.89

IUPAC Name: N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(triazolo[4,5-b]pyridin-3-yl)benzamide

SMILES: C1CC(CNC1)N(C2=C(C=CC=N2)Cl)C(=O)C3=CC=C(C=C3)N4C5=C(C=CC=N5)N=N4

InChIKey: FDTXHWQFIXYHCL-QGZVFWFLSA-N

InChI: InChI=1S/C22H20ClN7O/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21/h2-3,5-10,12-13,17,24H,1,4,11,14H2/t17-/m1/s1

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R-IMPP

规格或纯度 :

≥98%

CAS号 : 2133832-83-2 Compound CID : 122198706

分子式: C₂₄H₂₇N₃O₂ 分子量: 389.49

IUPAC Name: N-isoquinolin-1-yl-3-(4-methoxyphenyl)-N-[(3R)-piperidin-3-yl]propanamide

SMILES: COC1=CC=C(C=C1)CCC(=O)N(C2CCCNC2)C3=NC=CC4=CC=CC=C43

InChIKey: OKTGXQMSOIQCTJ-HXUWFJFHSA-N

InChI: InChI=1S/C24H27N3O2/c1-29-21-11-8-18(9-12-21)10-13-23(28)27(20-6-4-15-25-17-20)24-22-7-3-2-5-19(22)14-16-26-24/h2-3,5,7-9,11-12,14,16,20,25H,4,6,10,13,15,17H2,1H3/t20-/m1/s1

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R-IMPP

规格或纯度 :

10mM in DMSO

CAS号 : 2133832-83-2 Compound CID : 122198706

分子式: C₂₄H₂₇N₃O₂ 分子量: 389.49

IUPAC Name: N-isoquinolin-1-yl-3-(4-methoxyphenyl)-N-[(3R)-piperidin-3-yl]propanamide

SMILES: COC1=CC=C(C=C1)CCC(=O)N(C2CCCNC2)C3=NC=CC4=CC=CC=C43

InChIKey: OKTGXQMSOIQCTJ-HXUWFJFHSA-N

InChI: InChI=1S/C24H27N3O2/c1-29-21-11-8-18(9-12-21)10-13-23(28)27(20-6-4-15-25-17-20)24-22-7-3-2-5-19(22)14-16-26-24/h2-3,5,7-9,11-12,14,16,20,25H,4,6,10,13,15,17H2,1H3/t20-/m1/s1

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SBC-110736

规格或纯度 :

10mM in DMSO

CAS号 : 1629166-02-4 Compound CID : 78425817

分子式: C₂₆H₂₇N₃O₂ 分子量: 413.51

IUPAC Name: N-[4-[4-(4-methylphenyl)-2-phenylpiperazine-1-carbonyl]phenyl]acetamide

SMILES: CC1=CC=C(C=C1)N2CCN(C(C2)C3=CC=CC=C3)C(=O)C4=CC=C(C=C4)NC(=O)C

InChIKey: PILMFSWQYWYOJC-UHFFFAOYSA-N

InChI: InChI=1S/C26H27N3O2/c1-19-8-14-24(15-9-19)28-16-17-29(25(18-28)21-6-4-3-5-7-21)26(31)22-10-12-23(13-11-22)27-20(2)30/h3-15,25H,16-18H2,1-2H3,(H,27,30)

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