PARP - 表观遗传学 - 按“信号通路”分类

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AG14361

规格或纯度 :

Moligand™

≥98%

CAS号 : 328543-09-5 Compound CID : 9840076

分子式: C₁₉H₂₀N₄O 分子量: 320.4

IUPAC Name: 2-[4-[(dimethylamino)methyl]phenyl]-1,3,10-triazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-9-one

SMILES: CN(C)CC1=CC=C(C=C1)C2=NC3=CC=CC4=C3N2CCNC4=O

InChIKey: SEKJSSBJKFLZIT-UHFFFAOYSA-N

InChI: InChI=1S/C19H20N4O/c1-22(2)12-13-6-8-14(9-7-13)18-21-16-5-3-4-15-17(16)23(18)11-10-20-19(15)24/h3-9H,10-12H2,1-2H3,(H,20,24)

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AZD2461,PARP抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号 : 1174043-16-3 Compound CID : 44199317

分子式: C₂₂H₂₂FN₃O₃ 分子量: 395.43

IUPAC Name: 4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one

SMILES: COC1CCN(CC1)C(=O)C2=C(C=CC(=C2)CC3=NNC(=O)C4=CC=CC=C43)F

InChIKey: HYNBNUYQTQIHJK-UHFFFAOYSA-N

InChI: InChI=1S/C22H22FN3O3/c1-29-15-8-10-26(11-9-15)22(28)18-12-14(6-7-19(18)23)13-20-16-4-2-3-5-17(16)21(27)25-24-20/h2-7,12,15H,8-11,13H2,1H3,(H,25,27)

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ASP3026,间变性间变性淋巴瘤激酶（ALK）抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号 : 1097917-15-1 Compound CID : 25134326

分子式: C₂₉H₄₀N₈O₃S 分子量: 580.74

IUPAC Name: 2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine

SMILES: CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=N2)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC

InChIKey: MGGBYMDAPCCKCT-UHFFFAOYSA-N

InChI: InChI=1S/C29H40N8O3S/c1-21(2)41(38,39)27-8-6-5-7-25(27)33-29-31-20-30-28(34-29)32-24-10-9-23(19-26(24)40-4)36-13-11-22(12-14-36)37-17-15-35(3)16-18-37/h5-10,19-22H,11-18H2,1-4H3,(H2,30,31,32,33,34)

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3-氨基苯甲酰胺

规格或纯度 :

≥98%

CAS号 : 3544-24-9 Compound CID : 1645

分子式: C₇H₈N₂O 分子量: 136.15

IUPAC Name: 3-aminobenzamide

SMILES: C1=CC(=CC(=C1)N)C(=O)N

InChIKey: GSCPDZHWVNUUFI-UHFFFAOYSA-N

InChI: InChI=1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)

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MK-4827( 尼拉帕尼)

规格或纯度 :

Moligand™

≥98%

CAS号 : 1038915-60-4 Compound CID : 24958200

分子式: C₁₉H₂₀N₄O 分子量: 320.39

IUPAC Name: 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide

SMILES: C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N

InChIKey: PCHKPVIQAHNQLW-CQSZACIVSA-N

InChI: InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1

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奥拉帕尼 (AZD2281, Ku-0059436)

规格或纯度 :

Moligand™

≥98%

CAS号 : 763113-22-0 Compound CID : 23725625

分子式: C₂₄H₂₃FN₄O₃ 分子量: 434.46

IUPAC Name: 4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one

SMILES: C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F

InChIKey: FDLYAMZZIXQODN-UHFFFAOYSA-N

InChI: InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)

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贝母素乙

规格或纯度 :

分析标准品

≥98%

CAS号 : 18059-10-4 Compound CID : 167691

分子式: C₂₇H₄₃NO₃ 分子量: 429.64

IUPAC Name: (1R,2S,6S,9S,10S,11S,14S,15S,18S,20S,23R,24S)-10,20-dihydroxy-6,10,23-trimethyl-4-azahexacyclo[12.11.0.02,11.04,9.015,24.018,23]pentacosan-17-one

SMILES: CC1CCC2C(C3CCC4C(C3CN2C1)CC5C4CC(=O)C6C5(CCC(C6)O)C)(C)O

InChIKey: IQDIERHFZVCNRZ-YUYPDVIUSA-N

InChI: InChI=1S/C27H43NO3/c1-15-4-7-25-27(3,31)21-6-5-17-18(20(21)14-28(25)13-15)11-22-19(17)12-24(30)23-10-16(29)8-9-26(22,23)2/h15-23,25,29,31H,4-14H2,1-3H3/t15-,16-,17+,18+,19-,20-,21-,22-,23+,25-,26+,27-/m0/s1

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PJ34,PARPl/2 抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号 : 344458-19-1 Compound CID : 4858

分子式: C₁₇H₁₇N₃O₂ 分子量: 295.34

IUPAC Name: 2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide

SMILES: CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32

InChIKey: UYJZZVDLGDDTCL-UHFFFAOYSA-N

InChI: InChI=1S/C17H17N3O2/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22)

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PJ34 盐酸

规格或纯度 :

≥97%

CAS号 : 344458-15-7 Compound CID : 16760621

分子式: C₁₇H₁₇N₃O₂·HCl 分子量: 331.8

IUPAC Name: 2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide;hydrochloride

SMILES: CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.Cl

InChIKey: RURAZZMDMNRXMI-UHFFFAOYSA-N

InChI: InChI=1S/C17H17N3O2.ClH/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H

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吡啶酰胺

规格或纯度 :

≥98%(HPLC)

CAS号 : 1452-77-3 Compound CID : 15070

分子式: C₆H₆N₂O 分子量: 122.12

IUPAC Name: pyridine-2-carboxamide

SMILES: C1=CC=NC(=C1)C(=O)N

InChIKey: IBBMAWULFFBRKK-UHFFFAOYSA-N

InChI: InChI=1S/C6H6N2O/c7-6(9)5-3-1-2-4-8-5/h1-4H,(H2,7,9)

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Rucaparib (AG-014699,PF-01367338),PARP抑制剂

规格或纯度 :

≥99%

CAS号 : 459868-92-9 Compound CID : 9931953

分子式: C₁₉H₁₈FN₃O·H₃PO₄ 分子量: 421.36

IUPAC Name: 6-fluoro-2-[4-(methylaminomethyl)phenyl]-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-one;phosphoric acid

SMILES: CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=C3C(=CC(=C4)F)N2.OP(=O)(O)O

InChIKey: FCCGJTKEKXUBFZ-UHFFFAOYSA-N

InChI: InChI=1S/C19H18FN3O.H3O4P/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15;1-5(2,3)4/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24);(H3,1,2,3,4)

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