NAMPT - 代谢酶/蛋白酶 - 按“信号通路”分类

CB30865

CAS号 : 206275-15-2 Compound CID : 135528987

分子式: C₂₆H₂₂BrN₅O₂ 分子量: 516.39

IUPAC Name: 4-[(7-bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide

SMILES: CC1=NC2=C(C=C(C(=C2)Br)CN(CC#C)C3=CC=C(C=C3)C(=O)NCC4=CN=CC=C4)C(=O)N1

InChIKey: SHNBLWMBWXIKMR-UHFFFAOYSA-N

InChI: InChI=1S/C26H22BrN5O2/c1-3-11-32(16-20-12-22-24(13-23(20)27)30-17(2)31-26(22)34)21-8-6-19(7-9-21)25(33)29-15-18-5-4-10-28-14-18/h1,4-10,12-14H,11,15-16H2,2H3,(H,29,33)(H,30,31,34)

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FK866 (APO866, Daporinad),NAMPT抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号 : 658084-64-1 Compound CID : 6914657

分子式: C₂₄H₂₉N₃O₂ 分子量: 391.51

IUPAC Name: (E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-pyridin-3-ylprop-2-enamide

SMILES: C1CN(CCC1CCCCNC(=O)C=CC2=CN=CC=C2)C(=O)C3=CC=CC=C3

InChIKey: KPBNHDGDUADAGP-VAWYXSNFSA-N

InChI: InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+

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GMX1778,NF-κβ抑制剂

规格或纯度 :

≥98%(HPLC)

CAS号 : 200484-11-3 Compound CID : 148198

分子式: C₁₉H₂₂ClN₅O 分子量: 371.86

IUPAC Name: 2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine

SMILES: C1=CC(=CC=C1OCCCCCCN=C(NC#N)NC2=CC=NC=C2)Cl

InChIKey: BOIPLTNGIAPDBY-UHFFFAOYSA-N

InChI: InChI=1S/C19H22ClN5O/c20-16-5-7-18(8-6-16)26-14-4-2-1-3-11-23-19(24-15-21)25-17-9-12-22-13-10-17/h5-10,12-13H,1-4,11,14H2,(H2,22,23,24,25)

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GNE-617

规格或纯度 :

≥98%

CAS号 : 1362154-70-8 Compound CID : 68277611

分子式: C₂₁H₁₅F₂N₃O₃S 分子量: 427.42

IUPAC Name: N-[[4-(3,5-difluorophenyl)sulfonylphenyl]methyl]imidazo[1,2-a]pyridine-6-carboxamide

SMILES: C1=CC(=CC=C1CNC(=O)C2=CN3C=CN=C3C=C2)S(=O)(=O)C4=CC(=CC(=C4)F)F

InChIKey: XRDVXQQZLHVEQZ-UHFFFAOYSA-N

InChI: InChI=1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27)

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KPT 9274 ( ATG-019)

规格或纯度 :

Moligand™

≥98%

CAS号 : 1643913-93-2 Compound CID : 117779453

分子式: C₃₅H₂₉F₃N₄O₃ 分子量: 610.62

IUPAC Name: (E)-3-(6-aminopyridin-3-yl)-N-[[5-[4-(4,4-difluoropiperidine-1-carbonyl)phenyl]-7-(4-fluorophenyl)-1-benzofuran-2-yl]methyl]prop-2-enamide

SMILES: C1CN(CCC1(F)F)C(=O)C2=CC=C(C=C2)C3=CC(=C4C(=C3)C=C(O4)CNC(=O)C=CC5=CN=C(C=C5)N)C6=CC=C(C=C6)F

InChIKey: MRFOPLWJZULAQD-SWGQDTFXSA-N

InChI: InChI=1S/C35H29F3N4O3/c36-28-9-7-24(8-10-28)30-19-26(23-3-5-25(6-4-23)34(44)42-15-13-35(37,38)14-16-42)17-27-18-29(45-33(27)30)21-41-32(43)12-2-22-1-11-31(39)40-20-22/h1-12,17-20H,13-16,21H2,(H2,39,40)(H,41,43)/b12-2+

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SBI-797812

规格或纯度 :

≥98%

CAS号 : 2237268-08-3 Compound CID : 135222620

分子式: C₁₉H₂₂N₄O₄S 分子量: 402.47

IUPAC Name: 1-[4-(8-oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)phenyl]-3-(pyridin-4-ylmethyl)urea

SMILES: C1CC2CN(CC1O2)S(=O)(=O)C3=CC=C(C=C3)NC(=O)NCC4=CC=NC=C4

InChIKey: KTSOHNHLOLGQCY-UHFFFAOYSA-N

InChI: InChI=1S/C19H22N4O4S/c24-19(21-11-14-7-9-20-10-8-14)22-15-1-5-18(6-2-15)28(25,26)23-12-16-3-4-17(13-23)27-16/h1-2,5-10,16-17H,3-4,11-13H2,(H2,21,22,24)

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FK866 (APO866, Daporinad)

规格或纯度 :

Moligand™

10mM in DMSO

CAS号 : 658084-64-1 Compound CID : 6914657

分子式: C₂₄H₂₉N₃O₂ 分子量: 391.51

IUPAC Name: (E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-pyridin-3-ylprop-2-enamide

SMILES: C1CN(CCC1CCCCNC(=O)C=CC2=CN=CC=C2)C(=O)C3=CC=CC=C3

InChIKey: KPBNHDGDUADAGP-VAWYXSNFSA-N

InChI: InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+

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GNE-617

规格或纯度 :

10mM in DMSO

CAS号 : 1362154-70-8 Compound CID : 68277611

分子式: C₂₁H₁₅F₂N₃O₃S 分子量: 427.42

IUPAC Name: N-[[4-(3,5-difluorophenyl)sulfonylphenyl]methyl]imidazo[1,2-a]pyridine-6-carboxamide

SMILES: C1=CC(=CC=C1CNC(=O)C2=CN3C=CN=C3C=C2)S(=O)(=O)C4=CC(=CC(=C4)F)F

InChIKey: XRDVXQQZLHVEQZ-UHFFFAOYSA-N

InChI: InChI=1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27)

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GMX1778

规格或纯度 :

10mM in DMSO

CAS号 : 200484-11-3 Compound CID : 148198

分子式: C₁₉H₂₂ClN₅O 分子量: 371.86

IUPAC Name: 2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine

SMILES: C1=CC(=CC=C1OCCCCCCN=C(NC#N)NC2=CC=NC=C2)Cl

InChIKey: BOIPLTNGIAPDBY-UHFFFAOYSA-N

InChI: InChI=1S/C19H22ClN5O/c20-16-5-7-18(8-6-16)26-14-4-2-1-3-11-23-19(24-15-21)25-17-9-12-22-13-10-17/h5-10,12-13H,1-4,11,14H2,(H2,22,23,24,25)

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KPT 9274 ( ATG-019)

规格或纯度 :

Moligand™

10mM in DMSO

CAS号 : 1643913-93-2 Compound CID : 117779453

分子式: C₃₅H₂₉F₃N₄O₃ 分子量: 610.62

IUPAC Name: (E)-3-(6-aminopyridin-3-yl)-N-[[5-[4-(4,4-difluoropiperidine-1-carbonyl)phenyl]-7-(4-fluorophenyl)-1-benzofuran-2-yl]methyl]prop-2-enamide

SMILES: C1CN(CCC1(F)F)C(=O)C2=CC=C(C=C2)C3=CC(=C4C(=C3)C=C(O4)CNC(=O)C=CC5=CN=C(C=C5)N)C6=CC=C(C=C6)F

InChIKey: MRFOPLWJZULAQD-SWGQDTFXSA-N

InChI: InChI=1S/C35H29F3N4O3/c36-28-9-7-24(8-10-28)30-19-26(23-3-5-25(6-4-23)34(44)42-15-13-35(37,38)14-16-42)17-27-18-29(45-33(27)30)21-41-32(43)12-2-22-1-11-31(39)40-20-22/h1-12,17-20H,13-16,21H2,(H2,39,40)(H,41,43)/b12-2+

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OT-82

规格或纯度 :

≥98%

CAS号 : 1800487-55-1 Compound CID : 118203189

分子式: C₂₆H₂₁FN₄O 分子量: 424.5

IUPAC Name: 3-[2-(4-fluorophenyl)ethynyl]-N-[3-(1H-pyrazol-4-yl)propyl]-4-pyridin-4-ylbenzamide

SMILES: C1=CC(=CC=C1C#CC2=C(C=CC(=C2)C(=O)NCCCC3=CNN=C3)C4=CC=NC=C4)F

InChIKey: CEPAXRIKSUXHHB-UHFFFAOYSA-N

InChI: InChI=1S/C26H21FN4O/c27-24-8-4-19(5-9-24)3-6-22-16-23(7-10-25(22)21-11-14-28-15-12-21)26(32)29-13-1-2-20-17-30-31-18-20/h4-5,7-12,14-18H,1-2,13H2,(H,29,32)(H,30,31)

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