| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P426327-1ml |
1ml |
期货  |
|
| 英文别名 | pyridoxal phosphate | 54-47-7 | Codecarboxylase | pyridoxal 5'-phosphate | pyridoxal 5-phosphate | Pyridoxyl phosphate | Pyridoxal P | Pyridoxal-5'-phosphate | Biosechs | Hairoxal | Pidopidon | Pyromijin | Vitazechs | (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phos |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Pyridoxal 5′-phosphate hydrate |
| 生化机理 | 5′- 磷酸吡哆醛被用作多种酶的辅助因子，包括线粒体半胱氨酸脱硫酶、胱硫醚 γ-合成酶（CGS）、鸟氨酸 4,5-氨基变构酶（OAM）和 d-丝氨酸脱水酶。PLP 用于研究依赖 PLP 的酶活性位点。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
产品介绍： 吡哆醛5′-磷酸（PLP）通过多步反应合成。两条途径包括吡哆醛磷酸生物合成蛋白（PdxA）-吡哆醇5′-磷酸合成酶（PdxJ)途径以及吡哆醛5′-磷酸合成酶亚基PDX1/PDX2途径。PLP是吡哆醇的活性形式。 产品应用： 吡哆醇5′-磷酸还可用于：用作参考标准品，使用高效液相色谱法（HPLC）定量饲料和消化物样品中的维生素B6；在D氨基酸转氨酶反应（10）；用作LL-谷氨酸脱羧酶的辅酶 Product Description： Pyridoxal 5′-phosphate (PLP) is synthesized in a multiple-step process. The two pathways inlcude pyridoxal phosphate biosynthetic protein (PdxA)- pyridoxine-5′-phosphate synthase (PdxJ) pathway and the pyridoxal 5′-phosphate synthase subunit PDX1/PDX2 pathway. It is the active form of pyridoxine. Product Application： Pyridoxal 5′-phosphate hydrate has also been used: as a reference standard to quantify vitamin B6 in feed and digesta samples using high performance liquid chromatography (HPLC)； in D-amino acid transaminase reaction(10)；as a cofactor for L-glutamic acid decarboxylase |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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| EC号 | 200-208-3 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate |
| INCHI | InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14) |
| InChi Key | NGVDGCNFYWLIFO-UHFFFAOYSA-N |
| Canonical SMILES | CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O |
| Isomeric SMILES | CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O |
| WGK Germany | 3 |
| PubChem CID | 1051 |
| 分子量 | 247.14 |
| Beilstein号 | 234749 |
| 熔点 | 140-143°C |
|---|---|
| 分子量 | 247.140 g/mol |
| XLogP3 | -1.100 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 7 |
| 可旋转键计数Rotatable Bond Count | 4 |
| 精确质量Exact Mass | 247.025 Da |
| 单同位素质量Monoisotopic Mass | 247.025 Da |
| 拓扑极表面积Topological Polar Surface Area | 117.000 Ų |
| 重原子数Heavy Atom Count | 16 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 292.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| WGK Germany | 3 |
|---|---|
| 个人防护装备 | Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter |
| Concentration(Compounding value) | 9.0-11.0(mmol/L) |
|---|---|
| Record the entire process by video | Conform |
| 1. Hongpeng Wang, Mercy Vimbai Masuku, Yachen Tao, Jiayao Yang, Yi Kuang, Changjiang Lyu, Jun Huang, Shengxiang Yang. (2023) Improved Stability and Catalytic Efficiency of ω-Transaminase in Aqueous Mixture of Deep Eutectic Solvents. MOLECULES, 28 (9): (3895). [PMID:37175305] [10.3390/molecules28093895] |
| 2. Xingchang Cha, Juanjuan Ding, Wenyan Ba, Shengping You, Wei Qi, Rongxin Su. (2023) High Production of γ-Aminobutyric Acid by Activating the xyl Operon of Lactobacillus brevis. ACS Omega, 8 (8): (8101–8109). [PMID:36873027] [10.1021/acsomega.2c08272] |
| 3. Lian Xu, Dan Nie, Bing-Mei Su, Xin-Qi Xu, Juan Lin. (2023) A chemoenzymatic strategy for the efficient synthesis of amphenicol antibiotic chloramphenicol mediated by an engineered L-threonine transaldolase with high activity and stereoselectivity. Catalysis Science & Technology, 13 (3): (684-693). [10.1039/D2CY01670B] |
| 4. Sai Fang, Haoran Yu, Lanxin Xiao, Zhe Wang, Yixuan Lei, Gang Xu, Lirong Yang, Wenlong Zheng, Jianping Wu. (2022) Counteracting the Activity-Diastereoselectivity Trade-Off of l-Threonine Aldolase by Regulating the Proton Transfer Microenvironment. ADVANCED SYNTHESIS & CATALYSIS, 364 (24): (4363-4370). [10.1002/adsc.202201006] |
| 5. Guozeng Wang, Zhihao Jiang, Qing Xiao, Chang Jiang, Xian'ai Shi. (2022) Visible spectrophotometric assay for characterization of ω-transaminases. ANALYTICAL BIOCHEMISTRY, 658 (114933). [PMID:36208685] [10.1016/j.ab.2022.114933] |
| 6. Lichao Wang, Lian Xu, Bingmei Su, Wei Lin, Xinqi Xu, Juan Lin. (2021) Improving the Cβ Stereoselectivity of l-Threonine Aldolase for the Synthesis of l-threo-4-Methylsulfonylphenylserine by Modulating the Substrate-Binding Pocket To Control the Orientation of the Substrate Entrance. CHEMISTRY-A EUROPEAN JOURNAL, 27 (37): (9654-9660). [PMID:33843095] [10.1002/chem.202100752] |
| 7. Hongjie Hui, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng, Yujie Cai. (2020) Biosynthesis of Putrescine from L-arginine Using Engineered Escherichia coli Whole Cells. Catalysts, 10 (9): (947). [10.3390/catal10090947] |
| 8. Li-Chao Wang, Lian Xu, Xin-Qi Xu, Bing-Mei Su, Juan Lin. (2020) An L-threonine aldolase for asymmetric synthesis of β-hydroxy-α-amino acids. CHEMICAL ENGINEERING SCIENCE, 226 (115812). [10.1016/j.ces.2020.115812] |
| 9. Lian Xu, Li-Chao Wang, Xin-Qi Xu, Juan Lin. (2019) Characteristics of L-threonine transaldolase for asymmetric synthesis of β-hydroxy-α-amino acids. Catalysis Science & Technology, 9 (21): (5943-5952). [10.1039/C9CY01608B] |
| 10. Xiao-Ling Tang, Nan-Nan Zhang, Guo-Yan Ye, Yu-Guo Zheng. (2019) Efficient biosynthesis of (R)-3-amino-1-butanol by a novel (R)-selective transaminase from Actinobacteria sp.. JOURNAL OF BIOTECHNOLOGY, 295 (49). [PMID:30853639] [10.1016/j.jbiotec.2019.02.008] |
| 11. Zhang Zhi-Jun, Cai Rui-Feng, Xu Jian-He. (2018) Characterization of a new nitrilase from Hoeflea phototrophica DFL-43 for a two-step one-pot synthesis of (S)-β-amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 102 (14): (6047-6056). [PMID:29744634] [10.1007/s00253-018-9057-7] |
| 12. Ailin Xiao, Jing Li, Tianjian Liu, Zhuxi Liu, Chuanfei Wei, Xiaomeng Xu, Qin Li, Jingxin Li. (2016) l-Cysteine enhances nutrient absorption via a cystathionine-β-synthase-derived H2S pathway in rodent jejunum. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 43 (5): (562-568). [PMID:26901099] [10.1111/1440-1681.12562] |
| 13. S. Tang, D. Huang, N. An, D. Chen, D. Zhao. (2016) A novel pathway for the production of H2S by DAO in rat jejunum. NEUROGASTROENTEROLOGY AND MOTILITY, 28 (5): (687-692). [PMID:26813142] [10.1111/nmo.12765] |
| 14. Ailin Xiao,Hongjuan Wang,Xin Lu,Jianchun Zhu,Di Huang,Tonghui Xu,Jianqiang Guo,Chuanyong Liu,Jingxin Li. (2015-11-05) H2S, a novel gasotransmitter, involves in gastric accommodation.. Scientific reports, 5 (16086-16086). [PMID:26531221] |
| 1. Hongpeng Wang, Mercy Vimbai Masuku, Yachen Tao, Jiayao Yang, Yi Kuang, Changjiang Lyu, Jun Huang, Shengxiang Yang. (2023) Improved Stability and Catalytic Efficiency of ω-Transaminase in Aqueous Mixture of Deep Eutectic Solvents. MOLECULES, 28 (9): (3895). [PMID:37175305] [10.3390/molecules28093895] |
| 2. Xingchang Cha, Juanjuan Ding, Wenyan Ba, Shengping You, Wei Qi, Rongxin Su. (2023) High Production of γ-Aminobutyric Acid by Activating the xyl Operon of Lactobacillus brevis. ACS Omega, 8 (8): (8101–8109). [PMID:36873027] [10.1021/acsomega.2c08272] |
| 3. Lian Xu, Dan Nie, Bing-Mei Su, Xin-Qi Xu, Juan Lin. (2023) A chemoenzymatic strategy for the efficient synthesis of amphenicol antibiotic chloramphenicol mediated by an engineered L-threonine transaldolase with high activity and stereoselectivity. Catalysis Science & Technology, 13 (3): (684-693). [10.1039/D2CY01670B] |
| 4. Sai Fang, Haoran Yu, Lanxin Xiao, Zhe Wang, Yixuan Lei, Gang Xu, Lirong Yang, Wenlong Zheng, Jianping Wu. (2022) Counteracting the Activity-Diastereoselectivity Trade-Off of l-Threonine Aldolase by Regulating the Proton Transfer Microenvironment. ADVANCED SYNTHESIS & CATALYSIS, 364 (24): (4363-4370). [10.1002/adsc.202201006] |
| 5. Guozeng Wang, Zhihao Jiang, Qing Xiao, Chang Jiang, Xian'ai Shi. (2022) Visible spectrophotometric assay for characterization of ω-transaminases. ANALYTICAL BIOCHEMISTRY, 658 (114933). [PMID:36208685] [10.1016/j.ab.2022.114933] |
| 6. Lichao Wang, Lian Xu, Bingmei Su, Wei Lin, Xinqi Xu, Juan Lin. (2021) Improving the Cβ Stereoselectivity of l-Threonine Aldolase for the Synthesis of l-threo-4-Methylsulfonylphenylserine by Modulating the Substrate-Binding Pocket To Control the Orientation of the Substrate Entrance. CHEMISTRY-A EUROPEAN JOURNAL, 27 (37): (9654-9660). [PMID:33843095] [10.1002/chem.202100752] |
| 7. Hongjie Hui, Yajun Bai, Tai-Ping Fan, Xiaohui Zheng, Yujie Cai. (2020) Biosynthesis of Putrescine from L-arginine Using Engineered Escherichia coli Whole Cells. Catalysts, 10 (9): (947). [10.3390/catal10090947] |
| 8. Li-Chao Wang, Lian Xu, Xin-Qi Xu, Bing-Mei Su, Juan Lin. (2020) An L-threonine aldolase for asymmetric synthesis of β-hydroxy-α-amino acids. CHEMICAL ENGINEERING SCIENCE, 226 (115812). [10.1016/j.ces.2020.115812] |
| 9. Lian Xu, Li-Chao Wang, Xin-Qi Xu, Juan Lin. (2019) Characteristics of L-threonine transaldolase for asymmetric synthesis of β-hydroxy-α-amino acids. Catalysis Science & Technology, 9 (21): (5943-5952). [10.1039/C9CY01608B] |
| 10. Xiao-Ling Tang, Nan-Nan Zhang, Guo-Yan Ye, Yu-Guo Zheng. (2019) Efficient biosynthesis of (R)-3-amino-1-butanol by a novel (R)-selective transaminase from Actinobacteria sp.. JOURNAL OF BIOTECHNOLOGY, 295 (49). [PMID:30853639] [10.1016/j.jbiotec.2019.02.008] |
| 11. Zhang Zhi-Jun, Cai Rui-Feng, Xu Jian-He. (2018) Characterization of a new nitrilase from Hoeflea phototrophica DFL-43 for a two-step one-pot synthesis of (S)-β-amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 102 (14): (6047-6056). [PMID:29744634] [10.1007/s00253-018-9057-7] |
| 12. Ailin Xiao, Jing Li, Tianjian Liu, Zhuxi Liu, Chuanfei Wei, Xiaomeng Xu, Qin Li, Jingxin Li. (2016) l-Cysteine enhances nutrient absorption via a cystathionine-β-synthase-derived H2S pathway in rodent jejunum. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 43 (5): (562-568). [PMID:26901099] [10.1111/1440-1681.12562] |
| 13. S. Tang, D. Huang, N. An, D. Chen, D. Zhao. (2016) A novel pathway for the production of H2S by DAO in rat jejunum. NEUROGASTROENTEROLOGY AND MOTILITY, 28 (5): (687-692). [PMID:26813142] [10.1111/nmo.12765] |
| 14. Ailin Xiao,Hongjuan Wang,Xin Lu,Jianchun Zhu,Di Huang,Tonghui Xu,Jianqiang Guo,Chuanyong Liu,Jingxin Li. (2015-11-05) H2S, a novel gasotransmitter, involves in gastric accommodation.. Scientific reports, 5 (16086-16086). [PMID:26531221] |
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