| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| A301905-0.5ml |
0.5ml |
现货  |
|
| 英文别名 | Benzenesulfonyl fluoride, 4-(2-aminoethyl)-, hydrochloride | DHA6VL95HL | 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride [for biochemical research] | EX-A2487 | T70748 | AKOS015847774 | Pefabloc(R) SC, certified reference material, TraceCERT(R) | |
|---|---|
| 规格或纯度 | 50mg/ml in H2O |
| 英文名称 | AEBSF Solution |
| 生化机理 | 蛋白酶抑制剂，是一种水溶性的不可逆的丝氨酸蛋白酶抑制剂，它抑制蛋白酶如： 胰凝乳蛋白酶（chymotrypsin）, 激肽释放酶（kallikrein）, 血纤维蛋白溶酶（plasmin）, 凝血酶（thrombin）, 和胰蛋白酶（trypsin），有点类似于抑制剂PMSF, 不过 AEBSF 在低PH条件下更稳定。典型使用浓度为：0.1 - 1.0 mM. |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
4-( 2-氨乙基) 苯磺酰氟盐酸盐，分子量是239.5，溶于水，无毒，在低pH条件下，比PMSF更稳定。它是一种水溶性的不可逆的丝氨酸蛋白酶抑制剂，可以抑制胰凝乳蛋白酶, 激肽释放酶, 血纤维蛋白溶酶, 凝血酶和胰蛋白酶。 AEBSF Solution, in Water 工作浓度为0.1-1.0mg/mL。应用于蛋白提取等试验，用于抑制丝氨酸蛋白酶。 使用方法： 1.根据实验具体要求操作。 适用于一般生物学及医学研究 |
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride |
| INCHI | InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H |
| InChi Key | WRDABNWSWOHGMS-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl |
| Isomeric SMILES | C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl |
| WGK Germany | 3 |
| PubChem CID | 186136 |
| UN Number | 3261 |
| 分子量 | 239.69 |
| Beilstein号 | 7604627 |
| Reaxy-Rn | 7604627 |
| 溶解性 | Soluble in water 50 mg/mL or 100% ethanol. |
|---|---|
| 密度 | 0.729 |
| 敏感性 | 对湿度敏感 |
| 熔点 | 181-185°C |
| 分子量 | 239.700 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 239.018 Da |
| 单同位素质量Monoisotopic Mass | 239.018 Da |
| 拓扑极表面积Topological Polar Surface Area | 68.500 Ų |
| 重原子数Heavy Atom Count | 14 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 239.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 2 |
| Appearance（A301905） | colorless clear liquid |
|---|---|
| Solvent(H2O) | Conform |
| concentration | 49.95-50.05（mg/ml） |
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| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 F2110977 |
分析证书 | 23-05-12 | A301905 |
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| 2. Yi-Xuan Fu, Wu-Yingzheng Guo, Nan Wang, Yi-Jie Dai, Zi-Ye Zhang, Xin-Lin Sun, Wen-Chao Yang, Guang-Fu Yang. (2022) Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor. ANALYTICAL CHEMISTRY, 94 (50): (17692–17699). [PMID:36469707] [10.1021/acs.analchem.2c04614] |
| 3. Jingmin Zhang, Youmei Peng, Ying Li, Ning Wang, Yuna Chai, Chongzhen Qin, Xinru Wang, Suna Liu, Yubing Zhou, Xiaojian Zhang, Wenda Zhang. (2022) Development of a near-infrared fluorescent probe with large Stokes shift for carboxylesterases detection and its application in living systems. DYES AND PIGMENTS, 198 (109993). [10.1016/j.dyepig.2021.109993] |
| 4. Yu Zhu Yang, Zi Yi Xu, Nian Bing Li, Hong Qun Luo. (2021) Ultrasensitive fluorescent probe for visual biosensing of esterase activity in living cells and its imaging application. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 262 (120094). [PMID:34175764] [10.1016/j.saa.2021.120094] |
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| 6. Hui Zhou, Jinbao Tang, Jie Zhang, Bochao Chen, Jianfei Kan, Weifen Zhang, Jin Zhou, Huimin Ma. (2019) A red lysosome-targeted fluorescent probe for carboxylesterase detection and bioimaging. Journal of Materials Chemistry B, 7 (18): (2989-2996). [10.1039/C9TB00310J] |
| 7. Juan Wang, Mengmeng Song, Chengguo Hu, Kangbing Wu. (2018) Portable, Self-Powered, and Light-Addressable Photoelectrochemical Sensing Platforms Using pH Meter Readouts for High-Throughput Screening of Thrombin Inhibitor Drugs. ANALYTICAL CHEMISTRY, 90 (15): (9366–9373). [PMID:29998727] [10.1021/acs.analchem.8b01979] |
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