基本描述

别名	D-α-维生素E聚乙二醇琥珀酸酯 \| D-α-生育酚聚乙二醇琥珀酸酯 \| 维生素 E 聚乙二醇丁二酸酯 \| 维生素 E-TPGS
英文别名	Tocofersolan \| Vitamin E Polyethylene Glycol Succinate \| α-Tocopherol Polyethylene Glycol Succinate
规格或纯度	试剂级
英文名称	Vitamin E-TPGS
生化机理	维生素E聚乙二醇琥珀酸酯，是一种治疗儿童维生素E缺乏症的药物，在儿童慢性胆汁淤积症期间使用。TPGS通过下调抗凋亡蛋白从而在MCF-7和乳腺癌细胞中发挥抗肿瘤活性。TPGS在制备用于DNA标记的聚乳酸(lacc -co-glycolic acid, PLGA)颗粒中作为乳化剂，产生粒径均匀、包封效率高、亲水性好、不易团聚的颗粒。生育酚（TCP）（维生素E）是手性有机分子的系列（α、β、γ和δ），其手性有机分子的苯酚部分的甲基化程度不同。生育酚是脂溶性抗氧化剂，可保护细胞膜免受氧化损伤。α-生育酚是人类优先吸收的生育酚形式。维生素E聚乙二醇琥珀酸酯可用于制造生物降解聚合物和抗氧化表面活性剂。
储存温度	2-8°C储存,充氩
运输条件	冰袋运输
产品介绍	在采用双乳液(w1/o/w2)和纳米沉淀法合成聚乳酸-糖基乙酸(PLGA)颗粒作为DNA载体中，D-α-生育酚聚乙二醇1000琥珀酸酯被用作乳化剂。 D-α-Tocopherol polyethylene glycol 1000 succinate has been used as an emulsifier in the preparation of Poly(lactic-co-glycolic acid) (PLGA) particle as synthetic DNA carriers by double emulsion (w1/o/w2) and nanoprecipitation method

AI解读

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	小分子
Isomeric SMILES	CC1=C(C(=C(C2=C1O[C@](CC2)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C)OC(=O)CCC(=O)OCCO)C
WGK Germany	2
RTECS	TR1581200

化学和物理性质

密度	1.01
敏感性	对湿度、光、空气敏感
闪点(℉)	>392.0 °F
闪点(℃)	> 200 °C
熔点	>36°C

安全和危险性（GHS）

WGK Germany	2
RTECS	TR1581200
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

SDS英文版

技术规格说明书

Melting point	36-41（℃）
free tocopherol	0-1.5（%）
Appearance（T110277)	White to Light Brown Powder,Crystals,Solid ,Chunks
Infrared spectrum	Conforms to Structure
Solubility in H2O，faintly turbid,colorless to faintly yellow100mg/ml	pass
Assay（D-α-tocopherol）	25-35（%）

技术规格说明书

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批号(Lot Number)	证书类型	日期	货号
E2522061	分析证书	24-11-21	T110277
L2402595	分析证书	24-11-21	T110277
L2402596	分析证书	24-11-21	T110277
D2415159	分析证书	24-04-08	T110277
D2415160	分析证书	24-04-08	T110277
A2419697	分析证书	24-01-11	T110277
A2419700	分析证书	24-01-11	T110277
A2419702	分析证书	24-01-11	T110277
A2419701	分析证书	24-01-11	T110277
G2328146	分析证书	23-07-20	T110277
G2328153	分析证书	23-07-20	T110277
G2328163	分析证书	23-07-20	T110277
G2328168	分析证书	23-07-20	T110277
G23041104	分析证书	23-05-22	T110277
E2330456	分析证书	23-05-18	T110277
E2330459	分析证书	23-05-18	T110277
E2330465	分析证书	23-05-18	T110277
E2330466	分析证书	23-05-18	T110277
J2227666	分析证书	22-09-06	T110277
J2227675	分析证书	22-09-06	T110277
J2227680	分析证书	22-09-06	T110277
J2227681	分析证书	22-09-06	T110277
G2220066	分析证书	22-06-29	T110277
G2220067	分析证书	22-06-29	T110277
G2220173	分析证书	22-06-29	T110277
G2220178	分析证书	22-06-29	T110277

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