计算溶液所需的质量、体积或浓度。
活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
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T106639-200mg |
200mg |
期货 ![]() |
| |
T106639-1g |
1g |
现货 ![]() |
| |
T106639-5g |
5g |
现货 ![]() |
| |
T106639-25g |
25g |
期货 ![]() |
|
别名 | 2-氨基-6-巯基嘌呤 | 6-硫代鸟嘌呤 |
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英文别名 | Tioguanin | Tioguanina [INN-Spanish] | THG | WIX31ZPX66 | 2-Amino 6MP | SMR000857244 | Thioguanine2-Amino-6-purinethiol | Tioguaninum [INN-Latin] | DX4 | MLS001333131 | 2-Amino-1,7-dihydro-6H-purin-6-thion | 2-Amino-1,7-dihydro-6H-purin-6-thion [Czech] | |
规格或纯度 | Moligand™, ≥98% |
英文名称 | 6-Thioguanine |
生化机理 | 用于治疗白血病的抗代谢药。与次黄嘌呤和鸟嘌呤竞争次黄嘌呤-鸟嘌呤磷酸核糖转移酶,该酶催化生成嘌呤核苷酸的关键步骤。它与天然嘌呤碱基通过相同的途径进行核糖基化和磷酸化;作为核苷酸,它能抑制核酸合成过程中的各种细胞过程。抗代谢药。鸟嘌呤类似物。可结合到线粒体 DNA 中,诱导 DNA 双链断裂。在体内具有抗肿瘤、免疫抑制和抗炎作用。硫唑嘌呤的代谢产物。 |
应用 | 抗肿瘤。 |
运输条件 | 常规运输 |
作用类型 | 抑制剂 |
作用机制 | DNA 抑制剂 |
备注 | 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
产品介绍 |
6-Thioguanine is a chemotherapy drμg that demonstrates immunosuppressive, anti-neoplastic, and anti-cancer activities. This chemical is often used to treat leukemia and inflammatory diseases. Chemical produces dose-dependent inhibition of stimulated expression of TRAIL protein.抗肿瘤。 6-Thioguanine is a chemotherapy drug that demonstrates immunosuppressive, anti-neoplastic, and anti-cancer activities. This chemical is often used to treat leukemia and inflammatory diseases. Chemical produces dose-dependent inhibition of stimulated expression of TRAIL protein. |
ALogP | -0.1 |
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作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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PubChem SID | 504760785 |
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EC号 | 205-827-2 |
分子类型 | 小分子 |
IUPAC Name | 2-amino-3,7-dihydropurine-6-thione |
INCHI | InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) |
InChi Key | WYWHKKSPHMUBEB-UHFFFAOYSA-N |
Canonical SMILES | C1=NC2=C(N1)C(=S)N=C(N2)N |
Isomeric SMILES | C1=NC2=C(N1)C(=S)N=C(N2)N |
WGK Germany | 3 |
RTECS | UP0740000 |
PubChem CID | 2723601 |
UN Number | 2811 |
Packing Group | I |
分子量 | 167.19 |
Beilstein号 | 157765 |
Reaxy-Rn | 1074099 |
溶解性 | Soluble in dilute solutions of alkali hydroxides and hot alcohol. Insoluble in water. |
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熔点 | 360°C |
分子量 | 167.190 g/mol |
XLogP3 | -0.100 |
氢键供体数Hydrogen Bond Donor Count | 3 |
氢键受体数Hydrogen Bond Acceptor Count | 2 |
可旋转键计数Rotatable Bond Count | 0 |
精确质量Exact Mass | 167.027 Da |
单同位素质量Monoisotopic Mass | 167.027 Da |
拓扑极表面积Topological Polar Surface Area | 111.000 Ų |
重原子数Heavy Atom Count | 11 |
形式电荷Formal Charge | 0 |
复杂度Complexity | 225.000 |
同位素原子数Isotope Atom Count | 0 |
定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
所有立体化学键的总数The total count of all stereochemical bonds | 0 |
共价键合单元计数Covalently-Bonded Unit Count | 1 |
象形图 | GHS06, GHS08 |
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信号词 | Danger |
危险声明 |
H301: 吞咽会中毒 H341: 怀疑引起遗传缺陷 |
预防措施声明 |
P321: 特殊处理(请参阅此标签上的...)。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P281: 根据需要使用个人防护设备。 P270: 使用本产品时,请勿进食、饮水或吸烟。 P330: 漱口 P203: 使用前,获取、阅读并遵守所有安全说明。 P301+P316: 如果吞咽:立即寻求紧急医疗救助。 P318: 如果暴露或担心,请就医。 |
WGK Germany | 3 |
RTECS | UP0740000 |
Reaxy-Rn | 1074099 |
Class | 6.1 |
Merck Index | 9337 |
个人防护装备 | Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges |
Purity(HPLC) | 98-100(%) |
---|---|
Appearance(T106639) | White to Yellow-Green Powder |
Solubility in 1 M NaOH,Colorless to Light Green,Clear to Hazy,50 mg/ml | pass |
Infrared spectrum | Conforms to Structure |
Carbon by Elemental Analysis | 35.15-36.65(%) |
Nitrogen by Elemental Analysis | 41.00-42.75(%) |
1. Jia Wang, Deyue Yan, Wei Huang. (2022) A fluorescence zinc metal-organic framework for the effective detection of Fe3+ and Fe2+ in water. INORGANIC CHEMISTRY COMMUNICATIONS, 138 (109282). [10.1016/j.inoche.2022.109282] |
2. Yu Zhang, Xin Xu, Bing Yan. (2022) A multicolor-switchable fluorescent lanthanide MOFs triggered by anti-cancer drugs: multifunctional platform for anti-cancer drug sensing and information anticounterfeiting. Journal of Materials Chemistry C, 10 (9): (3576-3584). [10.1039/D1TC05935A] |
3. Bingyong Lin, Yueliang Wang, Yuanyuan Yao, Lifen Chen, Yanbo Zeng, Lei Li, Zhenyu Lin, Longhua Guo. (2021) Oil-Free Gold Nanobipyramid@Ag Microgels as a Functional SERS Substrate for Direct Detection of Small Molecules in a Complex Sample Matrix. ANALYTICAL CHEMISTRY, 93 (49): (16727–16733). [PMID:34851090] [10.1021/acs.analchem.1c04797] |
4. Wen-Shu Zhang, Ya-Ning Wang, Yue Wang, Zhang-Run Xu. (2019) Highly reproducible and fast detection of 6-thioguanine in human serum using a droplet-based microfluidic SERS system. SENSORS AND ACTUATORS B-CHEMICAL, 283 (532). [10.1016/j.snb.2018.12.077] |
5. Shuai Yue, Xiao-Ting Sun, Yue Wang, Wen-Shu Zhang, Zhang-Run Xu. (2018) Microparticles with size/charge selectivity and pH response for SERS monitoring of 6-thioguanine in blood serum. SENSORS AND ACTUATORS B-CHEMICAL, 273 (1539). [10.1016/j.snb.2018.07.062] |
6. Junling Duan, Yuanhong Zhang, Yanbin Yin, Houshen Li, Jun Wang, Lusheng Zhu. (2018) A novel “on-off-on” fluorescent sensor for 6-thioguanine and Hg2+ based on g-C3N4 nanosheets. SENSORS AND ACTUATORS B-CHEMICAL, 257 (504). [10.1016/j.snb.2017.10.071] |
7. Jingjie Cui, Jing Chen, Shaowei Chen, Li Gao, Ping Xu, Hong Li. (2016) Au/TiO2 nanobelt heterostructures for the detection of cancer cells and anticancer drug activity by potential sensing. NANOTECHNOLOGY, 27 (9): (95603). [PMID:26822679] [10.1088/0957-4484/27/9/095603] |
8. Hongli Li, Xiaoli Chong, Yufeng Chen, Lei Yang, Lan Luo, Bing Zhao, Yuan Tian. (2016) Detection of 6-Thioguanine by surface-enhanced Raman scattering spectroscopy using silver nanoparticles-coated silicon wafer. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 493 (52). [10.1016/j.colsurfa.2016.01.032] |
9. Xu Wang, Ziqiang Tan, Yuanhu Pan, Awais Ihsan, Qianying Liu, Lingli Huang, Guyue Cheng, Dongmei Chen, Yanfei Tao, Zhenli Liu, Zonghui Yuan. (2015) Safety assessment of aditoprim acute, subchronic toxicity and mutagenicity studies. JOURNAL OF APPLIED TOXICOLOGY, 35 (11): (1415-1426). [PMID:25663419] [10.1002/jat.3107] |
1. Moreau AC, Paul S, Del Tedesco E, Rinaudo-Gaujous M, Boukhadra N, Genin C, Peyrin-Biroulet L, Roblin X. (2014) Association between 6-thioguanine nucleotides levels and clinical remission in inflammatory disease: a meta-analysis.. Inflamm Bowel Dis, 20 (3): (464-71). [PMID:24418904] [10.1021/op500134e] |
2. Jia Wang, Deyue Yan, Wei Huang. (2022) A fluorescence zinc metal-organic framework for the effective detection of Fe3+ and Fe2+ in water. INORGANIC CHEMISTRY COMMUNICATIONS, 138 (109282). [10.1016/j.inoche.2022.109282] |
3. Yu Zhang, Xin Xu, Bing Yan. (2022) A multicolor-switchable fluorescent lanthanide MOFs triggered by anti-cancer drugs: multifunctional platform for anti-cancer drug sensing and information anticounterfeiting. Journal of Materials Chemistry C, 10 (9): (3576-3584). [10.1039/D1TC05935A] |
4. Bingyong Lin, Yueliang Wang, Yuanyuan Yao, Lifen Chen, Yanbo Zeng, Lei Li, Zhenyu Lin, Longhua Guo. (2021) Oil-Free Gold Nanobipyramid@Ag Microgels as a Functional SERS Substrate for Direct Detection of Small Molecules in a Complex Sample Matrix. ANALYTICAL CHEMISTRY, 93 (49): (16727–16733). [PMID:34851090] [10.1021/acs.analchem.1c04797] |
5. Wen-Shu Zhang, Ya-Ning Wang, Yue Wang, Zhang-Run Xu. (2019) Highly reproducible and fast detection of 6-thioguanine in human serum using a droplet-based microfluidic SERS system. SENSORS AND ACTUATORS B-CHEMICAL, 283 (532). [10.1016/j.snb.2018.12.077] |
6. Shuai Yue, Xiao-Ting Sun, Yue Wang, Wen-Shu Zhang, Zhang-Run Xu. (2018) Microparticles with size/charge selectivity and pH response for SERS monitoring of 6-thioguanine in blood serum. SENSORS AND ACTUATORS B-CHEMICAL, 273 (1539). [10.1016/j.snb.2018.07.062] |
7. Junling Duan, Yuanhong Zhang, Yanbin Yin, Houshen Li, Jun Wang, Lusheng Zhu. (2018) A novel “on-off-on” fluorescent sensor for 6-thioguanine and Hg2+ based on g-C3N4 nanosheets. SENSORS AND ACTUATORS B-CHEMICAL, 257 (504). [10.1016/j.snb.2017.10.071] |
8. Jingjie Cui, Jing Chen, Shaowei Chen, Li Gao, Ping Xu, Hong Li. (2016) Au/TiO2 nanobelt heterostructures for the detection of cancer cells and anticancer drug activity by potential sensing. NANOTECHNOLOGY, 27 (9): (95603). [PMID:26822679] [10.1088/0957-4484/27/9/095603] |
9. Hongli Li, Xiaoli Chong, Yufeng Chen, Lei Yang, Lan Luo, Bing Zhao, Yuan Tian. (2016) Detection of 6-Thioguanine by surface-enhanced Raman scattering spectroscopy using silver nanoparticles-coated silicon wafer. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 493 (52). [10.1016/j.colsurfa.2016.01.032] |
10. Xu Wang, Ziqiang Tan, Yuanhu Pan, Awais Ihsan, Qianying Liu, Lingli Huang, Guyue Cheng, Dongmei Chen, Yanfei Tao, Zhenli Liu, Zonghui Yuan. (2015) Safety assessment of aditoprim acute, subchronic toxicity and mutagenicity studies. JOURNAL OF APPLIED TOXICOLOGY, 35 (11): (1415-1426). [PMID:25663419] [10.1002/jat.3107] |