重组人源化XVII型胶原蛋白

功能和特点
  • 表达系统: 毕赤酵母
  • Accession #: Q9UMD9
  • 蛋白标签: His
  • 内毒素水平: <5.0 EU/mg
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库存信息

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库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
rp212899-1mg
1mg 现货 Stock Image
rp212899-5mg
5mg 现货 Stock Image
rp212899-25mg
25mg 现货 Stock Image
rp212899-100mg
100mg 现货 Stock Image
rp212899-1g
1g 现货 Stock Image

基本描述

产品名称 重组人源化XVII型胶原蛋白
别名 重组人XVII型胶原蛋白
英文别名 COL17A1 | ERED | JEB4 | BP180 | BPA-2 | BPAG2 | LAD-1 | BA16H23.2 | Collagen XVII | Collagen 17
规格或纯度 用于分子生物学, 无动物源, 无载体, 低内毒素, 无菌过滤, ≥95%(SDS-PAGE)
生化机理 May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies. Post-translational: The intracellular/endo domain is disulfide-linked. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. The ectodomain is shedded from the surface of keratinocytes resulting in a 120-kDa soluble form, also named as 120 kDa linear IgA disease antigen. The shedding is mediated by membrane-bound metalloproteases. This cleavage is inhibited by phosphorylation at Ser-544.
产品介绍

XVII型胶原蛋白(XVII collagen,COL17)是表皮基底层的一种跨膜蛋白,具有维持表皮真皮之间的紧密连接,以促进表皮更替、稳固基底膜的功能,从基底膜带上实现抗衰修复。已有证据表明,COL17水解可引起毛囊微型化最终导致脱发。COL17因其特有的生理功能,在延缓治疗脱发有很好的应用前景。
本产品是重组的人源化XVII型胶原蛋白,来源于微生物。该产品具有优异的水溶性和稳定性,并具有很好的亲水性和保湿性。采用毕赤酵母菌发酵工艺,确保产品内毒素更低、更安全。
产品特性:
PH: 5-8
电泳纯度:≥95% (SDS-PAGE)
蛋白含量:>90%
干燥失重:<10%
热稳定性: 60℃保存4小时蛋白无变色析出,条带无降解
细菌内毒素:<0.5 EU/mg
微生物:<5 cfu/g
重金属残留:<10 ppm

Type XVII collagen (COL17) is a transmembrane protein in the basal layer of epidermis, which has the functions of maintaining close connection between epidermis and dermis, promoting epidermis replacement and stabilizing basement membrane, and realizing anti-aging repair from basement membrane belt. It has been proved that hydrolysis of COL17 can cause hair follicle miniaturization and eventually lead to hair loss. COL17 has a good application prospect in delaying the treatment of alopecia because of its unique physiological function. This product is a recombinant humanized XVII collagen, which comes from microorganisms. The product has excellent water solubility and stability, and has good hydrophilicity and moisture retention. Pichia pastoris fermentation process is adopted to ensure that the endotoxin of the product is lower and safer.
Product Features:
PH: 5-8
Electrophoretic purity: ≥95% (SDS-PAGE)
Protein content : >90%
Loss on drying: <10%
Thermal stability: The protein stored at 60℃ for 4 hours has no discoloration and no degradation.
Bacterial endotoxin: <0.5 EU/mg
Microorganism: <5 cfu/g
Heavy metal: <10 ppm

内毒素水平 <5.0 EU/mg
表达系统 毕赤酵母
种属 人(Human)
蛋白标签 His
无载体 Yes
无动物源 Yes
Accession # Q9UMD9
来源 重组表达
预测分子量 10 kDa
SDS-PAGE 10-15 kDa

产品规格参数

物理形态 冻干(Lyophilized)
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 Store at -20℃ for 1 year. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS编号和信息 9064-67-9
分子类型 蛋白质

安全和危险性(GHS)

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找到5个结果

批号(Lot Number) 证书类型 日期 货号
ZJ25F0318972 分析证书 25-03-12 rp212899
ZJ25F0117027 分析证书 25-01-16 rp212899
ZJ25F0117026 分析证书 25-01-16 rp212899
ZJ25F0117025 分析证书 25-01-16 rp212899
ZJ25F0117024 分析证书 25-01-16 rp212899

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