计算溶液所需的质量、体积或浓度。
活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
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R109804-10mg |
10mg |
现货 ![]() |
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R109804-20mg |
20mg |
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R109804-100mg |
100mg |
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R109804-500mg |
500mg |
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R109804-1g |
1g |
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R109804-5g |
5g |
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别名 | (R)-O-(3,4-二羟基肉桂酰)-3-(3,4-二羟苯基)乳酸 | 3,4-二羟基肉桂酸 ( R )-1-羧基-2-(3,4-二羟基苯基)乙酯 | 酪萨维 | 罗丹酚酸 | 肉桂醇甙 |
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英文别名 | (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxypropanoic acid | (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-propanoic acid | HMS3649C22 | SMR000445579 | MFCD00017740 | AS-35341 | R-(+)-2-(3,4-Dih |
规格或纯度 | 分析标准品, ≥97% |
英文名称 | Rosmarinic acid |
生化机理 | 迷迭香酸具有抗氧化、抗炎和抗菌活性。在认知能力、阿尔茨海默病预防、肾脏疾病治疗、心脏保护和肿瘤化学预防等方面具有广阔的应用前景。 |
储存温度 | 2-8°C储存 |
运输条件 | 冰袋运输 |
备注 | 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
产品介绍 |
迷迭香酸是一种具有抗氧化和抗炎作用的生物活性植物酚类化合物。 An activator of GPR35. |
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作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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分子类型 | 小分子 |
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IUPAC Name | (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxypropanoic acid |
INCHI | InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1 |
InChi Key | DOUMFZQKYFQNTF-WUTVXBCWSA-N |
Canonical SMILES | OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c(O)c2 |
Isomeric SMILES | C1=CC(=C(C=C1C[C@H](C(=O)O)OC(=O)/C=C/C2=CC(=C(C=C2)O)O)O)O |
WGK Germany | 3 |
PubChem CID | 5281792 |
分子量 | 360.31 |
Beilstein号 | 2227587 |
溶解性 | Soluble in water (100 mM), ethanol (~25 mg/ml), DMSO (~25 mg/ml), DMF (~25 mg/ml), and PBS (pH 7.2) (~15 mg/ml). |
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敏感性 | 对空气敏感 |
熔点 | 171-175°C |
分子量 | 360.300 g/mol |
XLogP3 | 2.400 |
氢键供体数Hydrogen Bond Donor Count | 5 |
氢键受体数Hydrogen Bond Acceptor Count | 8 |
可旋转键计数Rotatable Bond Count | 7 |
精确质量Exact Mass | 360.085 Da |
单同位素质量Monoisotopic Mass | 360.085 Da |
拓扑极表面积Topological Polar Surface Area | 145.000 Ų |
重原子数Heavy Atom Count | 26 |
形式电荷Formal Charge | 0 |
复杂度Complexity | 519.000 |
同位素原子数Isotope Atom Count | 0 |
定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
定义的键立体中心计数Defined Bond Stereocenter Count | 1 |
未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
所有立体化学键的总数The total count of all stereochemical bonds | 1 |
共价键合单元计数Covalently-Bonded Unit Count | 1 |
象形图 | GHS06, GHS09 |
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信号词 | Danger |
危险声明 |
H301: 吞咽会中毒 H400: 对水生生物有剧毒 |
预防措施声明 |
P273: 避免释放到环境中。 P321: 特殊处理(请参阅此标签上的...)。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时,请勿进食、饮水或吸烟。 P391: 收集溢出物 P330: 漱口 P301+P316: 如果吞咽:立即寻求紧急医疗救助。 |
WGK Germany | 3 |
个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
Purity(HPLC) | 97-100(%) |
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Appearance(R109804) | White to tan powder |
Proton NMR spectrum | Conforms to Structure |
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
批号(Lot Number) | 证书类型 | 日期 | 货号 |
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分析证书 | 25-03-04 | R109804 |
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分析证书 | 25-03-04 | R109804 |
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分析证书 | 24-05-09 | R109804 |
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分析证书 | 24-05-09 | R109804 |
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分析证书 | 24-05-09 | R109804 |
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分析证书 | 24-05-09 | R109804 |
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分析证书 | 24-02-01 | R109804 |
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分析证书 | 23-10-08 | R109804 |
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分析证书 | 23-09-21 | R109804 |
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分析证书 | 23-09-21 | R109804 |
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分析证书 | 23-09-06 | R109804 |
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分析证书 | 23-06-01 | R109804 |
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分析证书 | 23-06-01 | R109804 |
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分析证书 | 23-01-13 | R109804 |
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分析证书 | 22-11-10 | R109804 |
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分析证书 | 22-04-27 | R109804 |
¥118.90
1. Edidiong Joseph Bassey, Jun-Hu Cheng, Da-Wen Sun. (2024) Comparative elucidation of bioactive and antioxidant properties of red dragon fruit peel as affected by electromagnetic and conventional drying approaches. FOOD CHEMISTRY, 439 (138118). [PMID:38109834] [10.1016/j.foodchem.2023.138118] |
2. Liu Chengyi, Du Guicai, Guo Qunqun, Li Ronggui, He Hongwei, Li Changming. (2023) Synergistic antibacterial performance of rosemarinic acid - graphene oxide in electrospun polylactic acid membranes for air filtration. JOURNAL OF POLYMER RESEARCH, 30 (12): (1-10). [PMID:10454543] [10.1007/s10965-023-03827-y] |
3. Jingyuan Zeng, Xican Li, Rongxin Cai, Chunhou Li, Shaoman Chen. (2023) Jinhua Qinggan Granule UHPLC-Q-extractive-Orbitrap-MS assay: Putative identification of 45 potential anti-Covid-19 constituents, confidential addition, and pharmacopoeia quality-markers recommendation. JOURNAL OF FOOD AND DRUG ANALYSIS, 31 (3): ( 534–551). [10.38212/2224-6614.3466] |
4. Xiaxi Pan, Guixin Chen, Ting Xu, Lingyue Kong, Xinying Li, Defu Li, Changdao Mu, Zhilang Xu, Liming Ge. (2023) Gelatin-Based Active Edible Film with pH-Sensing for Maintaining and Monitoring Fish Freshness. ACS Food Science & Technology, 3 (8): (1366–1375). [10.1021/acsfoodscitech.3c00175] |
5. Linghong Zhang, Zhongwu Bei, Tao Li, Zhiyong Qian. (2023) An injectable conductive hydrogel with dual responsive release of rosmarinic acid improves cardiac function and promotes repair after myocardial infarction. Bioactive Materials, 29 (132). [PMID:37621769] [10.1016/j.bioactmat.2023.07.007] |
6. Nan Hu, Lin Chen, Yunpeng Li, Nan Yao, Huizhen Li, Zhijun Zhang. (2023) Foam fractionation of rosmarinic acid from perilla leaves using surface-modified Al2O3 nanoparticle as frother and collector. INDUSTRIAL CROPS AND PRODUCTS, 197 (116633). [10.1016/j.indcrop.2023.116633] |
7. Zhixin Xiao, Min Liu, Wentao Bi, David Da Yong Chen. (2023) Ionic liquid as hydrogen bond acceptor in the extraction of nutritional natural products. FOOD CHEMISTRY, 412 (135589). [PMID:36736187] [10.1016/j.foodchem.2023.135589] |
8. Ming Meng, Haofang Wan, Yida Bao, Yu He, Chang Li, Haitong Wan. (2023) Rapid identification, quantitation, and antioxidant activity evaluation of the components in Guanxin Shutong capsule with liquid chromatography and mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 224 (115194). [PMID:36512869] [10.1016/j.jpba.2022.115194] |
9. Xie Lixia, Li Zhineng, Li Haitao, Sun Jiayu, Liu Xueying, Tang Jianxin, Lin Xizhu, Xu Laijun, Zhu Yuefang, Liu Zhi, Wang Tong. (2023) Fast Quantitative Determination of Principal Phenolic Anti-oxidants in Rosemary Using Ultrasound-Assisted Extraction and Chemometrics-Enhanced HPLC–DAD Method. Food Analytical Methods, 16 (2): (386-400). [10.1007/s12161-022-02421-0] |
10. Jingtong Xia, Minhua Qian, Jiahao Zhou, Zhaoyan Wang, Hongli Li, Lei Zhou, Qiaosheng Pu. (2022) Integrated strategy of derivatization and separation for sensitive analysis of salvianolic acids using capillary electrophoresis with laser-induced fluorescence detection. JOURNAL OF CHROMATOGRAPHY A, 1685 (463607). [PMID:36334567] [10.1016/j.chroma.2022.463607] |
11. Given Chisha, Chunlu Li, Lei Xiao, Bo Wang, Yueyuan Chen, Zhifang Cui. (2022) Multiscale mechanism exploration and experimental optimization for rosmarinic acid extraction from Rosmarinus officinalis using natural deep eutectic solvents. INDUSTRIAL CROPS AND PRODUCTS, 188 (115637). [10.1016/j.indcrop.2022.115637] |
12. Min Shi, Ruiyan Zhu, Yi Zhang, Siwei Zhang, Tingyao Liu, Kunlun Li, Shucan Liu, Leran Wang, Yao Wang, Wei Zhou, Qiang Hua, Guoyin Kai. (2022) A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza. METABOLIC ENGINEERING, 73 (182). [PMID:35934177] [10.1016/j.ymben.2022.08.002] |
13. Shen Qing, Wang Haixing, Quan Bin, Sun Xiuhua, Wu Guohua, Huang Darong, Wang Qingcheng, Luo Pei. (2022) Rapid quantification of bioactive compounds in Salvia miltiorrhiza Bunge derived decoction pieces, dripping pill, injection, and tablets by polarity-switching UPLC-MS/MS. Frontiers in Chemistry, 10 [PMID:35910733] [10.3389/fchem.2022.964744] |
14. Meixuan Liu, Sha Liu, Xiaosu Zhu, Yiying Sun, Linyu Su, Hairong Yu, Deshuai Liu, Ying Li, Yuan Du, Rongxia Liu, Kaoxiang Sun. (2022) Tanshinone IIA-Loaded Micelles Functionalized with Rosmarinic Acid: A Novel Synergistic Anti-Inflammatory Strategy for Treatment of Atherosclerosis. JOURNAL OF PHARMACEUTICAL SCIENCES, 111 (2827). [PMID:35580692] [10.1016/j.xphs.2022.05.007] |
15. Changan Zhu, Shaofang Wu, Ting Sun, Zhiwen Zhou, Zhangjian Hu, Jingquan Yu. (2021) Rosmarinic Acid Delays Tomato Fruit Ripening by Regulating Ripening-Associated Traits. Antioxidants, 10 (11): (1821). [PMID:34829692] [10.3390/antiox10111821] |
16. Yanjun An, Jiandong Zhao, Yourui Zhang, Wen Wu, Jiangtao Hu, Haosen Hao, Yu Qiao, Ying Tao, Liping An. (2021) Rosmarinic Acid Induces Proliferation Suppression of Hepatoma Cells Associated with NF-κB Signaling Pathway. Asian Pacific Journal of Cancer Prevention, 22 (5): ( 1623–1631). [PMID:34048194] [10.31557/APJCP.2021.22.5.1623] |
17. Yunsheng Liu, Xiangping Xu, Han Tang, Yuchen Pan, Bing Hu, Guodong Huang. (2021) Rosmarinic acid inhibits cell proliferation, migration, and invasion and induces apoptosis in human glioma cells. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 47 (5): (1-11). [PMID:33649774] [10.3892/ijmm.2021.4900] |
18. Wenwei Zhong, Yingnan Zhao, Shunquan Chen, Jialun Zhong, LiWei Guo, Dongyang Zheng, Chun Xie, Chao Ji, Yi Guo, Guangxi Dong, Fengyuan Zhang, Alicia An, Shaoping Li, Sheng Li. (2021) Resources recycle of traditional Chinese medicine (TCM) wastewater 1: Effectiveness of the UF-MD hybrid system and MD process optimization. DESALINATION, 504 (114953). [10.1016/j.desal.2021.114953] |
19. Hongjie Dai, Xueke Chen, Lin Peng, Liang Ma, Yi Sun, Lin Li, Qiang Wang, Yuhao Zhang. (2020) The mechanism of improved myosin gel properties by low dose rosmarinic acid addition during gel formation. FOOD HYDROCOLLOIDS, 106 (105869). [10.1016/j.foodhyd.2020.105869] |
20. Xu Wen-hao, Wang Han-tao, Sun Ying, Xue Zhen-cheng, Liang Ming-li, Su Wei-ke. (2020) Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice. JOURNAL OF PHARMACY AND PHARMACOLOGY, 72 (4): (551-560). [PMID:31910301] [10.1111/jphp.13222] |
21. Houmei Liu, Hui Yu, Pian Jin, Mi Jiang, Guozheng Zhu, Yu Duan, Ziyuan Yang, Hongdeng Qiu. (2020) Preparation of mesoporous silica materials functionalized with various amino-ligands and investigation of adsorption performances on aromatic acids. CHEMICAL ENGINEERING JOURNAL, 379 (122405). [10.1016/j.cej.2019.122405] |
22. Yusong Jin, Yunhui Zhang, Dongmei Liu, Dewen Liu, Chunying Zhang, Huijuan Qi, Huiyan Gu, Lei Yang, Zhiqiang Zhou. (2019) Efficient Homogenization-Ultrasound-Assisted Extraction of Anthocyanins and Flavonols from Bog Bilberry (Vaccinium uliginosum L.) Marc with Carnosic Acid as an Antioxidant Additive. MOLECULES, 24 (14): (2537). [PMID:31336730] [10.3390/molecules24142537] |
23. Hongxia Liu, Huifang Zhao, Lianfei Lyu, Zhengjin Huang, Sufan Fan, Wenlong Wu, Weilin Li. (2019) Synergistic effect of natural antifungal agents for postharvest diseases of blackberry fruits. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 99 (7): (3343-3349). [PMID:30578531] [10.1002/jsfa.9551] |
24. Zili Guo, Xianrui Liang, Yuanyuan Xie. (2019) Qualitative and quantitative analysis on the chemical constituents in Orthosiphon stamineus Benth. using ultra high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 164 (135). [PMID:30390555] [10.1016/j.jpba.2018.10.023] |
25. Liming Ge, Mingjin Zhu, Xinying Li, Yongbin Xu, Xiaonan Ma, Rong Shi, Defu Li, Changdao Mu. (2018) Development of active rosmarinic acid-gelatin biodegradable films with antioxidant and long-term antibacterial activities. FOOD HYDROCOLLOIDS, 83 (308). [10.1016/j.foodhyd.2018.04.052] |
26. Jia Zou, Yang Chen, Maggie Pui Man Hoi, Jun Li, Tao Wang, Ying Zhang, Yu Feng, Jianli Gao, Simon Ming Yuen Lee, Guozhen Cui. (2018) Discovery of a Novel ERp57 Inhibitor as Antiplatelet Agent from Danshen (Salvia miltiorrhiza). Evidence-based Complementary and Alternative Medicine, 2018 (9387568). [PMID:29849736] [10.1155/2018/9387568] |
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28. Shan Ye, Wang Dan-Dan, Xu Yu-Xia, Wang Chu, Cao Lan, Liu Yun-Sheng, Zhu Cui-Qing. (2015) Aging as a Precipitating Factor in Chronic Restraint Stress-Induced Tau Aggregation Pathology, and the Protective Effects of Rosmarinic Acid. JOURNAL OF ALZHEIMERS DISEASE, 49 (3): (829-844). [PMID:26577520] [10.3233/JAD-150486] |
29. Kitty S.C. Tang, Izabela Konczak, Jian Zhao. (2016) Identification and quantification of phenolics in Australian native mint (Mentha australis R. Br.). FOOD CHEMISTRY, 192 (698). [PMID:26304400] [10.1016/j.foodchem.2015.07.032] |
30. Xin Peng, Xiangchao Wang, Wei Qi, Rongxin Su, Zhimin He. (2016) Affinity of rosmarinic acid to human serum albumin and its effect on protein conformation stability. FOOD CHEMISTRY, 192 (178). [PMID:26304336] [10.1016/j.foodchem.2015.06.109] |
31. Xin Peng, Xiangchao Wang, Wei Qi, Renliang Huang, Rongxin Su, Zhimin He. (2015) Deciphering the binding patterns and conformation changes upon the bovine serum albumin–rosmarinic acid complex. Food & Function, 6 (8): (2712-2726). [PMID:26146359] [10.1039/C5FO00597C] |
32. Xin Peng, Wei Qi, Renliang Huang, Rongxin Su, Zhimin He. (2015) Elucidating the Influence of Gold Nanoparticles on the Binding of Salvianolic Acid B and Rosmarinic Acid to Bovine Serum Albumin. PLoS One, 10 (4): (e0118274). [PMID:25861047] [10.1371/journal.pone.0118274] |
33. Xican Li. (2013-07-23) Solvent effects and improvements in the deoxyribose degradation assay for hydroxyl radical-scavenging.. Food chemistry, 141 ((3)): (2083-2088). [PMID:23870931] |
1. Mirza FJ & Zahid S. (2022) Ursolic acid and rosmarinic acid ameliorate alterations in hippocampal neurogenesis and social memory induced by amyloid beta in mouse model of Alzheimer's disease.. Front Pharmacol, 13 (1058358). [PMID:36618920] |
2. Edidiong Joseph Bassey, Jun-Hu Cheng, Da-Wen Sun. (2024) Comparative elucidation of bioactive and antioxidant properties of red dragon fruit peel as affected by electromagnetic and conventional drying approaches. FOOD CHEMISTRY, 439 (138118). [PMID:38109834] [10.1016/j.foodchem.2023.138118] |
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