| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| R107314-100mg |
100mg |
现货  |
|
| 别名 | 芪三酚 | 3,4',5-三羟基芪 |
|---|---|
| 英文别名 | Q369O8926L | CHEBI:27881 | CU-01000001503-3 | HMS1792H15 | NSC133100 | BPBio1_000479 | NCGC00344093-09 | RESVERATROL (MART.) | MLS000069735 | MLS001076538 | Stilbene, 2f | (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol | MLS002222231 | TaxusChinensisi |
| 规格或纯度 | Moligand™, 分析标准品 |
| 英文名称 | Resveratrol |
| 生化机理 | 白藜芦醇是一种酚类植物素，存在于葡萄皮和其他植物中。白藜芦醇对培养的 DA 神经元具有神经营养作用。白藜芦醇可通过cGMP/PKG信号通路使GSK-3β失活，从而减轻氧化剂诱导的胚胎大鼠心肌细胞线粒体损伤，这与NO相关机制无关。由于白藜芦醇具有抗炎、抗氧化和降甘油三酯的作用，补充白藜芦醇可能会对健康吸烟者增加的心血管风险产生有益影响。反式白藜芦醇是一种存在于葡萄和红葡萄酒中的强效酚类抗氧化剂，也具有抗增殖和抗炎活性。反式白藜芦醇还是环氧化酶-1（COX-1）的选择性抑制剂。它能抑制 COX-1 的 COX 和过氧化物酶活性，ED50 值分别为 15 和 3.7 M；对 COX 活性基本上没有抑制作用。具有多种生物活性，包括抗氧化、抗血小板、抗肿瘤、抗炎和心脏保护作用。此外，还具有抗淀粉样蛋白生成和纤维稳定作用。 |
| 应用 | COX−1选择性抑制剂。 白藜芦醇是一种酚类植物抗毒素,发现于葡萄皮和其他植物中。它具有细胞内抗氧化活性激活去乙酰化酶SIRT1。白藜芦醇的抗糖尿病、神经保护和抗脂特性都可能是去乙酰化酶SIRT1激活所致。 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | COX-2 抑制剂；TAS2R14 激动剂；过氧化物酶体增殖激活受体-γ 拮抗剂 |
| 备注 | 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| 产品介绍 |
无味，完全溶解于乙醇。 COX−1选择性抑制剂。 白藜芦醇是一种酚类植物抗毒素,发现于葡萄皮和其他植物中。它具有细胞内抗氧化活性激活去乙酰化酶SIRT1。白藜芦醇的抗糖尿病、神经保护和抗脂特性都可能是去乙酰化酶SIRT1激活所致。 |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 610-504-8 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol |
| INCHI | InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+ |
| InChi Key | LUKBXSAWLPMMSZ-OWOJBTEDSA-N |
| Canonical SMILES | C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O |
| Isomeric SMILES | C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O |
| WGK Germany | 3 |
| RTECS | CZ8987000 |
| 关联CAS | 501-36-0 |
| PubChem CID | 445154 |
| NSC Number | 327430 |
| MeSH Entry Terms | 3,4',5-stilbenetriol;3,4',5-Trihydroxystilbene;3,5,4'-trihydroxystilbene;cis Resveratrol;cis-resveratrol;resveratrol;Resveratrol 3 sulfate;Resveratrol, (Z)-;resveratrol-3-sulfate;SRT 501;SRT-501;SRT501;trans Resveratrol;trans Resveratrol 3 O sulfate;trans |
| 分子量 | 228.24 |
| 密度 | 1.359 |
|---|---|
| 熔点 | 267 °C |
| 分子量 | 228.240 g/mol |
| XLogP3 | 3.100 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 228.079 Da |
| 单同位素质量Monoisotopic Mass | 228.079 Da |
| 拓扑极表面积Topological Polar Surface Area | 60.700 Ų |
| 重原子数Heavy Atom Count | 17 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 246.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 1 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 1 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H319: 引起严重眼睛刺激 |
| 预防措施声明 |
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | CZ8987000 |
| Merck Index | 8158 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Faceshields,Gloves |
| Purity(GC) | 99.5-100（%） |
|---|---|
| Appearance（R107314) | White to Off-White Powder |
| Proton NMR spectrum | Conforms to Structure |
| Solubility in Acetone，Faint Yellow,Clear,50 mg/ml | pass |
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 H1617086 |
分析证书 | 23-12-20 | R107314 |
| 1. Song Yu, Lianpeng Zou, Jiawei Zhao, Yiping Zhu. (2023) Resveratrol alleviates fumonisin-induced intestinal cytotoxicity by modulating apoptosis, tight junction, and inflammation in IPEC-J2 porcine intestinal epithelial cells. ENVIRONMENTAL TOXICOLOGY, (15): [PMID:37955343] [10.1002/tox.24033] |
| 2. Yifan Ma, Yi Qian, Yuteng Chen, Xiaoxu Ruan, Xiaoya Peng, Yi Sun, Jue Zhang, Jingjing Luo, Songlin Zhou, Chao Deng. (2023) Resveratrol modulates the inflammatory response in hPDLSCs via the NRF2/HO-1 and NF-κB pathways and promotes osteogenic differentiation. JOURNAL OF PERIODONTAL RESEARCH, [PMID:37905727] [10.1111/jre.13200] |
| 3. Dong Wu, Huihui Ming, Wei Wu, Wenjie Yu, Gaowei Zhang, Jinzhu Gu, Meng Cui, Xueyong Huang, Fangjian Ning, Liping Luo. (2024) In situ neutral desorption-extractive electrospray ionization mass spectrometry reveals red-blue light promoted the accumulation of amino acids and polyphenols in Anoectochilus roxburghii. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 125 (105761). [PMID:18810425] [10.1016/j.jfca.2023.105761] |
| 4. Nayun Kim, Junhye Kwon, Ui Sup Shin, Joohee Jung. (2023) Stimulatory Anticancer Effect of Resveratrol Mediated by G Protein-Coupled Estrogen Receptor in Colorectal Cancer. Biomolecules & Therapeutics, 31 (6): ( 655–660). [PMID:37817377] [10.4062/biomolther.2023.072] |
| 5. Yuan Gu, Yanjun Cai, Yige Kou, Erzhuo Cheng, Hanjie Bi, Min Hu, Songyao Wu, Yong Jiang, Jingxi Zhang, Qingting Wu, Yunyi Li, Bin Yang. (2023) Construction of multifunctional targeted nano-prodrugs based on PAMAM dendrimers for tumor therapy. EUROPEAN POLYMER JOURNAL, 200 (12): (112486). [PMID:21709241] [10.1016/j.eurpolymj.2023.112486] |
| 6. Liu Xinru, Ma Qianwei, Sun Yongjun, Ju Wenming, Kumrungsee Thanutchaporn, Zhou Zhongkai, Wang Lijuan, Cao Ruge. (2023) Effects of Processings and Complexation on Solubility, Antioxidant and Antibacterial Properties of Buckwheat Polyphenols. Food and Bioprocess Technology, (8): (1-13). [PMID:18063578] [10.1007/s11947-023-03217-8] |
| 7. Chen Wang, Ding Tang, Wei Xu, Yan Liu, Zhao-He Huang, Pang-Chui Shaw, Ren-Wang Jiang. (2023) Glycosylation of the polyphenols from Resina draconis by glycosyltransferase YjiC1. NATURAL PRODUCT RESEARCH, [PMID:35437081] [10.1080/14786419.2022.2066100] |
| 8. Zhiyu Sun, Yongbin Zhou, Wenxu Zhu, You Yin. (2023) Assessment of the Fruit Chemical Characteristics and Antioxidant Activity of Different Mulberry Cultivars (Morus spp.) in Semi-Arid, Sandy Regions of China. Foods, 12 (18): (3495). [PMID:37761204] [10.3390/foods12183495] |
| 9. Li Yanyan, Wang Hongling, Shi Haiming, Guo Qin, Zhang Yuquan, Shi Aimin, Jiang Yuanrong, Wang Qiang. (2023) Quantification of Resveratrol in Peanut Oils Using Stable Isotope Dilution Ultra-high Performance Liquid Chromatography-Mass Spectrometry. Food Analytical Methods, 16 (11): (1673-1679). [PMID:17160893] [10.1007/s12161-023-02534-0] |
| 10. Yao Ke, Mou Qianxue, Lou Xiaotong, Ye Meng, Zhao Bowen, Hu Yuanyuan, Luo Jing, Zhang Hong, Li Xing, Zhao Yin. (2023) Microglial SIRT1 activation attenuates synapse loss in retinal inner plexiform layer via mTORC1 inhibition. Journal of Neuroinflammation, 20 (1): (1-18). [PMID:37670386] [10.1186/s12974-023-02886-8] |
| 11. Yajie Zhang, Changjiao Shang, Chaofan Sun, Lingling Wang. (2024) Simultaneously regulating absorption capacities and antioxidant activities of four stilbene derivatives utilizing substitution effect: A theoretical and experimental study against UVB radiation. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 304 (123325). [PMID:37678043] [10.1016/j.saa.2023.123325] |
| 12. Chen-Xi Bi, Kai-Qi Jin, Jing Yan, Yu Qin, Feng Hong, Wei-Hua Huang, Yan-Ling Liu. (2023) Nanofiber-based Stretchable Electrodes for Oriented Culture and Mechanotransduction Monitoring of Smooth Muscle Cells. ACS Sensors, 8 (8): (3248–3256). [PMID:37581426] [10.1021/acssensors.3c01135] |
| 13. Lu Tan, Menghuan Li, Hang Chen, Yuchen Zhang, Yuan Liu, Maohua Chen, Zhong Luo, Kaiyong Cai, Yan Hu. (2023) Dynamic hydrogel with environment-adaptive autonomous wound-compressing ability enables rapid hemostasis and inflammation amelioration for hemorrhagic wound healing. Nano Today, 52 (101962). [10.1016/j.nantod.2023.101962] |
| 14. Hao Guan, Zhiyong Li, Qinlong Xu, Jingjing Meng, Kai Guo. (2023) Dual bio-based epoxy resin as green substitute for DGEBA analogue with high performances. REACTIVE & FUNCTIONAL POLYMERS, 191 (105687). [10.1016/j.reactfunctpolym.2023.105687] |
| 15. Minghui Cai, Haijuan Sun, Yujia Huang, Haixu Yao, Chen Zhao, Jiao Wang, Hui Zhu. (2023) Resveratrol Protects Rat Ovarian Luteinized Granulosa Cells from H2O2-Induced Dysfunction by Activating Autophagy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (13): (10914). [PMID:37446088] [10.3390/ijms241310914] |
| 16. Maolin Li, Xin Zhang, Dandan Han, Songgu Wu, Junbo Gong. (2023) Systematic study on lysozyme-hyaluronan complexes: Multi-spectroscopic characterization and molecular dynamics simulation. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 246 (125642). [PMID:37394210] [10.1016/j.ijbiomac.2023.125642] |
| 17. Song Yu, Lianpeng Zou, Jiawei Zhao, Yiping Zhu. (2023) Individual and Combined Cytotoxic Effects of Co-Occurring Fumonisin Family Mycotoxins on Porcine Intestinal Epithelial Cell. Foods, 12 (13): (2555). [PMID:37444293] [10.3390/foods12132555] |
| 18. Duoduo Li, Zihao Wei, Xiaolong Li. (2023) Development, Characterization and Resveratrol Delivery of Hollow Gliadin Nanoparticles: Advantages over Solid Gliadin Nanoparticles. Foods, 12 (13): (2436). [PMID:37444174] [10.3390/foods12132436] |
| 19. Feifei Liu, Ying Chen, Jianle Chen, Enbo Xu, Haibo Pan, Shiguo Chen, Xingqian Ye, Huan Cheng. (2023) Characteristic aroma improvement mechanisms of heat-sterilized bayberry juice regulated by exogenous polyphenols. FOOD CHEMISTRY, 427 (136644). [PMID:37390737] [10.1016/j.foodchem.2023.136644] |
| 20. Chen Shengnan, Li Bo, Chen Lei, Jiang Hongli. (2023) Uncovering the mechanism of resveratrol in the treatment of diabetic kidney disease based on network pharmacology, molecular docking, and experimental validation. Journal of Translational Medicine, 21 (1): (1-14). [PMID:37308949] [10.1186/s12967-023-04233-0] |
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