核糖核酸酶A 来源于牛胰腺

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  • Accession #: P61823
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货号 (SKU) 包装规格 是否现货 价格 数量
R104906-10mg
10mg 现货 Stock Image
R104906-50mg
50mg 现货 Stock Image
R104906-250mg
250mg 现货 Stock Image
R104906-500mg
500mg 现货 Stock Image
R104906-1g
1g 现货 Stock Image

基本描述

产品名称 核糖核酸酶A 来源于牛胰腺
别名 RNA酶,RNase A ,RNase I
英文别名 DL-(3-aminopropanoyl)histidine | L-Histidine, N-.beta.-alanyl- | SCHEMBL33768 | NSC524045 | NSC-524045 | L-HISTIDINE, N-beta-ALANYL- | MFCD00005207 | 2-(3-amino-propanoylamino)-3-(1H-imidazol-4-yl)-propionic acid | DTXSID50861860 | 2-(3-aminopropanoylamin
规格或纯度 EnzymoPure™, ≥ 50 Kunitz units/mg
产品介绍

核糖核酸酶能专一性地作用于嘧啶碱基,分解RNA从而得到含有3'-UMP,3'-CMP,及其低聚核苷酸。核糖核酸酶是由单链多肽链组成,为分子量约1.4万的球状蛋白质,虽对于稀酸、热、蛋白质分解酶极为稳定,但在碱中不稳定。• RNase 保护检测 • 去除非特异结合的RNA • 分析RNA 序列 • 水解蛋白样品中的RNA • 纯化DNA


Accession # P61823

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关联靶点(人)

ACHN (49357 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAKI-1 (44928 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CCRF-CEM (65223 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
COLO 205 (50209 活性数据)
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DU-145 (51482 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HL-60 (67320 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-29 (80576 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
K562 (73714 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KM12 (47707 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
M14 (47487 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 活性数据)
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MOLT-4 (49676 活性数据)
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OVCAR-3 (48710 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-4 (44535 活性数据)
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OVCAR-5 (45555 活性数据)
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OVCAR-8 (47708 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-3 (62116 活性数据)
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RPMI-8226 (44974 活性数据)
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SF-295 (48000 活性数据)
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SK-MEL-2 (46422 活性数据)
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SK-MEL-28 (48833 活性数据)
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SK-MEL-5 (47095 活性数据)
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SN12C (47755 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SNB-19 (46794 活性数据)
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TK-10 (45540 活性数据)
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U-251 (51189 活性数据)
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UACC-257 (46019 活性数据)
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UO-31 (46270 活性数据)
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786-0 (47912 活性数据)
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A549 (127892 活性数据)
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NCI/ADR-RES (33767 活性数据)
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T47D (39041 活性数据)
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EKVX (44102 活性数据)
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NCI-H322M (45589 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCC 2998 (41480 活性数据)
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HCT-116 (91556 活性数据)
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HOP-92 (41141 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hs-578T (29457 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H460 (60772 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SF-268 (49410 活性数据)
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IGROV-1 (47897 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LOX IMVI (44321 活性数据)
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HOP-62 (47048 活性数据)
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MDA-MB-435 (38290 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-N (28205 活性数据)
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Malme-3M (44254 活性数据)
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MDA-MB-231 (73002 活性数据)
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SNB-75 (44215 活性数据)
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NCI-H226 (44470 活性数据)
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NCI-H23 (49055 活性数据)
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作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

产品规格参数

浓度 ≥ 50 Kunitz units/mg
储存温度 -20°C储存
运输条件 超低温冰袋运输
CAS编号和信息 9001-99-4
酶学委员会编号 3.1.27.5
单位定义 在 25℃、pH5.0 时,一定量的酶使 RNA 按比率水解,速度常数 k 等于单位
分子类型 小分子

安全和危险性(GHS)

象形图 GHS08
信号词 Danger
危险声明

H334: 吸入可能引起过敏或哮喘病症状或呼吸困难

预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P501: 将内容物/容器处理到。。。

P284: 如果通风不良,请佩戴呼吸防护装置。

P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。

P342+P316: 如果出现呼吸道症状:立即寻求急救。

技术规格说明书

Loss on drying 0-5(%)
potency 50-100(IU/mg OR I.U./mg)
Appearance(R104906) White or pale yellow lyophilized powder
DNases none detected

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到19个结果

批号(Lot Number) 证书类型 日期 货号
H2324352 分析证书 25-05-12 R104906
H2324353 分析证书 25-05-12 R104906
H2324354 分析证书 25-05-12 R104906
J2226749 分析证书 24-06-15 R104906
J2226748 分析证书 24-06-03 R104906
F2213080 分析证书 24-03-20 R104906
F2213081 分析证书 24-03-20 R104906
A2422160 分析证书 24-01-26 R104906
A2422294 分析证书 24-01-26 R104906
A2422159 分析证书 24-01-26 R104906
C2013135 分析证书 23-10-10 R104906
B2514027 分析证书 23-07-11 R104906
H2324351 分析证书 23-07-11 R104906
I2124359 分析证书 23-06-16 R104906
J2226747 分析证书 22-08-03 R104906
J2226750 分析证书 22-08-03 R104906
J2226751 分析证书 22-08-03 R104906
F2213083 分析证书 22-06-04 R104906
F2213420 分析证书 22-06-04 R104906

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此产品的引用文献

1. Ningning Lei, Xu Peng, Mengyue Hu, Chang Wan, Xixun Yu.  (2023)  Research on essential performance of oxidized chitosan-crosslinked acellular porcine aorta modified with bioactive SCPP/DOPA for esophageal scaffold with enhanced mechanical strength, biocompatibility and anti-inflammatory.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  241  (124522).  [PMID:37100332] [10.1016/j.ijbiomac.2023.124522]
2. Qing Liu, Chao Yan, Yan Wang.  (2023)  Submicron Nonporous Silica Particles for Enhanced Separation Performance in pCEC.  MOLECULES,  28  (8): (3542).  [PMID:37110774] [10.3390/molecules28083542]
3. Tingting Wu, Xushun Liu, Hanjun Chen, Ying Liu, Yu Cao.  (2023)  An in situ exosomal miRNA sensing biochip based on multi-branched localized catalytic hairpin assembly and photonic crystals.  BIOSENSORS & BIOELECTRONICS,  222  (115013).  [PMID:36529054] [10.1016/j.bios.2022.115013]
4. Hui-Zhen Zhang, Mei Shu, Wen-Yu Yang, Hong Pan, Men-Xuan Tang, Yuan-Yang Zhao, Chan Zhong, Guo-Ping Wu.  (2023)  Isolation and characterization of a novel Salmonella bacteriophage JNwz02 capable of lysing Escherichia coli O157:H7 and its antibacterial application in foods.  LWT-FOOD SCIENCE AND TECHNOLOGY,  173  (114251).  [10.1016/j.lwt.2022.114251]
5. Can Cheng, Xu Peng, Linjie Xi, Yihao Luo, Yuhang Wang, Yufan Zhou, Xixun Yu.  (2022)  Feasibility study of oxidized naringin as a novel crosslinking agent for crosslinking decellularized porcine Achilles tendon and its potential application for anterior cruciate ligament repair.  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,  111  (2): (170-184).  [PMID:36054309] [10.1002/jbm.a.37440]
6. Zhi-Heng Pan, Shi-Song Yu, Chen-Chen Bai, Wen-Yu Yin, Yi-Rong Ma, Zi-Ang Xue, Qin-Yue Lu, Lin-Yi Dong, Xian-Hua Wang.  (2022)  Poly(caffeic acid)-coated molecularly imprinted magnetic nanoparticles for specific and ultrasensitive detection of glycoprotein.  TALANTA,  241  (123240).  [PMID:35065346] [10.1016/j.talanta.2022.123240]
7. Shuwen Guo, Qiaoxian Huang, Jianwen Wei, Shengpeng Wang, Yitao Wang, Leyong Wang, Ruibing Wang.  (2022)  Efficient intracellular delivery of native proteins facilitated by preorganized guanidiniums on pillar[5]arene skeleton.  Nano Today,  43  (101396).  [10.1016/j.nantod.2022.101396]
8. Jiasheng Shi, Henan Zhang, Qian Wang, Zhengyu Duan, Li Xu, Fenghao Guo, Yunfeng Xie, Zhiyong Chen.  (2022)  Biomimetic rigid cryogels with aligned micro-sized tubular structures prepared by conventional redox-induced cryopolymerization in a freezer.  CHEMICAL ENGINEERING JOURNAL,  427  (131903).  [10.1016/j.cej.2021.131903]
9. Yu Luo, Shenyu Huang, Lie Ma.  (2021)  A novel detergent-based decellularization combined with carbodiimide crosslinking for improving anti-calcification of bioprosthetic heart valve.  Biomedical Materials,  16  (4): (45022).  [PMID:33979785] [10.1088/1748-605X/ac0088]
10. Jie Xing, Fang Wang, Hailin Cong, Song Wang, Youqing Shen, Bing Yu.  (2021)  Analysis of proteins and chiral drugs based on vancomycin covalent capillary electrophoretic coating.  ANALYST,  146  (4): (1320-1325).  [PMID:33367313] [10.1039/D0AN02018D]
11. Rui Duan, Chao Peng, Lu Sun, Lu-Xia Zhang, Chen-Chen Bai, Lin-Yi Dong, Xian-Hua Wang.  (2021)  Integrating boronate affinity controllable-oriented surface imprinting nylon wire and pH-triggered allochroic-graphene oxide for ultrasensitive detection of glycoprotein.  SENSORS AND ACTUATORS B-CHEMICAL,  330  (129310).  [10.1016/j.snb.2020.129310]
12. Yu Luo, Lie Ma.  (2020)  Bioprosthetic heart valves with reduced immunogenic residuals using vacuum-assisted decellularization treatment.  Biomedical Materials,  15  (6): (65012).  [PMID:33016260] [10.1088/1748-605X/abaabf]
13. Jie Xing, Ming-Hong Wang, Song Wang, Hai-Lin Cong, You-Qing Shen, Bing Yu.  (2020)  Analysis of proteins by capillary electrophoresis with a novel diazoresin/β-Cyclodextrin covalent capillary coating method.  FERROELECTRICS,  [10.1080/00150193.2020.1760608]
14. Qiuyue Sha, Ruixue Guan, Huiying Su, Liang Zhang, Bi-Feng Liu, Zhaoyu Hu, Xin Liu.  (2020)  Carbohydrate-protein template synthesized high mannose loading gold nanoclusters: A powerful fluorescence probe for sensitive Concanavalin A detection and specific breast cancer cell imaging.  TALANTA,  218  (121130).  [PMID:32797887] [10.1016/j.talanta.2020.121130]
15. Ying Jia, Han Gao, Mengmeng Tong, Donald M. Anderson.  (2019)  Cell cycle regulation of the mixotrophic dinoflagellate Dinophysis acuminata: Growth, photosynthetic efficiency and toxin production.  HARMFUL ALGAE,  89  (101672).  [PMID:31672228] [10.1016/j.hal.2019.101672]
16. Yameng Han, Zhongju Ye, Fuyan Wang, Tianyu Chen, Lin Wei, Langxing Chen, Lehui Xiao.  (2019)  Single-particle enumeration-based ultrasensitive enzyme activity quantification with fluorescent polymer nanoparticles.  Nanoscale,  11  (31): (14793-14801).  [PMID:31353389] [10.1039/C9NR01817D]
17. Wei Chen, Min Fu, Xixi Zhu, Qingyun Liu.  (2019)  A close-packed imprinted colloidal array for naked-eye detection of glycoproteins under physiological pH.  BIOSENSORS & BIOELECTRONICS,  142  (111499).  [PMID:31306955] [10.1016/j.bios.2019.111499]
18. Yu Luo, Dong Lou, Lie Ma, Changyou Gao.  (2019)  Optimizing detergent concentration and processing time to balance the decellularization efficiency and properties of bioprosthetic heart valves.  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,  107  (10): (2235-2243).  [PMID:31125175] [10.1002/jbm.a.36732]
19. Manman Han, Wan Li, Rui Chen, Yangyang Han, Xiuhua Liu, Tingting Wang, Huaizhong Guo, Xiaoqiang Qiao.  (2018)  Amino acid and ionic liquid modified polyhedral oligomeric silsesquioxane-based hybrid monolithic column for high-efficiency capillary liquid chromatography.  JOURNAL OF CHROMATOGRAPHY A,  1572  (82).  [PMID:30153983] [10.1016/j.chroma.2018.08.045]
20. Qi-Qing LI, Jian ZHANG, Ji-Hua LIU, Bo-Yang YU.  (2018)  Morphological and chemical studies of artificial Andrographis paniculata polyploids.  Chinese Journal of Natural Medicines,  16  (81).  [PMID:29455732] [10.1016/S1875-5364(18)30033-5]
21. Yi Hao, Ruixia Gao, Dechun Liu, Gaiyan He, Yuhai Tang, Zengjun Guo.  (2016)  A facile and general approach for preparation of glycoprotein-imprinted magnetic nanoparticles with synergistic selectivity.  TALANTA,  153  (211).  [PMID:27130111] [10.1016/j.talanta.2016.03.005]
22. Yu Tian, Yunfang Li, Jie Mei, Bo Cai, Jinfeng Dong, Zhiguo Shi, Yuxiu Xiao.  (2015)  Simultaneous separation of acidic and basic proteins using gemini pyrrolidinium surfactants and hexafluoroisopropanol as dynamic coating additives in capillary electrophoresis.  JOURNAL OF CHROMATOGRAPHY A,  1412  (151).  [PMID:26300480] [10.1016/j.chroma.2015.08.020]
23. Yuanting Xu, Chengcheng Huang, Li Li, Xixun Yu, Xu Wang, Hong Peng, Zhipeng Gu, Yaping Wang.  (2013)  In vitro enzymatic degradation of a biological tissue fixed by alginate dialdehyde.  CARBOHYDRATE POLYMERS,  95  (148).  [PMID:23618251] [10.1016/j.carbpol.2013.03.021]
24. Yuanting Xu, Li Li, Hao Wang, Xixun Yu, Zhipeng Gu, Chengcheng Huang, Hong Peng.  (2013)  In vitro cytocompatibility evaluation of alginate dialdehyde for biological tissue fixation.  CARBOHYDRATE POLYMERS,  92  (448).  [PMID:23218319] [10.1016/j.carbpol.2012.09.096]
25. Yujie Zhang,Renling Lu,Ming Chen,Shouyong Zhou,Dabing Zhang,Haifeng Han,Mingliang Zhang,Hongdeng Qiu.  (2020-08-17)  A highly efficient acyl-transfer approach to urea-functionalized silanes and their immobilization onto silica gel as stationary phases for liquid chromatography..  Journal of chromatography. A,  1626  (461366-461366).  [PMID:32797845]

参考文献

1. Ningning Lei, Xu Peng, Mengyue Hu, Chang Wan, Xixun Yu.  (2023)  Research on essential performance of oxidized chitosan-crosslinked acellular porcine aorta modified with bioactive SCPP/DOPA for esophageal scaffold with enhanced mechanical strength, biocompatibility and anti-inflammatory.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  241  (124522).  [PMID:37100332] [10.1016/j.ijbiomac.2023.124522]
2. Qing Liu, Chao Yan, Yan Wang.  (2023)  Submicron Nonporous Silica Particles for Enhanced Separation Performance in pCEC.  MOLECULES,  28  (8): (3542).  [PMID:37110774] [10.3390/molecules28083542]
3. Tingting Wu, Xushun Liu, Hanjun Chen, Ying Liu, Yu Cao.  (2023)  An in situ exosomal miRNA sensing biochip based on multi-branched localized catalytic hairpin assembly and photonic crystals.  BIOSENSORS & BIOELECTRONICS,  222  (115013).  [PMID:36529054] [10.1016/j.bios.2022.115013]
4. Hui-Zhen Zhang, Mei Shu, Wen-Yu Yang, Hong Pan, Men-Xuan Tang, Yuan-Yang Zhao, Chan Zhong, Guo-Ping Wu.  (2023)  Isolation and characterization of a novel Salmonella bacteriophage JNwz02 capable of lysing Escherichia coli O157:H7 and its antibacterial application in foods.  LWT-FOOD SCIENCE AND TECHNOLOGY,  173  (114251).  [10.1016/j.lwt.2022.114251]
5. Can Cheng, Xu Peng, Linjie Xi, Yihao Luo, Yuhang Wang, Yufan Zhou, Xixun Yu.  (2022)  Feasibility study of oxidized naringin as a novel crosslinking agent for crosslinking decellularized porcine Achilles tendon and its potential application for anterior cruciate ligament repair.  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,  111  (2): (170-184).  [PMID:36054309] [10.1002/jbm.a.37440]
6. Zhi-Heng Pan, Shi-Song Yu, Chen-Chen Bai, Wen-Yu Yin, Yi-Rong Ma, Zi-Ang Xue, Qin-Yue Lu, Lin-Yi Dong, Xian-Hua Wang.  (2022)  Poly(caffeic acid)-coated molecularly imprinted magnetic nanoparticles for specific and ultrasensitive detection of glycoprotein.  TALANTA,  241  (123240).  [PMID:35065346] [10.1016/j.talanta.2022.123240]
7. Shuwen Guo, Qiaoxian Huang, Jianwen Wei, Shengpeng Wang, Yitao Wang, Leyong Wang, Ruibing Wang.  (2022)  Efficient intracellular delivery of native proteins facilitated by preorganized guanidiniums on pillar[5]arene skeleton.  Nano Today,  43  (101396).  [10.1016/j.nantod.2022.101396]
8. Jiasheng Shi, Henan Zhang, Qian Wang, Zhengyu Duan, Li Xu, Fenghao Guo, Yunfeng Xie, Zhiyong Chen.  (2022)  Biomimetic rigid cryogels with aligned micro-sized tubular structures prepared by conventional redox-induced cryopolymerization in a freezer.  CHEMICAL ENGINEERING JOURNAL,  427  (131903).  [10.1016/j.cej.2021.131903]
9. Yu Luo, Shenyu Huang, Lie Ma.  (2021)  A novel detergent-based decellularization combined with carbodiimide crosslinking for improving anti-calcification of bioprosthetic heart valve.  Biomedical Materials,  16  (4): (45022).  [PMID:33979785] [10.1088/1748-605X/ac0088]
10. Jie Xing, Fang Wang, Hailin Cong, Song Wang, Youqing Shen, Bing Yu.  (2021)  Analysis of proteins and chiral drugs based on vancomycin covalent capillary electrophoretic coating.  ANALYST,  146  (4): (1320-1325).  [PMID:33367313] [10.1039/D0AN02018D]
11. Rui Duan, Chao Peng, Lu Sun, Lu-Xia Zhang, Chen-Chen Bai, Lin-Yi Dong, Xian-Hua Wang.  (2021)  Integrating boronate affinity controllable-oriented surface imprinting nylon wire and pH-triggered allochroic-graphene oxide for ultrasensitive detection of glycoprotein.  SENSORS AND ACTUATORS B-CHEMICAL,  330  (129310).  [10.1016/j.snb.2020.129310]
12. Yu Luo, Lie Ma.  (2020)  Bioprosthetic heart valves with reduced immunogenic residuals using vacuum-assisted decellularization treatment.  Biomedical Materials,  15  (6): (65012).  [PMID:33016260] [10.1088/1748-605X/abaabf]
13. Jie Xing, Ming-Hong Wang, Song Wang, Hai-Lin Cong, You-Qing Shen, Bing Yu.  (2020)  Analysis of proteins by capillary electrophoresis with a novel diazoresin/β-Cyclodextrin covalent capillary coating method.  FERROELECTRICS,  [10.1080/00150193.2020.1760608]
14. Qiuyue Sha, Ruixue Guan, Huiying Su, Liang Zhang, Bi-Feng Liu, Zhaoyu Hu, Xin Liu.  (2020)  Carbohydrate-protein template synthesized high mannose loading gold nanoclusters: A powerful fluorescence probe for sensitive Concanavalin A detection and specific breast cancer cell imaging.  TALANTA,  218  (121130).  [PMID:32797887] [10.1016/j.talanta.2020.121130]
15. Ying Jia, Han Gao, Mengmeng Tong, Donald M. Anderson.  (2019)  Cell cycle regulation of the mixotrophic dinoflagellate Dinophysis acuminata: Growth, photosynthetic efficiency and toxin production.  HARMFUL ALGAE,  89  (101672).  [PMID:31672228] [10.1016/j.hal.2019.101672]
16. Yameng Han, Zhongju Ye, Fuyan Wang, Tianyu Chen, Lin Wei, Langxing Chen, Lehui Xiao.  (2019)  Single-particle enumeration-based ultrasensitive enzyme activity quantification with fluorescent polymer nanoparticles.  Nanoscale,  11  (31): (14793-14801).  [PMID:31353389] [10.1039/C9NR01817D]
17. Wei Chen, Min Fu, Xixi Zhu, Qingyun Liu.  (2019)  A close-packed imprinted colloidal array for naked-eye detection of glycoproteins under physiological pH.  BIOSENSORS & BIOELECTRONICS,  142  (111499).  [PMID:31306955] [10.1016/j.bios.2019.111499]
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