| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P275736-50mg |
50mg |
现货  |
| |
| P275736-250mg |
250mg |
期货 |
|
| 别名 | 1-[1-[4,4-双(4-氟苯基)丁基]-4-哌啶基]-1,3-二氢-2H-苯并咪唑-2-酮 |
|---|---|
| 英文别名 | Orap | R6238 | MLS000028410 | Pimozidum | PIMOZIDE [USP MONOGRAPH] | Prestwick0_000308 | HMS501D08 | Opiran | BSPBio_001439 | GTPL90 | KBio2_006061 | Pimozide (USAN:USP:INN:BAN:JAN) | Prestwick2_000308 | 5-24-02-00367 (Beilstein Handbook Reference) | Lopa |
| 规格或纯度 | Moligand™, ≥98% |
| 英文名称 | Pimozide |
| 生化机理 | D 2-受体拮抗剂。抗精神病药。与5-HT 7受体具有高亲和力（K i = 0.5 nM）。降低STAT5酪氨酸磷酸化。 |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 作用类型 | 拮抗剂 |
| 作用机制 | 多巴胺受体拮抗剂 |
| 备注 | 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| 产品介绍 |
Pimozide 是 dopamine receptor 的拮抗剂，对 dopamine D2，D3 和 D1 受体的 Ki 值分别为 1.4 nM，2.5 nM 和 588 nM，同时对 α1-adrenoceptor 也有较高亲和性，Ki 值为 39 nM；Pimozide 也是 STAT3 和 STAT5 的抑制剂。 产品应用： Pimozide (Orap, R6238) 是一种 Dopamine Receptors 的拮抗剂，对dopamine D3，D2和D1受体的Ki值分别为0.83 nM，3.0 nM和6600 nM。Pimozide 在5-HT1A和α1-adrenoceptor 处也表现出结合亲和力，对应的Ki值分别为310 nM、39 nM。Pimozide 是一种具有抗肿瘤活性的抗精神病药物，可抑制 STAT3 和 STAT5 活性。 |
| ALogP | 6.3 |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 504752750 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1H-benzimidazol-2-one |
| INCHI | InChI=1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34) |
| InChi Key | YVUQSNJEYSNKRX-UHFFFAOYSA-N |
| Canonical SMILES | C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F |
| Isomeric SMILES | C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F |
| PubChem CID | 16362 |
| 分子量 | 461.55 |
| 溶解性 | Soluble in DMSO to 100 mM |
|---|---|
| 分子量 | 461.500 g/mol |
| XLogP3 | 6.300 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 7 |
| 精确质量Exact Mass | 461.228 Da |
| 单同位素质量Monoisotopic Mass | 461.228 Da |
| 拓扑极表面积Topological Polar Surface Area | 35.600 Ų |
| 重原子数Heavy Atom Count | 34 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 632.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| Purity(HPLC area) | |
|---|---|
| NMR Spectrum 1H | Conforms to Structure |
| LC-MS for identification | Conforms |
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