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普鲁卡因, RyR1 通道阻断剂；RyR2 通道阻断剂

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货号 (SKU) 包装规格 是否现货 价格 数量
P160609-5g
 5g 现货 Stock Image
P160609-25g
 25g 现货 Stock Image
P160609-100g
 100g 现货 Stock Image
P160609-500g
 500g 现货 Stock Image
P160609-2.5kg
 2.5kg 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
查看相关系列
Cell Cycle/DNA Damage (2603) DNA/RNA Synthesis (362) Histone Demethylase (97) RyR1 Channel blocker (2) RyR2 Channel blocker (2) 药物靶标 (3) 表观遗传学 (1496)
main product photo

基本描述

别名 4-氨基苯甲酸-2-(二乙氨基)乙酯 | 普鲁卡因 | 奴夫卡因 | 奴佛卡因 | 奴呋卡因
英文别名 beta-(Diethylamino)ethyl p-aminobenzoate | KBio3_001731 | NCGC00015864-02 | Spinocaine | HMS3885F16 | KBioSS_001318 | Prestwick2_000041 | MFCD00007893 | KBio2_003886 | KBio2_006454 | NSC 169497 | NSC169497 | NSC-169497 | procaine | 4Z8Y51M438 | beta-Dieth
规格或纯度 Moligand™, ≥98%(HPLC)
英文名称 Procaine
生化机理 普鲁卡因是一种 DNA 去甲基化剂。普鲁卡因通过多个靶点发挥作用，起效慢，作用时间短。
储存温度 -20°C储存
运输条件 超低温冰袋运输
作用类型 通道阻滞剂
作用机制 RyR1 通道阻断剂；RyR2 通道阻断剂
产品介绍

Procaine 是 DNA 脱甲基剂。Procaine 通过多个靶标起作用，起效缓慢，作用持续时间短。

AI解读

关联靶点（人）

RYR1 Tclin 瑞安诺丁受体 1(Ryanodine receptor 1) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
RYR2 Tclin 瑞安诺丁受体 2(Ryanodine receptor 2) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
INSR Tclin Insulin receptor (5558 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR4 Tclin Serotonin 4 (5-HT4) receptor (2068 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Sigmar1 Sigma opioid receptor (160 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cckar Cholecystokinin A receptor (90 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pde4d Phosphodiesterase 4D (4 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pneumocystis carinii (749 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania infantum (5912 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma brucei (78846 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma brucei brucei (13300 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Entamoeba histolytica (2676 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cryptosporidium parvum (1150 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania amazonensis (3813 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania donovani (89745 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania major (2877 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania mexicana (936 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma cruzi (99888 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trichomonas vaginalis (2376 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Toxoplasma gondii (4585 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cavia porcellus (23802 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Felis catus (3858 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma brucei rhodesiense (7991 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRC5 cell line (91 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasma (328 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Heart (171 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Aorta (2975 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Scn2a Sodium channel alpha subunits; brain (Types I, II, III) (344 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Glra2 Glycine receptor (1745 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 488179867
分子类型 小分子
IUPAC Name 2-(diethylamino)ethyl 4-aminobenzoate
INCHI InChI=1S/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3
InChi Key MFDFERRIHVXMIY-UHFFFAOYSA-N
Canonical SMILES CCN(CC)CCOC(=O)C1=CC=C(C=C1)N
Isomeric SMILES CCN(CC)CCOC(=O)C1=CC=C(C=C1)N
RTECS DG2100000
PubChem CID 4914
分子量 236.32
Reaxy-Rn 913480

化学和物理性质

溶解性 可溶于乙醚、苯、甲醇、氯仿
熔点 60-64°C
分子量 236.310 g/mol
XLogP3 1.900
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 4
可旋转键计数Rotatable Bond Count 7
精确质量Exact Mass 236.152 Da
单同位素质量Monoisotopic Mass 236.152 Da
拓扑极表面积Topological Polar Surface Area 55.600 Ų
重原子数Heavy Atom Count 17
形式电荷Formal Charge 0
复杂度Complexity 221.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 Warning
危险声明

H302: 吞食有害
预防措施声明

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P330: 漱口

P301+P317: 如果被吞咽：请寻求医疗帮助。
RTECS DG2100000
Reaxy-Rn 913480
Merck Index 7757

 SDS英文版

技术规格说明书

Purity(HPLC) 98-100（%）
Melting point 60-64（℃）
Proton NMR spectrum Conforms to Structure

 技术规格说明书

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批号(Lot Number) 证书类型 日期 货号
B2528542 分析证书 25-02-11 P160609
B2528565 分析证书 25-02-11 P160609
B2528566 分析证书 25-02-11 P160609
B2528567 分析证书 25-02-11 P160609
B2528568 分析证书 25-02-11 P160609
A2506235 分析证书 24-06-11 P160609
F2428358 分析证书 24-06-11 P160609
F2428356 分析证书 24-06-11 P160609
F2428357 分析证书 24-06-11 P160609
D2422255 分析证书 24-03-26 P160609
L2315280 分析证书 23-12-08 P160609
L2315281 分析证书 23-12-08 P160609
L2315282 分析证书 23-12-08 P160609
L2315283 分析证书 23-12-08 P160609
E23161012 分析证书 22-12-21 P160609
E23261013 分析证书 22-12-21 P160609
E23261015 分析证书 22-12-21 P160609
E23261016 分析证书 22-12-21 P160609
E23261020 分析证书 22-12-21 P160609
E23261022 分析证书 22-12-21 P160609
E23261062 分析证书 22-12-21 P160609

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此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Xiao-Dong Cheng, Zheng Zhang, Yun-Ping Li.  (2023)  A facile approach to undecylenic acid-functionalized stationary phases for per aqueous liquid chromatography.  ANALYTICA CHIMICA ACTA,  1265  (341337).  [PMID:37230580] [10.1016/j.aca.2023.341337]
2. Zhang Yi, Jin Zhenkai, Zeng Qingsong, Huang Yanmei, Gu Hang, He Jiahua, Liu Yangyang, Chen Shili, Sun Hui, Lai Jiaping.  (2019)  Visual test for the presence of the illegal additive ethyl anthranilate by using a photonic crystal test strip.  MICROCHIMICA ACTA,  186  (11): (1-10).  [PMID:31591665] [10.1007/s00604-019-3800-3]
3. Shili Chen, Hui Sun, Zhenjian Huang, Zhenkai Jin, Siyang Fang, Jiahua He, Yangyang Liu, Yi Zhang, Jiaping Lai.  (2019)  The visual detection of anesthetics in fish based on an inverse opal photonic crystal sensor.  RSC Advances,  9  (29): (16831-16838).  [PMID:35516400] [10.1039/C9RA01600G]
4. Shi Li Chen, Hui Sun, Zhen Jian Huang, Si Yang Fang, Jia Hua He, Yang Yang Liu, Jia Ping Lai.  (2019)  Molecular Imprinted Photonic Crystal Sensor for the Rapid and Visual Detection of Benzocaine in Fish.  KEY ENGINEERING MATERIALS,  803  (129-133).  [10.4028/www.scientific.net/KEM.803.129]
5. Min Lin, Hong Yan Zou, Tong Yang, Ze Xi Liu, Hui Liu, Cheng Zhi Huang.  (2016)  An inner filter effect based sensor of tetracycline hydrochloride as developed by loading photoluminescent carbon nanodots in the electrospun nanofibers.  Nanoscale,  8  (5): (2999-3007).  [PMID:26781447] [10.1039/C5NR08177G]

参考文献

1. Xiao-Dong Cheng, Zheng Zhang, Yun-Ping Li.  (2023)  A facile approach to undecylenic acid-functionalized stationary phases for per aqueous liquid chromatography.  ANALYTICA CHIMICA ACTA,  1265  (341337).  [PMID:37230580] [10.1016/j.aca.2023.341337]
2. Zhang Yi, Jin Zhenkai, Zeng Qingsong, Huang Yanmei, Gu Hang, He Jiahua, Liu Yangyang, Chen Shili, Sun Hui, Lai Jiaping.  (2019)  Visual test for the presence of the illegal additive ethyl anthranilate by using a photonic crystal test strip.  MICROCHIMICA ACTA,  186  (11): (1-10).  [PMID:31591665] [10.1007/s00604-019-3800-3]
3. Shili Chen, Hui Sun, Zhenjian Huang, Zhenkai Jin, Siyang Fang, Jiahua He, Yangyang Liu, Yi Zhang, Jiaping Lai.  (2019)  The visual detection of anesthetics in fish based on an inverse opal photonic crystal sensor.  RSC Advances,  9  (29): (16831-16838).  [PMID:35516400] [10.1039/C9RA01600G]
4. Shi Li Chen, Hui Sun, Zhen Jian Huang, Si Yang Fang, Jia Hua He, Yang Yang Liu, Jia Ping Lai.  (2019)  Molecular Imprinted Photonic Crystal Sensor for the Rapid and Visual Detection of Benzocaine in Fish.  KEY ENGINEERING MATERIALS,  803  (129-133).  [10.4028/www.scientific.net/KEM.803.129]
5. Min Lin, Hong Yan Zou, Tong Yang, Ze Xi Liu, Hui Liu, Cheng Zhi Huang.  (2016)  An inner filter effect based sensor of tetracycline hydrochloride as developed by loading photoluminescent carbon nanodots in the electrospun nanofibers.  Nanoscale,  8  (5): (2999-3007).  [PMID:26781447] [10.1039/C5NR08177G]

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