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原花青素B2

8篇引用文献
  • ≥90%
有货

库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
P136147-1mg
 1mg 现货 Stock Image
P136147-5mg
 5mg 期货 Stock Image
P136147-25mg
 25mg 期货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
查看相关系列
Immunology/Inflammation (1941) Metabolic Enzyme/Protease (4888) NF-κB (753) Reactive Oxygen Species (316)
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基本描述

别名 原花青素 B2
英文别名 BDBM50553253 | P17914 | AKOS008901339 | Proanthocyanidin B2 | PROCYANIDIN B2, (+)- | (2R,2'R,3R,3'R,4R)-2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-2H,2'H-4,8'-bichromene-3,3',5,5',7,7'-hexol | (4,8'-BI-2H-1-BENZOPYRAN)-3,3',5,5',7,7'-HEXOL, 2,2'-B
规格或纯度 ≥90%
英文名称 ProcyanidinB2
生化机理 原花青素 B2 在减少颗粒细胞凋亡和诱导自噬过程中发挥了有效和有益的作用，并对糖尿病并发症产生了多种强效的药理保护作用。在体外：原花青素 B2 可降低 FoxO1 蛋白水平，提高颗粒细胞活力，上调 LC3-II 蛋白水平，降低颗粒细胞凋亡率。在氧化应激条件下，青花素 B2 逆转了 FoxO1 的核定位，提高了其在细胞质中的水平。此外，FoxO1基因敲除抑制了原花青素B2诱导的保护作用。
应用 Procyanidin B2能够诱导自噬，减少颗粒细胞凋亡,并且对能够降低糖尿病并发症的发生。
储存温度 2-8°C储存,充氩
运输条件 冰袋运输
产品介绍

Procyanidin B2能够诱导自噬，减少颗粒细胞凋亡,并且对能够降低糖尿病并发症的发生。

Procyanidin B2 exerts a potent and beneficial role in reducing granulosa cell apoptosis and inducing autophagy process,and exerts a variety of potent protective pharmacological effects on diabetic complications.

AI解读

关联靶点（人）

F2 Tclin Thrombin (11687 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APP Tclin Amyloid-beta A4 protein (8510 活性数据)
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HCT-8 (3484 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MT4 (17854 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TE-671 (161 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KB (17409 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PBMC (10003 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LPO Tbio Lactoperoxidase (15 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SNCA Tchem Alpha-synuclein (10960 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

pol Human immunodeficiency virus type 1 reverse transcriptase (18245 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
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Salmonella paratyphi (588 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Enterobacter cloacae (7976 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Streptococcus pyogenes (16140 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mycolicibacterium fortuitum (1335 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human immunodeficiency virus 1 (70413 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human immunodeficiency virus (3636 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trpa1 Transient receptor potential cation channel subfamily A member 1 (1003 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Potato virus X (11 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Simplexvirus (54 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Liver microsome (341 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504756878
分子类型 小分子
IUPAC Name (2R,3R)-2-(3,4-dihydroxyphenyl)-8-[(2R,3R,4R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromene-3,5,7-triol
INCHI InChI=1S/C30H26O12/c31-13-7-20(37)24-23(8-13)41-29(12-2-4-16(33)19(36)6-12)27(40)26(24)25-21(38)10-17(34)14-9-22(39)28(42-30(14)25)11-1-3-15(32)18(35)5-11/h1-8,10,22,26-29,31-40H,9H2/t22-,26-,27-,28-,29-/m1/s1
InChi Key XFZJEEAOWLFHDH-NFJBMHMQSA-N
Canonical SMILES C1C(C(OC2=C1C(=CC(=C2C3C(C(OC4=CC(=CC(=C34)O)O)C5=CC(=C(C=C5)O)O)O)O)O)C6=CC(=C(C=C6)O)O)O
Isomeric SMILES C1[C@H]([C@H](OC2=C1C(=CC(=C2[C@@H]3[C@H]([C@H](OC4=CC(=CC(=C34)O)O)C5=CC(=C(C=C5)O)O)O)O)O)C6=CC(=C(C=C6)O)O)O
PubChem CID 122738
分子量 578.52

化学和物理性质

折光率 1.8
沸点 955.32° C
熔点 197-198°C
分子量 578.500 g/mol
XLogP3 2.400
氢键供体数Hydrogen Bond Donor Count 10
氢键受体数Hydrogen Bond Acceptor Count 12
可旋转键计数Rotatable Bond Count 3
精确质量Exact Mass 578.142 Da
单同位素质量Monoisotopic Mass 578.142 Da
拓扑极表面积Topological Polar Surface Area 221.000 Ų
重原子数Heavy Atom Count 42
形式电荷Formal Charge 0
复杂度Complexity 925.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 5
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

 SDS英文版

技术规格说明书

Purity(HPLC) 90-100（%）
Appearance（P136147) Light Beige to Dark Brown Powder or Solid
Proton NMR spectrum Conforms to Structure

 技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到4个结果

批号(Lot Number) 证书类型 日期 货号
C2526049 分析证书 25-04-14 P136147
L2116322 分析证书 23-10-07 P136147
L2116283 分析证书 23-10-07 P136147
L2116284 分析证书 23-10-07 P136147

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Lei He, Qian Hu, Jiukai Zhang, Ranran Xing, Yongsheng Zhao, Ning Yu, Ying Chen.  (2023)  An integrated untargeted metabolomic approach reveals the quality characteristics of black soybeans from different geographical origins in China.  FOOD RESEARCH INTERNATIONAL,  169  (112908).  [PMID:37254343] [10.1016/j.foodres.2023.112908]
2. Lei He, Qian Hu, Liyang Wei, Xuliyang Ge, Ning Yu, Ying Chen.  (2023)  Unravelling dynamic changes in non-volatile and volatile metabolites of pulses during soaking: An integrated metabolomics approach.  FOOD CHEMISTRY,  422  (136231).  [PMID:37141754] [10.1016/j.foodchem.2023.136231]
3. Su Xuexia, Bai Cuihua, Wang Xianghe, Liu Huilin, Zhu Yongcong, Wei Leping, Cui Zixiao, Yao Lixian.  (2022)  Potassium Sulfate Spray Promotes Fruit Color Preference via Regulation of Pigment Profile in Litchi Pericarp.  Frontiers in Plant Science,  13  [PMID:35774808] [10.3389/fpls.2022.925609]
4. Yuting Fan, Qingyu He, Chao Gan, Zhen Wen, Jiang Yi.  (2022)  Investigation of binding interaction between bovine α-lactalbumin and procyanidin B2 by spectroscopic methods and molecular docking.  FOOD CHEMISTRY,  384  (132509).  [PMID:35217463] [10.1016/j.foodchem.2022.132509]
5. Zhang Haipin, Song Huijia, Tian Xuemeng, Wang Yue, Hao Yi, Wang Wenting, Gao Ruixia, Yang Wan, Ke YuShen, Tang Yuhai.  (2021)  Magnetic imprinted nanoparticles with synergistic tailoring of covalent and non-covalent interactions for purification and detection of procyanidin B2.  MICROCHIMICA ACTA,  188  (1): (1-12).  [PMID:33403455] [10.1007/s00604-020-04693-x]
6. Taotao Dai, Jun Chen, David Julian McClements, Ti Li, Chengmei Liu.  (2019)  Investigation the interaction between procyanidin dimer and α-glucosidase: Spectroscopic analyses and molecular docking simulation.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  130  (315).  [PMID:30794902] [10.1016/j.ijbiomac.2019.02.105]
7. Qian Li, Chengmei Liu, Ti Li, David Julian McClements, Yinxin Fu, Jiyan Liu.  (2018)  Comparison of phytochemical profiles and antiproliferative activities of different proanthocyanidins fractions from Choerospondias axillaris fruit peels.  FOOD RESEARCH INTERNATIONAL,  113  (298).  [PMID:30195524] [10.1016/j.foodres.2018.07.006]
8. Jie Zheng, Yu-yan An, Xin-xin Feng, Liang-ju Wang.  (2017)  Rhizospheric application with 5-aminolevulinic acid improves coloration and quality in ‘Fuji’ apples.  SCIENTIA HORTICULTURAE,  224  (74).  [10.1016/j.scienta.2017.06.004]

参考文献

1. Lei He, Qian Hu, Jiukai Zhang, Ranran Xing, Yongsheng Zhao, Ning Yu, Ying Chen.  (2023)  An integrated untargeted metabolomic approach reveals the quality characteristics of black soybeans from different geographical origins in China.  FOOD RESEARCH INTERNATIONAL,  169  (112908).  [PMID:37254343] [10.1016/j.foodres.2023.112908]
2. Lei He, Qian Hu, Liyang Wei, Xuliyang Ge, Ning Yu, Ying Chen.  (2023)  Unravelling dynamic changes in non-volatile and volatile metabolites of pulses during soaking: An integrated metabolomics approach.  FOOD CHEMISTRY,  422  (136231).  [PMID:37141754] [10.1016/j.foodchem.2023.136231]
3. Su Xuexia, Bai Cuihua, Wang Xianghe, Liu Huilin, Zhu Yongcong, Wei Leping, Cui Zixiao, Yao Lixian.  (2022)  Potassium Sulfate Spray Promotes Fruit Color Preference via Regulation of Pigment Profile in Litchi Pericarp.  Frontiers in Plant Science,  13  [PMID:35774808] [10.3389/fpls.2022.925609]
4. Yuting Fan, Qingyu He, Chao Gan, Zhen Wen, Jiang Yi.  (2022)  Investigation of binding interaction between bovine α-lactalbumin and procyanidin B2 by spectroscopic methods and molecular docking.  FOOD CHEMISTRY,  384  (132509).  [PMID:35217463] [10.1016/j.foodchem.2022.132509]
5. Zhang Haipin, Song Huijia, Tian Xuemeng, Wang Yue, Hao Yi, Wang Wenting, Gao Ruixia, Yang Wan, Ke YuShen, Tang Yuhai.  (2021)  Magnetic imprinted nanoparticles with synergistic tailoring of covalent and non-covalent interactions for purification and detection of procyanidin B2.  MICROCHIMICA ACTA,  188  (1): (1-12).  [PMID:33403455] [10.1007/s00604-020-04693-x]
6. Taotao Dai, Jun Chen, David Julian McClements, Ti Li, Chengmei Liu.  (2019)  Investigation the interaction between procyanidin dimer and α-glucosidase: Spectroscopic analyses and molecular docking simulation.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  130  (315).  [PMID:30794902] [10.1016/j.ijbiomac.2019.02.105]
7. Qian Li, Chengmei Liu, Ti Li, David Julian McClements, Yinxin Fu, Jiyan Liu.  (2018)  Comparison of phytochemical profiles and antiproliferative activities of different proanthocyanidins fractions from Choerospondias axillaris fruit peels.  FOOD RESEARCH INTERNATIONAL,  113  (298).  [PMID:30195524] [10.1016/j.foodres.2018.07.006]
8. Jie Zheng, Yu-yan An, Xin-xin Feng, Liang-ju Wang.  (2017)  Rhizospheric application with 5-aminolevulinic acid improves coloration and quality in ‘Fuji’ apples.  SCIENTIA HORTICULTURAE,  224  (74).  [10.1016/j.scienta.2017.06.004]

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