| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| O101698-20mg |
20mg |
现货  |
|
| 别名 | 7-甲氧基-8-异戊烯基香豆素 | 7-甲氧基-8-（3-甲基-2-丁烯基）香豆素 |
|---|---|
| 英文别名 | KBioSS_002022 | NSC 31868 | SDCCGMLS-0066780.P001 | 7-methoxy-8-(3-methylpent-2-enyl)coumarin | A827530 | KBio3_002589 | Spectrum2_000723 | 2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-butenyl)- | DivK1c_007042 | AMY40671 | BBL013019 | Osthole (Osthol) |
| 规格或纯度 | Moligand™, 分析标准品, ≥99.5% |
| 英文名称 | Osthole |
| 应用 | 具有解痉、降血压、抗心律失常、增强免疫功能及广谱抗菌作用。 |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 作用类型 | 通道阻滞剂 |
| 作用机制 | TRPV3 通道阻断剂 |
| 产品介绍 |
属香豆素类化合物。棱柱状结晶（乙醚）、针状结晶（稀乙醇）。溶于碱溶液、乙醇、氯仿、丙酮等，不溶于水和石油醚。 |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 610-421-7 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one |
| INCHI | InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3 |
| InChi Key | MBRLOUHOWLUMFF-UHFFFAOYSA-N |
| Canonical SMILES | CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C |
| Isomeric SMILES | CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C |
| WGK Germany | 1 |
| RTECS | GN7700000 |
| 关联CAS | 484-12-8 |
| PubChem CID | 10228 |
| NSC Number | 31868 |
| MeSH Entry Terms | 7-methoxy-8-(3-methylpent-2-enyl)coumarin;osthol;osthole |
| 分子量 | 244.29 |
| Reaxy-Rn | 1288399 |
| 密度 | 1.126 |
|---|---|
| 沸点 | 145～150°C |
| 熔点 | 83-84°C |
| 分子量 | 244.280 g/mol |
| XLogP3 | 3.800 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 244.11 Da |
| 单同位素质量Monoisotopic Mass | 244.11 Da |
| 拓扑极表面积Topological Polar Surface Area | 35.500 Ų |
| 重原子数Heavy Atom Count | 18 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 366.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| WGK Germany | 1 |
|---|---|
| RTECS | GN7700000 |
| Reaxy-Rn | 1288399 |
| Merck Index | 6895 |
| Melting point | 83-84（℃） |
|---|---|
| Purity(HPLC) | 99.5-100（%） |
| Appearance（O101698) | White powder |
| Infrared spectrum | Conforms to Structure |
| Proton NMR spectrum | Conforms to Structure |
| 1. Duo Lai, Delin Wang, Xuehua Shao, Jian Qin, Qingli Zhuang, Hanhong Xu, Weiqiang Xiao. (2024) Comparative physiological and transcriptome analysis provide insights into the inhibitory effect of osthole on Penicillium choerospondiatis. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 198 (105749). [PMID:38225092] [10.1016/j.pestbp.2023.105749] |
| 2. Huang Hui, Xue Jie, Xie Mei-Lin, Xie Tao. (2023) Osthole inhibits GSK-3β/AMPK/mTOR pathway-controlled glycolysis and increases radiosensitivity of subcutaneous transplanted hepatocellular carcinoma in nude mice. STRAHLENTHERAPIE UND ONKOLOGIE, (1-9). [PMID:37963994] [10.1007/s00066-023-02173-8] |
| 3. Ke Hu, Rongyu Li, Feixu Mo, Yi Ding, Aiai Zhou, Xue Guo, Ruotong Li, Min Li, Minggui Ou, Ming Li. (2023) Natural product osthole can significantly disrupt cell wall integrity and dynamic balance of Fusarium oxysporum. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 196 (24): (105623). [PMID:37945232] [10.1016/j.pestbp.2023.105623] |
| 4. Chuanyi Gu, Chunru Wang, Wenjie Ma, Yunli Gao, Junyao Li, Qing Jin, Xiaochen Wu. (2023) Drug-Loaded Konjac Glucomannan/Metal–Organic Framework Composite Hydrogels as Antibacterial and Anti-Inflammatory Cell Scaffolds. ACS Applied Materials & Interfaces, 15 (35): (41287–41298). [PMID:37632730] [10.1021/acsami.3c06996] |
| 5. Weizhen Wang, Linan He, Zhuzhu Zhang, Wenzhi Li, Jia Chen, Tingting Chen, Youhua Long. (2023) Activity of the botanical compound thymol against kiwifruit rot caused by Fusarium tricinctum and the underlying mechanisms. PEST MANAGEMENT SCIENCE, [PMID:36864770] [10.1002/ps.7431] |
| 6. Ruige Yang, Zhiyan Liu, Meiyue Han, Liping Cui, Yong Guo. (2022) Preparation and Biological Evaluation of Novel Osthole-Derived N-Benzoylthioureas as Insecticide Candidates. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (50): (15737–15746). [PMID:36508570] [10.1021/acs.jafc.2c06558] |
| 7. Huang Hui, Xue Jie, Xie Tao, Xie Mei-Lin. (2023) Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 396 (4): (683-692). [PMID:36445387] [10.1007/s00210-022-02347-8] |
| 8. Kuang Yi, Xia Yunlong, Wang Xing, Rao Qingqing, Yang Shengxiang. (2022) Magnetic Surface Molecularly Imprinted Polymer for Selective Adsorption of 4-Hydroxycoumarin. Frontiers in Chemistry, 10 [PMID:35464201] [10.3389/fchem.2022.862777] |
| 9. Pan Liuliu, Zhang Xiaodan, Wang Danhan, Huang Min, Huang Qiusui, Duan Ping, Mei Jie. (2021) DCLK1 might be a therapeutic target of osthole against cervical cancer. PHARMAZIE, 76 (10): (503-506). [PMID:34620279] [10.1691/ph.2021.1641] |
| 10. Lijun Fang, Wei Wang, Jiazheng Chen, Anju Zuo, Hongmei Gao, Tao Yan, Pengqi Wang, Yujia Lu, Ruijuan Lv, Feng Xu, Yuguo Chen, Linmao Lyu. (2021) Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice. Oxidative Medicine and Cellular Longevity, 2021 (3309944). [PMID:34527170] [10.1155/2021/3309944] |
| 11. Xing-Hua Zhou, Jian Kang, Zhen-Dong Zhong, Yue Cheng. (2021) Osthole induces apoptosis of the HT‑29 cells via endoplasmic reticulum stress and autophagy. Oncology Letters, 22 (4): (1-9). [PMID:34429766] [10.3892/ol.2021.12987] |
| 12. Jie Mei, Tiejun Wang, Shaojie Zhao, Yan Zhang. (2021) Osthole Inhibits Breast Cancer Progression through Upregulating Tumor Suppressor GNG7. Journal of Oncology, 2021 (6610511). [PMID:33727922] [10.1155/2021/6610511] |
| 13. Yasi Mo, Yong Wu, Xin Li, Hui Rao, Xianxiang Tian, Danni Wu, Zhenpeng Qiu, Guohua Zheng, Junjie Hu. (2020) Osthole delays hepatocarcinogenesis in mice by suppressing AKT/FASN axis and ERK phosphorylation. EUROPEAN JOURNAL OF PHARMACOLOGY, 867 (172788). [PMID:31712058] [10.1016/j.ejphar.2019.172788] |
| 14. Xiaohong Xu, Vinothakumar Rajamanicham, Sujing Xu, Zhoudi Liu, Tao Yan, Guang Liang, Guilong Guo, Huiping Zhou, Yi Wang. (2019) Schisandrin A inhibits triple negative breast cancer cells by regulating Wnt/ER stress signaling pathway. BIOMEDICINE & PHARMACOTHERAPY, 115 (108922). [PMID:31048190] [10.1016/j.biopha.2019.108922] |
| 15. Dai Xuanxuan, Yin Changtian, Zhang Yi, Guo Guilong, Zhao Chengguang, Wang Ouchen, Xiang Youqun, Zhang Xiaohua, Liang Guang. (2018) Osthole inhibits triple negative breast cancer cells by suppressing STAT3. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 37 (1): (1-11). [PMID:30577812] [10.1186/s13046-018-0992-z] |
| 16. Botao Wang, Xin Zheng, Jing Liu, Zhen Zhang, Chongyang Qiu, Lei Yang, Lanqiu Zhang, Qi Zhang, Hongwei Gao, Ximo Wang. (2018) Osthole inhibits pancreatic cancer progression by directly exerting negative effects on cancer cells and attenuating tumor-infiltrating M2 macrophages. JOURNAL OF PHARMACOLOGICAL SCIENCES, 137 (290). [PMID:30098910] [10.1016/j.jphs.2018.07.007] |
| 17. Yiyi Jin, Jianchang Qian, Xin Ju, Xiaodong Bao, Li Li, Suqing Zheng, Xiong Chen, Zhongxiang Xiao, Xuemei Chen, Weiwei Zhu, Weixin Li, Wencan Wu, Guang Liang. (2018) Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation. MEDIATORS OF INFLAMMATION, 2018 (4934592). [PMID:30057486] [10.1155/2018/4934592] |
| 18. Xu Renguo, Liu Zhen, Hou Jiande, Huang Tao, Yang Ming. (2018) Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress. CELLULAR & MOLECULAR BIOLOGY LETTERS, 23 (1): (1-11). [PMID:29743895] [10.1186/s11658-018-0086-0] |
| 1. Sun XY, Sun LL, Qi H, Gao Q, Wang GX, Wei NN, Wang K. (2018) Antipruritic Effect of Natural Coumarin Osthole through Selective Inhibition of Thermosensitive TRPV3 Channel in the Skin.. Mol Pharmacol, 94 (4): (1164-1173). [PMID:30108138] [10.1021/op500134e] |
| 2. Duo Lai, Delin Wang, Xuehua Shao, Jian Qin, Qingli Zhuang, Hanhong Xu, Weiqiang Xiao. (2024) Comparative physiological and transcriptome analysis provide insights into the inhibitory effect of osthole on Penicillium choerospondiatis. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 198 (105749). [PMID:38225092] [10.1016/j.pestbp.2023.105749] |
| 3. Huang Hui, Xue Jie, Xie Mei-Lin, Xie Tao. (2023) Osthole inhibits GSK-3β/AMPK/mTOR pathway-controlled glycolysis and increases radiosensitivity of subcutaneous transplanted hepatocellular carcinoma in nude mice. STRAHLENTHERAPIE UND ONKOLOGIE, (1-9). [PMID:37963994] [10.1007/s00066-023-02173-8] |
| 4. Ke Hu, Rongyu Li, Feixu Mo, Yi Ding, Aiai Zhou, Xue Guo, Ruotong Li, Min Li, Minggui Ou, Ming Li. (2023) Natural product osthole can significantly disrupt cell wall integrity and dynamic balance of Fusarium oxysporum. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 196 (24): (105623). [PMID:37945232] [10.1016/j.pestbp.2023.105623] |
| 5. Chuanyi Gu, Chunru Wang, Wenjie Ma, Yunli Gao, Junyao Li, Qing Jin, Xiaochen Wu. (2023) Drug-Loaded Konjac Glucomannan/Metal–Organic Framework Composite Hydrogels as Antibacterial and Anti-Inflammatory Cell Scaffolds. ACS Applied Materials & Interfaces, 15 (35): (41287–41298). [PMID:37632730] [10.1021/acsami.3c06996] |
| 6. Weizhen Wang, Linan He, Zhuzhu Zhang, Wenzhi Li, Jia Chen, Tingting Chen, Youhua Long. (2023) Activity of the botanical compound thymol against kiwifruit rot caused by Fusarium tricinctum and the underlying mechanisms. PEST MANAGEMENT SCIENCE, [PMID:36864770] [10.1002/ps.7431] |
| 7. Ruige Yang, Zhiyan Liu, Meiyue Han, Liping Cui, Yong Guo. (2022) Preparation and Biological Evaluation of Novel Osthole-Derived N-Benzoylthioureas as Insecticide Candidates. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (50): (15737–15746). [PMID:36508570] [10.1021/acs.jafc.2c06558] |
| 8. Huang Hui, Xue Jie, Xie Tao, Xie Mei-Lin. (2023) Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 396 (4): (683-692). [PMID:36445387] [10.1007/s00210-022-02347-8] |
| 9. Kuang Yi, Xia Yunlong, Wang Xing, Rao Qingqing, Yang Shengxiang. (2022) Magnetic Surface Molecularly Imprinted Polymer for Selective Adsorption of 4-Hydroxycoumarin. Frontiers in Chemistry, 10 [PMID:35464201] [10.3389/fchem.2022.862777] |
| 10. Pan Liuliu, Zhang Xiaodan, Wang Danhan, Huang Min, Huang Qiusui, Duan Ping, Mei Jie. (2021) DCLK1 might be a therapeutic target of osthole against cervical cancer. PHARMAZIE, 76 (10): (503-506). [PMID:34620279] [10.1691/ph.2021.1641] |
| 11. Lijun Fang, Wei Wang, Jiazheng Chen, Anju Zuo, Hongmei Gao, Tao Yan, Pengqi Wang, Yujia Lu, Ruijuan Lv, Feng Xu, Yuguo Chen, Linmao Lyu. (2021) Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice. Oxidative Medicine and Cellular Longevity, 2021 (3309944). [PMID:34527170] [10.1155/2021/3309944] |
| 12. Xing-Hua Zhou, Jian Kang, Zhen-Dong Zhong, Yue Cheng. (2021) Osthole induces apoptosis of the HT‑29 cells via endoplasmic reticulum stress and autophagy. Oncology Letters, 22 (4): (1-9). [PMID:34429766] [10.3892/ol.2021.12987] |
| 13. Jie Mei, Tiejun Wang, Shaojie Zhao, Yan Zhang. (2021) Osthole Inhibits Breast Cancer Progression through Upregulating Tumor Suppressor GNG7. Journal of Oncology, 2021 (6610511). [PMID:33727922] [10.1155/2021/6610511] |
| 14. Yasi Mo, Yong Wu, Xin Li, Hui Rao, Xianxiang Tian, Danni Wu, Zhenpeng Qiu, Guohua Zheng, Junjie Hu. (2020) Osthole delays hepatocarcinogenesis in mice by suppressing AKT/FASN axis and ERK phosphorylation. EUROPEAN JOURNAL OF PHARMACOLOGY, 867 (172788). [PMID:31712058] [10.1016/j.ejphar.2019.172788] |
| 15. Xiaohong Xu, Vinothakumar Rajamanicham, Sujing Xu, Zhoudi Liu, Tao Yan, Guang Liang, Guilong Guo, Huiping Zhou, Yi Wang. (2019) Schisandrin A inhibits triple negative breast cancer cells by regulating Wnt/ER stress signaling pathway. BIOMEDICINE & PHARMACOTHERAPY, 115 (108922). [PMID:31048190] [10.1016/j.biopha.2019.108922] |
| 16. Dai Xuanxuan, Yin Changtian, Zhang Yi, Guo Guilong, Zhao Chengguang, Wang Ouchen, Xiang Youqun, Zhang Xiaohua, Liang Guang. (2018) Osthole inhibits triple negative breast cancer cells by suppressing STAT3. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 37 (1): (1-11). [PMID:30577812] [10.1186/s13046-018-0992-z] |
| 17. Botao Wang, Xin Zheng, Jing Liu, Zhen Zhang, Chongyang Qiu, Lei Yang, Lanqiu Zhang, Qi Zhang, Hongwei Gao, Ximo Wang. (2018) Osthole inhibits pancreatic cancer progression by directly exerting negative effects on cancer cells and attenuating tumor-infiltrating M2 macrophages. JOURNAL OF PHARMACOLOGICAL SCIENCES, 137 (290). [PMID:30098910] [10.1016/j.jphs.2018.07.007] |
| 18. Yiyi Jin, Jianchang Qian, Xin Ju, Xiaodong Bao, Li Li, Suqing Zheng, Xiong Chen, Zhongxiang Xiao, Xuemei Chen, Weiwei Zhu, Weixin Li, Wencan Wu, Guang Liang. (2018) Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation. MEDIATORS OF INFLAMMATION, 2018 (4934592). [PMID:30057486] [10.1155/2018/4934592] |
| 19. Xu Renguo, Liu Zhen, Hou Jiande, Huang Tao, Yang Ming. (2018) Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress. CELLULAR & MOLECULAR BIOLOGY LETTERS, 23 (1): (1-11). [PMID:29743895] [10.1186/s11658-018-0086-0] |
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