| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| N412450-25mg |
25mg |
期货  |
|
| 规格或纯度 | Moligand™ |
|---|---|
| 英文名称 | NI-57 |
| 生化机理 | NI-57 是一种含溴结构域和植物同源结构域指（BRPF）家族蛋白的抑制剂，对 BRPF1、BRPF2 (BRD1) 和 BRPF3 的 IC50 分别为 3.1 nM、46 nM 和 140 nM。 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 含溴结构域和 PHD 指的 1;含溴结构域和 PHD 指的 3;含溴结构域和 PHD 指的 1 的抑制剂 |
| 产品介绍 |
Information NI-57 is an inhibitor of bromodomain and plant homeodomain finger-containing (BRPF) famlily of proteins with IC50 of 3.1 nM, 46 nM and 140 nM for BRPF1, BRPF2 (BRD1) and BRPF3, respectively. |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-methoxybenzenesulfonamide |
| INCHI | InChI=1S/C19H17N3O4S/c1-12-8-14-10-15(5-6-16(14)22(2)19(12)23)21-27(24,25)18-7-4-13(11-20)9-17(18)26-3/h4-10,21H,1-3H3 |
| InChi Key | UEMQPCYDWCSVCU-UHFFFAOYSA-N |
| Canonical SMILES | CC1=CC2=C(C=CC(=C2)NS(=O)(=O)C3=C(C=C(C=C3)C#N)OC)N(C1=O)C |
| Isomeric SMILES | CC1=CC2=C(C=CC(=C2)NS(=O)(=O)C3=C(C=C(C=C3)C#N)OC)N(C1=O)C |
| PubChem CID | 91827373 |
| 分子量 | 383.42 |
| 分子量 | 383.400 g/mol |
|---|---|
| XLogP3 | 2.100 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 6 |
| 可旋转键计数Rotatable Bond Count | 4 |
| 精确质量Exact Mass | 383.094 Da |
| 单同位素质量Monoisotopic Mass | 383.094 Da |
| 拓扑极表面积Topological Polar Surface Area | 108.000 Ų |
| 重原子数Heavy Atom Count | 27 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 764.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
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