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头孢硝噻吩

发色性头孢菌素β-内酰胺酶底物
5篇引用文献
  • ≥90%
有货

库存信息

关闭

库存信息

关闭

库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
N163020-1mg
 1mg 现货 Stock Image
N163020-5mg
 5mg 现货 Stock Image
N163020-25mg
 25mg 现货 Stock Image
N163020-100mg
 100mg 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
查看相关系列
抗生素 (38)
main product photo

基本描述

别名 头孢硝噻 | 3-（2，4-二硝基苯乙烯基）-（6R，7R）-7-（2-噻吩基乙酰胺基）-头孢-3-EM-4-羧酸
英文别名 (6R,7R)-7-[[(E)-4-(2,4-Dinitrophenyl)-2-(2-thienyl)but-3-enoyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | EWP54G0J8F | (6R,7R)-3-[(E)-2-(2,4-dinitrophenyl)ethenyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]
规格或纯度 ≥90%
英文名称 Nitrocefin
生化机理 发色性头孢菌素β-内酰胺酶底物。通过红色指示β-内酰胺酶的活性，该颜色与硝基硝基芬的原始浓度成正比。
储存温度 -20°C储存,充氩
运输条件 超低温冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Nitrocefin is a chromogenic β-lactamase substrate that undergoes colour change from yellow to red as the amide bond in the β-Lactam ring is hydrolyzed by β-lactamase. Nitrocefin undergoes colour changes induced by lactamases produced by Gram-positive and Gram-negative bacteria. Several studies have utilized the colour changing properties of Nitrocefin for the detection of β-lactamase activity from bacterial cell extracts by isoelectric focusing and spectroscopy. Nitrocefin has also been used in studies involving β-lactamase resistant antibiotics.

Nitrocefin is a chromogenic β-lactamase substrate that undergoes colour change from yellow to red as the amide bond in the β-Lactam ring is hydrolyzed by β-lactamase. Nitrocefin undergoes colour changes induced by lactamases produced by Gram-positive and Gram-negative bacteria. Several studies have utilized the colour changing properties of Nitrocefin for the detection of β-lactamase activity from bacterial cell extracts by isoelectric focusing and spectroscopy. Nitrocefin has also been used in studies involving β-lactamase resistant antibiotics.

AI解读

关联靶点（其它种属）

blaZ Beta-lactamase (285 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
nmcA Imipenem-hydrolyzing beta-lactamase (46 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
blaPER-2 PER-2 beta-lactamase (51 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
bla Beta-lactamase OXA-10 (127 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
bla Carbepenem-hydrolyzing beta-lactamase KPC (120 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
blaVIM-2 Beta-lactamase VIM-2 (381 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
blaVIM-4 Beta-lactamase VIM-4 (18 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
blaGES-13 Beta-lactamase GES-13 (25 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Metallo-beta-lactamase VIM-11 (37 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
blaVIM-2 Metallo-beta-lactamase VIM-2 (37 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
blaDIM-1 Metallo-beta-lactamase (33 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
pbpX Penicillin-binding protein 2X (99 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
bla OXA-48 (65 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
blaVIM-7 Metallo-b-lactamase (66 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
sugE Efflux transporter (20 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
bla Class C beta-lactamase CMY-36 (20 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
blaIND-6 Metallo-beta-lactamase IND-6 (42 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
blaB1 Carbapenem-hydrolyzing beta-lactamase BlaB-1 (12 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Napepld N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (16 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 小分子
Canonical SMILES C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CS3)C(=O)O)/C=C/C4=C(C=C(C=C4)[N+](=O)[O-])[N+](=O)[O-]
Isomeric SMILES C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CS3)C(=O)O)/C=C/C4=C(C=C(C=C4)[N+](=O)[O-])[N+](=O)[O-]
PubChem CID 6436140
分子量 516.5

化学和物理性质

溶解性 DMSO (Slightly), Methanol (Slightly)
敏感性 对湿度敏感；对光线敏感
熔点 >99℃
分子量 516.500 g/mol
XLogP3 2.200
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 10
可旋转键计数Rotatable Bond Count 6
精确质量Exact Mass 516.041 Da
单同位素质量Monoisotopic Mass 516.041 Da
拓扑极表面积Topological Polar Surface Area 232.000 Ų
重原子数Heavy Atom Count 35
形式电荷Formal Charge 0
复杂度Complexity 991.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 2
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 1
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 1
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS05,   GHS07
信号词 Danger
危险声明

H315: 引起皮肤刺激

H318: 造成严重的眼睛损伤

H317: 可能引起皮肤过敏反应
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染：用水充分清洗。

P264: 处理后要彻底洗手。

P272: 被污染的工作服不允许离开工作场所

 SDS英文版

技术规格说明书

Purity(HPLC) 90-100
Proton NMR spectrum Conforms to Structure

 技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到9个结果

批号(Lot Number) 证书类型 日期 货号
G2307136 分析证书 25-04-07 N163020
G2307172 分析证书 25-04-07 N163020
G2412464 分析证书 24-06-26 N163020
G2412491 分析证书 24-06-26 N163020
C2202581 分析证书 23-12-19 N163020
C2202582 分析证书 23-12-19 N163020
C2202583 分析证书 23-12-19 N163020
A2429354 分析证书 22-12-30 N163020
G2307174 分析证书 22-12-30 N163020

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Aparna Vasudevan, Dinesh Kumar Kesavan, Liang Wu, Zhaoliang Su, Shengjun Wang, Mohan Kumar Ramasamy, Waheeta Hopper, Huaxi Xu.  (2022)  In Silico and In Vitro Screening of Natural Compounds as Broad-Spectrum β-Lactamase Inhibitors against Acinetobacter baumannii New Delhi Metallo-β-lactamase-1 (NDM-1).  Biomed Research International,  2022  (4230788).  [PMID:35372567] [10.1155/2022/4230788]
2. Haonan Sun, Yunjian Yu, Yufei Zhang, Jie Li, Yijie Cheng, Siyuan Huang, Wenbo Wang, Xinge Zhang.  (2021)  Glycosylated Nanotherapeutics with β-Lactamase Reversible Competitive Inhibitory Activity Reinvigorates Antibiotics against Gram-Negative Bacteria.  BIOMACROMOLECULES,  22  (7): (2834–2849).  [PMID:34164980] [10.1021/acs.biomac.1c00231]
3. Maohu Chen, Bo Qiu, Zhanlin Zhang, Shuang Xie, Yuan Liu, Tian Xia, Xiaohong Li.  (2021)  Light-triggerable and pH/lipase-responsive release of antibiotics and β-lactamase inhibitors from host-guest self-assembled micelles to combat biofilms and resistant bacteria.  CHEMICAL ENGINEERING JOURNAL,  424  (130330).  [10.1016/j.cej.2021.130330]
4. Dongmei Zhao, Hongru Li, Chengcheng Yue, Kaili Sun, Yuanyuan Dai, Hui Zhang, Yanyan Liu, Yufeng Gao, Jiabin Li.  (2021)  Captopril potentiated meropenem activity against MBL-producing carbapenem-resistant Klebsiella pneumoniae: in vitro and in vivo study.  JOURNAL OF INORGANIC BIOCHEMISTRY,  218  (111381).  [PMID:33647540] [10.1016/j.jinorgbio.2021.111381]
5. Minrui Liu, Hongyuhang Ni, Ling Yang, Gang Chen, Xiaojun Yan, Xiaoyun Leng, Pu Liu, Xiangkai Li.  (2019)  Pretreatment of swine manure containing β-lactam antibiotics with whole-cell biocatalyst to improve biogas production.  Journal of Cleaner Production,  240  (118070).  [10.1016/j.jclepro.2019.118070]

参考文献

1. Gardner TJ et al..  (2022)  Engineering CAR-T cells to activate small-molecule drugs in situ..  Nat Chem Biol,  18  (2): (216-225).  [PMID:34969970]
2. Aparna Vasudevan, Dinesh Kumar Kesavan, Liang Wu, Zhaoliang Su, Shengjun Wang, Mohan Kumar Ramasamy, Waheeta Hopper, Huaxi Xu.  (2022)  In Silico and In Vitro Screening of Natural Compounds as Broad-Spectrum β-Lactamase Inhibitors against Acinetobacter baumannii New Delhi Metallo-β-lactamase-1 (NDM-1).  Biomed Research International,  2022  (4230788).  [PMID:35372567] [10.1155/2022/4230788]
3. Haonan Sun, Yunjian Yu, Yufei Zhang, Jie Li, Yijie Cheng, Siyuan Huang, Wenbo Wang, Xinge Zhang.  (2021)  Glycosylated Nanotherapeutics with β-Lactamase Reversible Competitive Inhibitory Activity Reinvigorates Antibiotics against Gram-Negative Bacteria.  BIOMACROMOLECULES,  22  (7): (2834–2849).  [PMID:34164980] [10.1021/acs.biomac.1c00231]
4. Maohu Chen, Bo Qiu, Zhanlin Zhang, Shuang Xie, Yuan Liu, Tian Xia, Xiaohong Li.  (2021)  Light-triggerable and pH/lipase-responsive release of antibiotics and β-lactamase inhibitors from host-guest self-assembled micelles to combat biofilms and resistant bacteria.  CHEMICAL ENGINEERING JOURNAL,  424  (130330).  [10.1016/j.cej.2021.130330]
5. Dongmei Zhao, Hongru Li, Chengcheng Yue, Kaili Sun, Yuanyuan Dai, Hui Zhang, Yanyan Liu, Yufeng Gao, Jiabin Li.  (2021)  Captopril potentiated meropenem activity against MBL-producing carbapenem-resistant Klebsiella pneumoniae: in vitro and in vivo study.  JOURNAL OF INORGANIC BIOCHEMISTRY,  218  (111381).  [PMID:33647540] [10.1016/j.jinorgbio.2021.111381]
6. Minrui Liu, Hongyuhang Ni, Ling Yang, Gang Chen, Xiaojun Yan, Xiaoyun Leng, Pu Liu, Xiangkai Li.  (2019)  Pretreatment of swine manure containing β-lactam antibiotics with whole-cell biocatalyst to improve biogas production.  Journal of Cleaner Production,  240  (118070).  [10.1016/j.jclepro.2019.118070]

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