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新橙皮甙二氢查尔酮

8篇引用文献
  • ≥95%
有货

库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
N140621-1g
 1g 现货 Stock Image
N140621-5g
 5g 现货 Stock Image
N140621-25g
 25g 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
查看相关系列
Immunology/Inflammation (1941) Metabolic Enzyme/Protease (4888) NF-κB (753) Reactive Oxygen Species (316)
main product photo

基本描述

英文别名 3,5-dihydroxy-4-[3-(3-hydroxy-4-methoxyphenyl)propanoyl]phenyl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside | 1-(4-((2-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-
规格或纯度 ≥95%
英文名称 Neohesperidin dihydrochalcone
应用 具有抗氧化活性的黄酮类甜味剂
储存温度 -20°C储存
运输条件 超低温冰袋运输
产品介绍

糖度是蔗糖的1500倍。具有抗氧化活性的黄酮类甜味剂

关联靶点（人）

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Homo sapiens (32628 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TAS1R3 Tbio T1R1/T1R3 (473 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Cruzipain (33337 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504753412
EC号 243-978-6
分子类型 小分子
IUPAC Name 1-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one
INCHI InChI=1S/C28H36O15/c1-11-21(34)23(36)25(38)27(40-11)43-26-24(37)22(35)19(10-29)42-28(26)41-13-8-16(32)20(17(33)9-13)14(30)5-3-12-4-6-18(39-2)15(31)7-12/h4,6-9,11,19,21-29,31-38H,3,5,10H2,1-2H3/t11-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1
InChi Key ITVGXXMINPYUHD-CUVHLRMHSA-N
Canonical SMILES CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C(C(=C3)O)C(=O)CCC4=CC(=C(C=C4)OC)O)O)CO)O)O)O)O)O
Isomeric SMILES C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=CC(=C(C(=C3)O)C(=O)CCC4=CC(=C(C=C4)OC)O)O)CO)O)O)O)O)O
WGK Germany 3
RTECS LZ5785000
PubChem CID 30231
分子量 612.58
Reaxy-Rn 4285336

化学和物理性质

密度 1.61
熔点 156-158°C
分子量 612.600 g/mol
XLogP3 -0.300
氢键供体数Hydrogen Bond Donor Count 9
氢键受体数Hydrogen Bond Acceptor Count 15
可旋转键计数Rotatable Bond Count 10
精确质量Exact Mass 612.205 Da
单同位素质量Monoisotopic Mass 612.205 Da
拓扑极表面积Topological Polar Surface Area 245.000 Ų
重原子数Heavy Atom Count 43
形式电荷Formal Charge 0
复杂度Complexity 882.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 10
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

WGK Germany 3
RTECS LZ5785000
Reaxy-Rn 4285336
Merck Index 6452
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

 SDS英文版

技术规格说明书

Water by Karl Fischer 0-12（%）
Purity(HPLC) 95-100（%）
Appearance（n140621) White to Off-White Powder
13C NMR Spectrum Conforms to Structure
Proton NMR spectrum Conforms to Structure
Solubility in H2O，Yellow Clear to Hazy(50 mg/ml) pass

 技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number) 证书类型 日期 货号
G2424008 分析证书 24-08-01 N140621
H2323050 分析证书 23-09-04 N140621
H2323047 分析证书 23-08-24 N140621

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Chengyun He, Lu Bai, Daqun Liu, Benguo Liu.  (2023)  Interaction mechanism of okra (Abelmoschus esculentus L.) seed protein and flavonoids: Fluorescent and 3D-QSAR studies.  Food Chemistry-X,  20  (17): (101023).  [PMID:38144792] [10.1016/j.fochx.2023.101023]
2. Caiying Zhang, Yuelong Li, Abdus Samad, Hongliang He, Huan Ma, Yang Chen, Tengchuan Jin.  (2024)  Kyasanur Forest disease virus NS3 helicase: Insights into structure, activity, and inhibitors.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  254  (127856).  [PMID:37924898] [10.1016/j.ijbiomac.2023.127856]
3. Liang Zhang, Junhui Xu, Jing Qian, Yazhen Wang.  (2023)  A novel detection method for neohesperidin dihydrochalcone (NHDC) based on ZIF-8/ErGO composite modified electrode in milk.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,  123  (105584).  [10.1016/j.jfca.2023.105584]
4. Zilong Chen, Hongdong Liu, Jie Chen, Weifeng Zhu, Yong Liu, Jianxin Min, Xiaotian Chen, Bin Li, Xin Yang.  (2021)  Separation and enrichment of sibiskoside from Sibiraea angustat with magnetic surface dummy template molecularly imprinted polymers.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1178  (122767).  [PMID:34224966] [10.1016/j.jchromb.2021.122767]
5. Xiaomin Xia, Juanli Fu, Xiufang Song, Qiong Shi, Chuanyang Su, Erqun Song, Yang Song.  (2015)  Neohesperidin dihydrochalcone down-regulates MyD88-dependent and -independent signaling by inhibiting endotoxin-induced trafficking of TLR4 to lipid rafts.  FREE RADICAL BIOLOGY AND MEDICINE,  89  (522).  [PMID:26453923] [10.1016/j.freeradbiomed.2015.08.023]
6. Qiong Shi, Xiufang Song, Juanli Fu, Chuanyang Su, Xiaomin Xia, Erqun Song, Yang Song.  (2015)  Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice.  INTERNATIONAL IMMUNOPHARMACOLOGY,  29  (722).  [PMID:26362205] [10.1016/j.intimp.2015.09.003]
7. Chuanyang Su, Xiaomin Xia, Qiong Shi, Xiufang Song, Juanli Fu, Congxue Xiao, Hongjun Chen, Bin Lu, Zhiyin Sun, Shanmei Wu, Siyu Yang, Xuegang Li, Xiaoli Ye, Erqun Song, Yang Song.  (2015)  Neohesperidin Dihydrochalcone versus CCl4-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  63  (22): (5468–5475).  [PMID:25978654] [10.1021/acs.jafc.5b01750]
8. Lingxi Yang, Lu Wang, Kunjing Li, Baoxian Ye.  (2014)  Sensitive voltammetric determination of neohesperidin dihydrochalcone based on SWNTs modified glassy carbon electrode.  Analytical Methods,  6  (23): (9410-9418).  [10.1039/C4AY02004A]

参考文献

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3. M Naim,H Rogatka,T Yamamoto,U Zehavi.  (1982-06-01)  Taste responses to neohesperidin dihydrochalcone in rats and baboon monkeys..  Physiology & behavior,  28  ((6)): (979-986).  [PMID:6810399]
4. J H Shaw.  (1981-03-01)  Sweeteners--an overview. Part. 1..  Dental abstracts; a selection of world dental literature,  26  ((3)): (116-120).  [PMID:7014262]
5. R K Sahu,R Basu,A Sharma.  (1981-05-01)  Genetic toxicological of some plant flavonoids by the micronucleus test..  Mutation research,  89  ((1)): (69-74).  [PMID:7242547]
6. F Borrego,H Montijano,F J López-Cremades,J Cano,A Peris.  (2000-01-27)  Double functionality of sweeteners: a case of study..  World review of nutrition and dietetics,  85  (39-43).  [PMID:10647333]
7. A Ly,A Drewnowski.  (2000-12-22)  PROP (6-n-Propylthiouracil) tasting and sensory responses to caffeine,sucrose, neohesperidin dihydrochalcone and chocolate..  Chemical senses,  26  ((1)): (41-47).  [PMID:11124214]
8. Meirav Zubare-Samuelov,Irena Peri,Michael Tal,Mark Tarshish,Andrew I Spielman,Michael Naim.  (2003-07-04)  Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and alpha 2-adrenergic receptors in Xenopus laevis melanophores..  American journal of physiology. Cell physiology,  285  ((5)): (C1255-C1262).  [PMID:12839835]
9. Annett Braune,Wolfram Engst,Michael Blaut.  (2005-03-03)  Degradation of neohesperidin dihydrochalcone by human intestinal bacteria..  Journal of agricultural and food chemistry,  53  ((5)): (1782-1790).  [PMID:15740074]
10. Ahuva Frydman,Oori Weisshaus,David V Huhman,Lloyd W Sumner,Maor Bar-Peled,Efraim Lewinsohn,Robert Fluhr,Jonathan Gressel,Yoram Eyal.  (2005-12-08)  Metabolic engineering of plant cells for biotransformation of hesperedin into neohesperidin, a substrate for production of the low-calorie sweetener and flavor enhancer NHDC..  Journal of agricultural and food chemistry,  53  ((25)): (9708-9712).  [PMID:16332119]
11. Je-Min Choi,Byoung-Seok Yoon,Sang-Kyou Lee,Jae-Kwan Hwang,Ryung Ryang.  (2007-02-03)  Antioxidant properties of neohesperidin dihydrochalcone: inhibition of hypochlorous acid-induced DNA strand breakage, protein degradation, and cell death..  Biological & pharmaceutical bulletin,  30  ((2)): (324-330).  [PMID:17268074]
12. Marcel Winnig,Bernd Bufe,Nicole A Kratochwil,Jay P Slack,Wolfgang Meyerhof.  (2007-10-16)  The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor..  BMC structural biology,  7  (66-66).  [PMID:17935609]
13. Andrew W Moran,Miran A Al-Rammahi,Daleep K Arora,Daniel J Batchelor,Erin A Coulter,Kristian Daly,Catherine Ionescu,David Bravo,Soraya P Shirazi-Beechey.  (2010-03-27)  Expression of Na+/glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners..  The British journal of nutrition,  104  ((5)): (637-646).  [PMID:20338074]
14. Agata Zygler,Andrzej Wasik,Agata Kot-Wasik,Jacek Namieśnik.  (2011-04-06)  Determination of nine high-intensity sweeteners in various foods by high-performance liquid chromatography with mass spectrometric detection..  Analytical and bioanalytical chemistry,  400  ((7)): (2159-2172).  [PMID:21465096]
15. Elaheh Kashani-Amin,Bagher Larijani,Azadeh Ebrahim-Habibi.  (2013-02-05)  Neohesperidin dihydrochalcone: presentation of a small molecule activator of mammalian alpha-amylase as an allosteric effector..  FEBS letters,  587  ((6)): (652-658).  [PMID:23376024]
16. Lihua Hu,Lingrui Li,Demei Xu,Xiaomin Xia,Ruxian Pi,Duo Xu,Wenchao Wang,Hong Du,Erqun Song,Yang Song.  (2014-02-18)  Protective effects of neohesperidin dihydrochalcone against carbon tetrachloride-induced oxidative damage in vivo and in vitro..  Chemico-biological interactions,  213  (51-59).  [PMID:24530446]
17. J F Gent.  (1979-12-01)  An exponential model for adaptation in taste..  Sensory processes,  3  ((4)): (303-316).  [PMID:263646]
18. R L Rouseff.  (1988-07-01)  Liquid chromatographic determination of naringin and neohesperidin as a detector of grapefruit juice in orange juice..  Journal - Association of Official Analytical Chemists,  71  ((4)): (798-802).  [PMID:3417605]
19. H Montijano,F Borrego,I Canales,F A Tomás-Barberán.  (1997-01-10)  Validated high-performance liquid chromatographic method for quantitation of neohesperidine dihydrochalcone in foodstuffs..  Journal of chromatography. A,  758  ((1)): (163-166).  [PMID:9035388]
20. H Montijano,J Cano,F J López-Cremades,J Bañón,I Canales,F Borrego.  (2000-01-27)  An estimation of the detection and quantitation limits of neohesperidine DC by high-performance liquid chromatography..  World review of nutrition and dietetics,  85  (125-128).  [PMID:10647343]
21. J S Cho,S S Yoo,T K Cheong,M J Kim,Y Kim,K H Park.  (2000-02-26)  Transglycosylation of neohesperidin dihydrochalcone by Bacillus stearothermophilus maltogenic amylase..  Journal of agricultural and food chemistry,  48  ((2)): (152-154).  [PMID:10691608]
22. J H Kroeze.  (2000-10-04)  Neohesperidin dihydrochalcone is not a taste enhancer in aqueous sucrose solutions..  Chemical senses,  25  ((5)): (555-559).  [PMID:11015327]
23. O Benavente-García,J Castillo,M J Del Baño,J Lorente.  (2001-02-15)  Improved water solubility of neohesperidin dihydrochalcone in sweetener blends..  Journal of agricultural and food chemistry,  49  ((1)): (189-191).  [PMID:11170576]
24. M Nakazato,C Kobayashi,Y Yamajima,M Kawano,K Yasuda.  (2001-06-01)  [Determination of neohesperidin dihydrochalcone in foods]..  Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan,  42  ((1)): (40-44).  [PMID:11383155]
25. D H Waalkens-Berendsen,M E M Kuilman-Wahls,A Bär.  (2004-07-22)  Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats..  Regulatory toxicology and pharmacology : RTP,  40  ((1)): (74-79).  [PMID:15265608]
26. Luciana Malpezzi,Giovanni Fronza,Claudio Fuganti,Andrea Mele,Sergio Brückner.  (2004-07-29)  Crystal architecture and conformational properties of the inclusion complex, neohesperidin dihydrochalcone-cyclomaltoheptaose (beta-cyclodextrin), by X-ray diffraction..  Carbohydrate research,  339  ((12)): (2117-2125).  [PMID:15280056]
27. Paula Arbeláez,Francesc Borrull,Eva Pocurull,Rosa Maria Marcé.  (2015-04-05)  Determination of high-intensity sweeteners in river water and wastewater by solid-phase extraction and liquid chromatography-tandem mass spectrometry..  Journal of chromatography. A,  1393  (106-114).  [PMID:25840659]
28. Chengyun He, Lu Bai, Daqun Liu, Benguo Liu.  (2023)  Interaction mechanism of okra (Abelmoschus esculentus L.) seed protein and flavonoids: Fluorescent and 3D-QSAR studies.  Food Chemistry-X,  20  (17): (101023).  [PMID:38144792] [10.1016/j.fochx.2023.101023]
29. Caiying Zhang, Yuelong Li, Abdus Samad, Hongliang He, Huan Ma, Yang Chen, Tengchuan Jin.  (2024)  Kyasanur Forest disease virus NS3 helicase: Insights into structure, activity, and inhibitors.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  254  (127856).  [PMID:37924898] [10.1016/j.ijbiomac.2023.127856]
30. Liang Zhang, Junhui Xu, Jing Qian, Yazhen Wang.  (2023)  A novel detection method for neohesperidin dihydrochalcone (NHDC) based on ZIF-8/ErGO composite modified electrode in milk.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,  123  (105584).  [10.1016/j.jfca.2023.105584]
31. Zilong Chen, Hongdong Liu, Jie Chen, Weifeng Zhu, Yong Liu, Jianxin Min, Xiaotian Chen, Bin Li, Xin Yang.  (2021)  Separation and enrichment of sibiskoside from Sibiraea angustat with magnetic surface dummy template molecularly imprinted polymers.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1178  (122767).  [PMID:34224966] [10.1016/j.jchromb.2021.122767]
32. Xiaomin Xia, Juanli Fu, Xiufang Song, Qiong Shi, Chuanyang Su, Erqun Song, Yang Song.  (2015)  Neohesperidin dihydrochalcone down-regulates MyD88-dependent and -independent signaling by inhibiting endotoxin-induced trafficking of TLR4 to lipid rafts.  FREE RADICAL BIOLOGY AND MEDICINE,  89  (522).  [PMID:26453923] [10.1016/j.freeradbiomed.2015.08.023]
33. Qiong Shi, Xiufang Song, Juanli Fu, Chuanyang Su, Xiaomin Xia, Erqun Song, Yang Song.  (2015)  Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice.  INTERNATIONAL IMMUNOPHARMACOLOGY,  29  (722).  [PMID:26362205] [10.1016/j.intimp.2015.09.003]
34. Chuanyang Su, Xiaomin Xia, Qiong Shi, Xiufang Song, Juanli Fu, Congxue Xiao, Hongjun Chen, Bin Lu, Zhiyin Sun, Shanmei Wu, Siyu Yang, Xuegang Li, Xiaoli Ye, Erqun Song, Yang Song.  (2015)  Neohesperidin Dihydrochalcone versus CCl4-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  63  (22): (5468–5475).  [PMID:25978654] [10.1021/acs.jafc.5b01750]
35. Lingxi Yang, Lu Wang, Kunjing Li, Baoxian Ye.  (2014)  Sensitive voltammetric determination of neohesperidin dihydrochalcone based on SWNTs modified glassy carbon electrode.  Analytical Methods,  6  (23): (9410-9418).  [10.1039/C4AY02004A]

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