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无活菌素 来源于灰色链霉菌变种

选择性K +和NH 4 +单价阳离子离子载体
3篇引用文献
  • Moligand™
    •
  • ≥96%
  • A mixture of Nonactin, Monactin and Dinactin
  • CAS编号: 6833-84-7
  • 分子式: C40H64O12
  • 分子量: 736.93 (for Nonactin)
  • PubChem编号: 72519
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货号 (SKU) 包装规格 是否现货 价格 数量
N139792-5mg
 5mg 现货 Stock Image
N139792-25mg
 25mg 现货 Stock Image
N139792-100mg
 100mg 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
查看相关系列
Anti-infection (2825) Antibiotic (625) Bacterial (717) Influenza Virus (253) Metabolic Enzyme/Protease (4888) Mitochondrial Metabolism (118) Potassium Channel (254) 膜转运器/离子通道 (1833)
main product photo

基本描述

别名 铵离子载体
英文别名 Ferricon | NSC52141 | NSC-52141 | 4,13,22,31,37,38,39,40-OCTAOXAPENTACYCLO(32.2.1.17,10.116,19.125,28)TETRACONTANE-3,12,21,30-TETRONE, 2,5,11,14,20,23,29,32-OCTAMETHYL-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)- | NSC 56409 | Q7049170
规格或纯度 Moligand™, ≥96%, A mixture of Nonactin, Monactin and Dinactin
英文名称 Nonactin from Streptomyces griseus var griseus
生化机理 Nonactin 是一种大环内酯，可与钾和钠等碱性阳离子形成络合物。据报道，Nonactin 可抑制细胞质前体蛋白进入线粒体的过程。Nonactin 是氧化磷酸化的解偶联剂。抗生素制剂。诱导阳离子跨人工膜转运。抑制 P 糖蛋白介导的化疗药物外流。在体内显示抗生素效应。
储存温度 -20°C储存,充氩
运输条件 超低温冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Nonactin from Streptomyces Griseus: a mixture of the two homolog macrotetrolide antibiotics: Nonactin, Monactin. The Nonactin is not less than 80%, ballanced by Monactin only. The mixture does not contain Dinactin, Trinactin, Tetranactin. Nonactin batches released since May 2010 are better than 95% Nonactin by NMR; detailed information is available on requestNonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drμg-resistant cancer cells. Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade POLYNACTIN. Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is used in urea and ammonium specific electrodes.

Nonactin from Streptomyces Griseus: a mixture of the two homolog macrotetrolide antibiotics: Nonactin, Monactin. The Nonactin is not less than 80%, ballanced by Monactin only. The mixture does not contain Dinactin, Trinactin, Tetranactin. Nonactin batches released since May 2010 are better than 95% Nonactin by NMR; detailed information is available on request
Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells. Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade POLYNACTIN. Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is used in urea and ammonium specific electrodes.

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关联靶点（人）

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CAKI-1 (44928 活性数据)
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CCRF-CEM (65223 活性数据)
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COLO 205 (50209 活性数据)
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DU-145 (51482 活性数据)
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HL-60 (67320 活性数据)
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HT-29 (80576 活性数据)
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K562 (73714 活性数据)
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KM12 (47707 活性数据)
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M14 (47487 活性数据)
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MCF7 (126967 活性数据)
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MOLT-4 (49676 活性数据)
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OVCAR-3 (48710 活性数据)
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OVCAR-4 (44535 活性数据)
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OVCAR-5 (45555 活性数据)
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OVCAR-8 (47708 活性数据)
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PC-3 (62116 活性数据)
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RPMI-8226 (44974 活性数据)
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RXF 393 (41971 活性数据)
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SK-MEL-2 (46422 活性数据)
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SK-MEL-28 (48833 活性数据)
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SK-MEL-5 (47095 活性数据)
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SK-OV-3 (52876 活性数据)
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SN12C (47755 活性数据)
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SNB-19 (46794 活性数据)
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TK-10 (45540 活性数据)
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U-251 (51189 活性数据)
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UACC-257 (46019 活性数据)
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UACC-62 (47335 活性数据)
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UO-31 (46270 活性数据)
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786-0 (47912 活性数据)
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NCI/ADR-RES (33767 活性数据)
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HCC 2998 (41480 活性数据)
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HCT-116 (91556 活性数据)
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Hs-578T (29457 活性数据)
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NCI-H460 (60772 活性数据)
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HOP-62 (47048 活性数据)
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MDA-N (28205 活性数据)
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Malme-3M (44254 活性数据)
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关联靶点（其它种属）

GCN5 Histone acetyltransferase GCN5 (89 活性数据)
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Rorc Nuclear receptor ROR-gamma (89407 活性数据)
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作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 小分子
IUPAC Name (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone
INCHI InChI=1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-
InChi Key RMIXHJPMNBXMBU-QIIXEHPYSA-N
Canonical SMILES CC1CC2CCC(O2)C(C(=O)OC(CC3CCC(O3)C(C(=O)OC(CC4CCC(O4)C(C(=O)OC(CC5CCC(O5)C(C(=O)O1)C)C)C)C)C)C)C
Isomeric SMILES C[C@@H]1C[C@H]2CC[C@H](O2)[C@@H](C(=O)O[C@H](C[C@@H]3CC[C@@H](O3)[C@H](C(=O)O[C@@H](C[C@H]4CC[C@H](O4)[C@@H](C(=O)O[C@H](C[C@@H]5CC[C@@H](O5)[C@H](C(=O)O1)C)C)C)C)C)C)C
WGK Germany 3
PubChem CID 72519
分子量 736.93 (for Nonactin)

化学和物理性质

溶解性 Soluble in chloroform (9.80 - 10.20 mg/ml), ethanol (10 mM), DMSO (10 mg/ml), and methanol. Insoluble in water.
敏感性 对湿度敏感
熔点 145℃-146℃
分子量 736.900 g/mol
XLogP3 6.600
氢键供体数Hydrogen Bond Donor Count 0
氢键受体数Hydrogen Bond Acceptor Count 12
可旋转键计数Rotatable Bond Count 0
精确质量Exact Mass 736.44 Da
单同位素质量Monoisotopic Mass 736.44 Da
拓扑极表面积Topological Polar Surface Area 142.000 Ų
重原子数Heavy Atom Count 52
形式电荷Formal Charge 0
复杂度Complexity 1040.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 16
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

WGK Germany 3
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

 SDS英文版

技术规格说明书

Melting point 145-146（℃）
Appearance（N139792) Colorless or White Needle-like Crystals,Powder
13C NMR Spectrum Conforms to Structure
Solubility in DMSO/CH2CL2 Clear colorless solution at 10mg/ml
Purity(HPLC) 96-100（%）

 技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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找到12个结果

批号(Lot Number) 证书类型 日期 货号
J2418648 分析证书 24-10-09 N139792
J2418649 分析证书 24-10-09 N139792
J2418650 分析证书 24-10-09 N139792
A2305573 分析证书 22-10-11 N139792
A2305575 分析证书 22-10-11 N139792
A2305649 分析证书 22-10-11 N139792
J2218937 分析证书 22-07-20 N139792
J2218938 分析证书 22-07-20 N139792
J2218946 分析证书 22-07-20 N139792
B2215648 分析证书 22-01-17 N139792
B2215652 分析证书 22-01-17 N139792
B2215657 分析证书 22-01-17 N139792

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此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Yanzhou Bao, Jiabao Yan, Jie Hu, Jing Li.  (2024)  NH4+-selective electrode with superhydrophobic solid contact for actual wastewater monitoring.  SENSORS AND ACTUATORS B-CHEMICAL,  401  (4): (135066).  [PMID:12551915] [10.1016/j.snb.2023.135066]
2. Yanzhou Bao, Jiabao Yan, Jie Hu, Jing Li.  (2023)  Superhydrophobic polyaniline solid contact for potential stability improvement of NH4+-selective electrode.  SENSORS AND ACTUATORS B-CHEMICAL,  390  (133997).  [10.1016/j.snb.2023.133997]
3. Xuecui Mei, Jiao Yang, Jiang Liu, Yingchun Li.  (2023)  Wearable, nanofiber-based microfluidic systems with integrated electrochemical and colorimetric sensing arrays for multiplex sweat analysis.  CHEMICAL ENGINEERING JOURNAL,  454  (140248).  [10.1016/j.cej.2022.140248]

参考文献

1. Yanzhou Bao, Jiabao Yan, Jie Hu, Jing Li.  (2024)  NH4+-selective electrode with superhydrophobic solid contact for actual wastewater monitoring.  SENSORS AND ACTUATORS B-CHEMICAL,  401  (4): (135066).  [PMID:12551915] [10.1016/j.snb.2023.135066]
2. Yanzhou Bao, Jiabao Yan, Jie Hu, Jing Li.  (2023)  Superhydrophobic polyaniline solid contact for potential stability improvement of NH4+-selective electrode.  SENSORS AND ACTUATORS B-CHEMICAL,  390  (133997).  [10.1016/j.snb.2023.133997]
3. Xuecui Mei, Jiao Yang, Jiang Liu, Yingchun Li.  (2023)  Wearable, nanofiber-based microfluidic systems with integrated electrochemical and colorimetric sensing arrays for multiplex sweat analysis.  CHEMICAL ENGINEERING JOURNAL,  454  (140248).  [10.1016/j.cej.2022.140248]

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