首页   400-620-6333
为了更好地浏览阿拉丁的产品，请在使用“QQ浏览器”或“360浏览器”时切换到极速模式。查看明细
  • 登录
  • 注册
  • 英文站
切换导航
我的购物车
搜索
搜索444
高级搜索
菜单
登录
྾

Necrostatin-1,特异性坏死病抑制剂, 吲哚胺 2;3-二氧化酶 1 抑制剂；受体相互作用丝氨酸/苏氨酸激酶 1 抑制剂

有力的特异性坏死病抑制剂
1篇引用文献
有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
N125522-10mg
 10mg 现货 Stock Image
N125522-50mg
 50mg 现货 Stock Image
N125522-100mg
 100mg 现货 Stock Image
N125522-250mg
 250mg 现货 Stock Image
N125522-1g
 1g 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
查看相关系列
Apoptosis (1467) Autophagy (555) Ferroptosis (208) Indoleamine 2,3-Dioxygenase (IDO) (21) indoleamine 2，3-dioxygenase 1 Inhibitor (13) Metabolic Enzyme/Protease (4888) receptor interacting serine/threonine kinase 1 Inhibitor (26) RIP kinase (65)
main product photo

基本描述

别名 5-(1H-吲哚-3-基甲基)-3-甲基-2-硫代-4-咪唑啉酮, 5-(吲哚-3-基甲基)-3-甲基-2-硫代乙内酰脲, MTH-DL-色氨酸 | 5-[(1H-吲哚-3-基)甲基]-3-甲基-2-硫代咪唑啉-4-酮
英文别名 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanyl-3,5-dihydro-4H-imidazol-4-one | 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone | A826160 | HMS3229H21 | CCG-265032 | HY-15760 | Necrostatin 1 | 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxoimidazolidin-
规格或纯度 Moligand™, ≥99%
英文名称 Necrostatin-1
生化机理 Necrostatin-1是坏死性凋亡的抑制剂（非凋亡性细胞死亡途径）。有力的特异性坏死性肾病抑制剂（EC 50 = 490 nM）。死亡域受体相关衔接子激酶RIP1的选择性变构抑制剂体外（EC 50 = 182 nM）。半胱天冬酶独立的程序性坏死途径。
储存温度 -20°C储存,充氩
运输条件 超低温冰袋运输
作用类型 抑制剂
作用机制 吲哚胺 2;3-二氧化酶 1 抑制剂；受体相互作用丝氨酸/苏氨酸激酶 1 抑制剂
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Necrostatin-1has been used to investigate its effect on the regulation of interleukin (IL)-33 expression during liver injury in mice in vivo and in hepatic stellate cells in vitro.It has also been used as an inhibitor of receptor-interacting protein kinase 1 (RIPK1) in experimental studies.

Necrostatin-1has been used to investigate its effect on the regulation of interleukin (IL)-33 expression during liver injury in mice in vivo and in hepatic stellate cells in vitro.It has also been used as an inhibitor of receptor-interacting protein kinase 1 (RIPK1) in experimental studies.

AI解读

关联靶点（人）

RIPK1 Tchem 受体相互作用丝氨酸/苏氨酸蛋白激酶 1(Receptor-interacting serine/threonine-protein kinase 1) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
IDO1 Tchem 吲哚胺2,3-双加氧酶1(Indoleamine 2,3-dioxygenase 1) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
THRB Tclin Thyroid hormone receptor beta-1 (7926 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLA Tclin Alpha-galactosidase A (5444 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RIPK2 Tchem Serine/threonine-protein kinase RIPK2 (1546 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HL-60 (67320 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-29 (80576 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U-937 (7138 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Jurkat (10389 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IDO1 Tchem Indoleamine 2,3-dioxygenase (6650 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RIPK1 Tchem Receptor-interacting serine/threonine-protein kinase 1 (1548 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SMN1 Tchem Survival motor neuron protein (34246 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RIPK3 Tchem Receptor-interacting serine/threonine-protein kinase 3 (468 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSP90AA1 Tchem Heat shock protein HSP90 (3606 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LLC-PK1 (2135 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NIH3T3 (5395 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-22 (3261 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
L929 (3802 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504762223
分子类型 小分子
IUPAC Name 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one
INCHI InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
InChi Key TXUWMXQFNYDOEZ-UHFFFAOYSA-N
Canonical SMILES CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
Isomeric SMILES CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
WGK Germany 3
关联CAS 4311-88-0
PubChem CID 2828334
MeSH Entry Terms Nec-1 compound;necrostatin-1
分子量 259.33

化学和物理性质

溶解性 Soluble in DMSO (10-25 mg/ml), 100% ethanol (6 mg/ml), and methanol (5 mg/ml).
敏感性 对光线敏感；对空气敏感； 对热敏感
熔点 160.0 - 164.0 °C
分子量 259.329 g/mol
XLogP3 1.900
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 2
可旋转键计数Rotatable Bond Count 2
精确质量Exact Mass 259.078 Da
单同位素质量Monoisotopic Mass 259.078 Da
拓扑极表面积Topological Polar Surface Area 80.200 Ų
重原子数Heavy Atom Count 18
形式电荷Formal Charge 0
复杂度Complexity 373.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 1
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

WGK Germany 3
个人防护装备 Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

 SDS英文版

技术规格说明书

Purity(HPLC) 98-100（%）
NMR spectrum Conforms to Structure

 技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到11个结果

批号(Lot Number) 证书类型 日期 货号
D2307381 分析证书 25-01-09 N125522
K2415076 分析证书 24-11-21 N125522
K2401078 分析证书 24-11-07 N125522
L2425429 分析证书 24-04-13 N125522
B2108008 分析证书 22-12-14 N125522
K2316077 分析证书 22-03-23 N125522
E2225217 分析证书 22-03-23 N125522
E2225218 分析证书 22-03-23 N125522
E2225227 分析证书 22-03-23 N125522
E2225230 分析证书 22-03-23 N125522
E2225226 分析证书 22-03-23 N125522

显示更多⌵

相关技术文章

FAQ
PANoptosis: 一种促炎性程序性细胞死亡途径
分类: 技术文章
标签:
PAN凋亡

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Yao Li, Jie Wang, Yaru Li, Jiajia Luo, Fang Liu, Tiantian Chen, Yuting Ji, Hong Yang, Zheng Wang, Yanjun Zhao.  (2023)  Attenuating Uncontrolled Inflammation by Radical Trapping Chiral Polymer Micelles.  ACS Nano,  [PMID:37352508] [10.1021/acsnano.2c12356]

参考文献

1. Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G et al..  (2008)  Identification of RIP1 kinase as a specific cellular target of necrostatins..  Nat Chem Biol,  4  (5): (313-21).  [PMID:18408713] [10.1021/op500134e]
2. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J.  (2005)  Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury..  Nat Chem Biol,  1  (2): (112-9).  [PMID:16408008] [10.1021/op500134e]
3. Takahashi N, Duprez L, Grootjans S, Cauwels A, Nerinckx W, DuHadaway JB, Goossens V, Roelandt R, Van Hauwermeiren F, Libert C et al..  (2012)  Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models..  Cell Death Dis,  3  (13): (e437).  [PMID:23190609] [10.1021/op500134e]
4. Alegre-Cortés E et al..  (2020)  Toxicity of Necrostatin-1 in Parkinson's Disease Models..  Antioxidants (Basel),  9  (6): [PMID:32549347]
5. Li CJ et al..  (2015)  \nSynergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis.\n.  Sci Rep,  5  (9819).  [PMID:25909282]
6. Molnár T et al..  (2021)  Caspase-9 acts as a regulator of necroptotic cell death..  FEBS J,  288  (22): (6476-6491).  [PMID:33899329]
7. Tsui KH et al..  (2017)  DHEA protects mitochondria against dual modes of apoptosis and necroptosis in human granulosa HO23 cells..  Reproduction,  154  (2): (101-110).  [PMID:28624766]
8. Lau H et al..  (2020)  Dose-dependent effects of necrostatin-1 supplementation to tissue culture media of young porcine islets..  PLoS One,  15  (12): (e0243506).  [PMID:33284818]
9. Matsuda H et al..  (2017)  HCaRG/COMMD5 inhibits ErbB receptor-driven renal cell carcinoma..  Oncotarget,  8  (41): (69559-69576).  [PMID:29050225]
10. Bockerstett KA et al..  (2018)  Interleukin-17A Promotes Parietal Cell Atrophy by Inducing Apoptosis..  Cell Mol Gastroenterol Hepatol,  5  (4): (678-690.e1).  [PMID:29930985]
11. Dallenga T et al..  (2017)  M.\xa0tuberculosis-Induced Necrosis of Infected Neutrophils Promotes Bacterial Growth Following Phagocytosis by Macrophages..  Cell Host Microbe,  22  (4): (519-530.e3).  [PMID:29024644]
12. Yan S et al..  (2021)  Necroptosis pathway blockage attenuates PFKFB3 inhibitor-induced cell viability loss and genome instability in colorectal cancer cells..  Am J Cancer Res,  11  (5): (2062-2080).  [PMID:34094669]
13. Yan B et al..  (2018)  Necrostatin-1 promotes ectopic periodontal tissue like structure regeneration in LPS-treated PDLSCs..  PLoS One,  13  (11): (e0207760).  [PMID:30462730]
14. Lau H et al..  (2019)  Necrostatin-1 supplementation enhances young porcine islet maturation and in vitro function..  Xenotransplantation,  (e12555).  [PMID:31532037]
15. Lau H et al..  (2021)  Necrostatin-1 Supplementation to Islet Tissue Culture Enhances the In-Vitro Development and Graft Function of Young Porcine Islets..  Int J Mol Sci,  22  (16): [PMID:34445075]
16. Lau H et al..  (2021)  The effects of necrostatin-1 on the in vitro development and function of young porcine islets over 14-day prolonged tissue culture..  Xenotransplantation,  28  (3): (e12667).  [PMID:33438288]
17. Trimova G et al..  (2020)  Tumour necrosis factor alpha promotes secretion of 14-3-3? by inducing necroptosis in macrophages..  Arthritis Res Ther,  22  (24).  [PMID:32051018]
18. Yao Li, Jie Wang, Yaru Li, Jiajia Luo, Fang Liu, Tiantian Chen, Yuting Ji, Hong Yang, Zheng Wang, Yanjun Zhao.  (2023)  Attenuating Uncontrolled Inflammation by Radical Trapping Chiral Polymer Micelles.  ACS Nano,  [PMID:37352508] [10.1021/acsnano.2c12356]

溶液计算器

上海阿拉丁生化科技股份有限公司
© 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。

上海工商 危险品化学品经营许可证（带存储）营业执照(三证合一)