基本描述

别名	美洛昔康 \| 4-羟基-2-甲基-N-(5-甲基-2-噻唑基)-2H-1,2-苯并噻嗪-3-甲酰胺1,1-二氧化物
英文别名	UH-AC 62XX \| Meloxicam (JAN/USP/INN) \| Meloxoral \| MLS006011422 \| QMIIZ ODT \| AMOXICILLIN CRYSTALLINE \| C14H13N3O4S2 \| MELOXICAM [EP MONOGRAPH] \| Meloxicam Solution for Injection \| VG2QF83CGL \| Vivlodex \| BIDD:GT0726 \| Emdocam \| Movatec \| Parocin \| Metaca
规格或纯度	Moligand™, ≥98%
英文名称	Meloxicam
生化机理	据报道，非甾体抗炎药美洛昔康（Meloxicam）可抑制 Cox-2 的诱导型异构体。美洛昔康是一种对 Cox-2 有选择性的抑制剂（IC50 为 4.7 μM），而不是 Cox-1（IC50 为 36.6 μM）。研究表明，美洛昔康对 Cox-2 具有优先选择性，因此其胃肠道毒性可能不会低于非选择性抗炎药物。研究表明，这种化合物还能抑制炎症细胞中类固醇的合成。此外，美洛昔康（Meloxicam）还在体外显示出非竞争性抑制红细胞 PGD（6-磷酸葡萄糖酸脱氢酶）活性的能力。选择性抑制 COX-2 而非 COX-1（IC 50 值分别为 4.7 和 36.3 μM）。镇痛作用。
储存温度	-20°C储存
运输条件	超低温冰袋运输
作用类型	抑制剂
作用机制	COX-1 抑制剂；COX-2 抑制剂
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参考SDS，以获取更多信息。需要更多有关溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	Meloxicam 是一种非甾体类抗炎剂，具有镇痛和降低发烧作用。An inhibitor of Cox-1 and Cox-2, selective for Cox-2. Meloxicam (Mobic) is a nonsteroidal anti-inflammatory agent with analgesic and fever reducer effects. An inhibitor of Cox-1 and Cox-2, selective for Cox-2.

AI解读

关联靶点（人）

PTGS1 Tclin 前列腺素 G/H 合酶 1(Prostaglandin G/H synthase 1) (1 活性数据)

点击查看靶蛋白信息： PTGS1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

PTGS2 Tclin 前列腺素 G/H 合酶 2(Prostaglandin G/H synthase 2) (6 活性数据)

点击查看靶蛋白信息： PTGS2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

名称和识别符

PubChem SID	504771345
分子类型	小分子
IUPAC Name	4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1λ6,2-benzothiazine-3-carboxamide
INCHI	InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)
InChi Key	ZRVUJXDFFKFLMG-UHFFFAOYSA-N
Canonical SMILES	CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O
Isomeric SMILES	CC1=CN=C(S1)NC(=O)C2=C(C3=CC=CC=C3S(=O)(=O)N2C)O
RTECS	DL0702000
PubChem CID	54677470
UN Number	2811
Packing Group	III
分子量	351.4
Reaxy-Rn	5886369

化学和物理性质

溶解性	H2O: 0.67 mg/mL (1.91 mM; 超声助溶)；DMSO: 25 mg/mL (71.14 mM; 超声助溶 (<60°C)；Ethanol: <1 mg/mL
敏感性	对热敏感
熔点	255°C
分子量	351.400 g/mol
XLogP3	3.000
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	7
可旋转键计数Rotatable Bond Count	2
精确质量Exact Mass	351.035 Da
单同位素质量Monoisotopic Mass	351.035 Da
拓扑极表面积Topological Polar Surface Area	136.000 Å²
重原子数Heavy Atom Count	23
形式电荷Formal Charge	0
复杂度Complexity	628.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS06, GHS08
信号词	Danger
危险声明	H301: 吞咽会中毒 H412: 对水生生物有害并具有长期持续影响 H360: 可能损害生育力或未出生的孩子
预防措施声明	P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P203: 使用前，获取、阅读并遵守所有安全说明。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P318: 如果暴露或担心，请就医。
RTECS	DL0702000
Reaxy-Rn	5886369
Class	6.1
Merck Index	5826

SDS英文版

技术规格说明书

Carbon by Elemental Analysis	46.3-48.3（%）
Purity(HPLC)	98-100（%）
Nitrogen by Elemental Analysis	11.2-12.5（%）
Appearance（M129228)	yellow powder
NMR spectrum	Conforms to Structure

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到10个结果

批号(Lot Number)	证书类型	日期	货号
L2409105	分析证书	24-09-14	M129228
K2217942	分析证书	24-09-14	M129228
K2217985	分析证书	24-09-14	M129228
K2217986	分析证书	24-09-14	M129228
K2217988	分析证书	24-09-14	M129228
D2422192	分析证书	24-03-26	M129228
D2422191	分析证书	24-03-26	M129228
G1515087	分析证书	23-05-09	M129228
D2117281	分析证书	23-02-08	M129228
D2117285	分析证书	23-02-08	M129228

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?

1. Gilbert Audira, Jong-Chin Huang, Kelvin H.-C. Chen, Kevin Adi Kurnia, Ross D. Vasquez, Marri Jmelou M. Roldan, Yu-Heng Lai, Chung-Der Hsiao, Cheng-Yo Yen. (2023) A comprehensive painkillers screening by assessing zebrafish behaviors after caudal fin amputation. BIOMEDICINE & PHARMACOTHERAPY, 168 (115641). [PMID:37806085] [10.1016/j.biopha.2023.115641]
2. Zhong-Xia Wang, Kai-Qi Liu, Xiang-Ying Meng, Feng Li, Heng-Ye Li, Hang Gao, Wei Wang. (2023) An eco-friendly fluorometric assay for high-sensitive meloxicam quantitation in biological matrices. ANALYST, 148 (18): (4339-4345). [PMID:37580992] [10.1039/D3AN01211E]
3. Meizhu Qin, Xinping Hu, Jingyan Guo. (2023) Preparation of a New Type of Expansion Flame Retardant and Application in Polystyrene. Coatings, 13 (4): (733). [10.3390/coatings13040733]
4. Jiana Lin, Xiaoyan Ouyang, Yuling Hu, Gongke Li, Qisheng Zhong. (2023) Primary amide-functionalized cyclotricatechylene covalent organic frameworks membrane for efficient enrichment of melamine and its derivatives in migration solution of food contact materials. JOURNAL OF SEPARATION SCIENCE, 46 (6): (202200862). [PMID:36680331] [10.1002/jssc.202200862]
5. Chenghua Song, Ruichao Wen, Jiaxuan Zhou, Xiaoyan Zeng, Zi Kou, Yufeng Li, Feng Yun, Rongqian Wu. (2022) UV C Light from a Light-Emitting Diode at 275 Nanometers Shortens Wound Healing Time in Bacterium- and Fungus-Infected Skin in Mice. Microbiology Spectrum, [PMID:36453911] [10.1128/spectrum.03424-22]
6. Chenghua Song, Ruichao Wen, Jiaxuan Zhou, Xiaoyan Zeng, Zi Kou, Jia Zhang, Tao Wang, Pengkang Chang, Yi Lv, Rongqian Wu. (2022) Antibacterial and Antifungal Properties of a Novel Antimicrobial Peptide GK-19 and Its Application in Skin and Soft Tissue Infections Induced by MRSA or Candida albicans. Pharmaceutics, 14 (9): (1937). [PMID:36145681] [10.3390/pharmaceutics14091937]
7. Xiaochun Hu, Yuqing Luo, Xianyue Wu, Jiabin Niu, Mingwu Tan, Zhiqiang Sun, Wen Liu. (2022) Heteroatom-doped microporous carbon nanosheets derived from pentaerythritol-melamine for supercapacitors and CO2 capture. Materials Today Energy, 27 (101010). [10.1016/j.mtener.2022.101010]
8. Ya Xu, Ru Zhou, Jingjing Mu, Yanming Ding, Juncheng Jiang. (2022) Synergistic flame retardancy of linear low-density polyethylene with surface modified intumescent flame retardant and zinc borate. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 640 (128400). [10.1016/j.colsurfa.2022.128400]
9. Xiaoqiang Feng, Zhengyi He, Lingyan Yu, Zhiduo Liu, Gang Wang, Siwei Yang, Guqiao Ding. (2021) Dual-enhanced Raman scattering sensors incorporating graphene plasmonic nanoresonators. Journal of Materials Chemistry C, 9 (37): (12768-12777). [10.1039/D1TC02461B]
10. Wei Zhu, Xiaoqiang Feng, Zhiduo Liu, Menghan Zhao, Peng He, Siwei Yang, Shiwei Tang, Da Chen, Qinglei Guo, Gang Wang, Guqiao Ding. (2021) Sensitive, Reusable, Surface-Enhanced Raman Scattering Sensors Constructed with a 3D Graphene/Si Hybrid. ACS Applied Materials & Interfaces, 13 (19): (23081–23091). [PMID:33957757] [10.1021/acsami.1c02182]
11. Ru Zhou, Jingjing Mu, Xiaoyan Sun, Yanming Ding, Juncheng Jiang. (2020) Application of intumescent flame retardant containing aluminum diethyphosphinate, neopentyl glycol, and melamine for polyethylene. SAFETY SCIENCE, 131 (104849). [10.1016/j.ssci.2020.104849]
12. Chen Xiao, Xi Zhiyu, Liang Huaibin, Sun Yuhao, Zhong Zhihong, Wang Baofeng, Bian Liuguan, Sun Qingfang. (2019) Melatonin Prevents Mice Cortical Astrocytes From Hemin-Induced Toxicity Through Activating PKCα/Nrf2/HO-1 Signaling in vitro. Frontiers in Neuroscience, 13 [PMID:31404262] [10.3389/fnins.2019.00760]
13. Tong Wang, Hai-Long Wu, Yong-Jie Yu, Wan-Jun Long, Li Cheng, An-Qi Chen, Ru-Qin Yu. (2019) A simple method for direct modeling of second-order liquid chromatographic data with retention time shifts and holding the second-order advantage. JOURNAL OF CHROMATOGRAPHY A, 1605 (360360). [PMID:31326090] [10.1016/j.chroma.2019.07.014]
14. Shouwu Yu, Shujuan Xiao, Zewen Zhao, Xiaowen Huo, Junfu Wei. (2019) Microencapsulated ammonium polyphosphate by polyurethane with segment of dipentaerythritol and its application in flame retardant polypropylene. CHINESE JOURNAL OF CHEMICAL ENGINEERING, 27 (1735). [10.1016/j.cjche.2019.04.023]
15. Sung Rae Kim, Myoung Jin Ho, Sang Hyun Kim, Ha Ra Cho, Han Sol Kim, Yong Seok Choi, Young Wook Choi, Myung Joo Kang. (2016) Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection. Drug Design Development and Therapy, [PMID:27895468] [10.2147/DDDT.S118145]
16. Wang Yu, Gao Lei, Qin Dongli, Chen Ligang. (2017) Analysis of Melamine in Milk Powder by CNT-MIP with Matrix Solid Phase Dispersion and LC-MS/MS. Food Analytical Methods, 10 (5): (1386-1396). [10.1007/s12161-016-0705-1]
17. Kim Han Sol, Cho Ha Ra, Ho Myoung Jin, Kang Myung Joo, Choi Yong Seok. (2016) Determination of piroxicam from rat articular tissue and plasma based on LC–MS/MS. ARCHIVES OF PHARMACAL RESEARCH, 39 (12): (1653-1662). [PMID:27752829] [10.1007/s12272-016-0845-2]
18. Rongli Zhang, Sheng Xu, Ye Zhu, Wei Zhao, Jing Luo, Xiaoya Liu, Dingxing Tang. (2016) Molecularly imprinted nanohybrids based on dopamine-modified poly(γ-glutamic acid) for electrochemical sensing of melamine. BIOSENSORS & BIOELECTRONICS, 85 (381). [PMID:27196255] [10.1016/j.bios.2016.05.030]
19. Xu Xiuzhu, Chen Shuixia, Zhuang Linzhou, Zheng Chunhao, Wu Yingzhu. (2014) Establishment of a novel surface-imprinting system for melamine recognition and mechanism of template–matrix interactions. JOURNAL OF MATERIALS SCIENCE, 49 (7): (2853-2863). [10.1007/s10853-013-7991-4]

参考文献

1. Gilbert Audira, Jong-Chin Huang, Kelvin H.-C. Chen, Kevin Adi Kurnia, Ross D. Vasquez, Marri Jmelou M. Roldan, Yu-Heng Lai, Chung-Der Hsiao, Cheng-Yo Yen. (2023) A comprehensive painkillers screening by assessing zebrafish behaviors after caudal fin amputation. BIOMEDICINE & PHARMACOTHERAPY, 168 (115641). [PMID:37806085] [10.1016/j.biopha.2023.115641]
2. Zhong-Xia Wang, Kai-Qi Liu, Xiang-Ying Meng, Feng Li, Heng-Ye Li, Hang Gao, Wei Wang. (2023) An eco-friendly fluorometric assay for high-sensitive meloxicam quantitation in biological matrices. ANALYST, 148 (18): (4339-4345). [PMID:37580992] [10.1039/D3AN01211E]
3. Meizhu Qin, Xinping Hu, Jingyan Guo. (2023) Preparation of a New Type of Expansion Flame Retardant and Application in Polystyrene. Coatings, 13 (4): (733). [10.3390/coatings13040733]
4. Jiana Lin, Xiaoyan Ouyang, Yuling Hu, Gongke Li, Qisheng Zhong. (2023) Primary amide-functionalized cyclotricatechylene covalent organic frameworks membrane for efficient enrichment of melamine and its derivatives in migration solution of food contact materials. JOURNAL OF SEPARATION SCIENCE, 46 (6): (202200862). [PMID:36680331] [10.1002/jssc.202200862]
5. Chenghua Song, Ruichao Wen, Jiaxuan Zhou, Xiaoyan Zeng, Zi Kou, Yufeng Li, Feng Yun, Rongqian Wu. (2022) UV C Light from a Light-Emitting Diode at 275 Nanometers Shortens Wound Healing Time in Bacterium- and Fungus-Infected Skin in Mice. Microbiology Spectrum, [PMID:36453911] [10.1128/spectrum.03424-22]
6. Chenghua Song, Ruichao Wen, Jiaxuan Zhou, Xiaoyan Zeng, Zi Kou, Jia Zhang, Tao Wang, Pengkang Chang, Yi Lv, Rongqian Wu. (2022) Antibacterial and Antifungal Properties of a Novel Antimicrobial Peptide GK-19 and Its Application in Skin and Soft Tissue Infections Induced by MRSA or Candida albicans. Pharmaceutics, 14 (9): (1937). [PMID:36145681] [10.3390/pharmaceutics14091937]
7. Xiaochun Hu, Yuqing Luo, Xianyue Wu, Jiabin Niu, Mingwu Tan, Zhiqiang Sun, Wen Liu. (2022) Heteroatom-doped microporous carbon nanosheets derived from pentaerythritol-melamine for supercapacitors and CO2 capture. Materials Today Energy, 27 (101010). [10.1016/j.mtener.2022.101010]
8. Ya Xu, Ru Zhou, Jingjing Mu, Yanming Ding, Juncheng Jiang. (2022) Synergistic flame retardancy of linear low-density polyethylene with surface modified intumescent flame retardant and zinc borate. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 640 (128400). [10.1016/j.colsurfa.2022.128400]
9. Xiaoqiang Feng, Zhengyi He, Lingyan Yu, Zhiduo Liu, Gang Wang, Siwei Yang, Guqiao Ding. (2021) Dual-enhanced Raman scattering sensors incorporating graphene plasmonic nanoresonators. Journal of Materials Chemistry C, 9 (37): (12768-12777). [10.1039/D1TC02461B]
10. Wei Zhu, Xiaoqiang Feng, Zhiduo Liu, Menghan Zhao, Peng He, Siwei Yang, Shiwei Tang, Da Chen, Qinglei Guo, Gang Wang, Guqiao Ding. (2021) Sensitive, Reusable, Surface-Enhanced Raman Scattering Sensors Constructed with a 3D Graphene/Si Hybrid. ACS Applied Materials & Interfaces, 13 (19): (23081–23091). [PMID:33957757] [10.1021/acsami.1c02182]
11. Ru Zhou, Jingjing Mu, Xiaoyan Sun, Yanming Ding, Juncheng Jiang. (2020) Application of intumescent flame retardant containing aluminum diethyphosphinate, neopentyl glycol, and melamine for polyethylene. SAFETY SCIENCE, 131 (104849). [10.1016/j.ssci.2020.104849]
12. Chen Xiao, Xi Zhiyu, Liang Huaibin, Sun Yuhao, Zhong Zhihong, Wang Baofeng, Bian Liuguan, Sun Qingfang. (2019) Melatonin Prevents Mice Cortical Astrocytes From Hemin-Induced Toxicity Through Activating PKCα/Nrf2/HO-1 Signaling in vitro. Frontiers in Neuroscience, 13 [PMID:31404262] [10.3389/fnins.2019.00760]
13. Tong Wang, Hai-Long Wu, Yong-Jie Yu, Wan-Jun Long, Li Cheng, An-Qi Chen, Ru-Qin Yu. (2019) A simple method for direct modeling of second-order liquid chromatographic data with retention time shifts and holding the second-order advantage. JOURNAL OF CHROMATOGRAPHY A, 1605 (360360). [PMID:31326090] [10.1016/j.chroma.2019.07.014]
14. Shouwu Yu, Shujuan Xiao, Zewen Zhao, Xiaowen Huo, Junfu Wei. (2019) Microencapsulated ammonium polyphosphate by polyurethane with segment of dipentaerythritol and its application in flame retardant polypropylene. CHINESE JOURNAL OF CHEMICAL ENGINEERING, 27 (1735). [10.1016/j.cjche.2019.04.023]
15. Sung Rae Kim, Myoung Jin Ho, Sang Hyun Kim, Ha Ra Cho, Han Sol Kim, Yong Seok Choi, Young Wook Choi, Myung Joo Kang. (2016) Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection. Drug Design Development and Therapy, [PMID:27895468] [10.2147/DDDT.S118145]
16. Wang Yu, Gao Lei, Qin Dongli, Chen Ligang. (2017) Analysis of Melamine in Milk Powder by CNT-MIP with Matrix Solid Phase Dispersion and LC-MS/MS. Food Analytical Methods, 10 (5): (1386-1396). [10.1007/s12161-016-0705-1]
17. Kim Han Sol, Cho Ha Ra, Ho Myoung Jin, Kang Myung Joo, Choi Yong Seok. (2016) Determination of piroxicam from rat articular tissue and plasma based on LC–MS/MS. ARCHIVES OF PHARMACAL RESEARCH, 39 (12): (1653-1662). [PMID:27752829] [10.1007/s12272-016-0845-2]
18. Rongli Zhang, Sheng Xu, Ye Zhu, Wei Zhao, Jing Luo, Xiaoya Liu, Dingxing Tang. (2016) Molecularly imprinted nanohybrids based on dopamine-modified poly(γ-glutamic acid) for electrochemical sensing of melamine. BIOSENSORS & BIOELECTRONICS, 85 (381). [PMID:27196255] [10.1016/j.bios.2016.05.030]
19. Xu Xiuzhu, Chen Shuixia, Zhuang Linzhou, Zheng Chunhao, Wu Yingzhu. (2014) Establishment of a novel surface-imprinting system for melamine recognition and mechanism of template–matrix interactions. JOURNAL OF MATERIALS SCIENCE, 49 (7): (2853-2863). [10.1007/s10853-013-7991-4]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

=

浓度

x

体积

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分子量

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稀释计算器

计算配制储备溶液所需的稀释度。

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体积 1 (V1)

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浓度 2 (C2)

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复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

=

质量（小瓶）

÷

所需的复溶浓度

货号 (SKU)	包装规格	是否现货
M129228-5g	5g	现货
M129228-10g	10g	现货
M129228-25g	25g	现货
M129228-100g	100g	现货

美洛昔康, COX-1 抑制剂；COX-2 抑制剂

库存信息

库存信息

库存信息

库存信息

基本描述

AI解读

关联靶点（人）

名称和识别符

化学和物理性质

安全和危险性（GHS）

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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此产品的引用文献

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器