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褪黑素, 5-HT 2B 受体拮抗剂；MT 1 受体激动剂；MT 2 受体激动剂

内源激素 MT 1和MT 2受体激动剂
41篇引用文献
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货号 (SKU) 包装规格 是否现货 价格 数量
M118674-5g
 5g 现货 Stock Image
M118674-25g
 25g 现货 Stock Image
M118674-100g
 100g 现货 Stock Image
M118674-500g
 500g 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
查看相关系列
5-HT2B receptor Antagonist (46) Apoptosis (1467) Autophagy (555) Endogenous Metabolite (981) GPCR/G Protein (3182) Melatonin Receptor (28) Metabolic Enzyme/Protease (4888) Mitophagy (30) MT1 receptor Agonist (29) MT2 receptor Agonist (33) 神经元信号传导 (3329)
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基本描述

别名 松果素 | N-乙酰基-5-甲氧基色胺 | 褪黑激素 | 美拉酮宁 | 抑黑素 | 松果腺素 | 松果体素
英文别名 N-Acetyl-5-methoxytryptamine
规格或纯度 Moligand™, ≥98%
英文名称 Melatonin
生化机理 激素；介导哺乳动物的光周期性；抑制小脑一氧化氮合成酶；过氧亚硝酸盐清除剂。 褪黑激素对凋亡途径具有复杂的作用，可抑制免疫细胞和神经元中的细胞凋亡但增强癌细胞的凋亡性细胞死亡。 通过抑制雌激素受体作用而抑制乳腺癌细胞的增殖/转移。 褪黑激素具有多种特性，如抗氧化、自体活性、paracoid和激素属性，以及抗炎和抗凋亡属性。褪黑激素与哺乳动物的季节性繁殖调节、能量代谢和体温调节有关。褪黑激素在减轻新生儿缺氧缺血（HI）诱导的内质网（ER）应激和保留sirtuin 1（SIRT-1）的表达中起重要作用。褪黑激素MT 1和MT 2受体的激动剂。内源激素在控制昼夜节律中很重要。广泛的病理生理功能，包括抗氧化和免疫调节作用。
储存温度 -20°C储存,充氩
运输条件 超低温冰袋运输
作用类型 激动剂
作用机制 5-HT 2B 受体拮抗剂；MT 1 受体激动剂；MT 2 受体激动剂
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

褪黑激素（N-乙酰基-5-甲氧基色胺）是由必需氨基酸色氨酸合成而来的。它是一种松果体神经激素。由褪黑激素诱导的直接、非受体介导的自由基清除活性使其与其他经典激素不同。褪黑激素在多种生物中表达，如细菌、藻类、真菌、植物、昆虫和包括人类在内的脊椎动物。褪黑激素已被实验性动物摄入用于以下研究： · 确定长期的褪黑激素摄入是否能够诱导生殖变化以及褪黑激素如何在排卵期间发挥其与大鼠卵巢中脂质氧化和抗氧化活性相关的保护作用。 · 确定褪黑激素对缺氧缺血后新生大鼠神经细胞内质网应激和sirtuin 1表达的影响。 · 在应激小鼠中研究褪黑激素慢性应激诱导的肠功能障碍的影响。

Melatonin (N-acetyl-5-methoxytryptamine) is synthesized from an essential amino acid tryptophan. It is a pineal gland neurohormone. Direct, non-receptor-mediated free radical scavenging activity induced by melatonin, makes it unique from other classic hormones. Melatonin is expressed in variety of organisms such as bacteria, algae, fungi, plants, insects, and vertebrates including humans.

AI解读

产品属性

ALogP 0.8

关联靶点（人）

HRH3 Tclin 组胺 H3 受体(Histamine H3 receptor) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR2B Tclin 5-羟色胺受体 2B(5-hydroxytryptamine receptor 2B) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
NQO2 Tchem 核糖二氢烟酰胺脱氢酶[醌](Ribosyldihydronicotinamide dehydrogenase [quinone]) (4 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
MTNR1A Tclin 褪黑激素受体 1A 型(Melatonin receptor type 1A) (81 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
MTNR1B Tclin 褪黑激素受体 1B 型(Melatonin receptor type 1B) (71 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ABL1 Tclin Tyrosine-protein kinase ABL (18331 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
F2 Tclin Thrombin (11687 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
INSR Tclin Insulin receptor (5558 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP19A1 Tclin Cytochrome P450 19A1 (6099 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CRHR1 Tclin Corticotropin releasing factor receptor 1 (2996 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Sigmar1 Sigma opioid receptor (160 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Melatonin receptor 1B (19 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cckar Cholecystokinin A receptor (90 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ntsr1 Neurotensin receptor 1 (48 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pde4d Phosphodiesterase 4D (4 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bdkrb1 Bradykinin B1 receptor (77 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Aplnr Apelin receptor (201 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Melatonin receptor 1C (17 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Faah Anandamide amidohydrolase (3907 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hcar2 Hydroxycarboxylic acid receptor 2 (55 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Xenopus laevis (337 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Oryctolagus cuniculus (11301 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-12 (7051 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
C6 (2371 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-22 (3261 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Melanophore (216 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Gpr119 Glucose-dependent insulinotropic receptor (270 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BCHE Cholinesterase (8742 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasma (328 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
clpP ATP-dependent Clp protease proteolytic subunit (245 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cacna1c Voltage-gated L-type calcium channel (1164 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Glra2 Glycine receptor (1745 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 488179568
EC号 200-797-7
分子类型 小分子
IUPAC Name N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
INCHI InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
InChi Key DRLFMBDRBRZALE-UHFFFAOYSA-N
Canonical SMILES CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC
Isomeric SMILES CC(=O)NCCC1=CNC2=C1C=C(C=C2)OC
RTECS AC5955000
关联CAS 73-31-4,8041-44-9
PubChem CID 896
NSC Number 56423
MeSH Entry Terms Melatonin
分子量 232.28
Beilstein号 205542
Reaxy-Rn 205542

化学和物理性质

溶解性 Soluble in ethanol to at least 50mg/ml
敏感性 对光线敏感； 对空气敏感
熔点 118°C
分子量 232.280 g/mol
XLogP3 0.800
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 2
可旋转键计数Rotatable Bond Count 4
精确质量Exact Mass 232.121 Da
单同位素质量Monoisotopic Mass 232.121 Da
拓扑极表面积Topological Polar Surface Area 54.100 Ų
重原子数Heavy Atom Count 17
形式电荷Formal Charge 0
复杂度Complexity 270.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

RTECS AC5955000
Reaxy-Rn 205542
Merck Index 5816

 SDS英文版

技术规格说明书

Purity(HPLC) 98-100（%）
Melting point 117-120（℃）
Appearance（M118674) white to light brown powder or crystals
Proton NMR spectrum Conforms to structure

 技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

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找到27个结果

批号(Lot Number) 证书类型 日期 货号
A2522078 分析证书 24-12-11 M118674
A2522083 分析证书 24-12-11 M118674
A2522084 分析证书 24-12-11 M118674
G2429395 分析证书 24-07-12 M118674
G2429396 分析证书 24-07-12 M118674
G2429397 分析证书 24-07-12 M118674
E2406133 分析证书 24-04-20 M118674
E2406101 分析证书 24-04-20 M118674
E2406102 分析证书 24-04-20 M118674
E2406112 分析证书 24-04-20 M118674
D2407404 分析证书 24-03-12 M118674
K2317116 分析证书 23-11-03 M118674
K2317119 分析证书 23-11-03 M118674
K2317122 分析证书 23-11-03 M118674
K2317200 分析证书 23-11-03 M118674
K2420126 分析证书 23-11-03 M118674
C2324918 分析证书 23-03-09 M118674
C23241132 分析证书 23-03-09 M118674
C23241134 分析证书 23-03-09 M118674
C23241138 分析证书 23-03-09 M118674
C23241209 分析证书 23-03-09 M118674
E2013132 分析证书 23-02-13 M118674
C2208286 分析证书 21-12-29 M118674
C2208287 分析证书 21-12-29 M118674
C2208289 分析证书 21-12-29 M118674
C2208303 分析证书 21-12-29 M118674
C2208304 分析证书 21-12-29 M118674

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1. Shanshan Tang, Miao Liu, Wei Wang, Axin Liang, Fulai Zhang, Aiqin Luo.  (2023)  An amorphous zinc/copper double transition metal hydroxides for electrochemical simultaneous detection of dopamine, serotonin, and melatonin.  NEW JOURNAL OF CHEMISTRY,  47  (35): (16337-16344).  [10.1039/D3NJ02297H]
2. Pan Hu, Xin Yan, Yijia Zeng, Zherui Jiang, Juan Liu, Wu-wen Feng.  (2023)  An UPLC-MS/MS method for targeted analysis of microbial and host tryptophan metabolism after administration of polysaccharides from Atractylodes macrocephala Koidz. in ulcerative colitis mice.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  235  (115585).  [PMID:37523866] [10.1016/j.jpba.2023.115585]
3. Ruiqing Bi, Renjian Li, Zhenyi Xu, Huanyu Cai, Juan Zhao, Yaru Zhou, Bangting Wu, Peng Sun, Wei Yang, Lu Zheng, Xiao-Lin Chen, Chao-Xi Luo, Huailong Teng, Qiang Li, Guotian Li.  (2023)  Melatonin targets MoIcl1 and works synergistically with fungicide isoprothiolane in rice blast control.  JOURNAL OF PINEAL RESEARCH,  75  (2): (e12896).  [PMID:37458404] [10.1111/jpi.12896]
4. Mingying Wang, Jin Xu, Zhaoyang Ding, Jing Xie.  (2023)  Prolong the postharvest shelf life of spinach through the antioxidative ability of melatonin.  Food Chemistry-X,  19  (100769).  [PMID:37780277] [10.1016/j.fochx.2023.100769]
5. Xiaofei Ren, Kui Xu, Jianming Xu, Qiao Mei.  (2023)  Melatonin attenuates monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats via activation of Sirtuin-3.  JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY,  (e23422).  [PMID:37350538] [10.1002/jbt.23422]
6. Lu Lu, Jingming Ren, Tong Yuan, Xinran Lu, Yinping Dong, Wenxuan Li, Xinyue Wang, Qidong Huo, Junling Zhang, Deguan Li, Saijun Fan.  (2023)  High-fat diet alters the radiation tolerance of female mice and the modulatory effect of melatonin.  Food & Function,  [PMID:37401725] [10.1039/D3FO01831H]
7. Tang Shanshan, Liang Axin, Liu Miao, Wang Wei, Zhang Fulai, Luo Aiqin.  (2023)  A glassy carbon electrode modified with a composite consisting of electrodeposited chitosan and carboxylated multi-walled carbon nanotubes for simultaneous voltammetric determination of dopamine, serotonin and melatonin.  Carbon Letters,  33  (7): (2129-2139).  [10.1007/s42823-023-00556-6]
8. Qixing Nie, Yonggan Sun, Mingzhi Li, Sheng Zuo, Chunhua Chen, Qiongni Lin, Shaoping Nie.  (2023)  Targeted modification of gut microbiota and related metabolites via dietary fiber.  CARBOHYDRATE POLYMERS,  316  (120986).  [PMID:37321707] [10.1016/j.carbpol.2023.120986]
9. Qi Lou, Lu Pan, Shengjin Xiang, Yueting Li, Jiahui Jin, Jingyang Tan, Baoshan Huang, Kaihui Nan, Sen Lin.  (2023)  Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyroptosis Using Melatonin-Loaded Liposomes to Inhibit Benzalkonium Chloride-Induced Dry Eye Disease.  International Journal of Nanomedicine,  [PMID:37192892] [10.2147/IJN.S403337]
10. Tingyan Liu, Caiyan Zhang, Jiayun Ying, Yaodong Wang, Gangfeng Yan, Yufeng Zhou, Guoping Lu.  (2023)  Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis.  Frontiers in Immunology,  14  (1134556).  [PMID:37205094] [10.3389/fimmu.2023.1134556]
11. Zhuoshi Lian, Ying Xu, Chan Wang, Ye Chen, Li Yuan, Zhongyu Liu, Yarui Liu, Peishi He, Zheng Cai, Jie Zhao.  (2023)  Gut microbiota-derived melatonin from Puerariae Lobatae Radix-resistant starch supplementation attenuates ischemic stroke injury via a positive microbial co-occurrence pattern.  PHARMACOLOGICAL RESEARCH,  190  (106714).  [PMID:36863429] [10.1016/j.phrs.2023.106714]
12. Qiuyang Huang, Xiaoling Zang, Zhiwei Zhang, Hang Yu, Baoyan Ding, Zhuangzhuang Li, Simin Cheng, Xin Zhang, Mustafa R.K. Ali, Xue Qiu, Zhihua Lv.  (2023)  Study on endogenous inhibitors against PD-L1: cAMP as a potential candidate.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  230  (123266).  [PMID:36646351] [10.1016/j.ijbiomac.2023.123266]
13. Xin Huang, Rui Wang, Yikai Wang, Changbao Chen, Shuying Liu.  (2023)  Investigation on property differences of ginseng and American ginseng by spatial metabolomics of neurochemicals with desorption electrospray ionization mass spectrometry imaging.  JOURNAL OF ETHNOPHARMACOLOGY,  303  (116006).  [PMID:36516905] [10.1016/j.jep.2022.116006]
14. Renjian Li, Ruiqing Bi, Huanyu Cai, Juan Zhao, Peng Sun, Weilong Xu, Yaru Zhou, Wei Yang, Lu Zheng, Xiao-Lin Chen, Guanghui Wang, Dongli Wang, Junfeng Liu, Huailong Teng, Guotian Li.  (2022)  Melatonin functions as a broad-spectrum antifungal by targeting a conserved pathogen protein kinase.  JOURNAL OF PINEAL RESEARCH,  74  (1): (e12839).  [PMID:36314656] [10.1111/jpi.12839]
15. Wang Hongbo, Li Jing, Jin Jianbo, Hu Jingbo, Yang Chunlin.  (2022)  Enhanced efficiency of melatonin by stepwise-targeting strategy for acute lung injury.  Frontiers in Bioengineering and Biotechnology,  10  [PMID:36159679] [10.3389/fbioe.2022.970743]
16. Giridhar Babu Anam, Dinneswara Reddy Guda, Young-Ho Ahn.  (2022)  Impact of melatonin on the hydrogen peroxide treatment efficacy in Microcystis aeruginosa: Cell growth, oxidative stress response, and gene transcription.  CHEMOSPHERE,  307  (136036).  [PMID:36007744] [10.1016/j.chemosphere.2022.136036]
17. Chen Dongmei, Lan Guihua, Li Ruomeng, Mei Yingxue, Shui Xindong, Gu Xi, Wang Long, Zhang Tao, Gan Chen-Ling, Xia Yongfang, Hu Li, Tian Yuan, Zhang Mi, Lee Tae Ho.  (2022)  Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer’s disease.  Translational Neurodegeneration,  11  (1): (1-19).  [PMID:35527277] [10.1186/s40035-022-00302-4]
18. Hongbin Chen, Hetong Lin, Xuanjing Jiang, Mengshi Lin, Zhongqi Fan.  (2022)  Amelioration of chilling injury and enhancement of quality maintenance in cold-stored guava fruit by melatonin treatment.  Food Chemistry-X,  14  (100297).  [PMID:35372825] [10.1016/j.fochx.2022.100297]
19. Xueqin Hou, Xinyu Qiu, Yaping Wang, Shuangshuang Song, Yifan Cong, Jifu Hao.  (2022)  Application and Efficacy of Melatonin Elastic Liposomes in Photoaging Mice.  Oxidative Medicine and Cellular Longevity,  2022  (7135125).  [PMID:35300175] [10.1155/2022/7135125]
20. Huizhen Deng, Jie Zhao, Shifan Zhao, Shuai Jiang, Guofeng Cui.  (2022)  A graphene-based electrochemical flow analysis device for simultaneous determination of dopamine, 5-hydroxytryptamine, and melatonin.  ANALYST,  147  (8): (1598-1610).  [PMID:35294958] [10.1039/D1AN02318G]
21. Ranran Xu, Limin Wang, Kexin Li, Jiankang Cao, Zhilei Zhao.  (2022)  Integrative transcriptomic and metabolomic alterations unravel the effect of melatonin on mitigating postharvest chilling injury upon plum (cv.Friar) fruit.  POSTHARVEST BIOLOGY AND TECHNOLOGY,  186  (111819).  [10.1016/j.postharvbio.2021.111819]
22. Man Zhang, Yang Bai, Chang Xu, Jinti Lin, JiaKang Jin, Ankai Xu, Jia Nan Lou, Chao Qian, Wei Yu, Yulian Wu, Yiying Qi, Huimin Tao.  (2021)  Novel optimized drug delivery systems for enhancing spinal cord injury repair in rats.  DRUG DELIVERY,  28  (1): (2548-2561).  [PMID:34854786] [10.1080/10717544.2021.2009937]
23. Huaxu Zhou, Xinyu Ma, Ajabkhan Sailjoi, Yanqi Zou, Xingyu Lin, Fei Yan, Bin Su, Jiyang Liu.  (2022)  Vertical silica nanochannels supported by nanocarbon composite for simultaneous detection of serotonin and melatonin in biological fluids.  SENSORS AND ACTUATORS B-CHEMICAL,  353  (131101).  [10.1016/j.snb.2021.131101]
24. Hu Jingbo, Tan Xueying, Wang Dongwei, Li Yixuan, Liang Hongze, Peng Jiejun, Li Fengyan, Zhou Quan, Geng Peiwu, Wang Shuanghu, Yu Yue, Liu Jin.  (2021)  RETRACTED ARTICLE: A stepwise-targeting strategy for the treatment of cerebral ischemic stroke.  JOURNAL OF NANOBIOTECHNOLOGY,  19  (1): (1-17).  [PMID:34789285] [10.1186/s12951-021-01118-6]
25. Zhang Yanfeng, He Yongzhi, Zhang Nan, Gan JiaJia, Zhang Shan, Dong Zhiyang.  (2021)  Combining protein and metabolic engineering strategies for biosynthesis of melatonin in Escherichia coli.  Microbial Cell Factories,  20  (1): (1-13).  [PMID:34454478] [10.1186/s12934-021-01662-8]
26. Renren Sun, Haixia He, Yameng Wan, Yueru Wang, Liyuan Li, Jiao Sha, Gaoliang Jiang, Yu Li, Tao Li, Baozeng Ren.  (2021)  Solubility of melatonin in ethyl acetate + (N, N-dimethylformamide, 2-methoxyethanol, 2-ethoxyethanol and methanol): Determination, correlation, thermodynamic properties and Hansen solubility parameter at saturation.  JOURNAL OF CHEMICAL THERMODYNAMICS,  156  (106372).  [10.1016/j.jct.2020.106372]
27. Yuanyuan Xia, Yuan Wang, Meng Zhang, Faqiong Zhao, Baizhao Zeng.  (2021)  A highly selective electrochemical sensor based on surface molecularly imprinted copolymer for the detection of 5-hydroxytryptamine.  MICROCHEMICAL JOURNAL,  160  (105748).  [10.1016/j.microc.2020.105748]
28. Feiyao He, Jinwei Yin, Tianzhi Wang, Juan Pu, Jianxiong Dai, Zhongjun Zhao, Yixiang Duan.  (2021)  Synergetic effect of laser and micro-fabricated glow discharge plasma in a new ion source for ambient mass spectrometry.  TALANTA,  225  (121847).  [PMID:33592690] [10.1016/j.talanta.2020.121847]
29. Wenjie Jing, Xiangkun Cui, Fanbo Kong, Wei Wei, Yunchao Li, Louzhen Fan, Xiaohong Li.  (2021)  Fe–N/C single-atom nanozyme-based colorimetric sensor array for discriminating multiple biological antioxidants.  ANALYST,  146  (1): (207-212).  [PMID:33089838] [10.1039/D0AN01447H]
30. Lingling Pang, Yan Wu, Yanfang Pan, Zhaojun Ban, Li Li, Xihong Li.  (2020)  Insights into exogenous melatonin associated with phenylalanine metabolism in postharvest strawberry.  POSTHARVEST BIOLOGY AND TECHNOLOGY,  168  (111244).  [10.1016/j.postharvbio.2020.111244]
31. Ruobing Wang, Yahui Liu, Xuguang Mi, Qingmin Chen, Peiqiang Jiang, Junjie Hou, Yifan Lin, Siqi Li, Bai Ji, Yanqiu Fang.  (2020)  Sirt3 promotes hepatocellular carcinoma cells sensitivity to regorafenib through the acceleration of mitochondrial dysfunction.  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,  689  (108415).  [PMID:32562663] [10.1016/j.abb.2020.108415]
32. Liao Naishun, Shi Yingjun, Wang Yingchao, Liao Fangyu, Zhao Bixing, Zheng Youshi, Zeng Yongyi, Liu Xiaolong, Liu Jingfeng.  (2020)  Antioxidant preconditioning improves therapeutic outcomes of adipose tissue-derived mesenchymal stem cells through enhancing intrahepatic engraftment efficiency in a mouse liver fibrosis model.  Stem Cell Research & Therapy,  11  (1): (1-11).  [PMID:32546282] [10.1186/s13287-020-01763-y]
33. Hangyue Zhao, Lei Wang, Tarun Belwal, Yunhong Jiang, Dong Li, Yanqun Xu, Zisheng Luo, Li Li.  (2020)  Chitosan-based melatonin bilayer coating for maintaining quality of fresh-cut products.  CARBOHYDRATE POLYMERS,  235  (115973).  [PMID:32122505] [10.1016/j.carbpol.2020.115973]
34. A. Sami, F. A. Shah, M. Abdullah, X. Zhou, Y. Yan, Z. Zhu, K. Zhou.  (2020)  Melatonin mitigates cadmium and aluminium toxicity through modulation of antioxidant potential in Brassica napus L.  PLANT BIOLOGY,  22  (4): (679-690).  [PMID:32003103] [10.1111/plb.13093]
35. Zi‑Wen Chen, Chao‑Bao Peng, Zhong Pei, Meng‑Ruo Zhang, Tian‑Chan Yun, Zhi‑Min Yang, Fu‑Ping Xu.  (2020)  Effects of tenuifolin on rest/wake behaviour in zebrafish.  Experimental and Therapeutic Medicine,  19  (3): (2326-2334).  [PMID:32104301] [10.3892/etm.2020.8476]
36. Liao Naishun, Shi Yingjun, Zhang Cuilin, Zheng Youshi, Wang Yingchao, Zhao Bixing, Zeng Yongyi, Liu Xiaolong, Liu Jingfeng.  (2019)  Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion.  Stem Cell Research & Therapy,  10  (1): (1-11).  [PMID:31623678] [10.1186/s13287-019-1404-9]
37. Jia Chunhua, Yu Xiaojing, Zhang Min, Liu Zhiguang, Zou Peng, Ma Jun, Xu Yachun.  (2020)  Application of Melatonin-Enhanced Tolerance to High-Temperature Stress in Cherry Radish (Raphanus sativus L. var. radculus pers).  JOURNAL OF PLANT GROWTH REGULATION,  39  (2): (631-640).  [10.1007/s00344-019-10006-1]
38. Jie Jiang, Dongmei Zhang, Hong Zhang, Kai Yu, Jing He, Xiangnan Zhang, Na Li.  (2019)  Rapid determination of melatonin by droplet spray ionization mass spectrometry.  INTERNATIONAL JOURNAL OF MASS SPECTROMETRY,  444  (116191).  [10.1016/j.ijms.2019.116191]
39. Zijian Chen, Kai Zhou, Wuzu Ha, Peihong Chen, Huijun Fu, Yudong Shen, Yuanming Sun, Zhenlin Xu.  (2019)  Development of a low-cost, simple, fast and quantitative lateral-flow immunochromatographic assay (ICA) strip for melatonin in health foods.  FOOD AND AGRICULTURAL IMMUNOLOGY,  30  (1): (497-509).  [10.1080/09540105.2019.1602112]
40. Niu Jiahua, Zhang Xiaoting, Qin Peige, Yang Yixin, Tian Shufang, Yang Hui, Lu Minghua.  (2018)  Simultaneous Determination of Melatonin, l-Tryptophan, and two l-Tryptophan-Derived Esters in Food by HPLC with Graphene Oxide/SiO2 Nanocomposite as the Adsorbent.  Food Analytical Methods,  11  (9): (2438-2446).  [10.1007/s12161-018-1213-2]
41. Dezhen Wang, Xinru Wang, Ping Zhang, Yao Wang, Renke Zhang, Jin Yan, Zhiqiang Zhou, Wentao Zhu.  (2017)  The fate of technical-grade chlordane in mice fed a high-fat diet and its roles as a candidate obesogen.  ENVIRONMENTAL POLLUTION,  222  (532).  [PMID:28041837] [10.1016/j.envpol.2016.11.028]

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16. Xiaofei Ren, Kui Xu, Jianming Xu, Qiao Mei.  (2023)  Melatonin attenuates monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats via activation of Sirtuin-3.  JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY,  (e23422).  [PMID:37350538] [10.1002/jbt.23422]
17. Lu Lu, Jingming Ren, Tong Yuan, Xinran Lu, Yinping Dong, Wenxuan Li, Xinyue Wang, Qidong Huo, Junling Zhang, Deguan Li, Saijun Fan.  (2023)  High-fat diet alters the radiation tolerance of female mice and the modulatory effect of melatonin.  Food & Function,  [PMID:37401725] [10.1039/D3FO01831H]
18. Tang Shanshan, Liang Axin, Liu Miao, Wang Wei, Zhang Fulai, Luo Aiqin.  (2023)  A glassy carbon electrode modified with a composite consisting of electrodeposited chitosan and carboxylated multi-walled carbon nanotubes for simultaneous voltammetric determination of dopamine, serotonin and melatonin.  Carbon Letters,  33  (7): (2129-2139).  [10.1007/s42823-023-00556-6]
19. Qixing Nie, Yonggan Sun, Mingzhi Li, Sheng Zuo, Chunhua Chen, Qiongni Lin, Shaoping Nie.  (2023)  Targeted modification of gut microbiota and related metabolites via dietary fiber.  CARBOHYDRATE POLYMERS,  316  (120986).  [PMID:37321707] [10.1016/j.carbpol.2023.120986]
20. Qi Lou, Lu Pan, Shengjin Xiang, Yueting Li, Jiahui Jin, Jingyang Tan, Baoshan Huang, Kaihui Nan, Sen Lin.  (2023)  Suppression of NLRP3/Caspase-1/GSDMD Mediated Corneal Epithelium Pyroptosis Using Melatonin-Loaded Liposomes to Inhibit Benzalkonium Chloride-Induced Dry Eye Disease.  International Journal of Nanomedicine,  [PMID:37192892] [10.2147/IJN.S403337]
21. Tingyan Liu, Caiyan Zhang, Jiayun Ying, Yaodong Wang, Gangfeng Yan, Yufeng Zhou, Guoping Lu.  (2023)  Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis.  Frontiers in Immunology,  14  (1134556).  [PMID:37205094] [10.3389/fimmu.2023.1134556]
22. Zhuoshi Lian, Ying Xu, Chan Wang, Ye Chen, Li Yuan, Zhongyu Liu, Yarui Liu, Peishi He, Zheng Cai, Jie Zhao.  (2023)  Gut microbiota-derived melatonin from Puerariae Lobatae Radix-resistant starch supplementation attenuates ischemic stroke injury via a positive microbial co-occurrence pattern.  PHARMACOLOGICAL RESEARCH,  190  (106714).  [PMID:36863429] [10.1016/j.phrs.2023.106714]
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25. Renjian Li, Ruiqing Bi, Huanyu Cai, Juan Zhao, Peng Sun, Weilong Xu, Yaru Zhou, Wei Yang, Lu Zheng, Xiao-Lin Chen, Guanghui Wang, Dongli Wang, Junfeng Liu, Huailong Teng, Guotian Li.  (2022)  Melatonin functions as a broad-spectrum antifungal by targeting a conserved pathogen protein kinase.  JOURNAL OF PINEAL RESEARCH,  74  (1): (e12839).  [PMID:36314656] [10.1111/jpi.12839]
26. Wang Hongbo, Li Jing, Jin Jianbo, Hu Jingbo, Yang Chunlin.  (2022)  Enhanced efficiency of melatonin by stepwise-targeting strategy for acute lung injury.  Frontiers in Bioengineering and Biotechnology,  10  [PMID:36159679] [10.3389/fbioe.2022.970743]
27. Giridhar Babu Anam, Dinneswara Reddy Guda, Young-Ho Ahn.  (2022)  Impact of melatonin on the hydrogen peroxide treatment efficacy in Microcystis aeruginosa: Cell growth, oxidative stress response, and gene transcription.  CHEMOSPHERE,  307  (136036).  [PMID:36007744] [10.1016/j.chemosphere.2022.136036]
28. Chen Dongmei, Lan Guihua, Li Ruomeng, Mei Yingxue, Shui Xindong, Gu Xi, Wang Long, Zhang Tao, Gan Chen-Ling, Xia Yongfang, Hu Li, Tian Yuan, Zhang Mi, Lee Tae Ho.  (2022)  Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer’s disease.  Translational Neurodegeneration,  11  (1): (1-19).  [PMID:35527277] [10.1186/s40035-022-00302-4]
29. Hongbin Chen, Hetong Lin, Xuanjing Jiang, Mengshi Lin, Zhongqi Fan.  (2022)  Amelioration of chilling injury and enhancement of quality maintenance in cold-stored guava fruit by melatonin treatment.  Food Chemistry-X,  14  (100297).  [PMID:35372825] [10.1016/j.fochx.2022.100297]
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