计算溶液所需的质量、体积或浓度。
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
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M111378-50mg |
50mg |
现货 ![]() |
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M111378-200mg |
200mg |
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M111378-250mg |
250mg |
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M111378-1g |
1g |
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M111378-5g |
5g |
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M111378-10g |
10g |
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M111378-25g |
25g |
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别名 | 5',5-二烯丙基-2,2'-联苯二酚 |
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英文别名 | NCGC00161609-01 | Ethylene glycol butyl ether | s2321 | STK801955 | Methyl n-dodecanoate | Magnolol,(S) | 5,5'-DI-2-PROPEN-1-YL-(1,1'-BIPHENYL)-2,2'-DIOL | MAGNOLOL [INCI] | Q-100598 | Magnolol, European Pharmacopoeia (EP) Reference Standard | UNII-001E35 |
规格或纯度 | Moligand™, ≥98%(HPLC) |
英文名称 | Magnolol |
生化机理 | 强大的抗氧化剂。抑制iNOS表达(IC 50 = 16.8μM)。抗炎,抗氧化,抗肿瘤,抗微生物和凋亡剂。通过上调p53和bax表达诱导凋亡。厚朴酚(Asc 647)异构体。 |
储存温度 | 2-8°C储存 |
运输条件 | 冰袋运输 |
备注 | 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
产品介绍 |
具有抗真菌、抗菌和抗氧化剂的生物活性物质,并通过干扰NF -κB的信号传导从而具有抗炎症活性。 Bioactive plant component with antifungal, antibacterial and antioxidant effects.Magnolol also demonstrates anti-inflammatory activity by interferring with NF-κB signaling. |
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作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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PubChem SID | 488184686 |
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分子类型 | 小分子 |
IUPAC Name | 2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol |
INCHI | InChI=1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2 |
InChi Key | VVOAZFWZEDHOOU-UHFFFAOYSA-N |
Canonical SMILES | C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O |
Isomeric SMILES | C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O |
WGK Germany | 3 |
RTECS | DV5105500 |
PubChem CID | 72300 |
UN Number | 3077 |
分子量 | 266.33 |
Beilstein号 | 6(4)6918 |
Reaxy-Rn | 1982224 |
密度 | 1.107 |
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敏感性 | 对热敏感 |
沸点 | 180 °C/1 mmHg |
熔点 | 101 °C |
分子量 | 266.300 g/mol |
XLogP3 | 5.000 |
氢键供体数Hydrogen Bond Donor Count | 2 |
氢键受体数Hydrogen Bond Acceptor Count | 2 |
可旋转键计数Rotatable Bond Count | 5 |
精确质量Exact Mass | 266.131 Da |
单同位素质量Monoisotopic Mass | 266.131 Da |
拓扑极表面积Topological Polar Surface Area | 40.500 Ų |
重原子数Heavy Atom Count | 20 |
形式电荷Formal Charge | 0 |
复杂度Complexity | 293.000 |
同位素原子数Isotope Atom Count | 0 |
定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
所有立体化学键的总数The total count of all stereochemical bonds | 0 |
共价键合单元计数Covalently-Bonded Unit Count | 1 |
象形图 | GHS09, GHS05, GHS07 |
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信号词 | Danger |
危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H411: 对水生生物有毒并具有长期持续影响 H318: 造成严重的眼睛损伤 |
预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染:用水充分清洗。 P321: 特殊处理(请参阅此标签上的...)。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。 P391: 收集溢出物 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P305+P354+P338: 如果进入眼睛:立即用水冲洗几分钟。取下隐形眼镜(如果有的话),并且操作简单。继续冲洗。 P317: 寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续:寻求医疗帮助。 P332+P317: 如果出现皮肤刺激:请寻求医疗帮助。 P319: 如果你感到不适,请寻求医疗帮助。 |
WGK Germany | 3 |
RTECS | DV5105500 |
Reaxy-Rn | 1982224 |
Merck Index | 5697 |
个人防护装备 | dust mask type N95 (US),Eyeshields,Gloves |
Purity(HPLC) | 98-100(%) |
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Appearance(M111378) | White to Off-White Powder |
Infrared spectrum | Conforms to Structure |
Proton NMR spectrum | Conforms to Structure |
Solubility,Colorless transparent(1.5 mg+1mL,MeOH) | pass |
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
批号(Lot Number) | 证书类型 | 日期 | 货号 |
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分析证书 | 25-03-18 | M111378 |
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分析证书 | 25-03-18 | M111378 |
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分析证书 | 24-05-17 | M111378 |
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分析证书 | 24-05-17 | M111378 |
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分析证书 | 24-05-17 | M111378 |
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分析证书 | 23-08-15 | M111378 |
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分析证书 | 23-08-15 | M111378 |
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分析证书 | 23-08-15 | M111378 |
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分析证书 | 23-08-15 | M111378 |
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分析证书 | 23-05-09 | M111378 |
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分析证书 | 23-05-09 | M111378 |
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分析证书 | 23-05-09 | M111378 |
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分析证书 | 23-05-08 | M111378 |
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分析证书 | 23-03-07 | M111378 |
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分析证书 | 23-03-07 | M111378 |
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分析证书 | 23-03-07 | M111378 |
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分析证书 | 23-03-07 | M111378 |
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分析证书 | 23-03-07 | M111378 |
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分析证书 | 23-02-08 | M111378 |
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分析证书 | 22-10-20 | M111378 |
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分析证书 | 22-01-27 | M111378 |
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分析证书 | 22-01-27 | M111378 |
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分析证书 | 22-01-27 | M111378 |
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分析证书 | 22-01-25 | M111378 |
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分析证书 | 22-01-25 | M111378 |
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分析证书 | 22-01-25 | M111378 |
1. Jietao Liu, Shenye Qu, Tao Wang, Bin Yang, Xiang Liu, Gaoxue Wang, Pengfei Li, Qing Yu, Fei Ling. (2024) Nanosuspensions as an approach for improved solubility and anti-Ichthyophthirius multifiliis activity of magnolol. AQUACULTURE, 579 (15): (740133). [PMID:10397721] [10.1016/j.aquaculture.2023.740133] |
2. Zhao Zhang, Jing Li, Gaoxue Wang, Fei Ling. (2023) The oral protective efficacy of magnolol against Aeromonas hydrophila and A. veronii infection via enhancing anti-inflammatory ability in goldfish (Carassius auratus). JOURNAL OF FISH DISEASES, 46 (12): (1413-1423). [PMID:37705318] [10.1111/jfd.13859] |
3. Mo Feixu, Long Youhua, Li Ming, Ding Yi, Wu Shuai, Li Rongyu. (2023) Effect of enzyme-response Mag@CMCS@CPSG film on rice sheath blight disease (caused by Rhizoctonia solani) control and rice quality. Frontiers in Sustainable Food Systems, 7 [10.3389/fsufs.2023.1204698] |
4. Lin Niu, Yu-jie Lu, Xing-wang Zu, Wen Yang, Fu-kui Shen, Yan-yan Xu, Min Jiang, Yang Xie, Su-yun Li, Jie Gao, Gang Bai. (2023) Magnolol alleviates pulmonary fibrosis inchronic obstructive pulmonary disease by targeting transient receptor potential vanilloid 4-ankyrin repeat domain. PHYTOTHERAPY RESEARCH, [PMID:37282760] [10.1002/ptr.7907] |
5. Guoyu Wei, Wei Zhao, Anlong Hu, Mingjian Ren, Yunxiao Huang, Huayang Xu. (2023) Identification of a New Pathogenic fungi Causing Sorghum Leaf Spot Disease and Its Management Using Natural Product and Microorganisms. Microorganisms, 11 (6): (1431). [PMID:37374932] [10.3390/microorganisms11061431] |
6. Tong Yin-Chao, Zhang Yi-Ning, Li Peng-Cheng, Cao Ya-Li, Ding Dong-Zhao, Yang Yang, Lin Qing-Yi, Gao Yi-Nuo, Sun Shao-Qiang, Fan Yun-Peng, Liu Ying-Qiu, Qing Su-Zhu, Ma Wu-Ren, Zhang Wei-Min. (2023) Detection of antibiotic-resistant canine origin Escherichia coli and the synergistic effect of magnolol in reducing the resistance of multidrug-resistant Escherichia coli. Frontiers in Veterinary Science, 10 [PMID:37008355] [10.3389/fvets.2023.1104812] |
7. Feixu Mo, Wenzhi Li, Youhua Long, Rongyu Li, Yi Ding, Ming Li. (2023) Magnolol Loaded on Carboxymethyl Chitosan Particles Improved the Antimicrobial Resistance and Storability of Kiwifruits. Foods, 12 (6): (1149). [PMID:36981076] [10.3390/foods12061149] |
8. Weizhen Wang, Linan He, Zhuzhu Zhang, Wenzhi Li, Jia Chen, Tingting Chen, Youhua Long. (2023) Activity of the botanical compound thymol against kiwifruit rot caused by Fusarium tricinctum and the underlying mechanisms. PEST MANAGEMENT SCIENCE, [PMID:36864770] [10.1002/ps.7431] |
9. Chen Kai, Qin Ting, Pan Liangkun, Bing Xuwen, Xi Bingwen, Xie Jun. (2023) Effects of glycyrrhetinic acid β on growth and virulence of Aeromonas hydrophila. Frontiers in Microbiology, 14 [PMID:36846766] [10.3389/fmicb.2023.1043838] |
10. Ziyu Liu, Xiaoli Wang, Xingyue Zhu, Yazhou Tian, Jue Cheng, Junying Zhang. (2022) Phase Change Energy Storage Material with Photocuring, Photothermal Conversion, and Self-Cleaning Performance via a Two-Layer Structure. ACS Applied Materials & Interfaces, 14 (51): (57299–57310). [PMID:36514297] [10.1021/acsami.2c18748] |
11. Xin-Yuan Jiang, Zong-Yi Ren, Nian-Kun Zhang, Ke-Chen Yang, Gao-Xue Wang, Hai-Feng Jiang. (2022) Screening and evaluating honokiol from Magnolia officinalis against Nocardia seriolae infection in largemouth bass (Micropterus Salmoides). JOURNAL OF FISH DISEASES, 45 (11): (1599-1607). [PMID:35801398] [10.1111/jfd.13683] |
12. Ziyu Liu, Xingyue Zhu, Yazhou Tian, Kaiyun Zhou, Jue Cheng, Junying Zhang. (2022) Bio-based recyclable Form-Stable phase change material based on thermally reversible Diels–Alder reaction for sustainable thermal energy storage. CHEMICAL ENGINEERING JOURNAL, 448 (137749). [10.1016/j.cej.2022.137749] |
13. Wenwen Guo, Fuwei Liang, Shun Chen, Kejing Yu, Jie Sun, Zengyuan Pang, Bin Fei. (2022) Magnolol-derived thiol-ene photo-polymerized membranes with intrinsic anti-flammability and high transparency. COMPOSITES PART B-ENGINEERING, 242 (110074). [10.1016/j.compositesb.2022.110074] |
14. Wenwen Guo, Fuwei Liang, Shun Chen, Diantang Zhang, Wenbing Li, Kun Qian, Yang Xu, Bin Fei. (2022) Synthesis of magnolol-derived bisphosphate for fabrication of bismaleimide resins with intrinsic anti-flammability and smoke suppression. POLYMER DEGRADATION AND STABILITY, 202 (110002). [10.1016/j.polymdegradstab.2022.110002] |
15. Lin Niu, Jie Wang, Fukui Shen, Jie Gao, Min Jiang, Gang Bai. (2022) Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle. JOURNAL OF ETHNOPHARMACOLOGY, 290 (115105). [PMID:35157953] [10.1016/j.jep.2022.115105] |
16. Feixu Mo, Xianfeng Hu, Yi Ding, Rongyu Li, Youhua Long, Xiaomao Wu, Ming Li. (2021) Naturally produced magnolol can significantly damage the plasma membrane of Rhizoctonia solani. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 178 (104942). [PMID:34446208] [10.1016/j.pestbp.2021.104942] |
17. Xueying Song, Liu Liu, Xiaoxia Wu, Yongfeng Liu, Jialu Yuan. (2021) Chitosan-Based Functional Films Integrated with Magnolol: Characterization, Antioxidant and Antimicrobial Activity and Pork Preservation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (15): (7769). [PMID:34360535] [10.3390/ijms22157769] |
18. Na Teng, Shimin Yang, Jinyue Dai, Shuaipeng Wang, Jun Zhao, Jin Zhu, Xiaoqing Liu. (2019) Making Benzoxazine Greener and Stronger: Renewable Resource, Microwave Irradiation, Green Solvent, and Excellent Thermal Properties. ACS Sustainable Chemistry & Engineering, 7 (9): (8715–8723). [10.1021/acssuschemeng.9b00607] |
19. Jie Cheng, Shuqi Dong, Litao Yi, Di Geng, Qing Liu. (2018) Magnolol abrogates chronic mild stress-induced depressive-like behaviors by inhibiting neuroinflammation and oxidative stress in the prefrontal cortex of mice. INTERNATIONAL IMMUNOPHARMACOLOGY, 59 (61). [PMID:29627576] [10.1016/j.intimp.2018.03.031] |
20. Zhihong Yao, Shishi Li, Zifei Qin, Xiaodan Hong, Yi Dai, Baojian Wu, Wencai Ye, Frank J. Gonzalez, Xinsheng Yao. (2017) Characterization of human UDP-glucuronosyltransferases responsible for glucuronidation and inhibition of norbakuchinic acid, a primary metabolite of hepatotoxicity and nephrotoxicity component bakuchiol in Psoralea corylifolia L.. RSC Advances, 7 (83): (52661-52671). [10.1039/C7RA10376J] |
21. Hongjun Zhang, Baoling Ju, Xiaoli Zhang, Yanfei Zhu, Ying Nie, Yuanhong Xu, Qiuxia Lei. (2017) Magnolol Attenuates Concanavalin A-induced Hepatic Fibrosis, Inhibits CD4+ T Helper 17 (Th17) Cell Differentiation and Suppresses Hepatic Stellate Cell Activation: Blockade of Smad3/Smad4 Signalling. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 120 (6): (560-570). [PMID:28032440] [10.1111/bcpt.12749] |
22. Liu Guishen, Ma Yanhui, Hou Xiaodong, huang Yina, Chen Jianpeng, Zhan Guoqing, Li Chunya. (2015) Synthesis of 1-[3-(N-pyrrole)propyl]-3-[1-tert-butoxycarbonylamino-propyl]-imidazolium tetrafluoroborate ionic liquid for application in electrochemical sensing of magnolol. IONICS, 21 (9): (2567-2574). [10.1007/s11581-015-1455-6] |
23. Zhenhao Li, Shun Xiao, Ni Ai, Kedi Luo, Xiaohui Fan, Yiyu Cheng. (2015) Derivative multiple reaction monitoring and single herb calibration approach for multiple components quantification of traditional Chinese medicine analogous formulae. JOURNAL OF CHROMATOGRAPHY A, 1376 (126). [PMID:25541090] [10.1016/j.chroma.2014.12.024] |
24. Xinjian Song, Bing Wang, Yina Huang, Liqing Li, Ting Li, Chunya Li, Shenghui Zhang. (2014) A novel nanoporous film electrode based on electrochemical polymerization of ionic liquid and its application in sensitive determination of magnolol. TALANTA, 119 (606). [PMID:24401462] [10.1016/j.talanta.2013.11.055] |
25. Xu T,Zheng Z,Guo Y,Bai LP. (2020) Semisynthesis of novel magnolol-based Mannich base derivatives that suppress cancer cells via inducing autophagy.. Eur J Med Chem, 205 (112663-112663). [PMID:32791403] [10.1016/j.ejmech.2020.112663] |
1. Jietao Liu, Shenye Qu, Tao Wang, Bin Yang, Xiang Liu, Gaoxue Wang, Pengfei Li, Qing Yu, Fei Ling. (2024) Nanosuspensions as an approach for improved solubility and anti-Ichthyophthirius multifiliis activity of magnolol. AQUACULTURE, 579 (15): (740133). [PMID:10397721] [10.1016/j.aquaculture.2023.740133] |
2. Zhao Zhang, Jing Li, Gaoxue Wang, Fei Ling. (2023) The oral protective efficacy of magnolol against Aeromonas hydrophila and A. veronii infection via enhancing anti-inflammatory ability in goldfish (Carassius auratus). JOURNAL OF FISH DISEASES, 46 (12): (1413-1423). [PMID:37705318] [10.1111/jfd.13859] |
3. Mo Feixu, Long Youhua, Li Ming, Ding Yi, Wu Shuai, Li Rongyu. (2023) Effect of enzyme-response Mag@CMCS@CPSG film on rice sheath blight disease (caused by Rhizoctonia solani) control and rice quality. Frontiers in Sustainable Food Systems, 7 [10.3389/fsufs.2023.1204698] |
4. Lin Niu, Yu-jie Lu, Xing-wang Zu, Wen Yang, Fu-kui Shen, Yan-yan Xu, Min Jiang, Yang Xie, Su-yun Li, Jie Gao, Gang Bai. (2023) Magnolol alleviates pulmonary fibrosis inchronic obstructive pulmonary disease by targeting transient receptor potential vanilloid 4-ankyrin repeat domain. PHYTOTHERAPY RESEARCH, [PMID:37282760] [10.1002/ptr.7907] |
5. Guoyu Wei, Wei Zhao, Anlong Hu, Mingjian Ren, Yunxiao Huang, Huayang Xu. (2023) Identification of a New Pathogenic fungi Causing Sorghum Leaf Spot Disease and Its Management Using Natural Product and Microorganisms. Microorganisms, 11 (6): (1431). [PMID:37374932] [10.3390/microorganisms11061431] |
6. Tong Yin-Chao, Zhang Yi-Ning, Li Peng-Cheng, Cao Ya-Li, Ding Dong-Zhao, Yang Yang, Lin Qing-Yi, Gao Yi-Nuo, Sun Shao-Qiang, Fan Yun-Peng, Liu Ying-Qiu, Qing Su-Zhu, Ma Wu-Ren, Zhang Wei-Min. (2023) Detection of antibiotic-resistant canine origin Escherichia coli and the synergistic effect of magnolol in reducing the resistance of multidrug-resistant Escherichia coli. Frontiers in Veterinary Science, 10 [PMID:37008355] [10.3389/fvets.2023.1104812] |
7. Feixu Mo, Wenzhi Li, Youhua Long, Rongyu Li, Yi Ding, Ming Li. (2023) Magnolol Loaded on Carboxymethyl Chitosan Particles Improved the Antimicrobial Resistance and Storability of Kiwifruits. Foods, 12 (6): (1149). [PMID:36981076] [10.3390/foods12061149] |
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