计算溶液所需的质量、体积或浓度。
活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
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M111176-10mg |
10mg |
现货 ![]() |
| |
M111176-20mg |
20mg |
现货 ![]() |
|
别名 | 杨梅酮,杨梅黄酮 |
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英文别名 | BIDD:PXR0079 | NCGC00015697-01 | NCGC00179517-01 | FLAVONE, 3,3',4',5,5',7-HEXAHYDROXY- | NCGC00015697-07 | Myricetin, >=96.0%, crystalline | NCGC00094083-01 | Prestwick1_000465 | Prestwick2_000465 | Spectrum_001501 | DTXSID8022400 | HMS2231L04 | NCGC0001 |
规格或纯度 | 分析标准品, ≥98% |
英文名称 | Myricetin |
生化机理 | 直接抑制MEK,JAK1,Akt和MKK4激酶活性。能够抑制细胞色素P450 3A4和2C9(IC 50分别为7.81和13.5μM)。 |
应用 | 强力抑制酵母α-葡(萄)糖苷酶、葡(萄)糖苷酶I、体外葡(萄)糖苷酶I和牛奶中的黄嘌呤氧化酶。 |
储存温度 | 2-8°C储存 |
运输条件 | 冰袋运输 |
备注 | 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
产品介绍 |
强力抑制酵母α-葡(萄)糖苷酶、葡(萄)糖苷酶I、体外葡(萄)糖苷酶I和牛奶中的黄嘌呤氧化酶。 |
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作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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EC号 | 208-463-2 |
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分子类型 | 小分子 |
IUPAC Name | 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one |
INCHI | InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H |
InChi Key | IKMDFBPHZNJCSN-UHFFFAOYSA-N |
Canonical SMILES | C1=C(C=C(C(=C1O)O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O |
Isomeric SMILES | C1=C(C=C(C(=C1O)O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O |
WGK Germany | 3 |
PubChem CID | 5281672 |
分子量 | 318.24 |
Beilstein号 | 332331 |
密度 | 1.912 |
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熔点 | 360°C |
分子量 | 318.230 g/mol |
XLogP3 | 1.200 |
氢键供体数Hydrogen Bond Donor Count | 6 |
氢键受体数Hydrogen Bond Acceptor Count | 8 |
可旋转键计数Rotatable Bond Count | 1 |
精确质量Exact Mass | 318.038 Da |
单同位素质量Monoisotopic Mass | 318.038 Da |
拓扑极表面积Topological Polar Surface Area | 148.000 Ų |
重原子数Heavy Atom Count | 23 |
形式电荷Formal Charge | 0 |
复杂度Complexity | 506.000 |
同位素原子数Isotope Atom Count | 0 |
定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
所有立体化学键的总数The total count of all stereochemical bonds | 0 |
共价键合单元计数Covalently-Bonded Unit Count | 1 |
象形图 | GHS07 |
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信号词 | Warning |
危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染:用水充分清洗。 P321: 特殊处理(请参阅此标签上的...)。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续:寻求医疗帮助。 P332+P317: 如果出现皮肤刺激:请寻求医疗帮助。 P319: 如果你感到不适,请寻求医疗帮助。 |
WGK Germany | 3 |
Merck Index | 6332 |
个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
Purity(HPLC) | 98-100(%) |
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Appearance(M111176) | Light yellow to brown powder or crystals or solid |
Infrared spectrum | Conforms to Structure |
1. Yu Zhang, Haitian Fang, Tong Wang, Zhigang Zhang, Tianxiang Zhu, Lei Xiong, Haiming Hu, Hongtao Liu. (2023) Lactobacillus acidophilus-Fermented Jujube Juice Ameliorates Chronic Liver Injury in Mice via Inhibiting Apoptosis and Improving the Intestinal Microecology. MOLECULAR NUTRITION & FOOD RESEARCH, (2300334). [PMID:38150643] [10.1002/mnfr.202300334] |
2. Xiao-Li Yin, Zhi-Xin Peng, Yuan Pan, Yi Lv, Wanjun Long, Hui-Wen Gu, Haiyan Fu, Yuanbin She. (2023) UHPLC-QTOF-MS-based untargeted metabolomic authentication of Chinese red wines according to their grape varieties. FOOD RESEARCH INTERNATIONAL, (113923). [PMID:38309902] [10.1016/j.foodres.2023.113923] |
3. Tian Yang, Zhong Zhang, Fangjian Ning, Li Yuan, Xingbin Yang, Liping Luo. (2024) New theoretical perspective for easy evaluation of the antioxidant properties of typical flavonoids. MICROCHEMICAL JOURNAL, 197 (109786). [10.1016/j.microc.2023.109786] |
4. Hui-Wen Yang, Yan Lan, An Li, Han Wu, Zi-Wei Song, Ai-Ling Wan, Yue Wang, Shi-Bao Li, Shuai Ji, Zhong-Cheng Wang, Xin-Yu Wu, Ting Lan. (2023) Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer. Frontiers in Pharmacology, 14 (15): (1288883). [PMID:38026996] [10.3389/fphar.2023.1288883] |
5. Jinxin Li, Hao Zhang, Ling Zhu, Gangcheng Wu, Hui Zhang. (2023) Influence of in vitro gastrointestinal digestion and colonic fermentation on carbonyl scavenging capacity of fiber-bound polyphenols from quinoa. Food & Function, 14 (23): (10581-10590). [PMID:37955444] [10.1039/D3FO03000H] |
6. Xiangrong Li, Ruonan Xu, Li Shi, Tianjun Ni. (2023) Design of flavonol-loaded cationic gold nanoparticles with enhanced antioxidant and antibacterial activities and their interaction with proteins. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 253 (23): (127074). [PMID:37769767] [10.1016/j.ijbiomac.2023.127074] |
7. Hao-Xiang Gao, Nan Chen, Qiang He, Bi Shi, Wei-Cai Zeng. (2024) Effects of structural characteristics of phenolic compounds on oxidation of glycerol trioleate: Action rule and mechanism. FOOD CHEMISTRY, 433 (137361). [PMID:37688816] [10.1016/j.foodchem.2023.137361] |
8. Xiangrong Li, Tianjun Ni, Ruonan Xu. (2023) Study on the preparation of novel flavonol-gold nanoparticles antioxidants and the mechanism of protein corona formation. JOURNAL OF MOLECULAR STRUCTURE, 1294 (136413). [10.1016/j.molstruc.2023.136413] |
9. Zhi-Quan Li, Xiao-Li Yin, Hui-Wen Gu, Dan Zou, Baomiao Ding, Zhenshun Li, Ying Chen, Wanjun Long, Haiyan Fu, Yuanbin She. (2023) Revealing the chemical differences and their application in the storage year prediction of Qingzhuan tea by SWATH-MS based metabolomics analysis. FOOD RESEARCH INTERNATIONAL, 173 (113238). [PMID:37803551] [10.1016/j.foodres.2023.113238] |
10. Xiao-Hua Zhang, Xiang-Dong Qing, Jing-Jing Zheng, Yan Yu, Jiaojiao Huang, Chao Kang, Zhi Liu. (2023) Aqueous two-phase systems coupled with chemometrics-enhanced HPLC-DAD for simultaneous extraction and determination of flavonoids in honey. Food Chemistry-X, 19 (100766). [PMID:37780266] [10.1016/j.fochx.2023.100766] |
11. Xiangrong Li, Ruonan Xu, Tianjun Ni. (2023) Effects of B-ring structures on binding behavior of flavonols with proteins: Experimental and molecular docking approaches. JOURNAL OF MOLECULAR STRUCTURE, 1287 (135614). [10.1016/j.molstruc.2023.135614] |
12. Huiqun Fan, Mingshun Chen, Taotao Dai, Lizhen Deng, Chengmei Liu, Wei Zhou, Jun Chen. (2023) Phenolic compounds profile of Amomum tsaoko Crevost et Lemaire and their antioxidant and hypoglycemic potential. Food Bioscience, 52 (102508). [10.1016/j.fbio.2023.102508] |
13. Jiao Wu, Bingjun Han, Xiaoyu Chen, Jinglin Gao, Shan Zhao, Liping Sun, Shijie Wang. (2023) Quantification of bioactive components and evaluation of microbial community and antibacterial activity from Heterotrigona itama and Tetrigona binghami honeys. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 58 (5): (2247-2257). [10.1111/ijfs.16325] |
14. Hongting Deng, Yuanju He, Hui Cao, Lei Chen, Hui Teng. (2022) New insight into the effect of hydroxyl substituted flavonoids on the cytotoxicity of 2-amino-3-methylimidazo[4,5-f]quinoline. Food Frontiers, 4 (1): (289-296). [10.1002/fft2.194] |
15. Gao Jie-Fang, Tang Liu, Luo Fei, Chen Lu, Zhang Yi-Yuan, Ding Hong. (2022) Myricetin treatment has ameliorative effects in DNFB-induced atopic dermatitis mice under high-fat conditions. TOXICOLOGICAL SCIENCES, 191 (2): (308-320). [PMID:36575998] [10.1093/toxsci/kfac138] |
16. Zhixu Chen, Jincai Wang, Jiaming Yuan, Zhen Wang, Zhengchao Tu, Jacques Crommen, Wenhui Luo, Jialiang Guo, Tingting Zhang, Zhengjin Jiang. (2023) Rapid screening of neuraminidase inhibitors using an at-line nanofractionation platform involving parallel oseltamivir-sensitive/resistant neuraminidase bioassays. JOURNAL OF CHROMATOGRAPHY A, 1687 (463693). [PMID:36516530] [10.1016/j.chroma.2022.463693] |
17. Wenjie Yu, Fengjie Sun, Ruixin Xu, Meng Cui, Yongquan Liu, Quanyuan Xie, Limin Guo, Chenxian Kong, Xin Li, Xiali Guo, Liping Luo. (2023) Chemical composition and anti-inflammatory activities of Castanopsis honey. Food & Function, 14 (1): (250-261). [PMID:36484340] [10.1039/D2FO02233H] |
18. Xiangrong Li, Linyu Han, Zhizhi Song, Ruonan Xu, Lixia Wang. (2023) Comparative study on the interaction between transferrin and flavonols: Experimental and computational modeling approaches. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 288 (122128). [PMID:36455462] [10.1016/j.saa.2022.122128] |
19. Yu Bo, Luo Shiyu, Ding Yuhan, Gong Zijie, Nie Ting. (2022) Insights into glycosidic bond specificity of an engineered selective α-L-rhamnosidase N12-Rha via activity assays and molecular modelling. AMB Express, 12 (1): (1-14). [PMID:36370155] [10.1186/s13568-022-01489-5] |
20. Lingli Zhao, Mengfei Zheng, Hao Cai, Juan Chen, Yan Lin, Fangbin Wang, Lu Wang, Xian Zhang, Jian Liu. (2023) The activity comparison of six dietary flavonoids identifies that luteolin inhibits 3T3-L1 adipocyte differentiation through reducing ROS generation. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 112 (109208). [PMID:36370929] [10.1016/j.jnutbio.2022.109208] |
21. Zhiqi Zhao, Yizhang Chen, Xiaoqiong Li, Liying Zhu, Xin Wang, Li Li, Haibiao Sun, Xiaoqiang Han, Jinjun Li. (2022) Myricetin relieves the symptoms of type 2 diabetes mice and regulates intestinal microflora. BIOMEDICINE & PHARMACOTHERAPY, 153 (113530). [PMID:36076610] [10.1016/j.biopha.2022.113530] |
22. Qiao Yang, Xiaoyi Zhang, Huini Qin, Feijun Luo, Jiali Ren. (2022) Phenolic Acid Profiling of Lactarius hatsudake Extracts, Anti-Cancer Function and Its Molecular Mechanisms. Foods, 11 (13): (1839). [PMID:35804655] [10.3390/foods11131839] |
23. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372] [10.1039/D1FO03816H] |
24. Fenglei Zhang, Xuejing Pei, Xiaoxia Peng, Dongxia Gou, Xiao Fan, Xuefei Zheng, Chengcheng Song, Yifa Zhou, Sisi Cui. (2022) Dual crosslinking of folic acid-modified pectin nanoparticles for enhanced oral insulin delivery. Biomaterials Advances, 135 (212746). [PMID:35929218] [10.1016/j.bioadv.2022.212746] |
25. Ying Li, Haiming Hu, Huabing Yang, Aizhen Lin, Hui Xia, Xue Cheng, Mingwang Kong, Hongtao Liu. (2022) Vine Tea (Ampelopsis grossedentata) Extract Attenuates CCl4-Induced Liver Injury by Restoring Gut Microbiota Dysbiosis in Mice. MOLECULAR NUTRITION & FOOD RESEARCH, 66 (9): (2100892). [PMID:35188709] [10.1002/mnfr.202100892] |
26. Hui-Wen Gu, Xiao-Li Yin, Tian-Qin Peng, Yuan Pan, Hui-Na Cui, Zhi-Quan Li, Weiqing Sun, Baomiao Ding, Xian-Chun Hu, Zi-Hong Zhang, Zhi Liu. (2022) Geographical origin identification and chemical markers screening of Chinese green tea using two-dimensional fingerprints technique coupled with multivariate chemometric methods. FOOD CONTROL, 135 (108795). [10.1016/j.foodcont.2021.108795] |
27. Xiangrong Li, Ruonan Xu, Zeqing Cheng, Zhizhi Song, Ziyang Wang, Hanxiao Duan, Xinzhe Wu, Tianjun Ni. (2021) Comparative study on the interaction between flavonoids with different core structures and hyaluronidase. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 262 (120079). [PMID:34175762] [10.1016/j.saa.2021.120079] |
28. Hou Xiudan, Wu Wei, Zhao Fangyuan, Xie Wancui, Yang Qingli. (2021) Construction of an electrochemical sensor with graphene aerogel doped with ZrO2 nanoparticles and chitosan for the selective detection of luteolin. MICROCHIMICA ACTA, 188 (3): (1-10). [PMID:33587171] [10.1007/s00604-021-04743-y] |
29. Tian-Qin Peng, Xiao-Li Yin, Hui-Wen Gu, Weiqing Sun, Baomiao Ding, Xian-Chun Hu, Li-An Ma, Shu-Dong Wei, Zhi Liu, Shi-Yi Ye. (2021) HPLC-DAD fingerprints combined with chemometric techniques for the authentication of plucking seasons of Laoshan green tea. FOOD CHEMISTRY, 347 (128959). [PMID:33465688] [10.1016/j.foodchem.2020.128959] |
30. Fei Zhou, Weisu Huang, Tao Xu, Lipeng Wu, Qi Chen, Jiyu Peng, Xin Liu, Baiyi Lu. (2020) Natural P-gp inhibitor EGCG improves the acteoside absorption in Caco-2 cell monolayers and increases the oral bioavailability of acteoside in rats. FOOD AND CHEMICAL TOXICOLOGY, 146 (111827). [PMID:33184029] [10.1016/j.fct.2020.111827] |
31. Rui Feng, Xin Hu, Yuxin Ma, Liping Sun, Yaying Lv, Kyung Ho Row, Tao Zhu. (2020) Synthesis of poly (styrene-divinylbenzene) by nano-TiO2 and the application for pipette-tip solid-phase extraction of flavonoid in Epipremnum aureum rhizome. SEPARATION SCIENCE AND TECHNOLOGY, [10.1080/01496395.2019.1624571] |
32. Zhang Xiao-Hua, Ma Yi-Xin, Yi Chong, Qing Xiang-Dong, Liu Zhi, Zheng Jing-Jing, Lin Fang, Lv Tian-Feng. (2020) Chemometrics-enhanced HPLC–DAD as a rapid and interference-free strategy for simultaneous quantitative analysis of flavonoids in Chinese propolis. EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 246 (10): (1909-1918). [10.1007/s00217-020-03543-7] |
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