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二甲双胍盐酸盐, 线粒体甘油-3-磷酸脱氢酶抑制剂

AMPK激活剂
47篇引用文献
  • ≥97%
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货号 (SKU) 包装规格 是否现货 价格 数量
M107827-5g
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M107827-25g
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M107827-100g
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M107827-500g
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M107827-2.5kg
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AMPK (94) Autophagy (555) PI3K/Akt/mTOR (764) 官能团化合物 (256) 药物成分 (367) 表观遗传学 (1496)
main product photo

基本描述

别名 甲福明 盐酸盐 | 1,1-二甲基双胍盐酸盐
英文别名 Denkaform | Mescorit | Walaphage | Apophage | Glucophage | Glucophage Retard | XIGDUO COMPONENT METFORMIN HYDROCHLORIDE | 1674364-49-8 | Meguan | METAGLIP COMPONENT METFORMIN HYDROCHLORIDE | Glyformin | Novo-Metformin | Glucomet | Gluformin | METFORMIN HY
规格或纯度 ≥97%
英文名称 Metformin hydrochloride
生化机理 甲福明是一种抗糖尿病药，可降低血糖水平，提高胰岛素灵敏度。其代谢作用（包括抑制肝脏糖异生作用）至少部分是通过激活 LKB1-AMPK（AMP-活化蛋白激酶）通路进行介导。该通路的激活也涉及到癌细胞系中甲福明的抗增殖和促凋亡作用。AMPK激活剂。体内抗糖尿病和抗癌活性。快速越过血脑屏障。
储存温度 -20°C储存,充氩
运输条件 超低温冰袋运输
作用类型 抑制剂
作用机制 线粒体甘油-3-磷酸脱氢酶抑制剂
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

1,1-二甲基双胍盐酸盐(盐酸二甲双胍)是一种强碱。它与过渡金属配合良好，形成颜色鲜艳的双配位基螯合物。盐酸二甲双胍(MET)以多种形式存在:强酸溶液中双质子化(H2MET)2+ ，弱酸溶液中单质子化(HMET)+ ，中性溶液中MET，强碱溶液中去质子化(MET)- 。这是一种口服降糖药。盐酸二甲双胍的药代动力学已得到研究。已采用HPLC-UV法测定人血浆中盐酸二甲双胍的含量。据报道二甲双胍可增加人血浆中活性的胰高血糖素样肽-1 (GLP-1)。盐酸二甲双胍是一种双胍类药物，适用于研究促进血浆中活性胰高血糖素样肽-1 (GLP-1)分泌方面的作用。它可应用于一下合成： · 双(1,1-二甲基双胍)八水铜（III） · 双(1,1-二甲基双胍)镍(II) · 1,1-四溴代二甲双胍(III)

1,1-Dimethylbiguanide hydrochloride (metformin) is a strong base. It forms well defined salts and possessing excellent coordination capacity with transition metals, forming highly colored bidentate chelate complexes. Metformin (MET) exists in various forms: diprotonated (H2MET)2+ in strong acidic solution, monoprotonated (HMET)+ in weak acid, MET in neutral and deprotonated (MET)- in strong alkali solution. It is an oral antidiabetic drug. Pharmacokinetics of metformin has been studied. Determination of metformin in human plasma has been described by simple HPLC-UV method. Metformin is reported to increase plasma active Glukagon-like peptide-1 (GLP-1) in humans.

AI解读

关联靶点（人）

PRKAA2 Tchem AMP-activated protein kinase, alpha-2 subunit (1328 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MTOR Tclin Serine/threonine-protein kinase mTOR (13850 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Homo sapiens (32628 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hs-578T (29457 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTT Tchem Huntingtin (19182 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Liver (3974 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TARDBP Tchem TAR DNA-binding protein 43 (40113 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

ampC Beta-lactamase AmpC (62480 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Streptococcus (3973 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Streptococcus sp. 'group A' (3417 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Kidney (1278 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ska Streptokinase A (5805 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 214-230-6
分子类型 小分子
IUPAC Name 3-(diaminomethylidene)-1,1-dimethylguanidine;hydrochloride
INCHI InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
InChi Key OETHQSJEHLVLGH-UHFFFAOYSA-N
Canonical SMILES CN(C)C(=N)N=C(N)N.Cl
Isomeric SMILES CN(C)C(=N)N=C(N)N.Cl
WGK Germany 3
RTECS DU1800000
PubChem CID 14219
分子量 165.62
Beilstein号 4(4)227
Reaxy-Rn 3626131

化学和物理性质

溶解性 Soluble in water (50 mg/ml), ethanol, and DMSO (50 mM).
敏感性 对湿度敏感
熔点 219-226 °C
分子量 165.620 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count 4
氢键受体数Hydrogen Bond Acceptor Count 1
可旋转键计数Rotatable Bond Count 2
精确质量Exact Mass 165.078 Da
单同位素质量Monoisotopic Mass 165.078 Da
拓扑极表面积Topological Polar Surface Area 91.500 Ų
重原子数Heavy Atom Count 10
形式电荷Formal Charge 0
复杂度Complexity 132.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 2

安全和危险性（GHS）

象形图 GHS07
信号词 Warning
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激

H412: 对水生生物有害并具有长期持续影响

H302: 吞食有害
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P273: 避免释放到环境中。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染：用水充分清洗。

P321: 特殊处理（请参阅此标签上的...）。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P271: 仅在室外或通风良好的地方使用。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P403+P233: 存放在通风良好的地方。保持容器密闭。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P330: 漱口

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P301+P317: 如果被吞咽：请寻求医疗帮助。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany 3
RTECS DU1800000
Reaxy-Rn 3626131
Merck Index 5938
个人防护装备 dust mask type N95 (US)， Eyeshields， Gloves

 SDS英文版

技术规格说明书

Melting point 223-236（℃）
Purity(HPLC) 97-100（%）
Appearance（M107827) White Powder, Crystals and/or Chunks
Infrared spectrum Conforms to Structure
Proton NMR spectrum Conforms to Structure

 技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到17个结果

批号(Lot Number) 证书类型 日期 货号
K2413106 分析证书 24-05-13 M107827
D2526020 分析证书 24-05-13 M107827
G2403288 分析证书 24-05-13 M107827
G2403289 分析证书 24-05-13 M107827
G2403290 分析证书 24-05-13 M107827
A2507190 分析证书 24-05-13 M107827
G2403287 分析证书 24-05-13 M107827
L2402058 分析证书 24-05-13 M107827
F2425426 分析证书 24-04-02 M107827
G2305910 分析证书 23-05-08 M107827
G23051229 分析证书 23-05-08 M107827
I2212084 分析证书 22-08-05 M107827
I2212085 分析证书 22-08-05 M107827
I2212086 分析证书 22-08-05 M107827
I2212087 分析证书 22-08-05 M107827
I2212088 分析证书 22-08-05 M107827
F2118341 分析证书 21-06-22 M107827

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