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L-正亮氨酸
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| L485252-100mg |
100mg |
现货  |
|
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基本描述
| 英文别名 | CS-W020710 | n-C4H9CH(NH2)COOH | (2S)-2-aminohexanoic acid | 2-Aminocaproate | Glycoleucine | (S)-2-aminohexanoate | (S)-2-amino-Hexanoate | AKOS006240047 | BRN 1721750 | .alpha.-Aminocaproic acid | Caprine | UNII-832C8OV84S | Hexanoic acid, 2-amino-, (S) |
|---|---|
| 规格或纯度 | 用于氨基酸分析, BioReagent |
| 英文名称 | L-Norleucine |
| 产品介绍 |
应用 所有氨基酸分析方法的高纯度内标物。 Description Highly purified internal standard for all amino acid analysis methods. |
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| PubChem SID | 504753029 |
|---|---|
| EC号 | 206-321-4 |
| 分子类型 | 小分子 |
| IUPAC Name | (2S)-2-aminohexanoic acid |
| INCHI | InChI=1S/C6H13NO2/c1-2-3-4-5(7)6(8)9/h5H,2-4,7H2,1H3,(H,8,9)/t5-/m0/s1 |
| InChi Key | LRQKBLKVPFOOQJ-YFKPBYRVSA-N |
| Canonical SMILES | CCCCC(C(=O)O)N |
| Isomeric SMILES | CCCC[C@@H](C(=O)O)N |
| WGK Germany | 3 |
| RTECS | RC6308000 |
| PubChem CID | 21236 |
| 分子量 | 131.17 |
| Beilstein号 | 1721750 |
| Reaxy-Rn | 1721750 |
化学和物理性质
| 比旋光度 | 23 ° (C=5, 5mol/L HCl) |
|---|---|
| 熔点 | 300°C |
| 分子量 | 131.170 g/mol |
| XLogP3 | -1.500 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 4 |
| 精确质量Exact Mass | 131.095 Da |
| 单同位素质量Monoisotopic Mass | 131.095 Da |
| 拓扑极表面积Topological Polar Surface Area | 63.300 Ų |
| 重原子数Heavy Atom Count | 9 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 93.100 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H317: 可能引起皮肤过敏反应 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P501: 将内容物/容器处理到。。。 P272: 被污染的工作服不允许离开工作场所 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 |
| WGK Germany | 3 |
| RTECS | RC6308000 |
| Reaxy-Rn | 1721750 |
| Merck Index | 6706 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Faceshields,Gloves |
技术规格说明书
| NMR Spectrum 1H | Conforms to Structure |
|---|---|
| Purity(NT) | 99-102.5（%） |
| Specific Rotation [a]20/D(c=5 in 5 M HCl) | 22-24（°） |
| Appearance(L485252) | White Powder or Crystals or Flakes |
| Water by Karl Fischer | 0-1（%） |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 F2306064 |
分析证书 | 23-06-10 | L485252 |
此产品的引用文献
| 1. Lu Gao, Jia-Hua Zhang, Xiao-Xu Chen, Hui-Li Ren, Xiu-Ling Feng, Jia-Ling Wang, Jun-Hua Xiao. (2019) Combination of L-Arginine and L-Norvaline protects against pulmonary fibrosis progression induced by bleomycin in mice. BIOMEDICINE & PHARMACOTHERAPY, 113 (108768). [PMID:30889486] [10.1016/j.biopha.2019.108768] |
| 2. Qing Xiong, Jing Jin, Liqiong Lv, Zhisi Bu, Shengqiang Tong. (2018) Chiral ligand exchange countercurrent chromatography: Enantioseparation of amino acids. JOURNAL OF SEPARATION SCIENCE, 41 (6): (1479-1488). [PMID:29323783] [10.1002/jssc.201701117] |
| 3. Zhang Qian, Wang Junsong, Liao Shanting, Li Pei, Xu Dingqiao, Lv Yan, Yang Minghua, Kong Lingyi. (2017) Optimization of Huang-Lian-Jie-Du-Decoction for Ischemic Stroke Treatment and Mechanistic Study by Metabolomic Profiling and Network Analysis. Frontiers in Pharmacology, 8 [PMID:28400733] [10.3389/fphar.2017.00165] |
| 4. Yuanhao Cai, Yulong Chen, Qijie Li, Liang Li, Haoxin Huang, Suying Wang, Weixing Wang. (2017) CO2 Hydrate Formation Promoted by a Natural Amino Acid l-Methionine for Possible Application to CO2 Capture and Storage. Energy Technology, 5 (8): (1195-1199). [10.1002/ente.201600731] |
参考文献
| 1. Geissler S, Hellwig M, Zwarg M, Markwardt F, Henle T, Brandsch M. (2010) Transport of the advanced glycation end products alanylpyrraline and pyrralylalanine by the human proton-coupled peptide transporter hPEPT1.. J Agric Food Chem, 58 (4): (2543-7). [PMID:20104847] [10.1021/op500134e] |
| 2. Kevin Guo,Liang Li. (2009-03-25) Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome.. Analytical chemistry, 81 ((10)): (3919-3932). [PMID:19309105] |
| 3. Petros Chatzigeorgiou,Nikos Papakonstantopoulos,Nikolitsa Tagaroulia,Evangelos Pollatos,Pantelis Xynogalas,Kyriakos Viras. (2010-01-02) Solid-solid phase transitions in DL-norvaline studied by differential scanning calorimetry and Raman spectroscopy.. The journal of physical chemistry. B, 114 ((3)): (1294-1300). [PMID:20043648] |
| 4. Francesco Misiti,M Elisabetta Clementi,Bruno Giardina. (2010-01-12) Oxidation of methionine 35 reduces toxicity of the amyloid beta-peptide(1-42) in neuroblastoma cells (IMR-32) via enzyme methionine sulfoxide reductase A expression and function.. Neurochemistry international, 56 ((4)): (597-602). [PMID:20060866] |
| 5. Silvia Lisa,Massimiliano Meli,Gema Cabello,Ruth Gabizon,Giorgio Colombo,María Gasset. (2010-05-11) The structural intolerance of the PrP alpha-fold for polar substitution of the helix-3 methionines.. Cellular and molecular life sciences : CMLS, 67 ((16)): (2825-2838). [PMID:20454997] |
| 6. Jeffery Escobar,Jason W Frank,Agus Suryawan,Hanh V Nguyen,Cynthia G Van Horn,Susan M Hutson,Teresa A Davis. (2010-06-11) Leucine and alpha-ketoisocaproic acid, but not norleucine, stimulate skeletal muscle protein synthesis in neonatal pigs.. The Journal of nutrition, 140 ((8)): (1418-1424). [PMID:20534881] |
| 7. Haiyan Wei,Lijiang Yang,Yi Qin Gao. (2010-08-24) Mutation of charged residues to neutral ones accelerates urea denaturation of HP-35.. The journal of physical chemistry. B, 114 ((36)): (11820-11826). [PMID:20726545] |
| 8. Sarah E Crider,Robert J Holbrook,Katherine J Franz. (2010-11-13) Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1.. Metallomics : integrated biometal science, 2 ((1)): (74-83). [PMID:21072377] |
| 9. Yu-Ying Yang,Markus Grammel,Anuradha S Raghavan,Guillaume Charron,Howard C Hang. (2010-11-26) Comparative analysis of cleavable azobenzene-based affinity tags for bioorthogonal chemical proteomics.. Chemistry & biology, 17 ((11)): (1212-1222). [PMID:21095571] |
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| 12. Diya M Abdeljabbar,Thomas J Klein,A James Link. (2011-06-15) An engineered methionyl-tRNA synthetase enables azidonorleucine incorporation in methionine prototrophic bacteria.. Chembiochem : a European journal of chemical biology, 12 ((11)): (1699-1702). [PMID:21671329] |
| 13. Divi Cornec,Adrian Tempescul,Solène Querellou,Pascal Hutin,Jacques-Olivier Pers,Christophe Jamin,Boutahar Bendaoud,Christian Berthou,Yves Renaudineau,Pierre Youinou. (2011-11-16) Identification of patients with indolent B cell lymphoma sensitive to rituximab monotherapy.. Annals of hematology, 91 ((5)): (715-721). [PMID:22083514] |
| 14. Eleftherios P Paschalis. (2011-12-02) Fourier transform infrared imaging of bone.. Methods in molecular biology (Clifton, N.J.), 816 (517-525). [PMID:22130948] |
| 15. Makoto Hibi,Takashi Kawashima,Pavel M Sokolov,Sergey V Smirnov,Tomohiro Kodera,Masakazu Sugiyama,Sakayu Shimizu,Kenzo Yokozeki,Jun Ogawa. (2012-05-16) L-leucine 5-hydroxylase of Nostoc punctiforme is a novel type of Fe(II)/α-ketoglutarate-dependent dioxygenase that is useful as a biocatalyst.. Applied microbiology and biotechnology, 97 ((6)): (2467-2472). [PMID:22584432] |
| 16. Amar R Mohite,Ramakrishna G Bhat. (2012-05-24) Enantiopure synthesis of side chain-modified α-amino acids and 5-cis-alkylprolines.. The Journal of organic chemistry, 77 ((12)): (5423-5428). [PMID:22616793] |
| 17. Michael Biermann,Bettina Bardl,Sebastian Vollstädt,Julia Linnemann,Uwe Knüpfer,Guido Seidel,Uwe Horn. (2013-01-12) Simultaneous analysis of the non-canonical amino acids norleucine and norvaline in biopharmaceutical-related fermentation processes by a new ultra-high performance liquid chromatography approach.. Amino acids, 44 ((4)): (1225-1231). [PMID:23306451] |
| 18. Alborz Mahdavi,Janek Szychowski,John T Ngo,Michael J Sweredoski,Robert L J Graham,Sonja Hess,Olaf Schneewind,Sarkis K Mazmanian,David A Tirrell. (2013-12-19) Identification of secreted bacterial proteins by noncanonical amino acid tagging.. Proceedings of the National Academy of Sciences of the United States of America, 111 ((1)): (433-438). [PMID:24347637] |
| 19. Shuying Huo,Jingran Dong,Shigang Shen,Yanli Ren,Changying Song,Jianzhong Xu,Tiesheng Shi. (2014-07-31) L-selenomethionine reduces platinum(IV) anticancer model compounds at strikingly faster rates than L-methionine.. Dalton transactions (Cambridge, England : 2003), 43 ((41)): (15328-15336). [PMID:25075569] |
| 20. Danique van Vliet,Karen Anjema,Rianne Jahja,Martijn J de Groot,Geertje B Liemburg,M Rebecca Heiner-Fokkema,Eddy A van der Zee,Terry G J Derks,Ido P Kema,Francjan J van Spronsen. (2014-12-04) BH4 treatment in BH4-responsive PKU patients: preliminary data on blood prolactin concentrations suggest increased cerebral dopamine concentrations.. Molecular genetics and metabolism, 114 ((1)): (29-33). [PMID:25466353] |
| 21. Mark C Wesley,Luis M Pereira,Laurie A Scharp,Sitaram M Emani,Francis X McGowan,James A DiNardo. (2015-01-15) Pharmacokinetics of tranexamic acid in neonates, infants, and children undergoing cardiac surgery with cardiopulmonary bypass.. Anesthesiology, 122 ((4)): (746-758). [PMID:25585004] |
| 22. Ma Paz Lorenzo,Danuta Dudzik,Elena Varas,Manuel Gibellini,Mariusz Skotnicki,Marcin Zorawski,Wieslaw Zarzycki,Federica Pellati,Antonia García. (2015-02-14) Optimization and validation of a chiral GC-MS method for the determination of free D-amino acids ratio in human urine: application to a gestational diabetes mellitus study.. Journal of pharmaceutical and biomedical analysis, 107 (480-487). [PMID:25679092] |
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| 29. Everton F Lima,Franklin Riet-Correa,Dale R Gardner,Severo S Barros,Rosane M T Medeiros,Mauro P Soares,Gabriela Riet-Correa. (2012-05-09) Poisoning by Indigofera lespedezioides in horses.. Toxicon : official journal of the International Society on Toxinology, 60 ((3)): (324-328). [PMID:22560887] |
| 30. Lu Gao, Jia-Hua Zhang, Xiao-Xu Chen, Hui-Li Ren, Xiu-Ling Feng, Jia-Ling Wang, Jun-Hua Xiao. (2019) Combination of L-Arginine and L-Norvaline protects against pulmonary fibrosis progression induced by bleomycin in mice. BIOMEDICINE & PHARMACOTHERAPY, 113 (108768). [PMID:30889486] [10.1016/j.biopha.2019.108768] |
| 31. Qing Xiong, Jing Jin, Liqiong Lv, Zhisi Bu, Shengqiang Tong. (2018) Chiral ligand exchange countercurrent chromatography: Enantioseparation of amino acids. JOURNAL OF SEPARATION SCIENCE, 41 (6): (1479-1488). [PMID:29323783] [10.1002/jssc.201701117] |
| 32. Zhang Qian, Wang Junsong, Liao Shanting, Li Pei, Xu Dingqiao, Lv Yan, Yang Minghua, Kong Lingyi. (2017) Optimization of Huang-Lian-Jie-Du-Decoction for Ischemic Stroke Treatment and Mechanistic Study by Metabolomic Profiling and Network Analysis. Frontiers in Pharmacology, 8 [PMID:28400733] [10.3389/fphar.2017.00165] |
| 33. Yuanhao Cai, Yulong Chen, Qijie Li, Liang Li, Haoxin Huang, Suying Wang, Weixing Wang. (2017) CO2 Hydrate Formation Promoted by a Natural Amino Acid l-Methionine for Possible Application to CO2 Capture and Storage. Energy Technology, 5 (8): (1195-1199). [10.1002/ente.201600731] |