L-鸟氨酸, GPRC6 受体激动剂

10篇引用文献

Moligand™

≥95%

CAS编号: 70-26-8
分子式: C₅H₁₂N₂O₂
分子量: 132.16
PubChem编号: 6262
PubChem SID: 488180032

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货号 (SKU)	包装规格	是否现货
L413185-100mg	100mg	期货
L413185-500mg	500mg	期货
L413185-1g	1g	期货
L413185-5g	5g	期货

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Endogenous Metabolite (981) GPRC6 receptor Agonist (10)

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基本描述

英文别名	AKOS006239312 \| GTPL725 \| L-Norvaline, 5-amino- \| (S)-2,5-diaminovaleric acid \| BRN 1722298 \| ORNITHINE, L- \| DB00129 \| Ornithinum \| 4-04-00-02644 (Beilstein Handbook Reference) \| ORNITHINE [MART.] \| CHEBI:15729 \| NSC 758894 \| Ornithine (INN) \| L-(-)-Orni
规格或纯度	Moligand™, ≥95%
英文名称	L-Ornithine
生化机理	L-鸟氨酸（(S)-2,5-二氨基戊酸）可提高能量消耗效率，促进氨的排泄，从而起到抗疲劳的作用。它是尿素循环的关键反应物之一。
储存温度	避光,-20°C储存
运输条件	超低温冰袋运输
作用类型	激动剂
作用机制	GPRC6 受体激动剂
产品介绍	Information L-ornithine ((S)-2,5-Diaminopentanoic acid) has an antifatigue effect by increasing the efficiency of energy consumption and promoting the excretion of ammonia. It is one of the key reactants in the urea cycle.

AI解读

产品属性

ALogP	-3.697
HBD Count	2
Rotatable Bond	4

关联靶点（人）

GPRC6A Tchem G 蛋白偶联受体家族 C 组 6 成员 A(G-protein coupled receptor family C group 6 member A) (1 活性数据)

点击查看靶蛋白信息： GPRC6A

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

F2 Tclin Thrombin (11687 活性数据)

点击查看靶蛋白信息： F2

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ESR1 Tclin Estrogen receptor alpha (17718 活性数据)

点击查看靶蛋白信息： ESR1

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PGR Tclin Progesterone receptor (8562 活性数据)

点击查看靶蛋白信息： PGR

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)

点击查看靶蛋白信息： CHRM2

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)

点击查看靶蛋白信息： HTR1A

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)

点击查看靶蛋白信息： ADRA2A

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AR Tclin Androgen Receptor (11781 活性数据)

点击查看靶蛋白信息： AR

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)

点击查看靶蛋白信息： CHRM1

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)

点击查看靶蛋白信息： GABRA1

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAOA Tclin Monoamine oxidase A (11911 活性数据)

点击查看靶蛋白信息： MAOA

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD1 Tclin Dopamine D1 receptor (9720 活性数据)

点击查看靶蛋白信息： DRD1

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHE Tclin Acetylcholinesterase (18204 活性数据)

点击查看靶蛋白信息： ACHE

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)

点击查看靶蛋白信息： PTGS1

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)

点击查看靶蛋白信息： SLC6A2

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A4 Tclin Serotonin transporter (12625 活性数据)

点击查看靶蛋白信息： SLC6A4

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)

点击查看靶蛋白信息： ADRA1A

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRM1 Tclin Mu opioid receptor (19785 活性数据)

点击查看靶蛋白信息： OPRM1

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD3 Tclin Dopamine D3 receptor (14368 活性数据)

点击查看靶蛋白信息： DRD3

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A3 Tclin Dopamine transporter (10535 活性数据)

点击查看靶蛋白信息： SLC6A3

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 活性数据)

点击查看靶蛋白信息： KCNH2

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)

点击查看靶蛋白信息： PDE3A

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 活性数据)

点击查看靶蛋白信息： HTR2B

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TBXA2R Tclin Thromboxane A2 receptor (5717 活性数据)

点击查看靶蛋白信息： TBXA2R

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ODC1 Tclin Ornithine decarboxylase (70 活性数据)

点击查看靶蛋白信息： ODC1

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDE4A Tclin Phosphodiesterase 4A (1943 活性数据)

点击查看靶蛋白信息： PDE4A

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADORA3 Tchem Adenosine A3 receptor (15931 活性数据)

点击查看靶蛋白信息： ADORA3

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HRH3 Tclin Histamine H3 receptor (10389 活性数据)

点击查看靶蛋白信息： HRH3

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDR Tclin Vascular endothelial growth factor receptor 2 (20924 活性数据)

点击查看靶蛋白信息： KDR

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

rep Replicase polyprotein 1ab (378 活性数据)

点击查看靶蛋白信息： rep

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	488180032
分子类型	小分子
IUPAC Name	(2S)-2,5-diaminopentanoic acid
INCHI	InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1
InChi Key	AHLPHDHHMVZTML-BYPYZUCNSA-N
Canonical SMILES	C(CC(C(=O)O)N)CN
Isomeric SMILES	C(C[C@@H](C(=O)O)N)CN
PubChem CID	6262
分子量	132.16

化学和物理性质

溶解性	Solubility (25°C) In vitro Water: 26 mg/mL (196.73 mM); DMSO: Insoluble; Ethanol: Insoluble;
敏感性	对湿度敏感
DMSO(mg / mL) Max Solubility	＜1
Water(mg / mL) Max Solubility	26
Water(mM) Max Solubility	196.731234866828
分子量	132.160 g/mol
XLogP3	-4.400
氢键供体数Hydrogen Bond Donor Count	3
氢键受体数Hydrogen Bond Acceptor Count	4
可旋转键计数Rotatable Bond Count	4
精确质量Exact Mass	132.09 Da
单同位素质量Monoisotopic Mass	132.09 Da
拓扑极表面积Topological Polar Surface Area	89.300 Å²
重原子数Heavy Atom Count	9
形式电荷Formal Charge	0
复杂度Complexity	95.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	1
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

SDS英文版

技术规格说明书

Appearance(L413185)	white to off white solid
Purity(HPLC area)	95-100（%）
NMR Spectrum 1H	Conforms to structure

技术规格说明书

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找到22个结果

批号(Lot Number)	证书类型	日期	货号
L2426444	分析证书	24-12-18	L413185
L2426445	分析证书	24-12-18	L413185
L2426446	分析证书	24-12-18	L413185
K2408082	分析证书	23-12-26	L413185
A2405312	分析证书	23-12-26	L413185
A2405313	分析证书	23-12-26	L413185
A2405314	分析证书	23-12-26	L413185
A2405315	分析证书	23-12-26	L413185
A2405316	分析证书	23-12-26	L413185
A2405317	分析证书	23-12-26	L413185
H2426106	分析证书	23-12-26	L413185
C2320195	分析证书	23-03-10	L413185
C2320196	分析证书	23-03-10	L413185
C2320197	分析证书	23-03-10	L413185
C2320198	分析证书	23-03-10	L413185
C2320199	分析证书	23-03-10	L413185
C2320200	分析证书	23-03-10	L413185
C2320201	分析证书	23-03-10	L413185
C2320203	分析证书	23-03-10	L413185
K2309073	分析证书	23-03-10	L413185
K2309075	分析证书	23-03-10	L413185
K2309079	分析证书	23-03-10	L413185

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1. Anqi Peng, Keke Yu, Shuwei Yu, Yingying Li, Hao Zuo, Ping Li, Juan Li, Jianan Huang, Zhonghua Liu, Jian Zhao. (2023) Aluminum and Fluoride Stresses Altered Organic Acid and Secondary Metabolism in Tea (Camellia sinensis) Plants: Influences on Plant Tolerance, Tea Quality and Safety. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (5): (4640). [PMID:36902071] [10.3390/ijms24054640]
2. Jia Xu, Xinzhou Yao, Yingying Lin, Shuyan Chi, Shuang Zhang, Junming Cao, Beiping Tan, Shiwei Xie. (2022) Schizochytrium limacinum altered antioxidant capacity and transcriptome profiles in Pacific white shrimp fed a low-fishmeal diet. Aquaculture Reports, 27 (101399). [10.1016/j.aqrep.2022.101399]
3. Wang Ying, Li ZhiRong, Chen RongXiang. (2022) Simultaneous Determination of Metabolites Related to Arginine Metabolism in Rat plasma by Hydrophilic Interaction Chromatography–Tandem Mass Spectrometry. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 61 (3): (203-210). [PMID:35704851] [10.1093/chromsci/bmac047]
4. Xiaoxiao Chen, Pu Li, Gaojun Wu, Zhe Wang, Chaobiao Huang. (2022) Turn-on signal fluorescence sensor based on DNA derived bio-dots/polydopamine nanoparticles for the detection of glutathione. RSC Advances, 12 (3): (1807-1812). [PMID:35425189] [10.1039/D1RA08107A]
5. Penghui Li, Yujie Xu, Yanrui Zhang, Jiamin Fu, Shuwei Yu, Huimin Guo, Zhihui Chen, Changsong Chen, Xiaogen Yang, Shucai Wang, Jian Zhao. (2020) Metabolite Profiling and Transcriptome Analysis Revealed the Chemical Contributions of Tea Trichomes to Tea Flavors and Tea Plant Defenses. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68 (41): (11389–11401). [PMID:32852206] [10.1021/acs.jafc.0c04075]
6. Mingjie Deng, Feiyan Lin, Caiping Zhou, Yuyan Chen, Leijie Xuan, Hongzhe Wang, Tiantian Feng, Lufeng Hu. (2020) Determination of 27 amino acids’ levels in seminal plasma of asthenospermia and oligospermia patients and diagnostic value analysis. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 184 (113211). [PMID:32126460] [10.1016/j.jpba.2020.113211]
7. Piaopiao Chen, Iqra Ilyas, Su He, Yichen Xing, Zhigang Jin, Chaobiao Huang. (2019) Ratiometric pH Sensing and Imaging in Living Cells with Dual-Emission Semiconductor Polymer Dots. MOLECULES, 24 (16): (2923). [PMID:31409040] [10.3390/molecules24162923]
8. Hao-Hua Deng, Xiao-Qiong Shi, Hua-Ping Peng, Quan-Quan Zhuang, Yu Yang, Ai-Lin Liu, Xing-Hua Xia, Wei Chen. (2018) Gold Nanoparticle-Based Photoluminescent Nanoswitch Controlled by Host–Guest Recognition and Enzymatic Hydrolysis for Arginase Activity Assay. ACS Applied Materials & Interfaces, 10 (6): (5358–5364). [PMID:29373021] [10.1021/acsami.7b19513]
9. Zhang Qian, Wang Junsong, Liao Shanting, Li Pei, Xu Dingqiao, Lv Yan, Yang Minghua, Kong Lingyi. (2017) Optimization of Huang-Lian-Jie-Du-Decoction for Ischemic Stroke Treatment and Mechanistic Study by Metabolomic Profiling and Network Analysis. Frontiers in Pharmacology, 8 [PMID:28400733] [10.3389/fphar.2017.00165]
10. Yinan Zhao, Shubiao Zhang, Yuan Zhang, Shaohui Cui, Huiying Chen, Defu Zhi, Yuhong Zhen, Shufen Zhang, Leaf Huang. (2014) Tri-peptide cationic lipids for gene delivery. Journal of Materials Chemistry B, 3 (1): (119-126). [PMID:25580248] [10.1039/C4TB01312C]

参考文献

1. Anqi Peng, Keke Yu, Shuwei Yu, Yingying Li, Hao Zuo, Ping Li, Juan Li, Jianan Huang, Zhonghua Liu, Jian Zhao. (2023) Aluminum and Fluoride Stresses Altered Organic Acid and Secondary Metabolism in Tea (Camellia sinensis) Plants: Influences on Plant Tolerance, Tea Quality and Safety. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (5): (4640). [PMID:36902071] [10.3390/ijms24054640]
2. Jia Xu, Xinzhou Yao, Yingying Lin, Shuyan Chi, Shuang Zhang, Junming Cao, Beiping Tan, Shiwei Xie. (2022) Schizochytrium limacinum altered antioxidant capacity and transcriptome profiles in Pacific white shrimp fed a low-fishmeal diet. Aquaculture Reports, 27 (101399). [10.1016/j.aqrep.2022.101399]
3. Wang Ying, Li ZhiRong, Chen RongXiang. (2022) Simultaneous Determination of Metabolites Related to Arginine Metabolism in Rat plasma by Hydrophilic Interaction Chromatography–Tandem Mass Spectrometry. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 61 (3): (203-210). [PMID:35704851] [10.1093/chromsci/bmac047]
4. Xiaoxiao Chen, Pu Li, Gaojun Wu, Zhe Wang, Chaobiao Huang. (2022) Turn-on signal fluorescence sensor based on DNA derived bio-dots/polydopamine nanoparticles for the detection of glutathione. RSC Advances, 12 (3): (1807-1812). [PMID:35425189] [10.1039/D1RA08107A]
5. Penghui Li, Yujie Xu, Yanrui Zhang, Jiamin Fu, Shuwei Yu, Huimin Guo, Zhihui Chen, Changsong Chen, Xiaogen Yang, Shucai Wang, Jian Zhao. (2020) Metabolite Profiling and Transcriptome Analysis Revealed the Chemical Contributions of Tea Trichomes to Tea Flavors and Tea Plant Defenses. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68 (41): (11389–11401). [PMID:32852206] [10.1021/acs.jafc.0c04075]
6. Mingjie Deng, Feiyan Lin, Caiping Zhou, Yuyan Chen, Leijie Xuan, Hongzhe Wang, Tiantian Feng, Lufeng Hu. (2020) Determination of 27 amino acids’ levels in seminal plasma of asthenospermia and oligospermia patients and diagnostic value analysis. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 184 (113211). [PMID:32126460] [10.1016/j.jpba.2020.113211]
7. Piaopiao Chen, Iqra Ilyas, Su He, Yichen Xing, Zhigang Jin, Chaobiao Huang. (2019) Ratiometric pH Sensing and Imaging in Living Cells with Dual-Emission Semiconductor Polymer Dots. MOLECULES, 24 (16): (2923). [PMID:31409040] [10.3390/molecules24162923]
8. Hao-Hua Deng, Xiao-Qiong Shi, Hua-Ping Peng, Quan-Quan Zhuang, Yu Yang, Ai-Lin Liu, Xing-Hua Xia, Wei Chen. (2018) Gold Nanoparticle-Based Photoluminescent Nanoswitch Controlled by Host–Guest Recognition and Enzymatic Hydrolysis for Arginase Activity Assay. ACS Applied Materials & Interfaces, 10 (6): (5358–5364). [PMID:29373021] [10.1021/acsami.7b19513]
9. Zhang Qian, Wang Junsong, Liao Shanting, Li Pei, Xu Dingqiao, Lv Yan, Yang Minghua, Kong Lingyi. (2017) Optimization of Huang-Lian-Jie-Du-Decoction for Ischemic Stroke Treatment and Mechanistic Study by Metabolomic Profiling and Network Analysis. Frontiers in Pharmacology, 8 [PMID:28400733] [10.3389/fphar.2017.00165]
10. Yinan Zhao, Shubiao Zhang, Yuan Zhang, Shaohui Cui, Huiying Chen, Defu Zhi, Yuhong Zhen, Shufen Zhang, Leaf Huang. (2014) Tri-peptide cationic lipids for gene delivery. Journal of Materials Chemistry B, 3 (1): (119-126). [PMID:25580248] [10.1039/C4TB01312C]

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