| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| K335691-10mg |
10mg |
期货  |
| |
| K335691-50mg |
50mg |
期货 |
|
| 英文别名 | KU-60019, >=98% (HPLC) | SW219699-1 | 2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-N-[5-(6-morpholin-4-yl-4-oxopyran-2-yl)-9H-thioxanthen-2-yl]acetamide | NCGC00229735-01 | BDBM50059640 | AC-32798 | 2-((2S,6R)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H |
|---|---|
| 规格或纯度 | ≥98% |
| 英文名称 | KU 60019 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
KU 60019是ATM激酶的有效抑制剂。对于一组229种蛋白激酶，它几乎没有或没有非特异性靶标作用，显示出与KU 55933相似的靶标选择性。KU 60019还显示出在体外抑制人神经胶质瘤细胞的侵袭和迁移。 KU 60019 is a potent inhibitor of ATM kinase. Against a panel of 229 protein kinases, it exhibits little to no nonspecific target effects, displaying similar target selectivity to KU 55933. KU 60019 has also been shown to Inhibit invasion and migration of human glioma cells|in vitro|. |
| IC50 | ATM kinase: IC₅₀= 6.3 nM |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-N-[5-(6-morpholin-4-yl-4-oxopyran-2-yl)-9H-thioxanthen-2-yl]acetamide |
| INCHI | InChI=1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+ |
| InChi Key | SCELLOWTHJGVIC-BGYRXZFFSA-N |
| Canonical SMILES | CC1CN(CC(O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C3)C=CC=C4C5=CC(=O)C=C(O5)N6CCOCC6 |
| Isomeric SMILES | C[C@@H]1CN(C[C@@H](O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C3)C=CC=C4C5=CC(=O)C=C(O5)N6CCOCC6 |
| PubChem CID | 15953870 |
| 分子量 | 547.67 |
| 溶解性 | Soluble in DMSO (100 mM), and ethanol (100 mM). |
|---|---|
| 密度 | 1.3 g/cm3(Predicted) |
| 折光率 | n20D1.65 (Predicted) |
| 沸点 | 786.6° C at 760 mmHg (Predicted) |
| 分子量 | 547.700 g/mol |
| XLogP3 | 3.500 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 8 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 547.214 Da |
| 单同位素质量Monoisotopic Mass | 547.214 Da |
| 拓扑极表面积Topological Polar Surface Area | 106.000 Ų |
| 重原子数Heavy Atom Count | 39 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 972.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 2 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
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