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  • 5-羟基色胺, 5-HT 1A 受体的激动剂;5-HT 1B 受体的激动剂;5-HT 1D 受体的激动剂;5-HT 1e 受体的激动剂;5-HT 1F 受体的激动剂;5-HT 2A 受体的激动剂;5-HT 2B 受体的激动剂;5-HT 2C 受体的激动剂;5-HT 3A；5-HT 3AB 受体激动剂;5-HT 4 受体激动剂;5-HT 5A 受体激动剂;5-HT 6 受体激动剂;5-HT 7 受体激动剂;D 1 受体激动剂;D 5 受体激动剂;质子偶联氨基酸转运体 1 的抑制剂

5-羟基色胺, 5-HT 1A 受体的激动剂;5-HT 1B 受体的激动剂;5-HT 1D 受体的激动剂;5-HT 1e 受体的激动剂;5-HT 1F 受体的激动剂;5-HT 2A 受体的激动剂;5-HT 2B 受体的激动剂;5-HT 2C 受体的激动剂;5-HT 3A；5-HT 3AB 受体激动剂;5-HT 4 受体激动剂;5-HT 5A 受体激动剂;5-HT 6 受体激动剂;5-HT 7 受体激动剂;D 1 受体激动剂;D 5 受体激动剂;质子偶联氨基酸转运体 1 的抑制剂

44篇引用文献
  • CAS编号: 50-67-9
  • 分子式: C10H12N2O
  • 分子量: 176.22
  • PubChem编号: 5202
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货号 (SKU) 包装规格 是否现货 价格 数量
H303833-5mg
 5mg 现货 Stock Image
H303833-25mg
 25mg 现货 Stock Image
H303833-100mg
 100mg 现货 Stock Image
H303833-250mg
 250mg 期货 Stock Image
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5-HT1A receptor Agonist (62) 5-HT1B receptor Agonist (45) 5-HT1D receptor Agonist (45) 5-ht1e receptor Agonist (26) 5-HT1F receptor Agonist (23) 5-HT2A receptor Agonist (39) 5-HT2B receptor Agonist (36) 5-HT2C receptor Agonist (33) 5-HT3A Agonist (8) 5-HT3AB Agonist (6) 5-HT4 receptor Agonist (23) 5-HT5A receptor Agonist (7) 5-HT6 receptor Agonist (27) 5-HT7 receptor Agonist (26) D1 receptor Agonist (21) D5 receptor Agonist (15) Proton-coupled Amino acid Transporter 1 Inhibitor (6)
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基本描述

别名 3-(2-氨乙酸)吲哚 | 3-(2-氨基乙基)-5-羟基吲哚 | 五羟色胺 | 血清素 | 5-羟色胺 | 3-(2-Aminoethyl)-5-hydroxyindole
英文别名 5-HT | 3-(b-Aminoethyl)-5-hydroxyindole | 5 Hydroxytryptamine | Serotonine | 3-(.beta.-Aminoethyl)-5-hydroxyindole | 3-(beta-Aminoethyl)-5-hydroxyindole | KBioGR_000452 | 3-(2-Amino-ethyl)-1H-indol-5-ol | 3-(2-Aminoethyl)-1H-indol-5-ol | Biomol-NT_000083
规格或纯度 Moligand™, ≥98%(HPLC)
英文名称 5-Hydroxytryptamine
储存温度 避光,-20°C储存,充氩,干燥
运输条件 超低温冰袋运输
作用类型 抑制剂
作用机制 5-HT 1A 受体的激动剂;5-HT 1B 受体的激动剂;5-HT 1D 受体的激动剂;5-HT 1e 受体的激动剂;5-HT 1F 受体的激动剂;5-HT 2A 受体的激动剂;5-HT 2B 受体的激动剂;5-HT 2C 受体的激动剂;5-HT 3A；5-HT 3AB 受体激动剂;5-HT 4 受体激动剂;5-HT 5A 受体激动剂;5-HT 6 受体激动剂;5-HT 7 受体激动剂;D 1 受体激动剂;D 5 受体激动剂;质子偶联氨基酸转运体 1 的抑制剂
产品介绍

血清素，又名5-羟色胺，是在中枢神经系统分布的一种重要的生物单胺类神经递质和神经调质。参与调节食欲、焦虑、睡眠、情绪和血压等多种生理过程。血清素水平下降会导致肥胖、精神分裂和抑郁等病症。

Serotonin, also known as 5-hydroxytryptamine, is an important biogenic monoamine neurotransmitter and a neuromodulator, found in the central nervous system. It is involved in regulating various physiological processes such as appetite, anxiety, sleep, mood, and blood pressure. A decrease in serotonin levels might result in disorders such as obesity, schizophrenia, and depression.

AI解读

关联靶点（人）

DRD1 Tclin D（1A）多巴胺受体(D(1A) dopamine receptor) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
SLC36A1 Tchem 质子偶联氨基酸转运体1(Proton-coupled amino acid transporter 1) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
DRD5 Tchem D（1B）多巴胺受体(D(1B) dopamine receptor) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR1B Tclin 5-羟色胺受体 1B(5-hydroxytryptamine receptor 1B) (20 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR5A Tchem 5-羟色胺受体 5A(5-hydroxytryptamine receptor 5A) (3 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR4 Tclin 5-羟色胺受体 4(5-hydroxytryptamine receptor 4) (5 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR2A Tclin 5-羟色胺受体 2A(5-hydroxytryptamine receptor 2A) (31 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR1E Tchem 5-羟色胺受体 1E(5-hydroxytryptamine receptor 1E) (3 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR7 Tclin 5-羟色胺受体 7(5-hydroxytryptamine receptor 7) (34 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR3B Tchem 5-羟色胺受体 3B(5-hydroxytryptamine receptor 3B) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR1D Tclin 5-羟色胺受体 1D(5-hydroxytryptamine receptor 1D) (10 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR1F Tclin 5-羟色胺受体 1F(5-hydroxytryptamine receptor 1F) (3 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR2C Tclin 5-羟色胺受体 2C(5-hydroxytryptamine receptor 2C) (41 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR1A Tclin 5-羟色胺受体 1A(5-hydroxytryptamine receptor 1A) (55 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR3A Tclin 5-羟色胺受体 3A(5-hydroxytryptamine receptor 3A) (4 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR6 Tchem 5-羟色胺受体 6(5-hydroxytryptamine receptor 6) (17 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR2B Tclin 5-羟色胺受体 2B(5-hydroxytryptamine receptor 2B) (25 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA2 Tclin Carbonic anhydrase II (17698 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TYR Tclin Tyrosinase (717 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1D Tclin Serotonin 1d (5-HT1d) receptor (2897 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC18A2 Tclin Synaptic vesicular amine transporter (118 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR4 Tclin Serotonin 4 (5-HT4) receptor (2068 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1F Tclin Serotonin 1f (5-HT1f) receptor (245 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA3 Tclin Carbonic anhydrase III (753 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA6 Tclin Carbonic anhydrase VI (993 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA1 Tclin Carbonic anhydrase I (13240 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MIF Tchem Macrophage migration inhibitory factor (979 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MPO Tchem Myeloperoxidase (1002 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1E Tchem Serotonin 1e (5-HT1e) receptor (696 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR5A Tchem Serotonin 5a (5-HT5a) receptor (1433 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR6 Tchem Serotonin 6 (5-HT6) receptor (9749 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRNA7 Tchem Neuronal acetylcholine receptor protein alpha-7 subunit (3524 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA5B Tclin Carbonic anhydrase VB (957 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA5A Tclin Carbonic anhydrase VA (1168 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA14 Tclin Carbonic anhydrase XIV (1305 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MTNR1A Tclin Melatonin receptor 1A (2519 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA12 Tclin Carbonic anhydrase XII (6231 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UGT1A4 Tbio UDP-glucuronosyltransferase 1A4 (288 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA9 Tclin Carbonic anhydrase IX (8255 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UGT2B7 Tchem UDP-glucuronosyltransferase 2B7 (787 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UGT2B17 Tbio UDP-glucuronosyltransferase 2B17 (197 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC22A1 Tchem Solute carrier family 22 member 1 (646 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MARK4 Tchem MAP/microtubule affinity-regulating kinase 4 (1536 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Liver microsomes (16955 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Htr7 Serotonin 7 (5-HT7) receptor (19 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ca7 Carbonic anhydrase VII (3 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Melatonin receptor 1B (19 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ca13 Carbonic anhydrase XIII (322 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA4 Carbonic anhydrase IV (1713 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Glra1 Glycine receptor subunit alpha-1 (65 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Carbonic anhydrase (69 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAL62 Alpha-glucosidase MAL62 (106 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bacillus subtilis (32866 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Caenorhabditis elegans (1055 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Canis familiaris (36305 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Oryctolagus cuniculus (11301 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
B16 (5829 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDCK (10148 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NG108-15 (132 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Taar1 Trace amine-associated receptor 1 (899 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
STR1 Strictosidine synthase (9 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ICL1 Isocitrate lyase (219 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
srtA Sortase A (641 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trpm8 Transient receptor potential cation channel subfamily M member 8 (889 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ca15 Carbonic anhydrase 15 (173 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Aorta (2975 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slc22a5 Solute carrier family 22 member 5 (44 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Impa1 Inositol monophosphatase 1 (16203 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAN2 Carbonic anhydrase 2 (140 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Slc22a3 Solute carrier family 22 member 3 (35 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Chrna3 Neuronal acetylcholine receptor; alpha3/beta4 (1368 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Gabrp GABA-A receptor; anion channel (5731 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Adra1b Adrenergic receptor alpha-1 (5652 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Htr2b Serotonin 2 (5-HT2) receptor (2078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Htr3a Serotonin 3 (5-HT3) receptor (1834 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Htr1b Serotonin 1 (5-HT1) receptor (408 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Htr3b Serotonin 3 receptor (5HT3) (84 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Htr2c Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (162 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Carbonic anhydrase-like protein, putative (25 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Esophagus (8 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 小分子
IUPAC Name 3-(2-aminoethyl)-1H-indol-5-ol
INCHI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
InChi Key QZAYGJVTTNCVMB-UHFFFAOYSA-N
Canonical SMILES C1=CC2=C(C=C1O)C(=CN2)CCN
Isomeric SMILES C1=CC2=C(C=C1O)C(=CN2)CCN
PubChem CID 5202
分子量 176.22

化学和物理性质

敏感性 对湿度、光线敏感
熔点 167.5 °C
分子量 176.210 g/mol
XLogP3 0.200
氢键供体数Hydrogen Bond Donor Count 3
氢键受体数Hydrogen Bond Acceptor Count 2
可旋转键计数Rotatable Bond Count 2
精确质量Exact Mass 176.095 Da
单同位素质量Monoisotopic Mass 176.095 Da
拓扑极表面积Topological Polar Surface Area 62.000 Ų
重原子数Heavy Atom Count 13
形式电荷Formal Charge 0
复杂度Complexity 174.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS06,   GHS08
信号词 Danger
危险声明

H301: 吞咽会中毒

H361: 怀疑破坏生育力或未出生的孩子
预防措施声明

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此产品的引用文献

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1. Kankan Chen, Jiawei Xu, Jingjing Song, Zhonggang Liu, Zheng Guo.  (2023)  A facile ratiometric electrochemical sensing platform with in-situ electropolymerized thionine on effective sensing of 5-hydroxytryptamine.  ELECTROANALYSIS,  36  (3): (e202300324).  [PMID:15522303] [10.1002/elan.202300324]
2. Zou Gang, Yu Ruihong, Zhao Dezhang, Duan Zhaohui, Guo Shimin, Wang Tingting, Ma Limei, Yuan Zhiyi, Yu Chao.  (2023)  Celastrol ameliorates energy metabolism dysfunction of hypertensive rats by dilating vessels to improve hemodynamics.  Journal of Natural Medicines,  (26): (1-17).  [PMID:38032498] [10.1007/s11418-023-01759-x]
3. Huimin Zhou, Anni Zhu, Caiyin Wang, Xiaoyu Guo, Ye Ying, Yiping Wu, Xinling Liu, Feng Wang, Ying Wen, Haifeng Yang.  (2024)  Preparation of gold nanoparticles loaded MOF-199 for SERS detection of 5-hydroxyindole-3-acetic acid in serum.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  304  (123280).  [PMID:37619474] [10.1016/j.saa.2023.123280]
4. Shanshan Tang, Miao Liu, Wei Wang, Axin Liang, Fulai Zhang, Aiqin Luo.  (2023)  An amorphous zinc/copper double transition metal hydroxides for electrochemical simultaneous detection of dopamine, serotonin, and melatonin.  NEW JOURNAL OF CHEMISTRY,  47  (35): (16337-16344).  [10.1039/D3NJ02297H]
5. Wenting Lin, Kan Li, Yingjun Qin, Xing Han, Xiaohui Chen, Yuan Ren.  (2023)  Flunitrazepam induces neurotoxicity in zebrafish through microbiota-gut-brain axis.  SCIENCE OF THE TOTAL ENVIRONMENT,  901  (165974).  [PMID:37532048] [10.1016/j.scitotenv.2023.165974]
6. Yichen Wang, Renjin Zheng, Pingping Wu, Youjia Wu, Lingyi Huang, Liying Huang.  (2023)  Determination of Multiple Neurotransmitters through LC-MS/MS to Confirm the Therapeutic Effects of Althaea rosea Flower on TTX-Intoxicated Rats.  MOLECULES,  28  (10): (4158).  [PMID:37241898] [10.3390/molecules28104158]
7. Pan Gao, Xi Liu, Tianle Zhu, Rui Gao, Jingjing Gao, Yao Zhang, Hui Jiang, Houbao Huang, Xiansheng Zhang.  (2023)  Vital function of DRD4 in dapoxetine medicated premature ejaculation treatment.  Andrology,  [PMID:36746766] [10.1111/andr.13390]
8. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv.  (2023)  Biotransformation of Penindolone, an Influenza A Virus Inhibitor.  MOLECULES,  28  (3): (1479).  [PMID:36771146] [10.3390/molecules28031479]
9. Xin Huang, Rui Wang, Yikai Wang, Changbao Chen, Shuying Liu.  (2023)  Investigation on property differences of ginseng and American ginseng by spatial metabolomics of neurochemicals with desorption electrospray ionization mass spectrometry imaging.  JOURNAL OF ETHNOPHARMACOLOGY,  303  (116006).  [PMID:36516905] [10.1016/j.jep.2022.116006]
10. Lina Ruan, Kaiyu Guan, Yue Wang, Ming Gu, Yue Chen, Lisha Cai, Ruixuan Ye, Zhengwei Huang, Anqi Guo, Zhengkang Su, Xi Li, Jianchun Pan.  (2023)  Baicalein exerts anxiolytic and antinociceptive effects in a mouse model of posttraumatic stress disorder: Involvement of the serotonergic system and spinal delta-opioid receptors.  PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,  122  (110689).  [PMID:36462602] [10.1016/j.pnpbp.2022.110689]
11. Hao Feng, Fan Wang, Junhua Li, Qian Wu, Ying Cui, Lingzhi He, Xing Liu, Zeng Liu, Dong Qian, Haixia Tong.  (2023)  Tuning the Fe/Co ratio towards a bimetallic Prussian blue analogue for the ultrasensitive electrochemical sensing of 5-hydroxytryptamine.  TALANTA,  254  (124138).  [PMID:36463803] [10.1016/j.talanta.2022.124138]
12. Yu Du, Chang Li, Shouchao Xu, Jiehong Yang, Haitong Wan, Yu He.  (2022)  LC-MS/MS combined with blood-brain dual channel microdialysis for simultaneous determination of active components of astragali radix-safflower combination and neurotransmitters in rats with cerebral ischemia reperfusion injury: Application in pharmacokinetic and pharmacodynamic study.  PHYTOMEDICINE,  106  (154432).  [PMID:36113188] [10.1016/j.phymed.2022.154432]
13. Weisu Kong, Da Zhu, Rengan Luo, Siqi Yu, Huangxian Ju.  (2022)  Framework-promoted charge transfer for highly selective photoelectrochemical biosensing of dopamine.  BIOSENSORS & BIOELECTRONICS,  211  (114369).  [PMID:35594626] [10.1016/j.bios.2022.114369]
14. Wang Yingying, Chen Xueman, Chen Qiaoyu, Zhou Ning, Wang Xin, Zhang Alei, Chen Kequan, Ouyang Pingkai.  (2022)  Construction of cell factory capable of efficiently converting l-tryptophan into 5-hydroxytryptamine.  Microbial Cell Factories,  21  (1): (1-9).  [PMID:35331215] [10.1186/s12934-022-01745-0]
15. Huizhen Deng, Jie Zhao, Shifan Zhao, Shuai Jiang, Guofeng Cui.  (2022)  A graphene-based electrochemical flow analysis device for simultaneous determination of dopamine, 5-hydroxytryptamine, and melatonin.  ANALYST,  147  (8): (1598-1610).  [PMID:35294958] [10.1039/D1AN02318G]
16. Huaxu Zhou, Xinyu Ma, Ajabkhan Sailjoi, Yanqi Zou, Xingyu Lin, Fei Yan, Bin Su, Jiyang Liu.  (2022)  Vertical silica nanochannels supported by nanocarbon composite for simultaneous detection of serotonin and melatonin in biological fluids.  SENSORS AND ACTUATORS B-CHEMICAL,  353  (131101).  [10.1016/j.snb.2021.131101]
17. Liu Zhen-zhen, Liu Xiao-ning, Fan Rui-cheng, Jia Yu-ping, Zhang Qing-ke, Gao Xin-qing, Wang Yu-qing, Yang Meng-qing, Ji Li-zhen, Zhou Yong-qing, Li Hong-li, Li Ping, Tang Bo.  (2021)  Identification of pimavanserin tartrate as a potent Ca2+-calcineurin-NFAT pathway inhibitor for glioblastoma therapy.  ACTA PHARMACOLOGICA SINICA,  42  (11): (1860-1874).  [PMID:34363007] [10.1038/s41401-021-00724-2]
18. Kai Hu, Tiantian Pang, Yanmei Shi, Pengzhao Han, Yuanqing Zhao, Wenjie Zhao, Huahui Zeng, Shusheng Zhang, Zhenqiang Zhang.  (2021)  Magnetic borate-modified Mxene: A highly affinity material for the extraction of catecholamines.  ANALYTICA CHIMICA ACTA,  1176  (338769).  [PMID:34399896] [10.1016/j.aca.2021.338769]
19. Yanqiu Chen, Mei Wan, Yi Zhong, Tingfang Gao, Yuehan Zhang, Fen Yan, Da Huang, Yuanzi Wu, Zuquan Weng.  (2021)  Partially Hydrolyzed Guar Gum Modulates Gut Microbiota, Regulates the Levels of Neurotransmitters, and Prevents CUMS-Induced Depressive-Like Behavior in Mice.  MOLECULAR NUTRITION & FOOD RESEARCH,  65  (16): (2100146).  [PMID:34125489] [10.1002/mnfr.202100146]
20. Xiupei Yang, Fangming Tian, Shaohua Wen, Hua Xu, Lin Zhang, Jie Zeng.  (2021)  Selective Determination of Dopamine in Pharmaceuticals and Human Urine Using Carbon Quantum Dots as a Fluorescent Probe.  Processes,  9  (1): (170).  [10.3390/pr9010170]
21. Yuanyuan Xia, Yuan Wang, Meng Zhang, Faqiong Zhao, Baizhao Zeng.  (2021)  A highly selective electrochemical sensor based on surface molecularly imprinted copolymer for the detection of 5-hydroxytryptamine.  MICROCHEMICAL JOURNAL,  160  (105748).  [10.1016/j.microc.2020.105748]
22. Xixia Liu, Yaoyao Hou, Sirui Chen, Juewen Liu.  (2021)  Controlling dopamine binding by the new aptamer for a FRET-based biosensor.  BIOSENSORS & BIOELECTRONICS,  173  (112798).  [PMID:33197768] [10.1016/j.bios.2020.112798]
23. Jun-Dan An, Tian-Tian Wang, Yang-Fan Shi, Jian-Zhong Huo, Xiang-Xia Wu, Yuan-Yuan Liu, Bin Ding.  (2021)  Convenient ultrasonic preparation of a water stable cluster-based Cadmium(II) coordination material and highly sensitive fluorescent sensing for biomarkers DPA and 5-HT.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  247  (119092).  [PMID:33120122] [10.1016/j.saa.2020.119092]
24. Xia Zhao, Zanling Huang, Wanying Zhang, Yuting Ke, Fushen Lu, Rongsheng Chen, Kaifu Huo, Liangsheng Hu, Paul K. Chu.  (2020)  Nitrogen-doped carbon coated TiC nanofiber arrays deposited on Ti-6Al-4V for selective and sensitive electrochemical detection of dopamine.  SURFACE & COATINGS TECHNOLOGY,  402  (126266).  [10.1016/j.surfcoat.2020.126266]
25. Pang Xi, Li Fusen, Huang Songqing, Yang Zeqi, Mo Qian, Huang Li, Xu Wanpeng, Chen Limin, Li Xinchun.  (2020)  Electrostatically mediated layer-by-layer assembly of nitrogen-doped graphene/PDDA/gold nanoparticle composites for electrochemical detection of uric acid.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  412  (3): (669-680).  [PMID:31834450] [10.1007/s00216-019-02275-2]
26. Liang Wenting, Rong Yanqin, Fan Lifang, Zhang Caihong, Dong Wenjuan, Li Jing, Niu Jianping, Yang Cheng, Shuang Shaomin, Dong Chuan, Wong Wai-Yeung.  (2019)  Simultaneous electrochemical sensing of serotonin, dopamine and ascorbic acid by using a nanocomposite prepared from reduced graphene oxide, Fe3O4 and hydroxypropyl-β-cyclodextrin.  MICROCHIMICA ACTA,  186  (12): (1-9).  [PMID:31701250] [10.1007/s00604-019-3861-3]
27. Hou Xingyu, Huang Wei, Tong Yukui, Tian Miaomiao.  (2019)  Hollow dummy template imprinted boronate-modified polymers for extraction of norepinephrine, epinephrine and dopamine prior to quantitation by HPLC.  MICROCHIMICA ACTA,  186  (11): (1-9).  [PMID:31595360] [10.1007/s00604-019-3801-2]
28. Yuanyuan Xia, Faqiong Zhao, Baizhao Zeng.  (2020)  A molecularly imprinted copolymer based electrochemical sensor for the highly sensitive detection of L-Tryptophan.  TALANTA,  206  (120245).  [PMID:31514823] [10.1016/j.talanta.2019.120245]
29. Maofang He, Rong Wang, Yijia He, Jiwei Shen, Chunye Liu, Chaozhan Wang, Yinmao Wei.  (2019)  Multidentate boronate magnetic adsorbent assembled with polyhedral oligomeric silsesquioxanes and intramolecular diboronic acid for improving the binding strength toward glycoproteins.  JOURNAL OF CHROMATOGRAPHY A,  1607  (460401).  [PMID:31376983] [10.1016/j.chroma.2019.460401]
30. Xue-Mei Han, Yan-Jie Qin, Ying Zhu, Xin-Lin Zhang, Nan-Xi Wang, Ying Rang, Xue-Jia Zhai, Yong-Ning Lu.  (2019)  Development of an underivatized LC-MS/MS method for quantitation of 14 neurotransmitters in rat hippocampus, plasma and urine: Application to CUMS induced depression rats.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  174  (683).  [PMID:31288191] [10.1016/j.jpba.2019.06.043]
31. Qiao Juan, Liu Qianrong, Wu Han, Cai Huiwu, Qi Li.  (2019)  Non-enzymatic detection of serum glucose using a fluorescent nanopolymer probe.  MICROCHIMICA ACTA,  186  (6): (1-7).  [PMID:31114937] [10.1007/s00604-019-3475-9]
32. Mengying Wei, Yuanyuan Liu, Zifeng Pi, Shizhe Li, Mingxin Hu, Yang He, Kexin Yue, Tianshu Liu, Zhiqiang Liu, Fengrui Song, Zhongying Liu.  (2019)  Systematically Characterize the Anti-Alzheimer’s Disease Mechanism of Lignans from S. chinensis Based on In-Vivo Ingredient Analysis and Target-Network Pharmacology Strategy by UHPLC–Q-TOF-MS.  MOLECULES,  24  (7): (1203).  [PMID:30934777] [10.3390/molecules24071203]
33. Chen Jia, Li Yunchun, Huang Yanni, Zhang Haijuan, Chen Xingguo, Qiu Hongdeng.  (2019)  Fluorometric dopamine assay based on an energy transfer system composed of aptamer-functionalized MoS2 quantum dots and MoS2 nanosheets.  MICROCHIMICA ACTA,  186  (2): (1-9).  [PMID:30617543] [10.1007/s00604-018-3143-5]
34. Wang Zhong-Xia, Gao Yuan-Fei, Yu Xian-He, Kong Fen-Ying, Lv Wei-Xin, Wang Wei.  (2018)  Photoluminescent coral-like carbon-branched polymers as nanoprobe for fluorometric determination of captopril.  MICROCHIMICA ACTA,  185  (9): (1-9).  [PMID:30128634] [10.1007/s00604-018-2961-9]
35. Chunyan Li, Chaozhan Wang, Yinmao Wei.  (2018)  Facile preparation of a high-capacity boronate-affinity adsorbent based on low-cost commercial supports for selective enrichment of cis-diol-containing biomolecules.  JOURNAL OF THE CHINESE CHEMICAL SOCIETY,  65  (9): (1090-1097).  [10.1002/jccs.201800053]
36. Yang Yiwen, Zeng Yanbo, Tang Chuangui, Zhu Xudong, Lu Xing, Liu Lingyu, Chen Zhidong, Li Lei.  (2018)  Voltammetric determination of 5-hydroxytryptamine based on the use of platinum nanoparticles coated with molecularly imprinted silica.  MICROCHIMICA ACTA,  185  (4): (1-8).  [PMID:29594696] [10.1007/s00604-018-2755-0]
37. Jianbo Li, Yanhui Wang, Yuanling Sun, Chaofan Ding, Yanna Lin, Weiyan Sun, Chuannan Luo.  (2017)  A novel ionic liquid functionalized graphene oxide supported gold nanoparticle composite film for sensitive electrochemical detection of dopamine.  RSC Advances,  7  (4): (2315-2322).  [10.1039/C6RA25627A]
38. Shanying Han, Tianyu Du, Lanmei Lai, Xuerui Jiang, Chuansheng Cheng, Hui Jiang, Xuemei Wang.  (2016)  Highly sensitive biosensor based on the synergistic effect of Fe3O4–Co3O4 bimetallic oxides and graphene.  RSC Advances,  6  (85): (82033-82039).  [10.1039/C6RA18242A]
39. Ling Zhu, Guanhong Xu, Quan Song, Tang Tang, Xu Wang, Fangdi Wei, Qin Hu.  (2016)  Highly sensitive determination of dopamine by a turn-on fluorescent biosensor based on aptamer labeled carbon dots and nano-graphite.  SENSORS AND ACTUATORS B-CHEMICAL,  231  (506).  [10.1016/j.snb.2016.03.084]
40. Nian-Gui Xu, Zhi-Jie Xiao, Ting Zou, Zhi-Ling Huang.  (2015)  Ameliorative effects of physcion 8-O-β-glucopyranoside isolated from Polygonum cuspidatum on learning and memory in dementia rats induced by Aβ1–40.  PHARMACEUTICAL BIOLOGY,  53  (11): (1632-1638).  [PMID:25856718] [10.3109/13880209.2014.997251]
41. Lu Lin, Hui-Ting Lian, Xiang-Ying Sun, Ya-Ming Yu, Bin Liu.  (2015)  An L-dopa electrochemical sensor based on a graphene doped molecularly imprinted chitosan film.  Analytical Methods,  7  (4): (1387-1394).  [10.1039/C4AY02524E]
42. Hua Fan,Chaozhan Wang,Yinmao Wei.  (2015-06-11)  Synthesis and application of boronic acid-functionalized magnetic adsorbent for sensitive analysis of salbutamol residues in pig tissues..  Biomedical chromatography : BMC,  29  ((12)): (1834-1841).  [PMID:26061980]
43. Yun Lei,Guanhong Xu,Fangdi Wei,Jing Yang,Qin Hu.  (2014-02-25)  Preparation of a stir bar coated with molecularly imprinted polymer and its application in analysis of dopamine in urine..  Journal of pharmaceutical and biomedical analysis,  94  (118-124).  [PMID:24561337]
44. Sai Zhang,Yuping Tang,Yanyan Chen,Juncai Zhang,Yinmao Wei.  (2020-01-03)  Boronic acid-modified polyhedral oligomeric silsesquioxanes on polydopamine-coated magnetized graphene oxide for selective and high-capacity extraction of the catecholamines epinephrine, dopamine and isoprenaline..  Mikrochimica acta,  187  ((1)): (77-77).  [PMID:31894422]

参考文献

1. Kankan Chen, Jiawei Xu, Jingjing Song, Zhonggang Liu, Zheng Guo.  (2023)  A facile ratiometric electrochemical sensing platform with in-situ electropolymerized thionine on effective sensing of 5-hydroxytryptamine.  ELECTROANALYSIS,  36  (3): (e202300324).  [PMID:15522303] [10.1002/elan.202300324]
2. Zou Gang, Yu Ruihong, Zhao Dezhang, Duan Zhaohui, Guo Shimin, Wang Tingting, Ma Limei, Yuan Zhiyi, Yu Chao.  (2023)  Celastrol ameliorates energy metabolism dysfunction of hypertensive rats by dilating vessels to improve hemodynamics.  Journal of Natural Medicines,  (26): (1-17).  [PMID:38032498] [10.1007/s11418-023-01759-x]
3. Huimin Zhou, Anni Zhu, Caiyin Wang, Xiaoyu Guo, Ye Ying, Yiping Wu, Xinling Liu, Feng Wang, Ying Wen, Haifeng Yang.  (2024)  Preparation of gold nanoparticles loaded MOF-199 for SERS detection of 5-hydroxyindole-3-acetic acid in serum.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  304  (123280).  [PMID:37619474] [10.1016/j.saa.2023.123280]
4. Shanshan Tang, Miao Liu, Wei Wang, Axin Liang, Fulai Zhang, Aiqin Luo.  (2023)  An amorphous zinc/copper double transition metal hydroxides for electrochemical simultaneous detection of dopamine, serotonin, and melatonin.  NEW JOURNAL OF CHEMISTRY,  47  (35): (16337-16344).  [10.1039/D3NJ02297H]
5. Wenting Lin, Kan Li, Yingjun Qin, Xing Han, Xiaohui Chen, Yuan Ren.  (2023)  Flunitrazepam induces neurotoxicity in zebrafish through microbiota-gut-brain axis.  SCIENCE OF THE TOTAL ENVIRONMENT,  901  (165974).  [PMID:37532048] [10.1016/j.scitotenv.2023.165974]
6. Yichen Wang, Renjin Zheng, Pingping Wu, Youjia Wu, Lingyi Huang, Liying Huang.  (2023)  Determination of Multiple Neurotransmitters through LC-MS/MS to Confirm the Therapeutic Effects of Althaea rosea Flower on TTX-Intoxicated Rats.  MOLECULES,  28  (10): (4158).  [PMID:37241898] [10.3390/molecules28104158]
7. Pan Gao, Xi Liu, Tianle Zhu, Rui Gao, Jingjing Gao, Yao Zhang, Hui Jiang, Houbao Huang, Xiansheng Zhang.  (2023)  Vital function of DRD4 in dapoxetine medicated premature ejaculation treatment.  Andrology,  [PMID:36746766] [10.1111/andr.13390]
8. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv.  (2023)  Biotransformation of Penindolone, an Influenza A Virus Inhibitor.  MOLECULES,  28  (3): (1479).  [PMID:36771146] [10.3390/molecules28031479]
9. Xin Huang, Rui Wang, Yikai Wang, Changbao Chen, Shuying Liu.  (2023)  Investigation on property differences of ginseng and American ginseng by spatial metabolomics of neurochemicals with desorption electrospray ionization mass spectrometry imaging.  JOURNAL OF ETHNOPHARMACOLOGY,  303  (116006).  [PMID:36516905] [10.1016/j.jep.2022.116006]
10. Lina Ruan, Kaiyu Guan, Yue Wang, Ming Gu, Yue Chen, Lisha Cai, Ruixuan Ye, Zhengwei Huang, Anqi Guo, Zhengkang Su, Xi Li, Jianchun Pan.  (2023)  Baicalein exerts anxiolytic and antinociceptive effects in a mouse model of posttraumatic stress disorder: Involvement of the serotonergic system and spinal delta-opioid receptors.  PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,  122  (110689).  [PMID:36462602] [10.1016/j.pnpbp.2022.110689]
11. Hao Feng, Fan Wang, Junhua Li, Qian Wu, Ying Cui, Lingzhi He, Xing Liu, Zeng Liu, Dong Qian, Haixia Tong.  (2023)  Tuning the Fe/Co ratio towards a bimetallic Prussian blue analogue for the ultrasensitive electrochemical sensing of 5-hydroxytryptamine.  TALANTA,  254  (124138).  [PMID:36463803] [10.1016/j.talanta.2022.124138]
12. Yu Du, Chang Li, Shouchao Xu, Jiehong Yang, Haitong Wan, Yu He.  (2022)  LC-MS/MS combined with blood-brain dual channel microdialysis for simultaneous determination of active components of astragali radix-safflower combination and neurotransmitters in rats with cerebral ischemia reperfusion injury: Application in pharmacokinetic and pharmacodynamic study.  PHYTOMEDICINE,  106  (154432).  [PMID:36113188] [10.1016/j.phymed.2022.154432]
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