计算溶液所需的质量、体积或浓度。
活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
---|
货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
---|---|---|---|---|
H136625-100mg |
100mg |
现货 ![]() |
| |
H136625-200mg |
200mg |
期货 ![]() |
| |
H136625-250mg |
250mg |
现货 ![]() |
| |
H136625-1g |
1g |
现货 ![]() |
| |
H136625-5g |
5g |
现货 ![]() |
| |
H136625-25g |
25g |
现货 ![]() |
|
别名 | 胡桃醌 | 胡桃酮 |
---|---|
英文别名 | 5-Hydroxy-1,4-naphthoquinone, 97% | 1, 8-hydroxy- | HMS503M13 | NSC 153189 | SDCCGMLS-0066542.P001 | CS-W017516 | KBio1_001026 | 1,4-Naphthoquinone, 5-hydroxy- | BDBM24777 | Juglone - CAS 481-39-0 | Bio1_000930 | 5-Hydroxy-1,4-naphthoquinone | 5-Hydroxy-1 |
规格或纯度 | ≥97%(GC) |
英文名称 | 5-Hydroxy-1,4-naphthoquinone |
生化机理 | Jμglone 通过改变巯基和阻断启动前复合物的组装来抑制 Pol II(RNA 聚合酶 II)的转录。其他研究表明,Jμglone 不会阻断 T7 RNA 聚合酶,但会抑制 Pol II 和 Pol III(RNA 聚合酶 II 和 III)。人类 Pin1、大肠杆菌 parvulin 和酵母 Ess1/Ptf1 都被 Jμglone 特异性地、不可逆地阻断。此外,Jμglone 还是一种抗纤维化化合物,可通过线粒体依赖途径促进细胞凋亡。Jμglone 是 Cyclophilin 和 Pin4 的抑制剂。 |
储存温度 | 2-8°C储存 |
运输条件 | 冰袋运输 |
产品介绍 |
A compound that inhibits RNA polymerases A compound that inhibits RNA polymerases |
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
---|
PubChem SID | 504750714 |
---|---|
分子类型 | 小分子 |
IUPAC Name | 5-hydroxynaphthalene-1,4-dione |
INCHI | InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H |
InChi Key | KQPYUDDGWXQXHS-UHFFFAOYSA-N |
Canonical SMILES | C1=CC2=C(C(=O)C=CC2=O)C(=C1)O |
Isomeric SMILES | C1=CC2=C(C(=O)C=CC2=O)C(=C1)O |
WGK Germany | 3 |
RTECS | QJ5775000 |
PubChem CID | 3806 |
UN Number | 2811 |
Packing Group | III |
分子量 | 174.16 |
Beilstein号 | 8308 |
Reaxy-Rn | 1909764 |
溶解性 | Soluble in DMSO (10 mg/ml), ethanol (10 mg/ml), benzene (Freely soluble), chloroform (Freely soluble), ether, aqueous solution of alkalies, and hot water. |
---|---|
敏感性 | 对光线敏感 |
闪点(℃) | 201.3ºC |
沸点 | 385.8ºC at 760 mmHg |
熔点 | 155°C(lit.) |
分子量 | 174.150 g/mol |
XLogP3 | 1.900 |
氢键供体数Hydrogen Bond Donor Count | 1 |
氢键受体数Hydrogen Bond Acceptor Count | 3 |
可旋转键计数Rotatable Bond Count | 0 |
精确质量Exact Mass | 174.032 Da |
单同位素质量Monoisotopic Mass | 174.032 Da |
拓扑极表面积Topological Polar Surface Area | 54.400 Ų |
重原子数Heavy Atom Count | 13 |
形式电荷Formal Charge | 0 |
复杂度Complexity | 280.000 |
同位素原子数Isotope Atom Count | 0 |
定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
所有立体化学键的总数The total count of all stereochemical bonds | 0 |
共价键合单元计数Covalently-Bonded Unit Count | 1 |
象形图 | GHS06, GHS09, GHS07 |
---|---|
信号词 | Danger |
危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H301: 吞咽会中毒 H400: 对水生生物有剧毒 |
预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染:用水充分清洗。 P321: 特殊处理(请参阅此标签上的...)。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时,请勿进食、饮水或吸烟。 P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。 P391: 收集溢出物 P330: 漱口 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P316: 如果吞咽:立即寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续:寻求医疗帮助。 P332+P317: 如果出现皮肤刺激:请寻求医疗帮助。 P319: 如果你感到不适,请寻求医疗帮助。 |
WGK Germany | 3 |
RTECS | QJ5775000 |
Reaxy-Rn | 1909764 |
Class | 6.1 |
Merck Index | 5269 |
个人防护装备 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
Purity(HPLC) | 97-100(%) |
---|---|
Appearance(H136625) | orange to brown powder or crystals |
Infrared spectrum | Conforms to Structure |
Proton NMR spectrum | Conforms to Structure |
1. Jialin Song, Daliang Xu, Yonghui Han, Xuewu Zhu, Zihan Liu, Guibai Li, Heng Liang. (2023) Surface modification of FeⅢ-juglone coating on nanofiltration membranes for efficient biofouling mitigation. WATER RESEARCH, 247 (14): (120795). [PMID:37931358] [10.1016/j.watres.2023.120795] |
2. Wenzhe Xu, Yang Chen, Ruixu Yang, Yiying Fu, Wanxin Zhuang, Yonggang Wang, Yi Liu, Hao Zhang. (2023) “Reaction”-Like Shaping of Self-Delivery Supramolecular Nanodrugs in the Nanoprecipitation Process. ACS Nano, 17 (18): (18227–18239). [PMID:37668306] [10.1021/acsnano.3c05229] |
3. Mengfei Tian, Xianming Meng, Naveed Ahmad, Chunying Li, Zhanyu Yuan, Zidan Luo, Yu Zhang, Chunyu Liang, Chunjian Zhao. (2023) Back extraction combined with magnetic solid phase extraction based on bubble column for separation and purification of juglone from Juglans mandshurica Maxim. coproducts. Chemical Engineering and Processing-Process Intensification, 183 (109257). [10.1016/j.cep.2022.109257] |
4. Mengfei Tian, Chunyu Liang, Naveed Ahmad, Chunying Li, Weihao Wang, Yu Zhang, Zidan Luo, Lequn Qiu, Chunjian Zhao. (2022) Proposal and application of a novel extraction and purification technology for juglone from Juglans mandshurica waste branches: Reverse micellar microemulsion combined with magnetic solid phase extraction. CHEMICAL ENGINEERING RESEARCH & DESIGN, 186 (661). [10.1016/j.cherd.2022.08.036] |
5. Mohsin Pasha, Saier Liu, Minjing Shang, Min Qiu, Yuanhai Su. (2022) A synergistic study on the synthesis of juglone via photooxidation in a UV–Vis LED based photomicroreactor. CHEMICAL ENGINEERING JOURNAL, 445 (136663). [10.1016/j.cej.2022.136663] |
6. Xiao-Fei Shang, Zhong-Min Zhao, Jun-Cai Li, Guan-Zhou Yang, Ying-Qian Liu, Li-Xia Dai, Zhi-Jun Zhang, Zhi-Gang Yang, Xiao-Lou Miao, Cheng-Jie Yang, Ji-Yu Zhang. (2019) Insecticidal and antifungal activities of Rheum palmatum L. anthraquinones and structurally related compounds. INDUSTRIAL CROPS AND PRODUCTS, 137 (508). [10.1016/j.indcrop.2019.05.055] |
7. Wenting Wu, Congcong Han, Qinhua Zhang, Qinggang Zhang, Zhongtao Li, David J. Gosztola, Gary P. Wiederrecht, Mingbo Wu. (2018) Functionalizing carbon nitride with heavy atom-free spin converters for enhanced 1O2 generation. JOURNAL OF CATALYSIS, 361 (222). [10.1016/j.jcat.2018.03.006] |
8. Xiao-Fei Shang,Ying-Qian Liu,Xiao Guo,Xiao-Lou Miao,Cheng Chen,Jun-Xiang Zhang,Xiao-Shan Xu,Guan-Zhou Yang,Cheng-Jie Yang,Jun-Cai Li,Xiao-Shuai Zhang. (2018-01-27) Application of Sustainable Natural Resources in Agriculture: Acaricidal and Enzyme Inhibitory Activities of Naphthoquinones and Their Analogs against Psoroptes cuniculi.. Scientific reports, 8 ((1)): (1609-1609). [PMID:29371639] |
1. Jialin Song, Daliang Xu, Yonghui Han, Xuewu Zhu, Zihan Liu, Guibai Li, Heng Liang. (2023) Surface modification of FeⅢ-juglone coating on nanofiltration membranes for efficient biofouling mitigation. WATER RESEARCH, 247 (14): (120795). [PMID:37931358] [10.1016/j.watres.2023.120795] |
2. Wenzhe Xu, Yang Chen, Ruixu Yang, Yiying Fu, Wanxin Zhuang, Yonggang Wang, Yi Liu, Hao Zhang. (2023) “Reaction”-Like Shaping of Self-Delivery Supramolecular Nanodrugs in the Nanoprecipitation Process. ACS Nano, 17 (18): (18227–18239). [PMID:37668306] [10.1021/acsnano.3c05229] |
3. Mengfei Tian, Xianming Meng, Naveed Ahmad, Chunying Li, Zhanyu Yuan, Zidan Luo, Yu Zhang, Chunyu Liang, Chunjian Zhao. (2023) Back extraction combined with magnetic solid phase extraction based on bubble column for separation and purification of juglone from Juglans mandshurica Maxim. coproducts. Chemical Engineering and Processing-Process Intensification, 183 (109257). [10.1016/j.cep.2022.109257] |
4. Mengfei Tian, Chunyu Liang, Naveed Ahmad, Chunying Li, Weihao Wang, Yu Zhang, Zidan Luo, Lequn Qiu, Chunjian Zhao. (2022) Proposal and application of a novel extraction and purification technology for juglone from Juglans mandshurica waste branches: Reverse micellar microemulsion combined with magnetic solid phase extraction. CHEMICAL ENGINEERING RESEARCH & DESIGN, 186 (661). [10.1016/j.cherd.2022.08.036] |
5. Mohsin Pasha, Saier Liu, Minjing Shang, Min Qiu, Yuanhai Su. (2022) A synergistic study on the synthesis of juglone via photooxidation in a UV–Vis LED based photomicroreactor. CHEMICAL ENGINEERING JOURNAL, 445 (136663). [10.1016/j.cej.2022.136663] |
6. Xiao-Fei Shang, Zhong-Min Zhao, Jun-Cai Li, Guan-Zhou Yang, Ying-Qian Liu, Li-Xia Dai, Zhi-Jun Zhang, Zhi-Gang Yang, Xiao-Lou Miao, Cheng-Jie Yang, Ji-Yu Zhang. (2019) Insecticidal and antifungal activities of Rheum palmatum L. anthraquinones and structurally related compounds. INDUSTRIAL CROPS AND PRODUCTS, 137 (508). [10.1016/j.indcrop.2019.05.055] |
7. Wenting Wu, Congcong Han, Qinhua Zhang, Qinggang Zhang, Zhongtao Li, David J. Gosztola, Gary P. Wiederrecht, Mingbo Wu. (2018) Functionalizing carbon nitride with heavy atom-free spin converters for enhanced 1O2 generation. JOURNAL OF CATALYSIS, 361 (222). [10.1016/j.jcat.2018.03.006] |
8. Xiao-Fei Shang,Ying-Qian Liu,Xiao Guo,Xiao-Lou Miao,Cheng Chen,Jun-Xiang Zhang,Xiao-Shan Xu,Guan-Zhou Yang,Cheng-Jie Yang,Jun-Cai Li,Xiao-Shuai Zhang. (2018-01-27) Application of Sustainable Natural Resources in Agriculture: Acaricidal and Enzyme Inhibitory Activities of Naphthoquinones and Their Analogs against Psoroptes cuniculi.. Scientific reports, 8 ((1)): (1609-1609). [PMID:29371639] |