| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| G421313-1ml |
1ml |
现货  |
|
| 别名 | 1-异丙基-N-[(6-甲基-2-氧代-4-丙基-1,2-二氢-3-吡啶基)甲基]-6-[2-(4-甲基-1-哌嗪基)-4-吡啶基]-1H-吲唑-4-甲酰胺 |
|---|---|
| 英文别名 | GSK343 | 1346704-33-3 | GSK 343 | GSK-343 | 1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-6-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-4-carboxamide | CHEMBL2204995 | 1-(1-Methylethyl)-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyri |
| 规格或纯度 | Moligand™, 2mM in DMSO |
| 英文名称 | GSK343 |
| 生化机理 | 它是组蛋白 H3 赖氨酸 27 (H3K27) 甲基转移酶 EZH2 的强效特异性抑制剂。GSK343 抑制 EZH2 酶活性的 IC50 为 4 nM。与 EZH1 相比，该化合物对 EZH2 的选择性为 60 倍，对其他组蛋白甲基转移酶的选择性为 1000 倍或更高。在 HCC1806 细胞中，抑制 H3K27 甲基化的 IC50 小于 200 nM。抑制 EZH2 酶活性（IC 50/xa0= 4 nM）。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 增强子宙斯特 1 多聚核抑制复合体 2 亚基抑制剂；增强子宙斯特 2 多聚核抑制复合体 2 亚基抑制剂 |
| 产品介绍 |
It is an epigenetic chemical probe available through a partnership between Sigma Life Science and the Structural Genomics Consortium (SGC). It is an epigenetic chemical probe available through a partnership between Sigma Life Science and the Structural Genomics Consortium (SGC). |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-propan-2-ylindazole-4-carboxamide |
| INCHI | InChI=1S/C31H39N7O2/c1-6-7-23-14-21(4)35-31(40)26(23)18-33-30(39)25-15-24(16-28-27(25)19-34-38(28)20(2)3)22-8-9-32-29(17-22)37-12-10-36(5)11-13-37/h8-9,14-17,19-20H,6-7,10-13,18H2,1-5H3,(H,33,39)(H,35,40) |
| InChi Key | ULNXAWLQFZMIHX-UHFFFAOYSA-N |
| Canonical SMILES | CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C |
| Isomeric SMILES | CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C |
| WGK Germany | 3 |
| PubChem CID | 71268957 |
| 分子量 | 541.69 |
| 分子量 | 541.700 g/mol |
|---|---|
| XLogP3 | 4.000 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 6 |
| 可旋转键计数Rotatable Bond Count | 8 |
| 精确质量Exact Mass | 541.317 Da |
| 单同位素质量Monoisotopic Mass | 541.317 Da |
| 拓扑极表面积Topological Polar Surface Area | 95.400 Ų |
| 重原子数Heavy Atom Count | 40 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 986.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| Concentration(Compounding value) | 1-3(mmol/L) |
|---|---|
| Appearance(Colorless Transparent Liquid) | Pass |
| Record the entire process by video | Conform |
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