| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| F421056-1ml |
1ml |
现货  |
|
| 别名 | 4-[4-(4-甲基苯基)-2-噻唑基]-2-丙基吡啶 |
|---|---|
| 英文别名 | FATOSTATIN | Fatostatin A | 125256-00-0 | 4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole | 2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole | CHEMBL1621019 | 4-[4-(4-methylphenyl)-1,3-thiazol-2-yl]-2-propylpyridine | MLS000332366 | SMR000221636 | 2-Propyl-4-(4-p-toly |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Fatostatin |
| 生化机理 | Fatostatin（125B11）是一种二芳基噻唑衍生物，是甾醇调节元件结合蛋白（SREBPs）活化的特异性抑制剂。Fatostatin 可与 SCAP（SREBP 切割激活蛋白）结合，抑制 SREBPs 在 ER-Golgi 的转运。Fatostatin 可抑制癌细胞的生长并促进其凋亡。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
说明： Fatostatin (125B11) 是一种diarylthiazole的衍生物，是 Sterol regulatory element binding proteins (SREBPs) 活化的特异性抑制剂。Fatostatin 可结合SCAP (SREBP cleavage-activating protein)，并抑制SREBP的ER-Golgi易位。Fatostatin 可抑制癌细胞生长并增强癌细胞的凋亡。 Information Fatostatin Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin suppresses growth and enhances apoptosis in cancer cells. Targets SREBP In vitro Fatostatin impairs the activation process of sterol regulatory element binding proteins (SREBPs), thereby decreasing the transcription of lipogenic genes in cells. Fatostatin inhibits the ER-Golgi translocation of SREBPs through binding to their escort protein, the SREBP cleavage-activating protein (SCAP), at a distinct site from the sterol-binding domain. In vivo Fatostatin blocks increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake. Fatostatin may serve as a tool for gaining further insights into the regulation of SREBP. Cell Research(from reference) Cell lines：CHO-K1 cells Concentrations：20 μM Incubation Time：20 h |
| ALogP | 4.898 |
|---|---|
| Rotatable Bond | 4 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole |
| INCHI | InChI=1S/C18H18N2S/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14/h5-12H,3-4H2,1-2H3 |
| InChi Key | ZROSUBKIGBSZCG-UHFFFAOYSA-N |
| Canonical SMILES | CCCC1=NC=CC(=C1)C2=NC(=CS2)C3=CC=C(C=C3)C |
| Isomeric SMILES | CCCC1=NC=CC(=C1)C2=NC(=CS2)C3=CC=C(C=C3)C |
| PubChem CID | 1889993 |
| 分子量 | 294.41 |
| DMSO(mg / mL) Max Solubility | 75 |
|---|---|
| DMSO(mM) Max Solubility | 254.746781698991 |
| Water(mg / mL) Max Solubility | ＜1 |
| 分子量 | 294.400 g/mol |
| XLogP3 | 4.800 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 4 |
| 精确质量Exact Mass | 294.119 Da |
| 单同位素质量Monoisotopic Mass | 294.119 Da |
| 拓扑极表面积Topological Polar Surface Area | 54.000 Ų |
| 重原子数Heavy Atom Count | 21 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 314.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| Concentration(Compounding value) | 9.0-11.0(mmol/L) |
|---|---|
| Record the entire process by video | Conform |
| 1. Xiaolin Zhang, Zhen Dong, Yuanmiao Yang, Chaolong Liu, Jisheng Li, Wenli Sun, Yikang Zhu, Yang Shen, Zhi Wang, Muhan Lü, Hongjuan Cui. (2023) Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, (19): [PMID:37870273] [10.1021/acs.jafc.3c01244] |
| 1. Xiaolin Zhang, Zhen Dong, Yuanmiao Yang, Chaolong Liu, Jisheng Li, Wenli Sun, Yikang Zhu, Yang Shen, Zhi Wang, Muhan Lü, Hongjuan Cui. (2023) Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, (19): [PMID:37870273] [10.1021/acs.jafc.3c01244] |
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