| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| F135527-1mg |
1mg |
期货  |
| |
| F135527-5mg |
5mg |
现货 |
|
| 别名 | 烟曲霉毒素 B1 | 伏马菌素B1 |
|---|---|
| 英文别名 | HSDB 7077 | EX-A8017 | Fumonisin B1 50 microg/mL in Acetonitrile/Water | fumonisin-B1 | SCHEMBL13555629 | fumonisin b1 | fumonisin B(1) | UNII-3ZZM97XZ32 | AKOS024457430 | FUMONISIN B1 [IARC] | DTXSID6020644 | HY-N6719 | 1,2,3-PROPANETRICARBOXYLIC ACID, 1 |
| 规格或纯度 | ≥98%(HPLC) |
| 英文名称 | Fumonisin B1 |
| 生化机理 | 真菌代谢物，可引起马脑白质软化症。霉菌毒素和蛋白丝氨酸/苏氨酸磷酸酶抑制剂（IC 50值为80μM（PP5），0.3（PP2Cα），0.4（PP2A），0.5（PP1γ2）和3 mM（PP2B））。细胞增殖抑制剂和凋亡诱导剂。 |
| 储存温度 | -20°C储存,充氩 |
| 运输条件 | 超低温冰袋运输 |
| 备注 | 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| 产品介绍 |
伏马菌素B1是由串珠镰刀菌产生的真菌代谢产物，已被证明可以抑制蛋白质丝氨酸/苏氨酸磷酸酶（PP1、PP2A、PP2B、PP2C和PP5/T/K/H），对PP5最有效。它已被证明可以刺激丝裂原活化蛋白激酶的激活。伏马菌素B1已被观察到抑制鞘脂生物合成，与神经元细胞中的鞘糖脂相比，优先抑制鞘磷脂生物合成。在原代大鼠肝细胞中，伏马菌素B1通过μgh LASS（神经酰胺合酶）抑制阻断了新生鞘脂的生物合成。伏马菌素B1与TNF受体结合诱导的Caspase-3激活或DNA片段化凋亡已在许多人类和大鼠细胞系中得到证实。伏马菌素B1通过增加IL-1β、TNFα、IFN-γ的表达显示出免疫毒性作用；（干扰素γ）、IL-1α、IL-6、IL-10、IL-18和IL-12在不同小鼠细胞中的表达。通过趋化因子CXCL9和IFN-γ的高表达，证明了伏马菌素B1对人树突状细胞的免疫毒性。此外，伏马菌素B1是Akt的激活剂。一种丝氨酸/苏氨酸磷酸酶抑制剂。
Fumonisin B1 is a fungal metabolite produced by Fusarium moniliforme, that has been shown to inhibit protein serine/threonine phosphatases (PP1, PP2A, PP2B, PP2C, and PP5/T/K/H), and is most effective with PP5. It has been shown to stimulate the activation of mitogen-activated protein kinase. Fumonisin B1 has been observed to inhibit sphingolipid biosynthesis, preferentially inhibiting sphingomyelin biosynthesis versus glycosphingolipids in neuronal cells. In primary rat liver cells, fumonisin B1 blocked biosynthesis of de novo sphingolipids through LASS (ceramide synthase) inhibition. Caspase-3 activated or DNA fragmented apoptosis induced by fumonisin B1 binding to a TNF receptor has been documented in many human and rat cell lines. Fumonisin B1 has displayed immunotoxic effects by increasing expression of IL-1β, TNFα, IFN-γ; (interferon γ), IL-1α, IL-6, IL-10, IL-18 and IL-12 in varying mouse cells. Immunotoxicity of fumonisin B1 in human dendritic cells has been demonstrated through expression of chemokine CXCL9 and IFN-γ. Further, fumonisin B1 is an activator of Akt. |
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | (2R)-2-[2-[(5R,6R,7S,9S,11R,16R,18S,19S)-19-amino-6-[(3R)-3,4-dicarboxybutanoyl]oxy-11,16,18-trihydroxy-5,9-dimethylicosan-7-yl]oxy-2-oxoethyl]butanedioic acid |
| INCHI | InChI=1S/C34H59NO15/c1-5-6-9-20(3)32(50-31(44)17-23(34(47)48)15-29(41)42)27(49-30(43)16-22(33(45)46)14-28(39)40)13-19(2)12-24(36)10-7-8-11-25(37)18-26(38)21(4)35/h19-27,32,36-38H,5-18,35H2,1-4H3,(H,39,40)(H,41,42)(H,45,46)(H,47,48)/t19-,20+,21-,22+,23+,24+,25+,26-,27-,32+/m0/s1 |
| InChi Key | UVBUBMSSQKOIBE-DSLOAKGESA-N |
| Canonical SMILES | CCCCC(C)C(C(CC(C)CC(CCCCC(CC(C(C)N)O)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O |
| Isomeric SMILES | CCCC[C@@H](C)[C@H]([C@H](C[C@@H](C)C[C@@H](CCCC[C@H](C[C@@H]([C@H](C)N)O)O)O)OC(=O)C[C@@H](CC(=O)O)C(=O)O)OC(=O)C[C@@H](CC(=O)O)C(=O)O |
| WGK Germany | 3 |
| RTECS | TZ8350000 |
| PubChem CID | 2733487 |
| 分子量 | 721.83 |
| 溶解性 | Soluble in water (25 mg/mL), methanol (10 mg/mL), acetonitrile, and DMSO (10 mM). |
|---|---|
| 敏感性 | 对光线和湿度敏感 |
| 分子量 | 721.800 g/mol |
| XLogP3 | -0.500 |
| 氢键供体数Hydrogen Bond Donor Count | 8 |
| 氢键受体数Hydrogen Bond Acceptor Count | 16 |
| 可旋转键计数Rotatable Bond Count | 31 |
| 精确质量Exact Mass | 721.388 Da |
| 单同位素质量Monoisotopic Mass | 721.388 Da |
| 拓扑极表面积Topological Polar Surface Area | 289.000 Ų |
| 重原子数Heavy Atom Count | 50 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 1070.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 10 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS08 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H351: 怀疑引起遗传缺陷 |
| 预防措施声明 |
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。 |
| WGK Germany | 3 |
| RTECS | TZ8350000 |
| 个人防护装备 | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| Purity(HPLC) | 98-100（%） |
|---|---|
| Carbon by Elemental Analysis(anhydrous) | 55.2-58（%） |
| Nitrogen by Elemental Analysis (anhydrous) | 1.6-2.2（%） |
| Appearance（F135527) | White to tan powder |
| Proton NMR spectrum | Conforms to Structure |
| Solubility in MeOH(4.80-5.20mg/ml),Colorless to Faint Yellow Clear | Pass |
¥13,389.90
| 1. Defeng Wen, Wantong Han, Quan Chen, Guanhui Qi, Mengling Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qirong Lu, Yinsheng Qiu. (2024) Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1–induced intestinal inflammatory injury. TOXICON, 237 (1): (107531). [PMID:38013056] [10.1016/j.toxicon.2023.107531] |
| 2. Ya-Hui Yu, Xin-Huai Zhao. (2023) Longan Polysaccharides with Covalent Selenylation Combat the Fumonisin B1-Induced Cell Toxicity and Barrier Disruption in Intestinal Epithelial (IEC-6) Cells. Nutrients, 15 (21): (4679). [PMID:37960333] [10.3390/nu15214679] |
| 3. Peifang Chen, Caiyun Jiang, Zhouping Wang, Hong-zhen Lian, Xiaoyuan Ma. (2023) 3D plasmonic SERS aptasensor for rapid detection of aflatoxin B1 combined with Au@Ag bimetallic nanostars and Fe3O4@MoS2 magnetic nanoflowers. MICROCHEMICAL JOURNAL, (109598). [PMID:14728084] [10.1016/j.microc.2023.109598] |
| 4. Ting Wang, Jie Cheng, Jinmao You, Zhiwei Sun. (2023) Highly selective and sensitive high performance liquid chromatography method for determination of fumonisins from feed samples with MIL-101 based dispersed micro-solid-phase extraction and precolumn fluorescence derivatization. MICROCHEMICAL JOURNAL, 194 (15): (109320). [PMID:15109303] [10.1016/j.microc.2023.109320] |
| 5. Guo Ge, Tianlin Wang, Zihou Liu, Xiaomeng Liu, Tiange Li, Yuntang Chen, Jialin Fan, Erkigul Bukye, Xianqing Huang, Lianjun Song. (2023) A self-assembled DNA double-crossover-based fluorescent aptasensor for highly sensitivity and selectivity in the simultaneous detection of aflatoxin M1 and aflatoxin B1. TALANTA, 265 (124908). [PMID:37442003] [10.1016/j.talanta.2023.124908] |
| 6. Zhang Hong, Wang Yuli, Lin Yingtong, Chu Wenjuan, Luo Zhen, Zhao Mingqin, Hu Jiandong, Miao Xiangmin, He Fan. (2023) A catalytic hairpin assembly–based Förster resonance energy transfer sensor for ratiometric detection of ochratoxin A in food samples. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 415 (5): (867-874). [PMID:36564526] [10.1007/s00216-022-04479-5] |
| 7. Zhu Jing, Xu Wenxing, Yang Ye, Kong Rongmei, Wang Junmei. (2023) ssDNA-C3N4 conjugates-based nanozyme sensor array for discriminating mycotoxins. MICROCHIMICA ACTA, 190 (1): (1-10). [PMID:36471087] [10.1007/s00604-022-05593-y] |
| 8. Pengfei Wang, Bin Luo, Ke Liu, Cheng Wang, Hongtu Dong, Xiaodong Wang, Peichen Hou, Aixue Li. (2022) A novel COOH–GO–COOH–MWNT/pDA/AuNPs based electrochemical aptasensor for detection of AFB1. RSC Advances, 12 (43): (27940-27947). [PMID:36320289] [10.1039/D2RA03883H] |
| 9. Kezhuo Zhang, Huadong Cai, Min Lu, Daixian Wei, Jiaqi Yin, Nengshui Ding, Weihua Lai, Juan Peng. (2022) Quantum dot nanobead immunochromatographic assay based on bispecific monoclonal antibody for the simultaneous detection of aflatoxin B1 and amantadine. FOOD AND AGRICULTURAL IMMUNOLOGY, 33 (1): (403-418). [10.1080/09540105.2022.2080188] |
| 10. Mei Liu, Jinxin Zhang, Shasha Liu, Baoxin Li. (2022) A label-free visual aptasensor for zearalenone detection based on target-responsive aptamer-cross-linked hydrogel and color change of gold nanoparticles. FOOD CHEMISTRY, 389 (133078). [PMID:35490524] [10.1016/j.foodchem.2022.133078] |
| 11. Fan Jia, Yuye Li, Qingfa Gong, Dong Liu, Shuyun Meng, Chengxi Zhu, Tianyan You. (2022) A Simple Ratiometric Electrochemical Aptasensor Based on the Thionine–Graphene Nanocomposite for Ultrasensitive Detection of Aflatoxin B2 in Peanut and Peanut Oil. Chemosensors, 10 (5): (154). [10.3390/chemosensors10050154] |
| 12. Ting Chen, Yuye Li, Shuyun Meng, Chang Liu, Dong Liu, Daming Dong, Tianyan You. (2022) Temperature and pH tolerance ratiometric aptasensor: Efficiently self-calibrating electrochemical detection of aflatoxin B1. TALANTA, 242 (123280). [PMID:35144069] [10.1016/j.talanta.2022.123280] |
| 13. Chengxi Zhu, Dong Liu, Yuye Li, Ting Chen, Tianyan You. (2022) Label-free ratiometric homogeneous electrochemical aptasensor based on hybridization chain reaction for facile and rapid detection of aflatoxin B1 in cereal crops. FOOD CHEMISTRY, 373 (131443). [PMID:34742048] [10.1016/j.foodchem.2021.131443] |
| 14. Xiaoyuan Ma, Baoyi Shao, Zhouping Wang. (2021) Gold@silver nanodumbbell based inter-nanogap aptasensor for the surface enhanced Raman spectroscopy determination of ochratoxin A. ANALYTICA CHIMICA ACTA, 1188 (339189). [PMID:34794565] [10.1016/j.aca.2021.339189] |
| 15. Xiaoya Bi, Lijun Luo, Libo Li, Xiaohong Liu, Bainian Chen, Tianyan You. (2020) A FRET-based aptasensor for ochratoxin A detection using graphitic carbon nitride quantum dots and CoOOH nanosheets as donor-acceptor pair. TALANTA, 218 (121159). [PMID:32797913] [10.1016/j.talanta.2020.121159] |
| 16. Yuye Li, Dong Liu, Chengxi Zhu, Xiuli Shen, Yang Liu, Tianyan You. (2020) Sensitivity programmable ratiometric electrochemical aptasensor based on signal engineering for the detection of aflatoxin B1 in peanut. JOURNAL OF HAZARDOUS MATERIALS, 387 (122001). [PMID:31901843] [10.1016/j.jhazmat.2019.122001] |
| 17. He Deyun, Wu Zhengzong, Cui Bo, Xu Enbo, Jin Zhengyu. (2019) Building a Fluorescent Aptasensor Based on Exonuclease-Assisted Target Recycling Strategy for One-Step Detection of T-2 Toxin. Food Analytical Methods, 12 (2): (625-632). [10.1007/s12161-018-1392-x] |
| 18. Zhengzong Wu, Enbo Xu, Muhammad F.J. Chughtai, Zhengyu Jin, Joseph Irudayaraj. (2017) Highly sensitive fluorescence sensing of zearalenone using a novel aptasensor based on upconverting nanoparticles. FOOD CHEMISTRY, 230 (673). [PMID:28407965] [10.1016/j.foodchem.2017.03.100] |
| 19. Xuejuan Chen, Xiaojing Bai, Huiyan Li, Bailin Zhang. (2015) Aptamer-based microcantilever array biosensor for detection of fumonisin B-1. RSC Advances, 5 (45): (35448-35452). [10.1039/C5RA04278J] |
| 1. Yu S et al.. (2020) Evaluation of the Individual and Combined Toxicity of Fumonisin Mycotoxins in Human Gastric Epithelial Cells.. Int J Mol Sci, 21 (16): [PMID:32824643] |
| 2. Yu S et al.. (2021) Fumonisin B1 triggers carcinogenesis via HDAC/PI3K/Akt signalling pathway in human esophageal epithelial cells.. Sci Total Environ, 787 (147405). [PMID:34000555] |
| 3. Defeng Wen, Wantong Han, Quan Chen, Guanhui Qi, Mengling Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qirong Lu, Yinsheng Qiu. (2024) Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1–induced intestinal inflammatory injury. TOXICON, 237 (1): (107531). [PMID:38013056] [10.1016/j.toxicon.2023.107531] |
| 4. Ya-Hui Yu, Xin-Huai Zhao. (2023) Longan Polysaccharides with Covalent Selenylation Combat the Fumonisin B1-Induced Cell Toxicity and Barrier Disruption in Intestinal Epithelial (IEC-6) Cells. Nutrients, 15 (21): (4679). [PMID:37960333] [10.3390/nu15214679] |
| 5. Peifang Chen, Caiyun Jiang, Zhouping Wang, Hong-zhen Lian, Xiaoyuan Ma. (2023) 3D plasmonic SERS aptasensor for rapid detection of aflatoxin B1 combined with Au@Ag bimetallic nanostars and Fe3O4@MoS2 magnetic nanoflowers. MICROCHEMICAL JOURNAL, (109598). [PMID:14728084] [10.1016/j.microc.2023.109598] |
| 6. Ting Wang, Jie Cheng, Jinmao You, Zhiwei Sun. (2023) Highly selective and sensitive high performance liquid chromatography method for determination of fumonisins from feed samples with MIL-101 based dispersed micro-solid-phase extraction and precolumn fluorescence derivatization. MICROCHEMICAL JOURNAL, 194 (15): (109320). [PMID:15109303] [10.1016/j.microc.2023.109320] |
| 7. Guo Ge, Tianlin Wang, Zihou Liu, Xiaomeng Liu, Tiange Li, Yuntang Chen, Jialin Fan, Erkigul Bukye, Xianqing Huang, Lianjun Song. (2023) A self-assembled DNA double-crossover-based fluorescent aptasensor for highly sensitivity and selectivity in the simultaneous detection of aflatoxin M1 and aflatoxin B1. TALANTA, 265 (124908). [PMID:37442003] [10.1016/j.talanta.2023.124908] |
| 8. Zhang Hong, Wang Yuli, Lin Yingtong, Chu Wenjuan, Luo Zhen, Zhao Mingqin, Hu Jiandong, Miao Xiangmin, He Fan. (2023) A catalytic hairpin assembly–based Förster resonance energy transfer sensor for ratiometric detection of ochratoxin A in food samples. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 415 (5): (867-874). [PMID:36564526] [10.1007/s00216-022-04479-5] |
| 9. Zhu Jing, Xu Wenxing, Yang Ye, Kong Rongmei, Wang Junmei. (2023) ssDNA-C3N4 conjugates-based nanozyme sensor array for discriminating mycotoxins. MICROCHIMICA ACTA, 190 (1): (1-10). [PMID:36471087] [10.1007/s00604-022-05593-y] |
| 10. Pengfei Wang, Bin Luo, Ke Liu, Cheng Wang, Hongtu Dong, Xiaodong Wang, Peichen Hou, Aixue Li. (2022) A novel COOH–GO–COOH–MWNT/pDA/AuNPs based electrochemical aptasensor for detection of AFB1. RSC Advances, 12 (43): (27940-27947). [PMID:36320289] [10.1039/D2RA03883H] |
| 11. Kezhuo Zhang, Huadong Cai, Min Lu, Daixian Wei, Jiaqi Yin, Nengshui Ding, Weihua Lai, Juan Peng. (2022) Quantum dot nanobead immunochromatographic assay based on bispecific monoclonal antibody for the simultaneous detection of aflatoxin B1 and amantadine. FOOD AND AGRICULTURAL IMMUNOLOGY, 33 (1): (403-418). [10.1080/09540105.2022.2080188] |
| 12. Mei Liu, Jinxin Zhang, Shasha Liu, Baoxin Li. (2022) A label-free visual aptasensor for zearalenone detection based on target-responsive aptamer-cross-linked hydrogel and color change of gold nanoparticles. FOOD CHEMISTRY, 389 (133078). [PMID:35490524] [10.1016/j.foodchem.2022.133078] |
| 13. Fan Jia, Yuye Li, Qingfa Gong, Dong Liu, Shuyun Meng, Chengxi Zhu, Tianyan You. (2022) A Simple Ratiometric Electrochemical Aptasensor Based on the Thionine–Graphene Nanocomposite for Ultrasensitive Detection of Aflatoxin B2 in Peanut and Peanut Oil. Chemosensors, 10 (5): (154). [10.3390/chemosensors10050154] |
| 14. Ting Chen, Yuye Li, Shuyun Meng, Chang Liu, Dong Liu, Daming Dong, Tianyan You. (2022) Temperature and pH tolerance ratiometric aptasensor: Efficiently self-calibrating electrochemical detection of aflatoxin B1. TALANTA, 242 (123280). [PMID:35144069] [10.1016/j.talanta.2022.123280] |
| 15. Chengxi Zhu, Dong Liu, Yuye Li, Ting Chen, Tianyan You. (2022) Label-free ratiometric homogeneous electrochemical aptasensor based on hybridization chain reaction for facile and rapid detection of aflatoxin B1 in cereal crops. FOOD CHEMISTRY, 373 (131443). [PMID:34742048] [10.1016/j.foodchem.2021.131443] |
| 16. Xiaoyuan Ma, Baoyi Shao, Zhouping Wang. (2021) Gold@silver nanodumbbell based inter-nanogap aptasensor for the surface enhanced Raman spectroscopy determination of ochratoxin A. ANALYTICA CHIMICA ACTA, 1188 (339189). [PMID:34794565] [10.1016/j.aca.2021.339189] |
| 17. Xiaoya Bi, Lijun Luo, Libo Li, Xiaohong Liu, Bainian Chen, Tianyan You. (2020) A FRET-based aptasensor for ochratoxin A detection using graphitic carbon nitride quantum dots and CoOOH nanosheets as donor-acceptor pair. TALANTA, 218 (121159). [PMID:32797913] [10.1016/j.talanta.2020.121159] |
| 18. Yuye Li, Dong Liu, Chengxi Zhu, Xiuli Shen, Yang Liu, Tianyan You. (2020) Sensitivity programmable ratiometric electrochemical aptasensor based on signal engineering for the detection of aflatoxin B1 in peanut. JOURNAL OF HAZARDOUS MATERIALS, 387 (122001). [PMID:31901843] [10.1016/j.jhazmat.2019.122001] |
| 19. He Deyun, Wu Zhengzong, Cui Bo, Xu Enbo, Jin Zhengyu. (2019) Building a Fluorescent Aptasensor Based on Exonuclease-Assisted Target Recycling Strategy for One-Step Detection of T-2 Toxin. Food Analytical Methods, 12 (2): (625-632). [10.1007/s12161-018-1392-x] |
| 20. Zhengzong Wu, Enbo Xu, Muhammad F.J. Chughtai, Zhengyu Jin, Joseph Irudayaraj. (2017) Highly sensitive fluorescence sensing of zearalenone using a novel aptasensor based on upconverting nanoparticles. FOOD CHEMISTRY, 230 (673). [PMID:28407965] [10.1016/j.foodchem.2017.03.100] |
| 21. Xuejuan Chen, Xiaojing Bai, Huiyan Li, Bailin Zhang. (2015) Aptamer-based microcantilever array biosensor for detection of fumonisin B-1. RSC Advances, 5 (45): (35448-35452). [10.1039/C5RA04278J] |
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