| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| E329503-500μg |
500μg |
期货  |
| |
| E329503-1mg |
1mg |
期货 |
|
| 别名 | 依贝内酯 A |
|---|---|
| 英文别名 | Ebelactone A microbial | NSC335650 | NSC-335650 | SCHEMBL10021628 | (3S,4S)-4-[(E,2S,6R,8S,9R,10R)-9-hydroxy-4,6,8,10-tetramethyl-7-oxododec-4-en-2-yl]-3-methyloxetan-2-one | ebelactone a | (E)-4-(9-hydroxy-4,6,8,10-tetramethyl-7-oxododec-4-en-2-yl)-3-met |
| 规格或纯度 | Moligand™, ≥98% |
| 英文名称 | Ebelactone A |
| 储存温度 | -20°C储存,充氩 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Ebelactone A是一种β-内酯酶抑制剂，首次从培养的土壤放线菌菌株中分离出来。它可以抑制细胞表面发现的酯酶、脂肪酶和N-甲酰蛋氨酸氨基肽酶（IC50分别为0.056、0.003和0.08µg/ml），这些酶已被证明可以刺激免疫细胞中的宿主防御。据报道，Ebelactone A还可以抑制真菌病原体产生的角质酶，从而显示出植物保护功能。
Ebelactone A is a β-lactone enzyme inhibitor that was first isolated from a cultured strain of soil actinomycetes. It can inhibit esterases, lipases, and N-formylmethionine aminopeptidases (IC50s = 0.056, 0.003, and 0.08 µg/ml, respectively) found on cell surfaces, which has been shown to stimulate host defense in immune cells. Ebelactone A is also reported to inhibit cutinases produced by fungal pathogens, thus demonstrating a plant-protective function.
|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 4-[(E)-9-hydroxy-4,6,8,10-tetramethyl-7-oxododec-4-en-2-yl]-3-methyloxetan-2-one |
| INCHI | InChI=1S/C20H34O4/c1-8-12(3)17(21)15(6)18(22)13(4)9-11(2)10-14(5)19-16(7)20(23)24-19/h9,12-17,19,21H,8,10H2,1-7H3/b11-9+ |
| InChi Key | WOISDAHQBUYEAF-PKNBQFBNSA-N |
| Canonical SMILES | CCC(C)C(C(C)C(=O)C(C)C=C(C)CC(C)C1C(C(=O)O1)C)O |
| Isomeric SMILES | CCC(C)C(C(C)C(=O)C(C)/C=C(\C)/CC(C)C1C(C(=O)O1)C)O |
| WGK Germany | 3 |
| RTECS | RQ7730000 |
| PubChem CID | 6369652 |
| 分子量 | 338.48 |
| 溶解性 | Soluble in water (partly), methanol (10 mg/ml), ethanol, and chloroform. |
|---|---|
| 密度 | ~1.0 g/cm3(Predicted) |
| 折光率 | n20D1.48 (Predicted) |
| 沸点 | ~462.8° C at 760 mmHg (Predicted) |
| 熔点 | 128.07° C (Predicted) |
| 分子量 | 338.500 g/mol |
| XLogP3 | 4.600 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 9 |
| 精确质量Exact Mass | 338.246 Da |
| 单同位素质量Monoisotopic Mass | 338.246 Da |
| 拓扑极表面积Topological Polar Surface Area | 63.600 Ų |
| 重原子数Heavy Atom Count | 24 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 482.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 7 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 1 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 1 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| WGK Germany | 3 |
|---|---|
| RTECS | RQ7730000 |
| Purity(HPLC) | 98-100（%） |
|---|---|
| LC-MS for identification | Conforms |
| Proton NMR spectrum | Conforms to Structure |
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