| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| E135204-1g |
1g |
期货  |
| |
| E135204-5g |
5g |
现货 |
|
| 别名 | 依他尼酸 |
|---|---|
| 英文别名 | 2,3-Dichloro-4-(2-methylenebutyryl)phenoxyacetic acid | Edecril | Etacrinic acid | ETACRYNIC ACID [MART.] | Kyselina 4-(2-(1-butenyl)karbonyl)-2,3-dichlorfenoxyoctova | SPBio_000054 | [2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid | ETHACRYNIC |
| 规格或纯度 | Moligand™, ≥98% |
| 英文名称 | Ethacrynic Acid |
| 生化机理 | 依他尼酸可增加苯丁酸氮芥对大鼠和人肿瘤细胞系的细胞毒性。依他尼酸是非磺胺类环状利尿剂，用于治疗高血压和充血性心力衰竭等疾病引起的水肿。依他尼酸可阻断钠-钾-氯离子共同转运。此外，依他尼酸可强效抑制谷胱甘肽 S-转移酶家族成员。研究显示，依他尼酸可有效抑制包括肺癌和胰腺癌在内的癌细胞的 Tgase-2（转谷氨酰胺酶-2）依赖性转移。 |
| 储存温度 | 2-8°C储存,避光 |
| 运输条件 | 冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 盐酸钠（钾）共转运体 2 抑制剂 |
| 备注 | 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| 产品介绍 |
Ethacrynic acid 具有抗炎抗癌活性。Ethacrynic acid 是一种口服有效的利尿剂。Ethacrynic acid 是谷胱甘肽 S-转移酶 (GSTs) 和 Wnt 信号通路的抑制剂。Ethacrynic acid 是一种放射增敏剂。Ethacrynic acid 可以抑制小鼠气道平滑肌 (ASM) 收缩。 Ethacrynic acid 可以增加眼睛房水流出用于青光眼的研究。
Ethacrynic acid is non sulfonamide loop diuretic that is used to treat high blood pressure and the swelling caused by diseases like congestive heart failure. Ethacrynic acid blocks sodium-potassium-chloride cotransport. Also, Ethacrynic acid potently inhibits glutathione S-transferase family members. Studies show that ethacrynic acid potently inhibits Tgase-2 (transglutaminase-2) dependent metastasis of cancer cells including lung and pancreatic cancers. |
| ALogP | 3.8 |
|---|
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 504750650 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid |
| INCHI | InChI=1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17) |
| InChi Key | AVOLMBLBETYQHX-UHFFFAOYSA-N |
| Canonical SMILES | CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl |
| Isomeric SMILES | CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl |
| WGK Germany | 1 |
| PubChem CID | 3278 |
| 分子量 | 303.14 |
| 溶解性 | Soluble in ethanol, chloroform, ether, ammonia, carbonates, and methanol. Insoluble in water., Soluble in ethanol, chloroform, ether, ammonia, carbonates, and methanol. Insoluble in water. |
|---|---|
| 敏感性 | 对光线敏感 |
| 分子量 | 303.130 g/mol |
| XLogP3 | 3.800 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 6 |
| 精确质量Exact Mass | 302.011 Da |
| 单同位素质量Monoisotopic Mass | 302.011 Da |
| 拓扑极表面积Topological Polar Surface Area | 63.600 Ų |
| 重原子数Heavy Atom Count | 19 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 370.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害 H312: 皮肤接触有害 H332: 吸入有害 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P330: 漱口 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P317: 寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 1 |
| Purity(Neutralization titration) | 97.5-102.5（%） |
|---|---|
| Melting point | 123-127（℃） |
| Purity(HPLC) | 98-100（%） |
| Appearance（E135204) | white to beige powder |
| Proton NMR spectrum | Conforms to Structure |
| Solubility in MeOH | almost transparency |
| LC-MS for identification | Conforms |
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
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|---|---|---|---|
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分析证书 | 23-08-10 | E135204 |
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¥205.90
| 1. Ying Wen, Zhiqing Long, Xiaoxia Bai, Fangjun Huo, Caixia Yin. (2022) Specific fluorescence release based on synergistic activation of enzymes and position-dependent of electrophilic groups to diagnose intrahepatic cholestasis of pregnancy. CHEMICAL ENGINEERING JOURNAL, 440 (135978). [10.1016/j.cej.2022.135978] |
| 1. D'Onofrio N et al.. (2021) SIRT3 and Metabolic Reprogramming Mediate the Antiproliferative Effects of Whey in Human Colon Cancer Cells.. Cancers (Basel), 13 (20): [PMID:34680344] |
| 2. Ying Wen, Zhiqing Long, Xiaoxia Bai, Fangjun Huo, Caixia Yin. (2022) Specific fluorescence release based on synergistic activation of enzymes and position-dependent of electrophilic groups to diagnose intrahepatic cholestasis of pregnancy. CHEMICAL ENGINEERING JOURNAL, 440 (135978). [10.1016/j.cej.2022.135978] |
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