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N-乙基顺丁烯二酰亚胺（NEM）

47篇引用文献
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货号 (SKU) 包装规格 是否现货 价格 数量
E100553-1g
 1g 现货 Stock Image
E100553-5g
 5g 现货 Stock Image
E100553-25g
 25g 现货 Stock Image
E100553-100g
 100g 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
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Apoptosis (1467) Cathepsin (64) Cell Cycle/DNA Damage (2603) Deubiquitinase (86) Metabolic Enzyme/Protease (4888) 吡咯啉类化合物 (2)
main product photo

基本描述

别名 N-乙基马来酰亚胺
英文别名 NEM | maleic acid N-ethylimide | NSC92547 | NSC-92547 | USAF B-121 | ethylmaleimide | HSCI1_000382 | N-ethylmaleimide | 1-Ethyl-1H-pyrrole-2,5-dione | EU-0100492 | GTPL5335 | N-Ethylmaleimide, purum p.a., >=99.0% (HPLC) | MFCD00005509 | NCGC00015415-04 |
规格或纯度 Moligand™, 超纯级, ≥99%
英文名称 N-Ethylmaleimide（NEM）
生化机理 使 NADP 依赖性异柠檬酸脱氢酶和许多核酸内切酶失活的巯基烷化?剂。 增强来自交感神经元的原生 M 通道的电流，并作为 KCNQ2、KCNQ4 和 KCNQ5 通道的开放剂。
储存温度 2-8°C储存,充氩
运输条件 冰袋运输
产品介绍

易溶于醇及醚，微溶于水。有刺激性，催泪。 蛋白质半胱氨酸残基的共价修饰试剂。

Reagent for the covalent modification of cysteine residues in proteins.

AI解读

关联靶点（人）

TYMS Tclin Thymidylate synthase (1651 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALB Tchem Serum albumin (2651 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK293 (82097 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H460 (60772 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SF-268 (49410 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MGLL Tchem Monoglyceride lipase (1909 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
THPO Tbio Thrombopoietin (834 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IDE Tchem Insulin-degrading enzyme (806 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ATG4B Tchem Cysteine protease ATG4B (985 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ANXA2 Tbio Annexin A2 (15 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SENP1 Tchem Sentrin-specific protease 1 (681 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
USP7 Tchem Ubiquitin carboxyl-terminal hydrolase 7 (837 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SENP2 Tchem Sentrin-specific protease 2 (79 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MEST Tbio Mesoderm-specific transcript homolog protein (25 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Faah Anandamide amidohydrolase (3907 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nannizzia gypsea (2039 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Aspergillus flavus (8875 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Aspergillus niger (16508 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Saccharomyces cerevisiae (19171 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Aspergillus fumigatus (16427 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida tropicalis (8381 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trichophyton rubrum (3646 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Npsr1 Neuropeptide S receptor (260 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trichophyton mentagrophytes (4846 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mboat4 Ghrelin O-acyltransferase (37 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
crtY Lycopene cyclase (9 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504750765
EC号 204-892-4
分子类型 小分子
IUPAC Name 1-ethylpyrrole-2,5-dione
INCHI InChI=1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3
InChi Key HDFGOPSGAURCEO-UHFFFAOYSA-N
Canonical SMILES CCN1C(=O)C=CC1=O
Isomeric SMILES CCN1C(=O)C=CC1=O
WGK Germany 3
RTECS UX9625000
关联CAS 25668-22-8,128-53-0,25668-22-8
NSC Number 7638
UN Number 2928
MeSH Entry Terms Ethylmaleimide;N Ethylmaleimide;N-Ethylmaleimide
分子量 125.13
Beilstein号 112448
Reaxy-Rn 112448

化学和物理性质

溶解性 Soluble in ethanol, water, chloroform, methanol and toluene.
密度 1.207
敏感性 对光、热、空气敏感
闪点(℉) 163.4℉
闪点(℃) 73°C
沸点 210°C
熔点 43-46°C
分子量 125.130 g/mol
XLogP3 0.900
氢键供体数Hydrogen Bond Donor Count 0
氢键受体数Hydrogen Bond Acceptor Count 2
可旋转键计数Rotatable Bond Count 1
精确质量Exact Mass 125.048 Da
单同位素质量Monoisotopic Mass 125.048 Da
拓扑极表面积Topological Polar Surface Area 37.400 Ų
重原子数Heavy Atom Count 9
形式电荷Formal Charge 0
复杂度Complexity 165.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS06,   GHS05,   GHS07
信号词 Danger
危险声明

H301: 吞咽会中毒

H311: 皮肤接触有毒

H314: 造成严重的皮肤灼伤和眼睛损伤

H317: 可能引起皮肤过敏反应

H300: 吞咽致命
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染：用水充分清洗。

P321: 特殊处理（请参阅此标签上的...）。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P301+P330+P331: 如误吞咽：漱口。不要诱导呕吐。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P363: 再次使用之前，请清洗受污染的衣物。

P272: 被污染的工作服不允许离开工作场所

P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P330: 漱口

P361+P364: 立即脱掉所有沾染的衣服，清洗后方可重新使用。

P301+P316: 如果吞咽：立即寻求紧急医疗救助。

P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。

P302+P361+P354: 如果接触皮肤：立即脱掉所有被污染的衣服。立即用水冲洗几分钟。

P316: 立即寻求紧急医疗救助。
WGK Germany 3
RTECS UX9625000
Reaxy-Rn 112448
Merck Index 3822
个人防护装备 Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

 SDS英文版

技术规格说明书

Sodium(Na) 0-50（ppm）
Magnesium (Mg) 0-5（ppm）
Zinc(Zn) 0-5（ppm）
lron(Fe) 0-5（ppm）
Manganese(Mn) 0-5（ppm）
Potassium(K) 0-50（ppm）
Strontium(Sr) 0-5（ppm）
Aluminum(Al) 0-5（ppm）
Bismuth(Bi) 0-5（ppm）
Cadmium(Cd) 0-5（ppm）
Cobalt (Co) 0-5（ppm）
Barium(Ba) 0-5（ppm）
Nickel(Ni) 0-5（ppm）
Melting point 44-47（℃）
Chloride (Cl-) 0-50（ppm）
Copper(Cu) 0-5（ppm）
Sulfate(SO42-) 0-100（ppm）
Purity(HPLC) 98-100（%）
Calcium (Ca) 0-10（ppm）
Chrome(Cr) 0-5（ppm）
(Pb)Lead 0-5（ppm）
Ignition Residue 0-0.05（%）
Lithium(Li) 0-5（ppm）
Appearance（E100553) white to off-white powder,crystals,flakes or chunk
Absorption absorption1M/382 nm, methanol cut-off
Infrared spectrum Conforms to Structure
Insoluble matter pass
Solubility in H2O Almost transparency
Solubility in MeOH，Clear,Colorless,1 M at 20 °C pass

 技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到23个结果

批号(Lot Number) 证书类型 日期 货号
E2507342 分析证书 25-04-26 E100553
E2507343 分析证书 25-04-26 E100553
E2507315 分析证书 25-04-26 E100553
E2507344 分析证书 25-04-26 E100553
A2517231 分析证书 25-01-07 E100553
A2417231 分析证书 25-01-07 E100553
A2517230 分析证书 25-01-07 E100553
A2517232 分析证书 25-01-07 E100553
A2517233 分析证书 25-01-07 E100553
C2303491 分析证书 24-12-17 E100553
C2303492 分析证书 24-12-17 E100553
C2303493 分析证书 24-12-17 E100553
C2303745 分析证书 24-12-12 E100553
C2303730 分析证书 24-12-12 E100553
C2303497 分析证书 24-12-12 E100553
C2303494 分析证书 24-12-12 E100553
F2202028 分析证书 24-03-18 E100553
F2214551 分析证书 24-03-18 E100553
F2214552 分析证书 24-03-18 E100553
F2214553 分析证书 24-03-18 E100553
K2110381 分析证书 23-08-02 E100553
I2404031 分析证书 22-11-25 E100553
F2202029 分析证书 22-02-14 E100553

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17. Ying-Jie Tang, Wen-Le Fang, Kui Ren, Xiao-Feng Guo, Hong Wang.  (2021)  A turn-on homodimer fluorescent probe based on homo-FRET for the sensing of biothiols in lysosome: a trial of a new turn-on strategy.  ANALYST,  146  (9): (2974-2982).  [PMID:33949411] [10.1039/D1AN00161B]
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