| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D424780-1ml |
1ml |
现货  |
|
| 别名 | DOC acetate | 乙酸去氧皮质酮 | Doca |
|---|---|
| 英文别名 | Deoxycorticosterone acetate | 56-47-3 | DESOXYCORTICOSTERONE ACETATE | DOCA | Desoxycortone acetate | Cortexone acetate | Percotol | DOC acetate | Decosteron | Decosterone | Sincortex | 11-Deoxycorticosterone acetate | Decostrate | Descorterone | Docaquosum | Dorcostrin | Krinocorts | Pri |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Deoxycorticosterone acetate |
| 生化机理 | 类固醇激素通常用于诱发实验动物的高血压。这种形式的高血压取决于对包括大脑肾素-血管紧张素系统在内的中枢升压机制的调节。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | 矿质皮质激素受体激动剂 |
| 产品介绍 |
Deoxycorticosterone acetate是一种类固醇激素，用于肌肉注射，是肾上腺皮质类固醇的代替疗法。 Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid. |
| ALogP | 3.1 |
|---|
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 200-275-9 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | [2-[(8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate |
| INCHI | InChI=1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1 |
| InChi Key | VPGRYOFKCNULNK-ACXQXYJUSA-N |
| Canonical SMILES | CC(=O)OCC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C |
| Isomeric SMILES | CC(=O)OCC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C |
| WGK Germany | 3 |
| RTECS | HG0525000 |
| PubChem CID | 5952 |
| 分子量 | 372.5 |
| Beilstein号 | 2570798 |
| 比旋光度 | 20/D： +170.0 to +180.0 deg(C=1, Dioxane) |
|---|---|
| 熔点 | 157°C |
| 分子量 | 372.500 g/mol |
| XLogP3 | 3.100 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 4 |
| 精确质量Exact Mass | 372.23 Da |
| 单同位素质量Monoisotopic Mass | 372.23 Da |
| 拓扑极表面积Topological Polar Surface Area | 60.400 Ų |
| 重原子数Heavy Atom Count | 27 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 707.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 6 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS08 |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H373: 通过长时间或反复暴露对器官造成损害 H360: 可能损害生育力或未出生的孩子 |
| 预防措施声明 |
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | HG0525000 |
| 个人防护装备 | Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter |
| concentration (1mL in DMSO) | 9.0-11.0（mmol/L） |
|---|---|
| NMR Spectrum 1H | Conforms to Structure |
| 1. Hao Jiameng, Chang Liping, Wang Dandong, Ji Chuanyuan, Zhang Shaolan, Hou Yunlong, Wu Yiling. (2023) Periplocin Alleviates Cardiac Remodeling in DOCA-Salt–Induced Heart Failure Rats. Journal of Cardiovascular Translational Research, 16 (1): (127-140). [PMID:35616880] [10.1007/s12265-022-10277-2] |
| 2. Yanhong Liu, Lingchao Li, Jiyong Liu, Mengnan Yang, Honglan Wang, Xuxin Chu, Jianping Zhou, Meirong Huo, Tingjie Yin. (2021) Biomineralization-inspired dasatinib nanodrug with sequential infiltration for effective solid tumor treatment. BIOMATERIALS, 267 (120481). [PMID:33189053] [10.1016/j.biomaterials.2020.120481] |
| 1. Hao Jiameng, Chang Liping, Wang Dandong, Ji Chuanyuan, Zhang Shaolan, Hou Yunlong, Wu Yiling. (2023) Periplocin Alleviates Cardiac Remodeling in DOCA-Salt–Induced Heart Failure Rats. Journal of Cardiovascular Translational Research, 16 (1): (127-140). [PMID:35616880] [10.1007/s12265-022-10277-2] |
| 2. Yanhong Liu, Lingchao Li, Jiyong Liu, Mengnan Yang, Honglan Wang, Xuxin Chu, Jianping Zhou, Meirong Huo, Tingjie Yin. (2021) Biomineralization-inspired dasatinib nanodrug with sequential infiltration for effective solid tumor treatment. BIOMATERIALS, 267 (120481). [PMID:33189053] [10.1016/j.biomaterials.2020.120481] |
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