| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D421897-1ml |
1ml |
现货  |
|
| 别名 | 色甘酸盐 | 色甘酸 |
|---|---|
| 英文别名 | CROMOLYN SODIUM | 15826-37-6 | Sodium cromoglycate | Disodium cromoglycate | sodium cromoglicate | Sodium cromolyn | Gastrocrom | Cromolyn sodium salt | Cromolyn disodium salt | Cromoptic | Nasalcrom | Opticrom | Crolom | Cromoglycate disodium | Intal | Natrii cromoglicas | Natrium crom |
| 规格或纯度 | 2mM in Water |
| 英文名称 | Disodium Cromoglycate |
| 生化机理 | 可逆性肺泡巨噬细胞阻滞剂和肥大细胞稳定剂。抗哮喘和抗炎剂。口服活性。具有体内和体外活性。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
A compound that blocks the release of pro-inflammatory mediators. This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 239-926-7 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | disodium;5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate |
| INCHI | InChI=1S/C23H16O11.2Na/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30;;/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30);;/q;2*+1/p-2 |
| InChi Key | VLARUOGDXDTHEH-UHFFFAOYSA-L |
| Canonical SMILES | C1=CC2=C(C(=C1)OCC(COC3=CC=CC4=C3C(=O)C=C(O4)C(=O)[O-])O)C(=O)C=C(O2)C(=O)[O-].[Na+].[Na+] |
| Isomeric SMILES | C1=CC2=C(C(=C1)OCC(COC3=CC=CC4=C3C(=O)C=C(O4)C(=O)[O-])O)C(=O)C=C(O2)C(=O)[O-].[Na+].[Na+] |
| WGK Germany | 2 |
| RTECS | DJ2380000 |
| PubChem CID | 27503 |
| 分子量 | 512.33 |
| Reaxy-Rn | 3647577 |
| 敏感性 | 对湿度敏感 |
|---|---|
| 分子量 | 512.299 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 11 |
| 可旋转键计数Rotatable Bond Count | 6 |
| 精确质量Exact Mass | 512.033 Da |
| 单同位素质量Monoisotopic Mass | 512.033 Da |
| 拓扑极表面积Topological Polar Surface Area | 172.000 Ų |
| 重原子数Heavy Atom Count | 36 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 824.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 3 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 2 |
| RTECS | DJ2380000 |
| Reaxy-Rn | 3647577 |
| Merck Index | 2590 |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
| concentration (1mL in DMSO) | 1.0-3.0（mmol/L） |
|---|---|
| NMR Spectrum 1H | Conforms to Structure |
| 1. Mingkang Zhang, Ruirui Cui, Yan Zhou, Yanrong Ma, Yongwen Jin, Lina Wang, Wen Kou, Xin’an Wu. (2023) Accumulation of Renal Fibrosis in Hyperuricemia Rats Is Attributed to the Recruitment of Mast Cells, Activation of the TGF-β1/Smad2/3 Pathway, and Aggravation of Oxidative Stress. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (13): (10839). [PMID:37446016] [10.3390/ijms241310839] |
| 2. Lei Wang, Anduo Zhou, Chongshuai Chen, Xia Huang, Shanfeng Zhang, Junying Chen. (2023) Preparation and properties of composite hydrogels for 3D bioprinting. POLYMERS FOR ADVANCED TECHNOLOGIES, 34 (7): (2369-2383). [10.1002/pat.6057] |
| 3. Mingkang Zhang, Ruirui Cui, Yan Zhou, Yanrong Ma, Yongwen Jin, Xueyan Gou, Jinru Yang, Xin’an Wu. (2023) Uric acid accumulation in the kidney triggers mast cell degranulation and aggravates renal oxidative stress. TOXICOLOGY, 483 (153387). [PMID:36464070] [10.1016/j.tox.2022.153387] |
| 4. Xiaojun Zhang, Wensi Wu, Zhenzhen Zheng, Liang Li, Junjun Chen, Junying Zhong, Le Zhao, Jiawei Chen, Zhi Wang, Fanqing Meng. (2022) Mast cell stabilizer disodium cromoglycate improves long-term cognitive impairment after general anesthesia exposure in neonatal mice. Frontiers in Neuroscience, 16 (990333). [PMID:36188474] [10.3389/fnins.2022.990333] |
| 5. Yan Zhou, Mengmeng Wei, Mingkang Zhang, Jianping Zhang, Fabing Tang, Xin’an Wu. (2022) Adefovir accumulation in the renal interstitium triggers mast cell degranulation and promotes renal interstitial fibrosis. TOXICOLOGY LETTERS, 359 (10). [PMID:35114312] [10.1016/j.toxlet.2022.01.018] |
| 1. Mingkang Zhang, Ruirui Cui, Yan Zhou, Yanrong Ma, Yongwen Jin, Lina Wang, Wen Kou, Xin’an Wu. (2023) Accumulation of Renal Fibrosis in Hyperuricemia Rats Is Attributed to the Recruitment of Mast Cells, Activation of the TGF-β1/Smad2/3 Pathway, and Aggravation of Oxidative Stress. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (13): (10839). [PMID:37446016] [10.3390/ijms241310839] |
| 2. Lei Wang, Anduo Zhou, Chongshuai Chen, Xia Huang, Shanfeng Zhang, Junying Chen. (2023) Preparation and properties of composite hydrogels for 3D bioprinting. POLYMERS FOR ADVANCED TECHNOLOGIES, 34 (7): (2369-2383). [10.1002/pat.6057] |
| 3. Mingkang Zhang, Ruirui Cui, Yan Zhou, Yanrong Ma, Yongwen Jin, Xueyan Gou, Jinru Yang, Xin’an Wu. (2023) Uric acid accumulation in the kidney triggers mast cell degranulation and aggravates renal oxidative stress. TOXICOLOGY, 483 (153387). [PMID:36464070] [10.1016/j.tox.2022.153387] |
| 4. Xiaojun Zhang, Wensi Wu, Zhenzhen Zheng, Liang Li, Junjun Chen, Junying Zhong, Le Zhao, Jiawei Chen, Zhi Wang, Fanqing Meng. (2022) Mast cell stabilizer disodium cromoglycate improves long-term cognitive impairment after general anesthesia exposure in neonatal mice. Frontiers in Neuroscience, 16 (990333). [PMID:36188474] [10.3389/fnins.2022.990333] |
| 5. Yan Zhou, Mengmeng Wei, Mingkang Zhang, Jianping Zhang, Fabing Tang, Xin’an Wu. (2022) Adefovir accumulation in the renal interstitium triggers mast cell degranulation and promotes renal interstitial fibrosis. TOXICOLOGY LETTERS, 359 (10). [PMID:35114312] [10.1016/j.toxlet.2022.01.018] |
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