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1-脱氧野尻霉素, α-葡萄糖苷酶抑制剂

有效的α-糖苷酶抑制剂。抗高血糖药。
4篇引用文献
  • CAS编号: 19130-96-2
  • 分子式: C6H13NO4
  • 分子量: 163.17
  • PubChem编号: 29435
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货号 (SKU) 包装规格 是否现货 价格 数量
D101242-10mg
 10mg 现货 Stock Image
D101242-20mg
 20mg 现货 Stock Image
D101242-50mg
 50mg 现货 Stock Image
D101242-100mg
 100mg 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
查看相关系列
alpha glucosidase Inhibitor (3) Glucosidase (71) Metabolic Enzyme/Protease (4888) PI3K (243) PI3K/Akt/mTOR (764)
main product photo

基本描述

英文别名 (2R,3R,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol | (2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol | (+)-1-Deoxynojirimycin | 1,5-Dideoxy-1,5-imino-D-sorbitol | DNJ
规格或纯度 Moligand™, 分析标准品, ≥98%
英文名称 1-Deoxynojirimycin
生化机理 有效的α-糖苷酶抑制剂（IC 50 = 30 nM）。抗高血糖药。下调SGLT1，Na + / K + -ATP和GLUT2的表达。降低MCP-1和TNF-α水平。在体内显示出抗糖尿病，抗病毒，抗肥胖和抗炎作用。
应用 An inhibitor of α-glucosidase I and II
储存温度 -20°C储存,充氩
运输条件 超低温冰袋运输
作用类型 抑制剂
作用机制 α-葡萄糖苷酶抑制剂
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Deoxynojirimycin is a Maltase-glucoamylase (α-glucosidase I and II) inhibitor. Interferes with N-linked glycosylation. Reported to inhibit trimming of oligosaccharides upon treatment of secretory glycoprotein IgD- and IgM-producing cells. Reported to inhibit secretion of IgD. Deoxynojirimycin is an inhibitor of β-glucosidase and Maltase-glucoamylase.An inhibitor of α-glucosidase I and II

Deoxynojirimycin is a Maltase-glucoamylase (α-glucosidase I and II) inhibitor. Interferes with N-linked glycosylation. Reported to inhibit trimming of oligosaccharides upon treatment of secretory glycoprotein IgD- and IgM-producing cells. Reported to inhibit secretion of IgD. Deoxynojirimycin is an inhibitor of β-glucosidase and Maltase-glucoamylase.
An inhibitor of α-glucosidase I and II

关联靶点（人）

GAA Tclin 溶酶体α-葡萄糖苷酶(Lysosomal alpha-glucosidase) (4 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
MGAM Tclin 麦芽糖酶-葡糖淀粉酶，肠道(Maltase-glucoamylase, intestinal) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
GANAB Tchem 中性α-葡萄糖苷酶AB(Neutral alpha-glucosidase AB) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
MGAM Tclin Maltase-glucoamylase (654 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
UGCG Tclin Ceramide glucosyltransferase (308 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLB1 Tchem Beta-galactosidase (339 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLA Tclin Alpha-galactosidase A (5444 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GBA1 Tclin Beta-glucocerebrosidase (14647 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GANAB Tchem Neutral alpha-glucosidase AB (90 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GANC Tchem Neutral alpha-glucosidase C (4 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TREH Tchem Trehalase (5 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
JAK1 Tclin Tyrosine-protein kinase JAK1 (8569 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GAA Tclin Lysosomal alpha-glucosidase (35701 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NAGA Tbio Alpha-galactosidase B (11 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NR1H3 Tchem LXR-alpha (2891 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MANBA Tchem Beta-mannosidase (62 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FUCA1 Tchem Alpha-L-fucosidase I (304 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAN2B1 Tchem Lysosomal alpha-mannosidase (172 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GBA2 Tchem Beta-glucosidase (258 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GBA3 Tbio Beta-glucosidase cytosolic (63 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SI Tchem Sucrase-isomaltase (84 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FUT10 Tdark Fucosyltransferase 10 (23 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAN2B2 Tbio Epididymis-specific alpha-mannosidase (14 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NR1H2 Tchem LXR-beta (3841 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BGC-823 (3035 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MCF7 (126967 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MOLT-4 (49676 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MT4 (17854 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCT-116 (91556 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HUVEC (11049 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PBMC (10003 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AGL Tbio Glycogen debranching enzyme (27 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LCT Tbio Lactase-phlorizin hydrolase (37 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCC1937 (423 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MS-1 (160 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MGAM Tclin Alpha glucosidase (860 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Gusb Beta-glucuronidase (17 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GAA Alpha-glucosidase (25 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Lct Lactase-glycosylceramidase (87 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Man2a1 Mannosidase 2 alpha 1 (15 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Man2c1 Alpha-mannosidase 2C1 (19 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Man2b1 Mannosidase 2, alpha B1 (9 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Gaa Acidic alpha-glucosidase (551 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
bglA Beta-glucosidase A (127 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
aglC Alpha-galactosidase C (14 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAL62 Alpha-glucosidase MAL62 (106 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
melA Alpha-galactosidase (10 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Man1 Alpha-mannosidase (188 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FUCA1 Alpha-L-fucosidase 1 (358 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IMA1 Oligo-1,6-glucosidase (218 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BCHE Cholinesterase (8742 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GBA1 Glucosylceramidase (58 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GCGR Uncharacterized protein (2 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 小分子
IUPAC Name (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol
INCHI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
InChi Key LXBIFEVIBLOUGU-JGWLITMVSA-N
Canonical SMILES C1C(C(C(C(N1)CO)O)O)O
Isomeric SMILES C1[C@@H]([C@H]([C@@H]([C@H](N1)CO)O)O)O
分子量 163.17
Reaxy-Rn 13313614
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13313614&ln=

化学和物理性质

溶解性 Soluble in water (25 mg/ml), and methanol., Soluble in water (25 mg/ml), and methanol.
密度 1.456
敏感性 对空气敏感
分子量 163.170 g/mol
XLogP3 -2.300
氢键供体数Hydrogen Bond Donor Count 5
氢键受体数Hydrogen Bond Acceptor Count 5
可旋转键计数Rotatable Bond Count 1
精确质量Exact Mass 163.084 Da
单同位素质量Monoisotopic Mass 163.084 Da
拓扑极表面积Topological Polar Surface Area 93.000 Ų
重原子数Heavy Atom Count 11
形式电荷Formal Charge 0
复杂度Complexity 132.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 4
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 Warning
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染：用水充分清洗。

P321: 特殊处理（请参阅此标签上的...）。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P271: 仅在室外或通风良好的地方使用。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P403+P233: 存放在通风良好的地方。保持容器密闭。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

P319: 如果你感到不适，请寻求医疗帮助。
Reaxy-Rn 13313614
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13313614&ln=

 SDS英文版

技术规格说明书

Purity(HPLC) 98-100（%）
Appearance（D101242) White to Off-White Powder
Proton NMR spectrum Conforms to Structure

 技术规格说明书

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批号(Lot Number) 证书类型 日期 货号
J2217436 分析证书 24-07-17 D101242
J2217445 分析证书 24-07-17 D101242
F2223192 分析证书 24-03-20 D101242
J2326039 分析证书 23-10-11 D101242
J2326040 分析证书 23-10-11 D101242
J2326208 分析证书 23-10-11 D101242
J2217437 分析证书 22-09-26 D101242
B2216221 分析证书 22-01-10 D101242
B2216222 分析证书 22-01-10 D101242
B2216220 分析证书 22-01-10 D101242

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此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Xinlin Chen, Ying Wu, Yucheng Gu, Jianguang Luo, Lingyi Kong.  (2023)  Efficient discovery of potent α-glucosidase inhibitors from Paeoniae lactiflora using enzyme–MOF nanocomposites and competitive indicators.  Food & Function,  14  (1): (171-180).  [PMID:36477546] [10.1039/D2FO02783F]
2. Yang Liu, Xue Zhou, Dan Zhou, Yongxing Jian, Jingfu Jia, Fahuan Ge.  (2022)  Isolation of Chalcomoracin as a Potential α-Glycosidase Inhibitor from Mulberry Leaves and Its Binding Mechanism.  MOLECULES,  27  (18): (5742).  [PMID:36144478] [10.3390/molecules27185742]
3. Yanfang Yu, Yuhuan Chen, Xuping Shi, Chuan Ye, Junwen Wang, Jinzhi Huang, Bing Zhang, Zeyuan Deng.  (2022)  Hepatoprotective effects of different mulberry leaf extracts against acute liver injury in rats by alleviating oxidative stress and inflammatory response.  Food & Function,  13  (16): (8593-8604).  [PMID:35894215] [10.1039/D2FO00282E]
4. Yanfang Yu, Hongyan Li, Bing Zhang, Junwen Wang, Xuping Shi, Jinzhi Huang, Jianyuan Yang, Yanfei Zhang, Zeyuan Deng.  (2018)  Nutritional and functional components of mulberry leaves from different varieties: Evaluation of their potential as food materials.  INTERNATIONAL JOURNAL OF FOOD PROPERTIES,  [10.1080/10942912.2018.1489833]

参考文献

1. Xinlin Chen, Ying Wu, Yucheng Gu, Jianguang Luo, Lingyi Kong.  (2023)  Efficient discovery of potent α-glucosidase inhibitors from Paeoniae lactiflora using enzyme–MOF nanocomposites and competitive indicators.  Food & Function,  14  (1): (171-180).  [PMID:36477546] [10.1039/D2FO02783F]
2. Yang Liu, Xue Zhou, Dan Zhou, Yongxing Jian, Jingfu Jia, Fahuan Ge.  (2022)  Isolation of Chalcomoracin as a Potential α-Glycosidase Inhibitor from Mulberry Leaves and Its Binding Mechanism.  MOLECULES,  27  (18): (5742).  [PMID:36144478] [10.3390/molecules27185742]
3. Yanfang Yu, Yuhuan Chen, Xuping Shi, Chuan Ye, Junwen Wang, Jinzhi Huang, Bing Zhang, Zeyuan Deng.  (2022)  Hepatoprotective effects of different mulberry leaf extracts against acute liver injury in rats by alleviating oxidative stress and inflammatory response.  Food & Function,  13  (16): (8593-8604).  [PMID:35894215] [10.1039/D2FO00282E]
4. Yanfang Yu, Hongyan Li, Bing Zhang, Junwen Wang, Xuping Shi, Jinzhi Huang, Jianyuan Yang, Yanfei Zhang, Zeyuan Deng.  (2018)  Nutritional and functional components of mulberry leaves from different varieties: Evaluation of their potential as food materials.  INTERNATIONAL JOURNAL OF FOOD PROPERTIES,  [10.1080/10942912.2018.1489833]

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