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哥伦宾
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C463852-1mg |
1mg |
期货  |
|
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基本描述
| 英文别名 | (1R,2S,3S,5S,8R,11R,12R)-5-(Furan-3-yl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione | CHEBI:3829 | Columbin | SCHEMBL2153783 | C09077 | HY-N0389 | Q27106207 | AS-82882 | AKOS030573585 | Columbin, >=95% (LC/MS- |
|---|---|
| 规格或纯度 | ≥95%(LC/MS-ELSD) |
| 英文名称 | Columbin |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Description Natural product derived from plant source.} |
产品属性
| ALogP | 1.849 |
|---|---|
| Rotatable Bond | 1 |
名称和识别符
| IUPAC Name | (1R,2S,3S,5S,8R,11R,12R)-5-(furan-3-yl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione |
|---|---|
| INCHI | InChI=1S/C20H22O6/c1-18-9-14(11-5-8-24-10-11)25-16(21)12(18)3-6-19(2)15(18)13-4-7-20(19,23)17(22)26-13/h4-5,7-8,10,12-15,23H,3,6,9H2,1-2H3/t12-,13+,14-,15-,18+,19+,20-/m0/s1 |
| InChi Key | AALLCALQGXXWNA-QJNFORGASA-N |
| Canonical SMILES | CC12CCC3C(=O)OC(CC3(C1C4C=CC2(C(=O)O4)O)C)C5=COC=C5 |
| Isomeric SMILES | C[C@@]12CC[C@H]3C(=O)O[C@@H](C[C@]3([C@@H]1[C@H]4C=C[C@@]2(C(=O)O4)O)C)C5=COC=C5 |
| PubChem CID | 442015 |
| 分子量 | 358.39 |
化学和物理性质
| DMSO(mg / mL) Max Solubility | 71 |
|---|---|
| DMSO(mM) Max Solubility | 198.11092582314 |
| 分子量 | 358.400 g/mol |
| XLogP3 | 2.200 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 6 |
| 可旋转键计数Rotatable Bond Count | 1 |
| 精确质量Exact Mass | 358.142 Da |
| 单同位素质量Monoisotopic Mass | 358.142 Da |
| 拓扑极表面积Topological Polar Surface Area | 86.000 Ų |
| 重原子数Heavy Atom Count | 26 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 702.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 7 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
技术规格说明书
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
参考文献
| 1. Hiroyuki Kohno,Masayo Maeda,Mikio Tanino,Yoshiaki Tsukio,Naomi Ueda,Keiji Wada,Shigeyuki Sugie,Hideki Mori,Takuji Tanaka. (2002-06-18) A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis.. Cancer letters, 183 ((2)): (131-139). [PMID:12065087] |
| 2. A J Nok,E Balogun,J A Lori,M S Abubakar. (2002-10-09) Inhibition of Naja nigricolis venom acidic phospholipase A2 catalysed hydrolysis of ghost red blood cells by columbin.. Journal of enzyme inhibition and medicinal chemistry, 17 ((1)): (55-59). [PMID:12365462] |
| 3. A J Nok,B A Sallau,E Onyike,N M Useh. (2005-10-07) Columbin inhibits cholesterol uptake in bloodstream forms of Trypanosoma brucei-A possible trypanocidal mechanism.. Journal of enzyme inhibition and medicinal chemistry, 20 ((4)): (365-368). [PMID:16206831] |
| 4. Siddig Ibrahim Abdelwahab,Waleed Syaed Koko,Manal Mohamed Elhassan Taha,Syam Mohan,Mouna Achoui,Mahmood Ameen Abdulla,Mohd Rais Mustafa,Syahida Ahmad,Mohamed Ibrahim Noordin,Chung Lip Yong,Mohd Roslan Sulaiman,Rozana Othman,Asfarina Amir Hassan. (2012-01-10) In vitro and in vivo anti-inflammatory activities of columbin through the inhibition of cycloxygenase-2 and nitric oxide but not the suppression of NF-κB translocation.. European journal of pharmacology, 678 ((1-3)): (61-70). [PMID:22227329] |
| 5. K Swaminathan,U C Sinha,S Ramakumar,R K Bhatt,B K Sabata. (1989-02-15) Structure of columbin, a diterpenoid furanolactone from Tinospora cordifolia Miers.. Acta crystallographica. Section C, Crystal structure communications, 45 ( Pt 2) (300-303). [PMID:2610972] |
| 6. K Wada,T Kurihara,M Yagi,R Kobayashi,H Kaminaga,K Toi,M Haga. (1995-04-01) Columbin isolated from calumbae radix affects the sleeping time of anesthetized mice.. Biological & pharmaceutical bulletin, 18 ((4)): (634-636). [PMID:7655444] |
| 7. Qirong Shi,Mingjin Liang,Weidong Zhang,Chuan Zhang,Runhui Liu,Yunheng Shen,Huiliang Li,Xiaolin Wang,Xiangwei Wang,Qiongqun Pan,Chunlin Chen. (2007-03-09) Quantitative LC/MS/MS method and pharmacokinetic studies of columbin, an anti-inflammation furanoditerpen isolated from Radix Tinosporae.. Biomedical chromatography : BMC, 21 ((6)): (642-648). [PMID:17345572] |