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氯霉素琥珀酸钠盐, 细菌 70S 核糖体抑制剂

1篇引用文献
  • ≥80%(HPLC)
有货

库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
C463077-5g
 5g 期货 Stock Image
C463077-25g
 25g 期货 Stock Image
C463077-100g
 100g 期货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
main product photo

基本描述

英文别名 sodium 4-((2R,3R)-2-(2,2-dichloroacetamido)-3-hydroxy-3-(4-nitrophenyl)propoxy)-4-oxobutanoate | Protophenicol | CCRIS 6204 | CHLORAMPHENICOL SODIUM SUCCINATE [USP MONOGRAPH] | Chloramphenicol succinate sodium | LEVOMYCETIN-NALCEIN | sodium;4-[(2R,3R)-2-[
规格或纯度 ≥80%(HPLC)
英文名称 Chloramphenicol succinate sodium salt
作用类型 抑制剂
作用机制 细菌 70S 核糖体抑制剂
产品介绍


Description

Chemical structure: phenicoleChloramphenicol is often used for bacterial selection in molecular biology applications at 10-20 μg/mL and as a selection agent for transformed cells containing chloramphenicol reistance genes.


Preparation instructions

Stock solutions can be prepared directly in the vial at any recommended concentration. A solution at 50 mg/mL in ethanol yields a clear, very faint, yellow solution. Degradation of chloramphenicol in aqueous solution is catalyzed by general acids and bases. This rate of degradation is independent of the ionic strength and pH.

关联靶点（人）

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 小分子
IUPAC Name sodium;4-[(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoate
INCHI InChI=1S/C15H16Cl2N2O8.Na/c16-14(17)15(24)18-10(7-27-12(22)6-5-11(20)21)13(23)8-1-3-9(4-2-8)19(25)26;/h1-4,10,13-14,23H,5-7H2,(H,18,24)(H,20,21);/q;+1/p-1/t10-,13-;/m1./s1
InChi Key RPLOPBHEZLFENN-HTMVYDOJSA-M
Canonical SMILES C1=CC(=CC=C1C(C(COC(=O)CCC(=O)[O-])NC(=O)C(Cl)Cl)O)[N+](=O)[O-].[Na+]
Isomeric SMILES C1=CC(=CC=C1[C@H]([C@@H](COC(=O)CCC(=O)[O-])NC(=O)C(Cl)Cl)O)[N+](=O)[O-].[Na+]
PubChem CID 656833
分子量 445.19

化学和物理性质

溶解性  水：50 毫克/毫升
熔点 >42ºC
分子量 445.200 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 8
可旋转键计数Rotatable Bond Count 9
精确质量Exact Mass 444.01 Da
单同位素质量Monoisotopic Mass 444.01 Da
拓扑极表面积Topological Polar Surface Area 162.000 Ų
重原子数Heavy Atom Count 28
形式电荷Formal Charge 0
复杂度Complexity 541.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 2
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 2

安全和危险性（GHS）

象形图 GHS08
信号词 Warning
危险声明

H351: 怀疑引起遗传缺陷
预防措施声明

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P203: 使用前，获取、阅读并遵守所有安全说明。

P318: 如果暴露或担心，请就医。

 SDS英文版

技术规格说明书

 技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Chang Liu, Diandian Deng, Di Xu, Kang Wu, Hong Yang, Kang Zhao, Jianguo Li, Anping Deng.  (2019)  Development of a monoclonal antibody based-ELISA for the detection of chloramphenicol in shrimp, feed and milk samples and validation by LC-MS/MS coupled with immunoaffinity clean-up.  Analytical Methods,  11  (4): (507-516).  [10.1039/C8AY02284D]

参考文献

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11. L Tammaro,U Costantino,A Bolognese,G Sammartino,G Marenzi,A Calignano,S Tetè,F Mastrangelo,L Califano,V Vittoria.  (2007-02-17)  Nanohybrids for controlled antibiotic release in topical applications..  International journal of antimicrobial agents,  29  ((4)): (417-423).  [PMID:17303393]
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30. Chang Liu, Diandian Deng, Di Xu, Kang Wu, Hong Yang, Kang Zhao, Jianguo Li, Anping Deng.  (2019)  Development of a monoclonal antibody based-ELISA for the detection of chloramphenicol in shrimp, feed and milk samples and validation by LC-MS/MS coupled with immunoaffinity clean-up.  Analytical Methods,  11  (4): (507-516).  [10.1039/C8AY02284D]

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