| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C425782-1ml |
1ml |
期货  |
|
| 别名 | 4-氯-DL-苯基丙氨酸 | CP-10188 | 芬克洛宁 |
|---|---|
| 英文别名 | Fenclonine | 7424-00-2 | 4-Chloro-DL-phenylalanine | DL-4-Chlorophenylalanine | 2-amino-3-(4-chlorophenyl)propanoic acid | p-chlorophenylalanine | Fenchlonine | Fenclonin | DL-p-Chlorophenylalanine | 4-Chlorophenylalanine | DL-PCPA | DL-3-(p-Chlorophenyl)alanine | C-Pal | para-Chl |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | 4-Chloro-DL-phenylalanine |
| 生化机理 | 4-氯-DL-苯丙氨酸（PCPA）是5-羟色胺（5-HT）合成抑制剂。有助于改善肺部组织炎症和重塑肺动脉。PCPA 可减少色氨酸羟化酶1（TPH1）、基质金属蛋白酶（MMP）和促炎因子的表达。 色氨酸羟化酶抑制剂。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 左旋苯丙氨酸羟化酶抑制剂；左旋色氨酸羟化酶 1 抑制剂；左旋色氨酸羟化酶 2 抑制剂 |
| 产品介绍 |
用途 4-氯-DL-苯丙氨酸用于： 作为色氨酸羟化酶1（TPH1）抑制剂，处理 kras+ 雄性斑马鱼 在大鼠模型中诱发失眠 处理胚胎，检查其对5-羟色胺的影响 选择带 pESentA32质粒的粪肠球菌（ Enterococcus faecalis ）转化体 饲喂苍蝇，研究5-羟色胺的作用 Application 4-Chloro-DL-phenylalanine has been used: as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras+ male zebrafish to induce insomnia in rat models used to treat embryos to examine its effect on serotonin for the selection of Enterococcus faecalis transformants with pESentA32 plasmid to feed flies to explore serotonin effect |
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 2-amino-3-(4-chlorophenyl)propanoic acid |
| INCHI | InChI=1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13) |
| InChi Key | NIGWMJHCCYYCSF-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC(=CC=C1CC(C(=O)O)N)Cl |
| Isomeric SMILES | C1=CC(=CC=C1CC(C(=O)O)N)Cl |
| RTECS | AY4390010 |
| PubChem CID | 4652 |
| 分子量 | 199.63 |
| Beilstein号 | 14(1)608 |
| Reaxy-Rn | 2805758 |
| 熔点 | >240°C |
|---|---|
| 分子量 | 199.630 g/mol |
| XLogP3 | -0.500 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 199.04 Da |
| 单同位素质量Monoisotopic Mass | 199.04 Da |
| 拓扑极表面积Topological Polar Surface Area | 63.300 Ų |
| 重原子数Heavy Atom Count | 13 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 178.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 1 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS06, GHS07 |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H301: 吞咽会中毒 H317: 可能引起皮肤过敏反应 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P272: 被污染的工作服不允许离开工作场所 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P330: 漱口 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 |
| RTECS | AY4390010 |
| Reaxy-Rn | 2805758 |
| Concentration | 9-11（mmol/L） |
|---|---|
| Proton NMR spectrum | Conforms to Structure |
| 1. Yu Yang, Zhe Chen, Guangli Yan, Ling Kong, Le Yang, Hui Sun, Ying Han, Jie Zhang, Xijun Wang. (2023) Mass spectrum oriented metabolomics for evaluating the efficacy and discovering the metabolic mechanism of Naoling Pian for insomnia. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 236 (6): (115756). [PMID:37776625] [10.1016/j.jpba.2023.115756] |
| 2. Sun Runbin, Jin Dandan, Fei Fei, Xu Zhi, Cao Bei, Li Juan. (2023) Mushroom polysaccharides from Grifola frondosa (Dicks.) Gray and Inonotus obliquus (Fr.) Pilat ameliorated dextran sulfate sodium-induced colitis in mice by global modulation of systemic metabolism and the gut microbiota. Frontiers in Pharmacology, 14 [PMID:37351508] [10.3389/fphar.2023.1172963] |
| 3. Yinfang Lai, Liping Hua, Jiali Yang, Juewen Xu, Junduo Chen, Shuangshuang Zhang, Shunyao Zhu, Jingjing Li, Senlin Shi. (2023) The Effect of Chinese Agarwood Essential Oil with Cyclodextrin Inclusion against PCPA-Induced Insomnia Rats. MOLECULES, 28 (2): (635). [PMID:36677694] [10.3390/molecules28020635] |
| 4. Peng Yu, Xu Zhang, Guohui Cheng, Haizhen Guo, Xiaoen Shi, Xinlu Zhang, Jun Zhou, Sheng Wang, Zhenggang Wu, Jin Chang. (2022) Construction of a new multifunctional insomnia drug delivery system. CHEMICAL ENGINEERING JOURNAL, 430 (132633). [10.1016/j.cej.2021.132633] |
| 5. Zhengke Zhang, Jialiang Liu, Donald J. Huber, Hongxia Qu, Ze Yun, Taotao Li, Yueming Jiang. (2021) Transcriptome, degradome and physiological analysis provide new insights into the mechanism of inhibition of litchi fruit senescence by melatonin. PLANT SCIENCE, 308 (110926). [PMID:34034874] [10.1016/j.plantsci.2021.110926] |
| 6. Cheng Hu, Ying Chen, Yiyuan Cao, Yiqun Jia, Jiaqi Zhang. (2020) Metabolomics analysis reveals the protective effect of quercetin-3-O-galactoside (Hyperoside) on liver injury in mice induced by acetaminophen. JOURNAL OF FOOD BIOCHEMISTRY, 44 (10): (e13420). [PMID:32744346] [10.1111/jfbc.13420] |
| 7. Cheng Hu, Jiawen Ye, Licong Zhao, Xiulong Li, Yu Wang, Xinhua Liu, Lingyun Pan, Lisha You, Long Chen, Yiqun Jia, Jiaqi Zhang. (2019) 5,7,3′,4′-flavan-on-ol (taxifolin) protects against acetaminophen-induced liver injury by regulating the glutathione pathway. LIFE SCIENCES, 236 (116939). [PMID:31593705] [10.1016/j.lfs.2019.116939] |
| 8. Licong Zhao, Jiaqi Zhang, Lingyun Pan, Long Chen, Yu Wang, Xinhua Liu, Lisha You, Yiqun Jia, Cheng Hu. (2019) Protective effect of 7,3′,4′-flavon-3-ol (fisetin) on acetaminophen-induced hepatotoxicity in vitro and in vivo. PHYTOMEDICINE, 58 (152865). [PMID:30831465] [10.1016/j.phymed.2019.152865] |
| 1. Yu Yang, Zhe Chen, Guangli Yan, Ling Kong, Le Yang, Hui Sun, Ying Han, Jie Zhang, Xijun Wang. (2023) Mass spectrum oriented metabolomics for evaluating the efficacy and discovering the metabolic mechanism of Naoling Pian for insomnia. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 236 (6): (115756). [PMID:37776625] [10.1016/j.jpba.2023.115756] |
| 2. Sun Runbin, Jin Dandan, Fei Fei, Xu Zhi, Cao Bei, Li Juan. (2023) Mushroom polysaccharides from Grifola frondosa (Dicks.) Gray and Inonotus obliquus (Fr.) Pilat ameliorated dextran sulfate sodium-induced colitis in mice by global modulation of systemic metabolism and the gut microbiota. Frontiers in Pharmacology, 14 [PMID:37351508] [10.3389/fphar.2023.1172963] |
| 3. Yinfang Lai, Liping Hua, Jiali Yang, Juewen Xu, Junduo Chen, Shuangshuang Zhang, Shunyao Zhu, Jingjing Li, Senlin Shi. (2023) The Effect of Chinese Agarwood Essential Oil with Cyclodextrin Inclusion against PCPA-Induced Insomnia Rats. MOLECULES, 28 (2): (635). [PMID:36677694] [10.3390/molecules28020635] |
| 4. Peng Yu, Xu Zhang, Guohui Cheng, Haizhen Guo, Xiaoen Shi, Xinlu Zhang, Jun Zhou, Sheng Wang, Zhenggang Wu, Jin Chang. (2022) Construction of a new multifunctional insomnia drug delivery system. CHEMICAL ENGINEERING JOURNAL, 430 (132633). [10.1016/j.cej.2021.132633] |
| 5. Zhengke Zhang, Jialiang Liu, Donald J. Huber, Hongxia Qu, Ze Yun, Taotao Li, Yueming Jiang. (2021) Transcriptome, degradome and physiological analysis provide new insights into the mechanism of inhibition of litchi fruit senescence by melatonin. PLANT SCIENCE, 308 (110926). [PMID:34034874] [10.1016/j.plantsci.2021.110926] |
| 6. Cheng Hu, Ying Chen, Yiyuan Cao, Yiqun Jia, Jiaqi Zhang. (2020) Metabolomics analysis reveals the protective effect of quercetin-3-O-galactoside (Hyperoside) on liver injury in mice induced by acetaminophen. JOURNAL OF FOOD BIOCHEMISTRY, 44 (10): (e13420). [PMID:32744346] [10.1111/jfbc.13420] |
| 7. Cheng Hu, Jiawen Ye, Licong Zhao, Xiulong Li, Yu Wang, Xinhua Liu, Lingyun Pan, Lisha You, Long Chen, Yiqun Jia, Jiaqi Zhang. (2019) 5,7,3′,4′-flavan-on-ol (taxifolin) protects against acetaminophen-induced liver injury by regulating the glutathione pathway. LIFE SCIENCES, 236 (116939). [PMID:31593705] [10.1016/j.lfs.2019.116939] |
| 8. Licong Zhao, Jiaqi Zhang, Lingyun Pan, Long Chen, Yu Wang, Xinhua Liu, Lisha You, Yiqun Jia, Cheng Hu. (2019) Protective effect of 7,3′,4′-flavon-3-ol (fisetin) on acetaminophen-induced hepatotoxicity in vitro and in vivo. PHYTOMEDICINE, 58 (152865). [PMID:30831465] [10.1016/j.phymed.2019.152865] |
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