| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C425087-1ml |
1ml |
现货  |
|
| 别名 | 5-氟-1-己基氨基甲酰基尿嘧啶 |
|---|---|
| 英文别名 | carmofur | 61422-45-5 | HCFU | Mifurol | 1-Hexylcarbamoyl-5-fluorouracil | 5-fluoro-N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide | 1(2H)-Pyrimidinecarboxamide, 5-fluoro-N-hexyl-3,4-dihydro-2,4-dioxo- | NSC-758963 | 5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carb |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Carmofur |
| 生化机理 | 强酸神经酰胺酶抑制剂（IC 50 = 29 nM）。抗代谢药。胞嘧啶嘧啶类似物衍生物的氟尿嘧啶（Asc 2387）。在体内显示抗肿瘤作用。口服具有活性 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
产品应用： Carmofur 已被用作酸性神经酰胺酶抑制剂，以研究其对人胚肾 293T (HEK293T) 细胞中葡萄糖基鞘氨醇 (GlcSph) 生成的影响。它还被用作酸性神经酰胺酶的抑制剂，以研究其对酸介导的神经酰胺水解的影响，神经酰胺会启动消耗和鞘氨醇的产生。 Product Application: Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine. |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide |
| INCHI | InChI=1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18) |
| InChi Key | AOCCBINRVIKJHY-UHFFFAOYSA-N |
| Canonical SMILES | CCCCCCNC(=O)N1C=C(C(=O)NC1=O)F |
| Isomeric SMILES | CCCCCCNC(=O)N1C=C(C(=O)NC1=O)F |
| WGK Germany | 3 |
| RTECS | UV7714000 |
| PubChem CID | 2577 |
| 分子量 | 257.27 |
| Reaxy-Rn | 888898 |
| 敏感性 | 对热敏感 |
|---|---|
| 熔点 | 112 °C(dec.) |
| 分子量 | 257.260 g/mol |
| XLogP3 | 2.600 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 257.118 Da |
| 单同位素质量Monoisotopic Mass | 257.118 Da |
| 拓扑极表面积Topological Polar Surface Area | 78.500 Ų |
| 重原子数Heavy Atom Count | 18 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 382.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS06, GHS08 |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H301: 吞咽会中毒 H361: 怀疑破坏生育力或未出生的孩子 |
| 预防措施声明 |
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P203: 使用前，获取、阅读并遵守所有安全说明。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P318: 如果暴露或担心，请就医。 |
| WGK Germany | 3 |
| RTECS | UV7714000 |
| Reaxy-Rn | 888898 |
| Merck Index | 1844 |
| Concentration | 9-11（mmol/L） |
|---|---|
| Proton NMR spectrum | Conforms to Structure |
| 1. Hanwen Liu, Ying Liu, Ting Zhou, Penghui Zhou, Jianguo Li, Anping Deng. (2022) Ultrasensitive and Specific Detection of Anticancer Drug 5-Fluorouracil in Blood Samples by a Surface-Enhanced Raman Scattering (SERS)-Based Lateral Flow Immunochromatographic Assay. MOLECULES, 27 (13): (4019). [PMID:35807264] [10.3390/molecules27134019] |
| 2. Ting Zhou, Guangzhao He, Changjia Hu, Kang Wu, Ying Liu, Jianguo Li, Anping Deng. (2022) Development of a highly sensitive and specific monoclonal antibody-based ELISA coupled with immuno-affinity extraction for the detection of anticancer drug 5-fluorouracil in blood samples. TALANTA, 249 (123655). [PMID:35696979] [10.1016/j.talanta.2022.123655] |
| 1. Hanwen Liu, Ying Liu, Ting Zhou, Penghui Zhou, Jianguo Li, Anping Deng. (2022) Ultrasensitive and Specific Detection of Anticancer Drug 5-Fluorouracil in Blood Samples by a Surface-Enhanced Raman Scattering (SERS)-Based Lateral Flow Immunochromatographic Assay. MOLECULES, 27 (13): (4019). [PMID:35807264] [10.3390/molecules27134019] |
| 2. Ting Zhou, Guangzhao He, Changjia Hu, Kang Wu, Ying Liu, Jianguo Li, Anping Deng. (2022) Development of a highly sensitive and specific monoclonal antibody-based ELISA coupled with immuno-affinity extraction for the detection of anticancer drug 5-fluorouracil in blood samples. TALANTA, 249 (123655). [PMID:35696979] [10.1016/j.talanta.2022.123655] |
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