货号 (SKU)

包装规格

是否现货

价格

数量

C411992-100μg

100μg

现货

C411992-1mg

1mg

现货

C411992-5mg

5mg

期货

C411992-10mg

10mg

期货

基本信息

产品名称	Cetuximab (anti-EGFR), 表皮生长因子受体抗体
别名	西妥昔单抗 \| EGFR抗体 \| EGFR单克隆抗体 \| EGFR药靶抗体 \| ERBB1抗体 \| ERBB1单克隆抗体 \| ERBB1药靶抗体
英文别名	C225 \| Recombinant Cetuximab Antibody \| Cetuximab (anti-EGFR) \| Cetuximab (C225) \| Anti-ERBB1 / EGFR / HER1 Reference Antibody (cetuximab) \| Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody \| Cell growth inhibiting protein 40 antibo
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
生化机理	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action.
宿主种属	人(Human)
特异性	ERBB1/EGFR/HER1
应用	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性	人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	抑制剂
作用机制	表皮生长因子受体抗体

AI解读

产品属性

抗体类型	Primary antibody
克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	28.4 kDa (Light Chain) & 53.4 kDa (Heavy Chain), under reducing conditions; 184.2 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	205923-56-4
分子类型	抗体

图片

Flow Cytometry: Cetuximab (anti-EGFR) (C411992)

Cetuximab (anti-EGFR) (C411992) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling EGFR (red) with Cetuximab (anti-EGFR) (C411992). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Cetuximab (anti-EGFR) (C411992)

Cetuximab (anti-EGFR) (C411992) - SEC
The purity of Cetuximab (anti-EGFR) (C411992) is more than 95% verified by HPLC.

ELISA: Cetuximab (anti-EGFR) (C411992)

Cetuximab (anti-EGFR) (C411992) - ELISA
Immobilized Human EGFR-Fc at 2 μg/mL can bind Cetuximab (anti-EGFR) (C411992) with the EC₅₀ of 10.67 ng/mL.

ELISA: Cetuximab (anti-EGFR) (C411992)

Cetuximab (anti-EGFR) (C411992) - ELISA
Immobilized Recombinant Human EGFR protein (rp176273) at 1.0 μg/mL can bind Cetuximab (anti-EGFR) (C411992) with the EC50 of 17.44 ng/mL.

关联靶点（人）

EGFR Tclin 表皮生长因子受体(Epidermal growth factor receptor) (0 活性数据)

点击查看靶蛋白信息： EGFR

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 活性数据)

点击查看靶蛋白信息： EGFR

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGFR Tclin MER intracellular domain/EGFR extracellular domain chimera (2 活性数据)

点击查看靶蛋白信息： EGFR

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGFR Tclin Protein cereblon/Epidermal growth factor receptor (191 活性数据)

点击查看靶蛋白信息： EGFR

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGFR Tclin EGFR/PPP1CA (1 活性数据)

点击查看靶蛋白信息： EGFR

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGFR Tclin VHL/EGFR (323 活性数据)

点击查看靶蛋白信息： EGFR

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

安全和危险性（GHS）

SDS英文版

技术规格说明书

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到4个结果

批号(Lot Number)	证书类型	日期	货号
ZJ24F0911235	分析证书	24-09-26	C411992
ZJ24F0911238	分析证书	24-09-26	C411992
ZJ23F0901157	分析证书	23-09-28	C411992
ZJ23F0901156	分析证书	23-09-28	C411992