| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C408360-1ml |
1ml |
现货  |
|
| 别名 | 坎地沙坦（CV-11974） |
|---|---|
| 英文别名 | 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Candesartan (CV-11974) |
| 生化机理 | 坎地沙坦（CV-11974）是一种血管紧张素 II 受体拮抗剂，IC50 值为 0.26 nM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 拮抗剂 |
| 作用机制 | AT 1 受体拮抗剂 |
| 产品介绍 |
Candesartan 是angiotensin II(血管紧张素II)受体拮抗剂， IC50为0.26 nM。A selective angiotensin II receptor antagonist. Information Candesartan (CV-11974) Candesartan (CV-11974) is an angiotensin II receptor antagonist with IC50 of 0.26 nM. Candesartan binds with high specificity to the angiotensin II AT1 receptors in CHO-AT1 cells with K−1 of 0.001 min−1. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%. In vivo Candesartan (10 mg/kg) inhibits the growth of engrafted tumors and reduces the microvessel density and VEGF expression in a mouse KU-19-19 xenograft model Candesartan (0.5 mg/kg) decreases blood pressure and inhibits AT1 binding in the subfornical organ (SFO), paraventricular nucleus of the hypothalamus (PVN), nucleus of the solitary tract (NTS) and area postrema (AP) in WKY rats. Candesartan (0.3 mg/kg) pretreatment decreases the infarct area by 31% in adult spontaneously hypertensive rats, reduces the CBF decrease at the peripheral area of ischemia and the cortical volume of severe ischemic lesion. cell lines：NCI-H2228 cells Concentrations：10 μM Incubation Time：48 hours Powder Purity:≥99% |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | CCOC1=NC2=C([N]1CC3=CC=C(C=C3)C4=CC=CC=C4C5=N[NH]N=N5)C(=CC=C2)C(O)=O |
| 分子量 | 440.45 |
| Concentration(Compounding value) | |
|---|---|
| Record the entire process by video | conform |
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