计算溶液所需的质量、体积或浓度。
活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
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货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
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C304513-100mg |
100mg |
现货 ![]() |
| |
C304513-500mg |
500mg |
现货 ![]() |
| |
C304513-1g |
1g |
现货 ![]() |
| |
C304513-5g |
5g |
期货 ![]() |
|
别名 | 头孢曲松 | 头孢三嗪 |
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英文别名 | 7-[2-(2-Amino-thiazol-4-yl)-2-methoxyimino-acetylamino]-3-(6-hydroxy-2-methyl-5-oxo-2,5-dihydro-[1,2,4]triazin-3-ylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Ceftriaxone) | J01DA13 | C06683 | DTXSID0022773 | 5-Thia-1-aza |
规格或纯度 | Moligand™, ≥95% |
英文名称 | Ceftriaxone |
储存温度 | 避光,-20°C储存,充氩 |
运输条件 | 超低温冰袋运输 |
产品介绍 |
Ceftriaxone 是第三代头孢菌素类抗生素,对多种革兰氏阴性菌有良好的抗菌活性,对大多数革兰氏阳性菌有合理的抗菌活性。具有抗炎和抗氧化特性。 |
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作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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分子类型 | 小分子 |
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IUPAC Name | (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
INCHI | InChI=1S/C18H18N8O7S3/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32)/b24-8-/t9-,15-/m1/s1 |
InChi Key | VAAUVRVFOQPIGI-SPQHTLEESA-N |
Canonical SMILES | CN1C(=NC(=O)C(=O)N1)SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)O |
Isomeric SMILES | CN1C(=NC(=O)C(=O)N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)O |
PubChem CID | 5479530 |
分子量 | 554.58 |
溶解性 | DMSO (Slightly), Methanol (Slightly) |
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敏感性 | 对光线敏感; 对湿度敏感 |
熔点 | >189°C |
分子量 | 554.600 g/mol |
XLogP3 | -1.300 |
氢键供体数Hydrogen Bond Donor Count | 4 |
氢键受体数Hydrogen Bond Acceptor Count | 13 |
可旋转键计数Rotatable Bond Count | 8 |
精确质量Exact Mass | 554.046 Da |
单同位素质量Monoisotopic Mass | 554.046 Da |
拓扑极表面积Topological Polar Surface Area | 288.000 Ų |
重原子数Heavy Atom Count | 36 |
形式电荷Formal Charge | 0 |
复杂度Complexity | 1110.000 |
同位素原子数Isotope Atom Count | 0 |
定义的原子立体中心计数Defined Atom Stereocenter Count | 2 |
未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
定义的键立体中心计数Defined Bond Stereocenter Count | 1 |
未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
所有立体化学键的总数The total count of all stereochemical bonds | 1 |
共价键合单元计数Covalently-Bonded Unit Count | 1 |
象形图 | GHS08, GHS07 |
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信号词 | Danger |
危险声明 |
H317: 可能引起皮肤过敏反应 H334: 吸入可能引起过敏或哮喘病症状或呼吸困难 |
预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染:用水充分清洗。 P321: 特殊处理(请参阅此标签上的...)。 P501: 将内容物/容器处理到。。。 P284: 如果通风不良,请佩戴呼吸防护装置。 P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。 P272: 被污染的工作服不允许离开工作场所 P333+P313: 如发生皮肤刺激或皮疹:求医/就诊。 P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。 P342+P316: 如果出现呼吸道症状:立即寻求急救。 |
Proton NMR spectrum | Conforms to structure |
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Purity(HPLC) | 98-100(%) |
Water by Karl Fischer | 0-1(%) |
Appearance(C304513) | White to off-white to pale yellow solid or liquid |
¥29.90
¥199.90
1. Yangfa Chao, Wenting Huang, Zhiheng Xu, Ping Li, Shaodong Gu. (2023) Effect of RUNX1/FOXP3 axis on apoptosis of T and B lymphocytes and immunosuppression in sepsis. Open Medicine, 18 (1): [PMID:37636994] [10.1515/med-2023-0728] |
2. Yexuan Mao, Yichao Fan, Ran Yang, Youyi Wang, Qingyue Li, Meng Dang, Xianqing Huang, Lianjun Song, Pingan Zhang, Miao Song, Liang Liu, Linli Wang, Shun Yu, Qiuyan Zhao, Xiya Zhang. (2023) A highly sensitive electrochemical sensor derived from peptide amphiphilic inspired self-assembled, ordered gold nanoparticles for determination of 22 β-lactams. ELECTROCHIMICA ACTA, 461 (142669). [10.1016/j.electacta.2023.142669] |
3. Junyu Qian, Haotian Qin, Peijie Zeng, Jiaming Hou, Xiaoshan Mo, Gang Shen, Hui Zeng, Wentai Zhang, Yingqi Chen, Guojiang Wan. (2023) Metal-organic Zn-zoledronic acid and 1-hydroxyethylidene-1,1-diphosphonic acid nanostick-mediated zinc phosphate hybrid coating on biodegradable Zn for osteoporotic fracture healing implants. Acta Biomaterialia, [PMID:37196904] [10.1016/j.actbio.2023.05.020] |
4. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723] [10.1016/j.mcpro.2022.100248] |
5. Shuangmin Wu, Wei Shen, Yushuang Chen, Yongli Zhu, Ren Hou, Menghong Dai, Dapeng Peng. (2022) Rapid Determination of Cephalexin in Animal-Derived Food by an Indirect Competitive Enzyme-Linked Immunosorbent Assay. ANALYTICAL LETTERS, 55 (17): (2803-2816). [10.1080/00032719.2022.2072857] |
6. Miao Z. H., Zhou W. X., Cheng R. Y., Liang H. J., Jiang F. L., Shen X., Lu J. H., Li M., He F.. (2021) Dysbiosis of intestinal microbiota in early life aggravates high-fat diet induced dysmetabolism in adult mice. BMC MICROBIOLOGY, 21 (1): (1-12). [PMID:34238228] [10.1186/s12866-021-02263-6] |
7. Ruyue Cheng, Jiawen Guo, Yujie Zhang, Guo Cheng, Wei Qian, ChaoMin Wan, Ming Li, Francesco Marotta, Xi Shen, Fang He. (2021) Impacts of ceftriaxone exposure during pregnancy on maternal gut and placental microbiota and its influence on maternal and offspring immunity in mice. EXPERIMENTAL ANIMALS, [PMID:33268669] [10.1538/expanim.20-0114] |
8. Yanan Cai, Jing He, Jinkang Zhang, Jicheng Li. (2020) Antibiotic contamination control mediated by manganese oxidizing bacteria in a lab-scale biofilter. Journal of Environmental Sciences, 98 (47). [PMID:33097157] [10.1016/j.jes.2020.05.024] |
9. Miao Zhonghua, Cheng Ruyue, Zhang Yujie, Liang Huijing, Jiang Fengling, Shen Xi, Chen Gong, Zhang Qisheng, He Fang, Li Ming. (2020) Antibiotics can cause weight loss by impairing gut microbiota in mice and the potent benefits of lactobacilli. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 84 (2): (411-420). [PMID:31661358] [10.1080/09168451.2019.1676696] |
10. Chen Lili, Xu Hui, Wang Li, Li Yong, Tian Xike. (2020) Portable ratiometric probe based on the use of europium(III) coordination polymers doped with carbon dots for visual fluorometric determination of oxytetracycline. MICROCHIMICA ACTA, 187 (2): (1-8). [PMID:31938900] [10.1007/s00604-019-4104-3] |
11. Yunlei Zhou, Fei Li, Hanwen Wu, Yan Chen, Huanshun Yin, Shiyun Ai, Jun Wang. (2019) Electrochemical aptasensing strategy for kanamycin detection based on target-triggered single-strand DNA adsorption on MoS2 nanosheets and enzymatic signal amplification. SENSORS AND ACTUATORS B-CHEMICAL, 296 (126664). [10.1016/j.snb.2019.126664] |
12. Cheng RuYue, Guo JiaWen, Pu FangFang, Wan ChaoMin, Shi Lei, Li HuaWen, Yang YuHong, Huang ChengYu, Li Ming, He Fang. (2019) Loading ceftriaxone, vancomycin, and Bifidobacteria bifidum TMC3115 to neonatal mice could differently and consequently affect intestinal microbiota and immunity in adulthood. Scientific Reports, 9 (1): (1-15). [PMID:30824845] [10.1038/s41598-018-35737-1] |
13. Tingting Fang, Hui Wang, Qijia Cui, Matt Rogers, Peiyan Dong. (2018) Diversity of potential antibiotic-resistant bacterial pathogens and the effect of suspended particles on the spread of antibiotic resistance in urban recreational water. WATER RESEARCH, 145 (541). [PMID:30199799] [10.1016/j.watres.2018.08.042] |
1. Yangfa Chao, Wenting Huang, Zhiheng Xu, Ping Li, Shaodong Gu. (2023) Effect of RUNX1/FOXP3 axis on apoptosis of T and B lymphocytes and immunosuppression in sepsis. Open Medicine, 18 (1): [PMID:37636994] [10.1515/med-2023-0728] |
2. Yexuan Mao, Yichao Fan, Ran Yang, Youyi Wang, Qingyue Li, Meng Dang, Xianqing Huang, Lianjun Song, Pingan Zhang, Miao Song, Liang Liu, Linli Wang, Shun Yu, Qiuyan Zhao, Xiya Zhang. (2023) A highly sensitive electrochemical sensor derived from peptide amphiphilic inspired self-assembled, ordered gold nanoparticles for determination of 22 β-lactams. ELECTROCHIMICA ACTA, 461 (142669). [10.1016/j.electacta.2023.142669] |
3. Junyu Qian, Haotian Qin, Peijie Zeng, Jiaming Hou, Xiaoshan Mo, Gang Shen, Hui Zeng, Wentai Zhang, Yingqi Chen, Guojiang Wan. (2023) Metal-organic Zn-zoledronic acid and 1-hydroxyethylidene-1,1-diphosphonic acid nanostick-mediated zinc phosphate hybrid coating on biodegradable Zn for osteoporotic fracture healing implants. Acta Biomaterialia, [PMID:37196904] [10.1016/j.actbio.2023.05.020] |
4. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723] [10.1016/j.mcpro.2022.100248] |
5. Shuangmin Wu, Wei Shen, Yushuang Chen, Yongli Zhu, Ren Hou, Menghong Dai, Dapeng Peng. (2022) Rapid Determination of Cephalexin in Animal-Derived Food by an Indirect Competitive Enzyme-Linked Immunosorbent Assay. ANALYTICAL LETTERS, 55 (17): (2803-2816). [10.1080/00032719.2022.2072857] |
6. Miao Z. H., Zhou W. X., Cheng R. Y., Liang H. J., Jiang F. L., Shen X., Lu J. H., Li M., He F.. (2021) Dysbiosis of intestinal microbiota in early life aggravates high-fat diet induced dysmetabolism in adult mice. BMC MICROBIOLOGY, 21 (1): (1-12). [PMID:34238228] [10.1186/s12866-021-02263-6] |
7. Ruyue Cheng, Jiawen Guo, Yujie Zhang, Guo Cheng, Wei Qian, ChaoMin Wan, Ming Li, Francesco Marotta, Xi Shen, Fang He. (2021) Impacts of ceftriaxone exposure during pregnancy on maternal gut and placental microbiota and its influence on maternal and offspring immunity in mice. EXPERIMENTAL ANIMALS, [PMID:33268669] [10.1538/expanim.20-0114] |
8. Yanan Cai, Jing He, Jinkang Zhang, Jicheng Li. (2020) Antibiotic contamination control mediated by manganese oxidizing bacteria in a lab-scale biofilter. Journal of Environmental Sciences, 98 (47). [PMID:33097157] [10.1016/j.jes.2020.05.024] |
9. Miao Zhonghua, Cheng Ruyue, Zhang Yujie, Liang Huijing, Jiang Fengling, Shen Xi, Chen Gong, Zhang Qisheng, He Fang, Li Ming. (2020) Antibiotics can cause weight loss by impairing gut microbiota in mice and the potent benefits of lactobacilli. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 84 (2): (411-420). [PMID:31661358] [10.1080/09168451.2019.1676696] |
10. Chen Lili, Xu Hui, Wang Li, Li Yong, Tian Xike. (2020) Portable ratiometric probe based on the use of europium(III) coordination polymers doped with carbon dots for visual fluorometric determination of oxytetracycline. MICROCHIMICA ACTA, 187 (2): (1-8). [PMID:31938900] [10.1007/s00604-019-4104-3] |
11. Yunlei Zhou, Fei Li, Hanwen Wu, Yan Chen, Huanshun Yin, Shiyun Ai, Jun Wang. (2019) Electrochemical aptasensing strategy for kanamycin detection based on target-triggered single-strand DNA adsorption on MoS2 nanosheets and enzymatic signal amplification. SENSORS AND ACTUATORS B-CHEMICAL, 296 (126664). [10.1016/j.snb.2019.126664] |
12. Cheng RuYue, Guo JiaWen, Pu FangFang, Wan ChaoMin, Shi Lei, Li HuaWen, Yang YuHong, Huang ChengYu, Li Ming, He Fang. (2019) Loading ceftriaxone, vancomycin, and Bifidobacteria bifidum TMC3115 to neonatal mice could differently and consequently affect intestinal microbiota and immunity in adulthood. Scientific Reports, 9 (1): (1-15). [PMID:30824845] [10.1038/s41598-018-35737-1] |
13. Tingting Fang, Hui Wang, Qijia Cui, Matt Rogers, Peiyan Dong. (2018) Diversity of potential antibiotic-resistant bacterial pathogens and the effect of suspended particles on the spread of antibiotic resistance in urban recreational water. WATER RESEARCH, 145 (541). [PMID:30199799] [10.1016/j.watres.2018.08.042] |