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5-氯-8-羟基喹啉

1篇引用文献
  • ≥97%
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
C118366-25g
 25g 现货 Stock Image
C118366-100g
 100g 现货 Stock Image
C118366-500g
 500g 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
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Anti-infection (2825) Cell Cycle/DNA Damage (2603) Fungal (385) Parasite (431) PPAR (156) Vitamin D Related/Nuclear Receptor (908) 卤代杂环砌块 (1171) 羟基喹啉配体 (12)
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基本描述

别名 氯羟喹 | 5-氯-8-喹啉醇 | 5-氯喹啉酚
英文别名 5-CHLORO-8-HYDROXYQUINOLINE | 5-Chlorooxine
规格或纯度 ≥97%
英文名称 5-Chloro-8-quinolinol
运输条件 常规运输

AI解读

关联靶点（人）

METAP2 Tchem 蛋氨酸氨基肽酶2(Methionine aminopeptidase 2) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
VDR Tclin Vitamin D receptor (26531 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TYR Tclin Tyrosinase (717 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
COMT Tclin Catechol O-methyltransferase (404 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
METAP1 Tchem Methionine aminopeptidase 1 (614 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLB1 Tchem Beta-galactosidase (339 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
METAP2 Tchem Methionine aminopeptidase 2 (1512 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MMP3 Tchem Matrix metalloproteinase 3 (3433 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MMP8 Tchem Matrix metalloproteinase 8 (1942 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSP90AA1 Tchem Heat shock protein HSP 90-alpha (4115 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTPN22 Tchem Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP (1215 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MMP1 Tchem Matrix metalloproteinase-1 (7046 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A-375 (9258 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Daoy (570 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MES-SA (905 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MES-SA/Dx5 (643 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MOLT-4 (49676 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MT4 (17854 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LNCaP (8286 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CCR6 Tchem C-C chemokine receptor type 6 (388 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ABCB11 Tchem Bile salt export pump (2311 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SNCA Tchem Alpha-synuclein (10960 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BRD4 Tchem Bromodomain-containing protein 4 (13122 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TARDBP Tchem TAR DNA-binding protein 43 (40113 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Mmp2 Matrix metalloproteinase-2 (12 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Galc Galactocerebrosidase (11 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
pol Human immunodeficiency virus type 1 integrase (9041 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mycobacterium tuberculosis (203094 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human immunodeficiency virus (3636 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
lef Anthrax lethal factor (7585 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
botA Botulinum neurotoxin type A (1303 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APE1 Vacuolar aminopeptidase 1 (9 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSP90 (947 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Burkholderia thailandensis (182 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504750612
EC号 204-978-1
分子类型 小分子
IUPAC Name 5-chloroquinolin-8-ol
INCHI InChI=1S/C9H6ClNO/c10-7-3-4-8(12)9-6(7)2-1-5-11-9/h1-5,12H
InChi Key CTQMJYWDVABFRZ-UHFFFAOYSA-N
Canonical SMILES C1=CC2=C(C=CC(=C2N=C1)O)Cl
Isomeric SMILES C1=CC2=C(C=CC(=C2N=C1)O)Cl
WGK Germany 3
RTECS VC4590000
PubChem CID 2817
分子量 179.6
Beilstein号 5289
Reaxy-Rn 5289

化学和物理性质

溶解性 Solubility in hot Methanol
熔点 122-124°C
分子量 179.600 g/mol
XLogP3 2.900
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 2
可旋转键计数Rotatable Bond Count 0
精确质量Exact Mass 179.014 Da
单同位素质量Monoisotopic Mass 179.014 Da
拓扑极表面积Topological Polar Surface Area 33.100 Ų
重原子数Heavy Atom Count 12
形式电荷Formal Charge 0
复杂度Complexity 165.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 Warning
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染：用水充分清洗。

P321: 特殊处理（请参阅此标签上的...）。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P271: 仅在室外或通风良好的地方使用。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P403+P233: 存放在通风良好的地方。保持容器密闭。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany 3
RTECS VC4590000
Reaxy-Rn 5289
Merck Index 2422
个人防护装备 dust mask type N95 (US),Eyeshields,Gloves

 SDS英文版

技术规格说明书

Purity(GC) 97-100（%）
Melting point 121-126（℃）
Appearance（C118366) White to pale brown or pale grey powder
Proton NMR spectrum Conforms to structure

 技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到13个结果

批号(Lot Number) 证书类型 日期 货号
K2412325 分析证书 24-11-01 C118366
L2108452 分析证书 24-09-18 C118366
L2108453 分析证书 24-09-18 C118366
D2424139 分析证书 24-04-09 C118366
D2424140 分析证书 24-04-09 C118366
D2424142 分析证书 24-04-09 C118366
C2409017 分析证书 24-02-29 C118366
C2409016 分析证书 24-02-29 C118366
C2409018 分析证书 24-02-29 C118366
C2409055 分析证书 24-02-29 C118366
C2409056 分析证书 24-02-29 C118366
K2009201 分析证书 23-09-05 C118366
H1916151 分析证书 22-06-20 C118366

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可替换产品

  1. 5-氯-8-羟基喹啉
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  2. 7-溴-5-氯-8-羟基喹啉
    7-溴-5-氯-8-羟基喹啉
    • ≥98%

    ¥152.90

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Hongyu Gong, Lin Li, Na Li, Lina Tian, Tao Zhang, Lexin Zhang, Tifeng Jiao.  (2023)  Preparation and Antibacterial Properties of PLA-Based Composite Nanofiber Membrane Material Loaded with Cationic Antibacterial Agent by Electrospinning.  Coatings,  13  (10): (1686).  [PMID:2734021] [10.3390/coatings13101686]

参考文献

1. E J Wojtowicz.  (1984-10-01)  Reverse-phase high-performance liquid chromatographic determination of halogenated 8-hydroxyquinoline compounds in pharmaceuticals and bulk drugs..  Journal of pharmaceutical sciences,  73  ((10)): (1430-1433).  [PMID:6239026]
2. Poonpilas Hongmanee,Kamolchanok Rukseree,Benjamas Buabut,Boontiwa Somsri,Prasit Palittapongarnpim.  (2006-12-21)  In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis..  Antimicrobial agents and chemotherapy,  51  ((3)): (1105-1106).  [PMID:17178795]
3. Jennifer A Jacobsen,Jessica L Fullagar,Melissa T Miller,Seth M Cohen.  (2010-12-30)  Identifying chelators for metalloprotein inhibitors using a fragment-based approach..  Journal of medicinal chemistry,  54  ((2)): (591-602).  [PMID:21189019]
4. Marcos N Soares,Elder F Moscardini,Lucildes P Mercuri,Izilda A Bagatin.  (2013-03-19)  Photoluminescence and thermoanalytical studies of complexes based on 5-Cl-8-hydroxyquinoline and calix[4]arene ligands..  Materials science & engineering. C, Materials for biological applications,  33  ((4)): (2213-2220).  [PMID:23498250]
5. Oleg V Larionov,David Stephens,Adelphe Mfuh,Gabriel Chavez.  (2014-01-15)  Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles from N-oxides..  Organic letters,  16  ((3)): (864-867).  [PMID:24410049]
6. Nikoleta Stoyanova,Dilyana Paneva,Rosica Mincheva,Antoniya Toncheva,Nevena Manolova,Philippe Dubois,Iliya Rashkov.  (2014-06-09)  Poly(L-lactide) and poly(butylene succinate) immiscible blends: from electrospinning to biologically active materials..  Materials science & engineering. C, Materials for biological applications,  41  (119-126).  [PMID:24907744]
7. V Arjunan,S Mohan,P Ravindran,C V Mythili.  (2008-12-30)  Vibrational spectroscopic investigations, ab initio and DFT studies on 7-bromo-5-chloro-8-hydroxyquinoline..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  72  ((4)): (783-788).  [PMID:19112045]
8. Hongyu Gong, Lin Li, Na Li, Lina Tian, Tao Zhang, Lexin Zhang, Tifeng Jiao.  (2023)  Preparation and Antibacterial Properties of PLA-Based Composite Nanofiber Membrane Material Loaded with Cationic Antibacterial Agent by Electrospinning.  Coatings,  13  (10): (1686).  [PMID:2734021] [10.3390/coatings13101686]

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