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阿糖胞苷, DNA 聚合酶（α/δ/epsilon）抑制剂

嘧啶核苷类似物
16篇引用文献
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货号 (SKU) 包装规格 是否现货 价格 数量
C111218-1g
 1g 现货 Stock Image
C111218-5g
 5g 现货 Stock Image
C111218-25g
 25g 现货 Stock Image
C111218-100g
 100g 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
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Anti-infection (2825) Apoptosis (1467) Autophagy (555) Cell Cycle/DNA Damage (2603) DNA/RNA Synthesis (362) Endogenous Metabolite (981) HSV (104) Metabolic Enzyme/Protease (4888) Nucleoside Antimetabolite/Analog (199) Orthopoxvirus (58) 六元杂环化合物 (1702) 嘧啶类 (541)
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基本描述

别名 阿糖胞嘧啶 | 胞嘧啶 β-D-呋喃阿拉伯糖苷 | 4-氨基-1-β-D-阿拉伯呋喃糖基-2(1H)-嘧啶酮
英文别名 Cytosar | Cytosine 1-beta-D-arabinofuranoside | Ara-cell | Cytosine arabinoside (VAN) | Cytosine-1-beta-arabinofuranoside | Cytarabine (USAN:USP:INN:BAN:JAN) | CYTARABINE (USP MONOGRAPH) | UNII-04079A1RDZ | Iretin | 1-beta-D-Arabinosylcytosine | 1beta-D-A
规格或纯度 Moligand™, ≥98%
英文名称 Cytosine β-D-arabinofuranoside
生化机理 嘧啶核苷类似物能够抑制DNA合成。在细胞周期的S期特别活跃。化学治疗剂。抗病毒和免疫抑制剂特性。
应用 Ara-C 插入DNA，靠和拓扑异构酶I（topoisomerase I）形成络合物抑制DNA复制，导致DNA裂解。不能抑制RNA合成。
储存温度 2-8°C储存
运输条件 冰袋运输
作用类型 抑制剂
作用机制 DNA 聚合酶（α/δ/epsilon）抑制剂
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

溶于水，部分溶于甲醇，几乎不溶于乙醚，本品以D-阿拉伯糖或5′-胞嘧啶核苷酸为原料制得。常用其盐酸盐。 Ara-C 插入DNA，靠和拓扑异构酶I（topoisomerase I）形成络合物抑制DNA复制，导致DNA裂解。不能抑制RNA合成。

AI解读

产品属性

ALogP -2.1

关联靶点（人）

MDM2 Tchem E3 泛素蛋白连接酶 Mdm2(E3 ubiquitin-protein ligase Mdm2) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DHFR Tclin Dihydrofolate reductase (3072 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TYMS Tclin Thymidylate synthase (1651 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
INSR Tclin Insulin receptor (5558 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

TK Thymidine kinase (276 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Agtr2 Angiotensin II type 2 (AT-2) receptor (803 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Deoxycytidylate deaminase (6 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Sigmar1 Sigma opioid receptor (160 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cda Cytidine deaminase (37 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cckar Cholecystokinin A receptor (90 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pde4d Phosphodiesterase 4D (4 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
dnk Deoxynucleoside kinase (95 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Streptococcus sp. (212 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Streptococcus pyogenes (16140 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pneumocystis carinii (749 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania infantum (5912 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma brucei (78846 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma brucei brucei (13300 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Entamoeba histolytica (2676 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cryptosporidium parvum (1150 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania amazonensis (3813 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania donovani (89745 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania major (2877 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Leishmania mexicana (936 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma cruzi (99888 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trichomonas vaginalis (2376 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Toxoplasma gondii (4585 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human alphaherpesvirus 2 (4932 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human respirovirus 3 (1674 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Suid alphaherpesvirus 1 (32 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Vaccinia virus (4609 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Human alphaherpesvirus 1 (11089 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hepatitis C virus (23859 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Vesicular stomatitis virus (4460 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trypanosoma brucei rhodesiense (7991 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
B16 (5829 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BSC-1 (357 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CCRF S-180 (1031 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 488180029
EC号 205-705-9
分子类型 小分子
IUPAC Name 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
INCHI InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1
InChi Key UHDGCWIWMRVCDJ-CCXZUQQUSA-N
Canonical SMILES C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
Isomeric SMILES C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)O
WGK Germany 3
RTECS HA5425000
PubChem CID 6253
分子量 243.22
Beilstein号 89175
Reaxy-Rn 89175

化学和物理性质

溶解性 可溶于水
密度 1.89
比旋光度 158 ° (C=1, H2O)
熔点 214°C
分子量 243.220 g/mol
XLogP3 -2.100
氢键供体数Hydrogen Bond Donor Count 4
氢键受体数Hydrogen Bond Acceptor Count 5
可旋转键计数Rotatable Bond Count 2
精确质量Exact Mass 243.086 Da
单同位素质量Monoisotopic Mass 243.086 Da
拓扑极表面积Topological Polar Surface Area 129.000 Ų
重原子数Heavy Atom Count 17
形式电荷Formal Charge 0
复杂度Complexity 383.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 4
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS08,   GHS07
信号词 Danger
危险声明

H317: 可能引起皮肤过敏反应

H360: 可能损害生育力或未出生的孩子

H340: 可能导致遗传缺陷

H361: 怀疑破坏生育力或未出生的孩子
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染：用水充分清洗。

P321: 特殊处理（请参阅此标签上的...）。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P281: 根据需要使用个人防护设备。

P272: 被污染的工作服不允许离开工作场所

P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P203: 使用前，获取、阅读并遵守所有安全说明。

P318: 如果暴露或担心，请就医。
WGK Germany 3
RTECS HA5425000
Reaxy-Rn 89175
Merck Index 2784
个人防护装备 Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

 SDS英文版

技术规格说明书

Specific Rotation [a]20/D(c=1 in H2O) 155-162（°）
Purity(HPLC) 98-100（%）
Appearance（C111218) White to Off-White Powder
Proton NMR spectrum Conforms to Structure

 技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到9个结果

批号(Lot Number) 证书类型 日期 货号
H2408320 分析证书 24-04-02 C111218
E2019049 分析证书 24-03-13 C111218
E2326874 分析证书 23-01-09 C111218
E2326877 分析证书 23-01-09 C111218
E2326878 分析证书 23-01-09 C111218
E2326879 分析证书 23-01-09 C111218
E2326903 分析证书 23-01-09 C111218
E2326905 分析证书 23-01-09 C111218
E2326907 分析证书 23-01-09 C111218

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FAQ
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标签:
抑制剂 DNA
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分类: 技术文章
标签:
核苷 核苷酸

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2. Yue-Ming Yu, Fan-Zhi Bu, Su-Su Meng, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li.  (2023)  The first nano-cocrystal formulation of marine drug cytarabine with uracil based on cocrystal nanonization strategy for long-acting injection exhibiting enhanced antitumor activity.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  644  (123300).  [PMID:37567370] [10.1016/j.ijpharm.2023.123300]
3. Lejiao Jia, Huatian Yang, Dandan Zheng, Jingjing Ye, Qian Zhou, Genjv Li, Ying Zhou, Xinyu Yang, Jinting Liu, Feng Ye, Yuliang Song, Daoxin Ma, Chunyan Ji.  (2023)  Smart and Generalizable Cytarabine Derivative-Triggered Nanoparticles for Synergistic Therapy of Relapsed/Refractory Acute Myeloid Leukemia.  ACS Applied Materials & Interfaces,  15  (23): (27624–27637).  [PMID:37249260] [10.1021/acsami.3c03632]
4. Siyu Wang, Lutong Wang, Jingwen Xu, Yihai Wang, Limin Xiang, Xiangjiu He.  (2023)  Synergistic Combination of the Total Steroidal Saponins from the Berries of Black Nightshade and Adriamycin to Overcome Leukemia Multidrug Resistance.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  71  (7): (3315–3324).  [PMID:36752041] [10.1021/acs.jafc.2c07740]
5. Wang Pengwei, Mao Senlin, Yi Tingting, Wang Lihua.  (2023)  LncRNA MALAT1 Targets miR-9-3p to Upregulate SAP97 in the Hippocampus of Mice with Vascular Dementia.  BIOCHEMICAL GENETICS,  61  (3): (916-930).  [PMID:36227424] [10.1007/s10528-022-10289-2]
6. Jie Zhao, Yue Wu, Shanshan Liang, Xiangyu Piao.  (2022)  Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis.  NEUROSCIENCE,  485  (78).  [PMID:35090880] [10.1016/j.neuroscience.2022.01.017]
7. Dan Shao, Qiang Gao, Yanshan Sheng, Shangji Li, Yong Kong.  (2022)  Construction of a dual-responsive dual-drug delivery platform based on the hybrids of mesoporous silica, sodium hyaluronate, chitosan and oxidized sodium carboxymethyl cellulose.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  202  (37).  [PMID:35033530] [10.1016/j.ijbiomac.2022.01.033]
8. Lefeng Liu, Zhiguo Xu, Yang Liu, Zheng-Zhi Yin, Yanshan Sheng, Chengqiang Ding, Yong Kong.  (2021)  Facile synthesis of calcium carbonate/polyacrylic acid hydrogels for pH-responsive delivery of cytarabine.  Journal of Saudi Chemical Society,  25  (101344).  [10.1016/j.jscs.2021.101344]
9. Yuzhe Chen, Wenxuan Zhao, Honglian Dai.  (2021)  Porous PLGA-PEG nerve conduit decorated with oriented electrospun chitosan-RGD nanofibre.  Journal of Materials Research and Technology-JMR&T,  15  (86).  [10.1016/j.jmrt.2021.07.117]
10. Kai Chen, Yong Qian, Chaoyang Wang, Dongjie Yang, Xueqing Qiu, Bernard P. Binks.  (2021)  Tumor microenvironment-responsive, high internal phase Pickering emulsions stabilized by lignin/chitosan oligosaccharide particles for synergistic cancer therapy.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  591  (352).  [PMID:33618293] [10.1016/j.jcis.2021.02.012]
11. Qiang Gao, Jun Gao, Chengqiang Ding, Shangji Li, Linhong Deng, Yong Kong.  (2021)  Construction of a pH- and near-infrared irradiation-responsive nanoplatform for chemo-photothermal therapy.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  593  (120112).  [PMID:33259903] [10.1016/j.ijpharm.2020.120112]
12. Yanshan Sheng, Wei Dai, Jun Gao, Hongda Li, Wensheng Tan, Jingwei Wang, Linhong Deng, Yong Kong.  (2020)  pH-sensitive drug delivery based on chitosan wrapped graphene quantum dots with enhanced fluorescent stability.  Materials Science & Engineering C-Materials for Biological Applications,  112  (110888).  [PMID:32409046] [10.1016/j.msec.2020.110888]
13. Zhigang Fang, Xiaozhen Wang, Yanling Sun, Ruifang Fan, Zhong Liu, Rui Guo, Deming Xie.  (2019)  Sgc8 aptamer targeted glutathione-responsive nanoassemblies containing Ara-C prodrug for the treatment of acute lymphoblastic leukemia.  Nanoscale,  11  (47): (23000-23012).  [PMID:31769777] [10.1039/C9NR07391D]
14. Jing Liu, Dujuan Zhao, Wenxiu He, Huiyuan Zhang, Zhonghao Li, Yuxia Luan.  (2017)  Nanoassemblies from amphiphilic cytarabine prodrug for leukemia targeted therapy.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  487  (239).  [PMID:27776282] [10.1016/j.jcis.2016.10.041]
15. Jing Liu, Jing Liu, Dujuan Zhao, Naxin Ma, Yuxia Luan.  (2016)  Highly enhanced leukemia therapy and oral bioavailability from a novel amphiphilic prodrug of cytarabine.  RSC Advances,  6  (42): (35991-35999).  [10.1039/C6RA02051H]
16. Yadong Tang,Boxin Huang,Yuqin Dong,Wenlong Wang,Xi Zheng,Wei Zhou,Kun Zhang,Zhiyun Du.  (2017-06-07)  Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy..  Journal of biomaterials science. Polymer edition,  28  ((14)): (1603-1616).  [PMID:28583017]

参考文献

1. Lautenschläger J et al..  (2018)  An Easy-to-Implement Protocol for Preparing Postnatal Ventral Mesencephalic Cultures..  Front Cell Neurosci,  12  (44).  [PMID:29556177]
2. Qiankun Quan, Xinxin Ma, Ming Li, Xi Li, Haifeng Yuan.  (2024)  Ginsenoside Rg1 promotes β‑amyloid peptide degradation through inhibition of the ERK/PPARγ phosphorylation pathway in an Alzheimer's disease neuronal model.  Experimental and Therapeutic Medicine,  27  (1): (1-13).  [PMID:38125359] [10.3892/etm.2023.12319]
3. Yue-Ming Yu, Fan-Zhi Bu, Su-Su Meng, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li.  (2023)  The first nano-cocrystal formulation of marine drug cytarabine with uracil based on cocrystal nanonization strategy for long-acting injection exhibiting enhanced antitumor activity.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  644  (123300).  [PMID:37567370] [10.1016/j.ijpharm.2023.123300]
4. Lejiao Jia, Huatian Yang, Dandan Zheng, Jingjing Ye, Qian Zhou, Genjv Li, Ying Zhou, Xinyu Yang, Jinting Liu, Feng Ye, Yuliang Song, Daoxin Ma, Chunyan Ji.  (2023)  Smart and Generalizable Cytarabine Derivative-Triggered Nanoparticles for Synergistic Therapy of Relapsed/Refractory Acute Myeloid Leukemia.  ACS Applied Materials & Interfaces,  15  (23): (27624–27637).  [PMID:37249260] [10.1021/acsami.3c03632]
5. Siyu Wang, Lutong Wang, Jingwen Xu, Yihai Wang, Limin Xiang, Xiangjiu He.  (2023)  Synergistic Combination of the Total Steroidal Saponins from the Berries of Black Nightshade and Adriamycin to Overcome Leukemia Multidrug Resistance.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  71  (7): (3315–3324).  [PMID:36752041] [10.1021/acs.jafc.2c07740]
6. Wang Pengwei, Mao Senlin, Yi Tingting, Wang Lihua.  (2023)  LncRNA MALAT1 Targets miR-9-3p to Upregulate SAP97 in the Hippocampus of Mice with Vascular Dementia.  BIOCHEMICAL GENETICS,  61  (3): (916-930).  [PMID:36227424] [10.1007/s10528-022-10289-2]
7. Jie Zhao, Yue Wu, Shanshan Liang, Xiangyu Piao.  (2022)  Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis.  NEUROSCIENCE,  485  (78).  [PMID:35090880] [10.1016/j.neuroscience.2022.01.017]
8. Dan Shao, Qiang Gao, Yanshan Sheng, Shangji Li, Yong Kong.  (2022)  Construction of a dual-responsive dual-drug delivery platform based on the hybrids of mesoporous silica, sodium hyaluronate, chitosan and oxidized sodium carboxymethyl cellulose.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  202  (37).  [PMID:35033530] [10.1016/j.ijbiomac.2022.01.033]
9. Lefeng Liu, Zhiguo Xu, Yang Liu, Zheng-Zhi Yin, Yanshan Sheng, Chengqiang Ding, Yong Kong.  (2021)  Facile synthesis of calcium carbonate/polyacrylic acid hydrogels for pH-responsive delivery of cytarabine.  Journal of Saudi Chemical Society,  25  (101344).  [10.1016/j.jscs.2021.101344]
10. Yuzhe Chen, Wenxuan Zhao, Honglian Dai.  (2021)  Porous PLGA-PEG nerve conduit decorated with oriented electrospun chitosan-RGD nanofibre.  Journal of Materials Research and Technology-JMR&T,  15  (86).  [10.1016/j.jmrt.2021.07.117]
11. Kai Chen, Yong Qian, Chaoyang Wang, Dongjie Yang, Xueqing Qiu, Bernard P. Binks.  (2021)  Tumor microenvironment-responsive, high internal phase Pickering emulsions stabilized by lignin/chitosan oligosaccharide particles for synergistic cancer therapy.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  591  (352).  [PMID:33618293] [10.1016/j.jcis.2021.02.012]
12. Qiang Gao, Jun Gao, Chengqiang Ding, Shangji Li, Linhong Deng, Yong Kong.  (2021)  Construction of a pH- and near-infrared irradiation-responsive nanoplatform for chemo-photothermal therapy.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  593  (120112).  [PMID:33259903] [10.1016/j.ijpharm.2020.120112]
13. Yanshan Sheng, Wei Dai, Jun Gao, Hongda Li, Wensheng Tan, Jingwei Wang, Linhong Deng, Yong Kong.  (2020)  pH-sensitive drug delivery based on chitosan wrapped graphene quantum dots with enhanced fluorescent stability.  Materials Science & Engineering C-Materials for Biological Applications,  112  (110888).  [PMID:32409046] [10.1016/j.msec.2020.110888]
14. Zhigang Fang, Xiaozhen Wang, Yanling Sun, Ruifang Fan, Zhong Liu, Rui Guo, Deming Xie.  (2019)  Sgc8 aptamer targeted glutathione-responsive nanoassemblies containing Ara-C prodrug for the treatment of acute lymphoblastic leukemia.  Nanoscale,  11  (47): (23000-23012).  [PMID:31769777] [10.1039/C9NR07391D]
15. Jing Liu, Dujuan Zhao, Wenxiu He, Huiyuan Zhang, Zhonghao Li, Yuxia Luan.  (2017)  Nanoassemblies from amphiphilic cytarabine prodrug for leukemia targeted therapy.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  487  (239).  [PMID:27776282] [10.1016/j.jcis.2016.10.041]
16. Jing Liu, Jing Liu, Dujuan Zhao, Naxin Ma, Yuxia Luan.  (2016)  Highly enhanced leukemia therapy and oral bioavailability from a novel amphiphilic prodrug of cytarabine.  RSC Advances,  6  (42): (35991-35999).  [10.1039/C6RA02051H]
17. Yadong Tang,Boxin Huang,Yuqin Dong,Wenlong Wang,Xi Zheng,Wei Zhou,Kun Zhang,Zhiyun Du.  (2017-06-07)  Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy..  Journal of biomaterials science. Polymer edition,  28  ((14)): (1603-1616).  [PMID:28583017]

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